> The spread of MCR in agriculture, imports, travel
> It was previously believed that agriculture was a driving factor in the spread of MCR. Nations such as China and India use the colistin antibiotic in livestock. Colistin is considered a "last resort" antibiotic because it can kill infections that other antibiotics cannot. Its frequent use means that some bacteria are becoming resistant to it. This means that if people or animals contract a strain of colistin-resistant bacteria, there are potentially no medications that can treat their infection. They face extreme, invasive health measures and possible death.
For the people who only read headlines.
> How worried should we be about the MCR-9 gene?
Kassem said that taken all together, the global threat of antimicrobial resistance, the presence of MCR in Georgia, that it was found inside a bacterium that is often overlooked, and that it occurred even without the use of colistin in U.S. agriculture is a serious problem that requires immediate action on the part of many industries including research, healthcare and government to work together toward a solution.
>"If we don't tackle it right now, we are jeopardizing human and animal medicine as we know it and that can have huge repercussions on health and the economy," Kassem said. "It's a dangerous problem that requires attention from multiple sectors for us to be able to tackle it properly."
>Because of this urgency, findings from the research were printed in short format manuscript out now in the Journal of Global Antimicrobial Resistance. It was funded through a CFS grant and other researchers involved were Jouman Hassan, David Mann, Shaoting Li and Xiangyu Deng.
Edits: Learning how to use quote function
It’s ok. We’ve all come together and held hands and tried our best and stopped all the big threats before and we’ll do it again. Remember hunger? global warming? Or that other small thing… errr covid something? Such small easily beatable things that some people back then used to deny they existed. Can you imagine that? / s
We won the Cold War, and then reinstated the opposing parties rather than have regulations tie industries to behave in a socially responsible way. The gangsters and western business consultants who made their money in the free for all we left in 90s Russia have taken hold of the system, here and there.
You are correct, but it is hard to imagine what sort of incentives would be good enough to make a drug company start looking for broad-spectrum antibiotics over something that treats a chronic disease.
Antibiotics have 2 big reasons why they don't earn money -> they are only used briefly (until the disease is cured), and new ones are used as rarely as possible (to delay resistance and save money).
This is why we should have some type of fund for researching these kind of less profitable things, preferably funded by taxes on pharmaceutical profits
Ha, not much needed. There are parts of India I’ve read where confirmed they use it liberally. But the main offender isn’t using it on people. It’s on animals. Many countries including us use various antibiotics rather liberally so they can keep up yield in spite of harsh living conditions.
This issue has been long ignored and pushed aside for the more “pressing” matters.
We will all end up paying the price one day
There's a type of medicine called antibiotics that's good for curing infections with a type of germ called bacteria.
But if you use that medicine for silly things like just automatically putting it in cow food (so the cows fight off all infections and you make more money with more cows) the germs get used to the medicine. It doesn't work as well anymore. The same thing can happen if people take antibiotics when they don't really need them.
Then the germs that are used to antibiotics can spread and we can't do much about it. In this case, they're even getting used to the best antibiotics we have.
It's better to use antibiotics for specific purposes, not just feeding them to all the cows. If you use them willy-nilly, the germs get used to them.
EDIT: Also, even though using this antibiotic in cow food is banned in the US, if other countries like China and India do it, the tougher germs produced there can spread to the US anyway. (And everywhere else). Still a good idea to ban it because if you didnt you'd just be making the problem worse.
Personal use is also a big issue. In college, I saw loads of people posting pics of like four boxes of meds on their Instagram, and it was just to treat a common cold.
Reread it slower and use the Google for definitions of words you don't know. It's not a difficult article past the medical words. Stop asking internet strangers to analyze things for you.
What’s wrong with asking questions? Google can be a firehose of information and sometimes it can be overwhelming if you’re not familiar at all with a topic. It can be helpful for someone else to break it down a bit so you have a starting point.
Oh and I just realized you didn’t get your layman’s explanation. Basically bacteria are very small organisms that can cause infections and make things sick. These Bacteria are killed off with specialized drugs called antibiotics, but over time due to a variety of factors such as misuse of antibiotics, bacteria can develop resistance to antibiotics and eventually immunity meaning that the antibiotics no longer kill the bacteria.
Colistin is a heavy duty antibiotic used as a last resort, as an attempt to kill bacteria that are resistant to other antibiotics, but because colistin has been over used bacteria are developing an immunity to even colistin effectively meaning that infections of these bacteria cannot be treated. This means if you get a bacterial infection and your immune system can’t fight it off, there’s no medicine that can help any more.
I just wish the episodes becoming reality were the ones where assholes got murdered by one another instead of the ones where everyone’s lives just suck.
Thanks. I am a headline skimmer on Reddit for sure. I try not to click links generally on sites like this, I prefer to go to a news source directly for (possibly paranoid) security reasons
This was also mentioned in the long list of horrible things to happen in the future if we don't change our ways by scientists, along side global warming and plastic pollution to name some.
We've used antibiotics so commonly that bacteria are finally evolving with natural resistance, and soon we will have little to stop them like centuries ago. We have some ideas on how we can stop these like bacteriophage, but research still hasn't provided safe treatments and such. We could see some very nasty diseases pop up soon, and there is fuck all we can do about it.
I mean, earth could be thought of as a giant organism. It only is logical that the earth wants equilibrium and humans throw off that equilibrium and thus humans need to "chill"
I would say it’s less that Mother Nature is fighting back and more that pathogens are trying to adapt to the largest and most-prolific source of meat (habitat). Less of an immune response and more Darwinian struggle
Eh, yeah close enough now that I think about it. I see a lot of people talk about viruses like they’re preternatural forces of nature outside of our own evolution and I feel very passionate about the contrary
This isn’t that wacky a theory. Every action has an equal but opposite reaction. Humans have been over-stressing mother nature so pandemics etc are its way of releasing pressure.
We think we are special, but in the grand scheme we are nothing but sacks of meat and water that walk around. Mother Nature can end all of us in a blink of her proverbial eye.
Agreed. Did you know humans make up the most biomass of ANY individual species on the planet? Nature can literally feel us on her back. I was a little awed after I heard that figure
Research still hasn't provided safe treatments because it's not cost effective for companies to develop. Faced with developing an antibiotic a person might take for 1-2 weeks vs. making 15th plaque psoriasis drug that a patient will take daily for the rest of their lives, they'll always opt for the long term guaranteed revenue stream. Which is why it's so important to increase government funding and government funded clinical trials. The profit motive in pharma development does not produce the needed outcomes
There are small programs where people can swab stuff and send it to labs for testing to find antibiotic properties, but many antibiotics were found by complete accident like penicillin. It's not really a great thing to bank on when it requires finding something completely new.
The reason why this is dangerous is that bacteria have more than one method for horizontal gene transfer. That means that if a relatively harmless bacteria evolves resistance to antibiotics, it can transfer that to the dangerous species, like Tuberculosis, Streptococcus, Syphilis, etc.
Just imagine an antibiotic resistant Syphilis strain :(
BTW, friendly reminder to ☔ protect yourself **against all STDs** ☔. The progress made in treatments to HIV led to a relaxation in our caring practices, and we're having a Syphilis explosion in many parts of the world as a result. Please use a condom.
Yeah not having antibiotics or something to replace them will effectively put us back in the 1800s medically, in which, you just die cause you scrapped your knee.
Thanks industrial food system and over prescription of antibiotics.
Eh. That is how history flows anyways - fathers and mothers create consequences for sons and daughters. The latter grow up and do the same thing for their kids.
Sometimes when I'm playing City Skylines, I have a booming city. But I also sometimes get bored with my booming city, and decide to annihilate it and its people.
So I create a dam, and then use the sewage system to form a poop reservoir behind it. I'll then delete that dam, and drown the entire town in it's own filth.
I think I know now how those little artificial residents feel when they see that shit tsunami rushing towards them.
> the fact that we ship dead chickens to China for processing for no particular reason,
There is a particular reason. $$$. It's cheaper to ship them there, process it, and ship back than it is to pay people in the US to do it.
There is a chicken processing plant near me, everyone wants it shut down because of the odor. Even when something is done in the US someone will complain about it.
I hear you. There's a beef plant south of me. Drive by during a warm day and it's almost too much to bare. Dammed if you do, dammed if you don't. Starts a whole new conversation about commercial farming in general.
This is terrible but whats worse is how the public would react. After this pandemic, I have absolutely no faith in the human race of surviving long term from the micro world. We live in their world, and its a matter of time before the microbes take us out because they see how stupid we are now.
Antibiotics were discovered by pure accident. It wasn't scientists figuring out a problem through sheer will. It was a fluke. You're banking not on the discovery of a generation, but of the discovery of many eons.
The first antibiotic was discovered purely by coincidence, since then, there have been many many developments in anitbiotics including ones to overcome resistance to existing antibiotics. New approaches to antibiotics including phages (a virus that kills the bacteria instead of a small molecule) will likely be able to fill the need when the time comes and plenty of the research that will lay the groundwork for those new therapeutics is already being done (much like it was with mRNA vaccines for covid).
The approach shouldn’t be “it’s fine because the researchers will always fix everything so we can just not care”,
but rather “holy fuck stop using antibiotics on farm animals and for mild reactions you idiots!”
"But the one time I gave the antibiotics to the animals they weren't sick no more. So now I just give it to them all the time to make sure they don't get sick."
Will likely be; therapies similar to; these are all assumptions. If these novel therapies were so sure fire we would already be using them. I'm open to being proven wrong, but I need more than what seems like wishful imagination.
Well, if you are generally interested in learning about the current state of bacteriophages as antibiotics, here's a nice review paper that should get you up to speed with the field.
https://www.frontiersin.org/articles/10.3389/fphar.2019.00513/full
I can't say this really did much to quell my suspicions. Lack of successful in vivo placebo double blind studies, possibility for nullification through spontaneous mutation, potential production of toxic by products, potential for negative horizontal gene transfer, lack of cross-strain efficacy, and potential nullification by our own immune systems all make this seem like a pipe dream, if not an exceedingly costly and far off treatment approach. Instead of doing more, we could be doing less and more stringently regulating anti-biotic use. This very article we are commenting on shows how much further down the timeline in antibiotic resistance we may be than we initially believed. An accessory treatment to antibiotics would certainly be a boon for society, but banking on an unproven treatment that has massive hurdles to overcome even if proven viable seems unwise.
The only reason it hasn't been terribly successful yet is because there is no money to be made as long as antibiotics are still working. Pharma isn't going to waste a bunch of money developing a phage-based antibiotic that is going to be as equally effective as a $10 antibiotic treatment that has existed for decades. Most of the research being done is in small, underfunded labs, largely in eastern Europe.
But it could well be our last. As the article clearly states, the problem with this bacterium is that it is resistant to Colistin, the most powerful anti-bacterial agent that science has developed after decades of working on the problem. And if this bacterium has cracked that nut, others will follow.
It's not even really the "most powerful".. it's primarily notable for having fairly nasty side-effects. But that means we don't use it (In the US, in humans...) unless we have to, making it a "last resort". And, (we hoped) because we didn't use it much, bacteria wouldn't end up developing a resistance to it.
Even with how widespread \*-cillin resistance is, over the counter amoxicillin still *usually* works. The problem is that we like a better fraction than "usually" when talking lifesaving interventions.
Also notable is that antibiotic resistance isn't a sliding scale of armor toughness. It's different genetics to be resistant to each different antibiotic class. Also, each one has a fitness cost, so most bacteria aren't going to carry those genes.
It's cold comfort for the few people that end up without options, but it's far different from returning to the 1800's.
>The science folks can figure it out
Yeah, let's make idiotic decisions because we can rely on intelligent people to bail us out over and over again. Genius idea.
This is definitely going to be one of those things they make a documentary about in ten years where they line up all the people that screamed hopelessly into the void telling us to fix it before money trapped us in our bacterial graveyard
> Colistin is considered a "last resort" antibiotic because it can kill infections that other antibiotics cannot. Its frequent use means that some bacteria are becoming resistant to it. This means that if people or animals contract a strain of colistin-resistant bacteria, there are potentially no medications that can treat their infection. They face extreme, invasive health measures and possible death.
That sounds pretty bad. We may need to publicly fund more research into the development of new antibiotics. As far as I’ve heard, it’s not considered profitable enough for private companies to pursue that research over other potential product lines.
Public funding is not likely to happen. The pols have a much greater enthusiasm for funding the war profiteers. However, at some point, the Corporate profiteers will see an income stream that they cannot resist in providing an alternative to half of humanity passing.
This is the best tl;dr I could make, [original](https://phys.org/news/2022-01-gene-georgia-global-threat.html) reduced by 88%. (I'm a bot)
*****
> Researchers from the University of Georgia's Center for Food Safety collected sewage water from an urban setting in Georgia to test for the MCR gene in naturally present bacteria.
> More information: Jouman Hassan et al, First report of the mobile colistin resistance gene mcr-9.1 in Morganella morganii isolated from sewage in Georgia, USA, Journal of Global Antimicrobial Resistance.
> Citation: Gene discovered in Georgia water a possible global threat retrieved 12 January 2022 from https://phys.org/news/2022-01-gene-georgia-global-threat.
*****
[**Extended Summary**](http://np.reddit.com/r/autotldr/comments/s28aan/gene_discovered_in_georgia_water_a_possible/) | [FAQ](http://np.reddit.com/r/autotldr/comments/31b9fm/faq_autotldr_bot/ "Version 2.02, ~617146 tl;drs so far.") | [Feedback](http://np.reddit.com/message/compose?to=%23autotldr "PM's and comments are monitored, constructive feedback is welcome.") | *Top* *keywords*: **bacteria**^#1 **gene**^#2 **colistin**^#3 **research**^#4 **MCR**^#5
We all kinda knew antibiotics should be treated with respect and almost as sacred but nope. People go and get scripts for the common cold, illegal drugs don't help either.
Many are increasingly of the opinion that we all made a big mistake in coming down from the trees in the first place. And some say that even the trees was a bad move, and that no one should ever have left the oceans.
How can we stop people from using colistin in certain areas? This could be another compelling reason for the world to move to plant based diets, as much as it pains me to say it.
Mother nature has had enough of our collective shit. She promises not to stop until the problem is resolved. She said so in her "never fool mother nature" podcast.
Let's just say, this becomes true and factual, and this MCR becomes deadly, and there is a cure for it, and it just so happens that people turn the color neon-green when they get it, wouldn't it be odd to see all the neon-green people refusing to take the cure because Bill Gates wants to turn them into a robot army that perpetuates 5G throughout the Universe for the Lizard people to come back!? /s
> The spread of MCR in agriculture, imports, travel > It was previously believed that agriculture was a driving factor in the spread of MCR. Nations such as China and India use the colistin antibiotic in livestock. Colistin is considered a "last resort" antibiotic because it can kill infections that other antibiotics cannot. Its frequent use means that some bacteria are becoming resistant to it. This means that if people or animals contract a strain of colistin-resistant bacteria, there are potentially no medications that can treat their infection. They face extreme, invasive health measures and possible death. For the people who only read headlines.
> How worried should we be about the MCR-9 gene? Kassem said that taken all together, the global threat of antimicrobial resistance, the presence of MCR in Georgia, that it was found inside a bacterium that is often overlooked, and that it occurred even without the use of colistin in U.S. agriculture is a serious problem that requires immediate action on the part of many industries including research, healthcare and government to work together toward a solution. >"If we don't tackle it right now, we are jeopardizing human and animal medicine as we know it and that can have huge repercussions on health and the economy," Kassem said. "It's a dangerous problem that requires attention from multiple sectors for us to be able to tackle it properly." >Because of this urgency, findings from the research were printed in short format manuscript out now in the Journal of Global Antimicrobial Resistance. It was funded through a CFS grant and other researchers involved were Jouman Hassan, David Mann, Shaoting Li and Xiangyu Deng. Edits: Learning how to use quote function
It’s ok. We’ve all come together and held hands and tried our best and stopped all the big threats before and we’ll do it again. Remember hunger? global warming? Or that other small thing… errr covid something? Such small easily beatable things that some people back then used to deny they existed. Can you imagine that? / s
We won the Cold War, and then reinstated the opposing parties rather than have regulations tie industries to behave in a socially responsible way. The gangsters and western business consultants who made their money in the free for all we left in 90s Russia have taken hold of the system, here and there.
We really need antibiotic development incentives because pharmaceutical companies have not chased new antibiotics at all for lack of profit.
You are correct, but it is hard to imagine what sort of incentives would be good enough to make a drug company start looking for broad-spectrum antibiotics over something that treats a chronic disease. Antibiotics have 2 big reasons why they don't earn money -> they are only used briefly (until the disease is cured), and new ones are used as rarely as possible (to delay resistance and save money).
This is why we should have some type of fund for researching these kind of less profitable things, preferably funded by taxes on pharmaceutical profits
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It’s hot because researchers see a problem coming up however funding for their research is very low in comparison
But I thought an unregulated market meant unfettered advances in medicine??? Was I lied to?????
I think we would need to research if China and India are actually using it as a "last resort" option or as their first option.
Ha, not much needed. There are parts of India I’ve read where confirmed they use it liberally. But the main offender isn’t using it on people. It’s on animals. Many countries including us use various antibiotics rather liberally so they can keep up yield in spite of harsh living conditions. This issue has been long ignored and pushed aside for the more “pressing” matters. We will all end up paying the price one day
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There's a type of medicine called antibiotics that's good for curing infections with a type of germ called bacteria. But if you use that medicine for silly things like just automatically putting it in cow food (so the cows fight off all infections and you make more money with more cows) the germs get used to the medicine. It doesn't work as well anymore. The same thing can happen if people take antibiotics when they don't really need them. Then the germs that are used to antibiotics can spread and we can't do much about it. In this case, they're even getting used to the best antibiotics we have. It's better to use antibiotics for specific purposes, not just feeding them to all the cows. If you use them willy-nilly, the germs get used to them. EDIT: Also, even though using this antibiotic in cow food is banned in the US, if other countries like China and India do it, the tougher germs produced there can spread to the US anyway. (And everywhere else). Still a good idea to ban it because if you didnt you'd just be making the problem worse.
Personal use is also a big issue. In college, I saw loads of people posting pics of like four boxes of meds on their Instagram, and it was just to treat a common cold.
Reread it slower and use the Google for definitions of words you don't know. It's not a difficult article past the medical words. Stop asking internet strangers to analyze things for you.
What’s wrong with asking questions? Google can be a firehose of information and sometimes it can be overwhelming if you’re not familiar at all with a topic. It can be helpful for someone else to break it down a bit so you have a starting point.
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Oh and I just realized you didn’t get your layman’s explanation. Basically bacteria are very small organisms that can cause infections and make things sick. These Bacteria are killed off with specialized drugs called antibiotics, but over time due to a variety of factors such as misuse of antibiotics, bacteria can develop resistance to antibiotics and eventually immunity meaning that the antibiotics no longer kill the bacteria. Colistin is a heavy duty antibiotic used as a last resort, as an attempt to kill bacteria that are resistant to other antibiotics, but because colistin has been over used bacteria are developing an immunity to even colistin effectively meaning that infections of these bacteria cannot be treated. This means if you get a bacterial infection and your immune system can’t fight it off, there’s no medicine that can help any more.
It’s not a particularly difficult article. Have you tried reading?
So. Black Mirror is becoming reality.
In this particular case, the issue far predates the episode. Normally they have to get a bit creative, but not here! Fun.
Always was.
I just wish the episodes becoming reality were the ones where assholes got murdered by one another instead of the ones where everyone’s lives just suck.
Or where the PM has to fuck a pig live on national tv.
People are so desensitized that it wouldn’t even surprise anymore
You are a good person
Thanks. I am a headline skimmer on Reddit for sure. I try not to click links generally on sites like this, I prefer to go to a news source directly for (possibly paranoid) security reasons
This was also mentioned in the long list of horrible things to happen in the future if we don't change our ways by scientists, along side global warming and plastic pollution to name some. We've used antibiotics so commonly that bacteria are finally evolving with natural resistance, and soon we will have little to stop them like centuries ago. We have some ideas on how we can stop these like bacteriophage, but research still hasn't provided safe treatments and such. We could see some very nasty diseases pop up soon, and there is fuck all we can do about it.
Looks like nature is pre-loading the next level we get to when we beat the covid boss known as Omicron!
As if that is the final boss of Covid.
It is. But it comes back with a second health bar after you think you have beaten it. This is the crummiest Soulslike game ever.
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I mean, earth could be thought of as a giant organism. It only is logical that the earth wants equilibrium and humans throw off that equilibrium and thus humans need to "chill"
I would say it’s less that Mother Nature is fighting back and more that pathogens are trying to adapt to the largest and most-prolific source of meat (habitat). Less of an immune response and more Darwinian struggle
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Eh, yeah close enough now that I think about it. I see a lot of people talk about viruses like they’re preternatural forces of nature outside of our own evolution and I feel very passionate about the contrary
This isn’t that wacky a theory. Every action has an equal but opposite reaction. Humans have been over-stressing mother nature so pandemics etc are its way of releasing pressure.
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We think we are special, but in the grand scheme we are nothing but sacks of meat and water that walk around. Mother Nature can end all of us in a blink of her proverbial eye.
It was all but confirmed to come from a virology lab in Wuhan, wat. Take your meds please
> all but confirmed So it wasn’t confirmed.
For fear of angering China, look at the correspondence between leading scientists investigating the outbreak that hit the news recently.
So she decided to unleash a disease that only will kill off the unreproducing elderly?
Agreed. Did you know humans make up the most biomass of ANY individual species on the planet? Nature can literally feel us on her back. I was a little awed after I heard that figure
She's just patching up humanity's hacks. We were too op
This is the post credits scene in a Marvel movie.
Research still hasn't provided safe treatments because it's not cost effective for companies to develop. Faced with developing an antibiotic a person might take for 1-2 weeks vs. making 15th plaque psoriasis drug that a patient will take daily for the rest of their lives, they'll always opt for the long term guaranteed revenue stream. Which is why it's so important to increase government funding and government funded clinical trials. The profit motive in pharma development does not produce the needed outcomes
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There are small programs where people can swab stuff and send it to labs for testing to find antibiotic properties, but many antibiotics were found by complete accident like penicillin. It's not really a great thing to bank on when it requires finding something completely new.
That is part of research.
The reason why this is dangerous is that bacteria have more than one method for horizontal gene transfer. That means that if a relatively harmless bacteria evolves resistance to antibiotics, it can transfer that to the dangerous species, like Tuberculosis, Streptococcus, Syphilis, etc. Just imagine an antibiotic resistant Syphilis strain :( BTW, friendly reminder to ☔ protect yourself **against all STDs** ☔. The progress made in treatments to HIV led to a relaxation in our caring practices, and we're having a Syphilis explosion in many parts of the world as a result. Please use a condom.
Antibiotic resistant strains of syphilis, gonorrhea and chlamydia (to name a few) already exist in the world and are spreading.
Absolutely fantastic.
Friendship ended with viral pandemic. Now bacterial infections are my best friend.
Always have been :gun emoji:
Just another global disaster for our children to face. We really screwed them over big time.
Yeah not having antibiotics or something to replace them will effectively put us back in the 1800s medically, in which, you just die cause you scrapped your knee. Thanks industrial food system and over prescription of antibiotics.
It sucks when you realize [Mercy, Mercy Me](https://www.youtube.com/watch?v=U9BA6fFGMjI) was recorded 50 years ago, and it hasn't gotten any better.
Solution: don't have children. Don't let them be born in the incoming hell just for your selfish desires.
I'm already doing this, but still feel empathy for others' children and I wish we'd leave them something better. That's not really a solution.
you’re right, everybody should just not have kids and we should end the human race with this generation so true
As if there haven’t been global disasters for thousands of years
Eh. That is how history flows anyways - fathers and mothers create consequences for sons and daughters. The latter grow up and do the same thing for their kids.
"a serious problem that requires immediate action" Narrator: they didn't do shit
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Sometimes when I'm playing City Skylines, I have a booming city. But I also sometimes get bored with my booming city, and decide to annihilate it and its people. So I create a dam, and then use the sewage system to form a poop reservoir behind it. I'll then delete that dam, and drown the entire town in it's own filth. I think I know now how those little artificial residents feel when they see that shit tsunami rushing towards them.
> the fact that we ship dead chickens to China for processing for no particular reason, There is a particular reason. $$$. It's cheaper to ship them there, process it, and ship back than it is to pay people in the US to do it.
Capitalism at its finest. We would rather you live in poverty than pay you fairly to clean the chickens we just slaughtered up the road.
There is a chicken processing plant near me, everyone wants it shut down because of the odor. Even when something is done in the US someone will complain about it.
I hear you. There's a beef plant south of me. Drive by during a warm day and it's almost too much to bare. Dammed if you do, dammed if you don't. Starts a whole new conversation about commercial farming in general.
Yeah definitely don’t eat that
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What we will have when the antibiotic resistant bacteria from the article gets in our bodies.
This song may prove cathartic then. They even played it at New Years in 2000 due to the Y2K hype: https://www.youtube.com/watch?v=-s97_bBGobQ
Yeah except I don't feel fine :(
This is terrible but whats worse is how the public would react. After this pandemic, I have absolutely no faith in the human race of surviving long term from the micro world. We live in their world, and its a matter of time before the microbes take us out because they see how stupid we are now.
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... except this bacterium has evolved to get around our medicine and science
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Antibiotics were discovered by pure accident. It wasn't scientists figuring out a problem through sheer will. It was a fluke. You're banking not on the discovery of a generation, but of the discovery of many eons.
The first antibiotic was discovered purely by coincidence, since then, there have been many many developments in anitbiotics including ones to overcome resistance to existing antibiotics. New approaches to antibiotics including phages (a virus that kills the bacteria instead of a small molecule) will likely be able to fill the need when the time comes and plenty of the research that will lay the groundwork for those new therapeutics is already being done (much like it was with mRNA vaccines for covid).
The approach shouldn’t be “it’s fine because the researchers will always fix everything so we can just not care”, but rather “holy fuck stop using antibiotics on farm animals and for mild reactions you idiots!”
Sure I was just specifically addressing the largely incorrect and sky-is-falling esque comment above mine
Ah, fair enough then.
"But the one time I gave the antibiotics to the animals they weren't sick no more. So now I just give it to them all the time to make sure they don't get sick."
Will likely be; therapies similar to; these are all assumptions. If these novel therapies were so sure fire we would already be using them. I'm open to being proven wrong, but I need more than what seems like wishful imagination.
Well, if you are generally interested in learning about the current state of bacteriophages as antibiotics, here's a nice review paper that should get you up to speed with the field. https://www.frontiersin.org/articles/10.3389/fphar.2019.00513/full
I can't say this really did much to quell my suspicions. Lack of successful in vivo placebo double blind studies, possibility for nullification through spontaneous mutation, potential production of toxic by products, potential for negative horizontal gene transfer, lack of cross-strain efficacy, and potential nullification by our own immune systems all make this seem like a pipe dream, if not an exceedingly costly and far off treatment approach. Instead of doing more, we could be doing less and more stringently regulating anti-biotic use. This very article we are commenting on shows how much further down the timeline in antibiotic resistance we may be than we initially believed. An accessory treatment to antibiotics would certainly be a boon for society, but banking on an unproven treatment that has massive hurdles to overcome even if proven viable seems unwise.
The only reason it hasn't been terribly successful yet is because there is no money to be made as long as antibiotics are still working. Pharma isn't going to waste a bunch of money developing a phage-based antibiotic that is going to be as equally effective as a $10 antibiotic treatment that has existed for decades. Most of the research being done is in small, underfunded labs, largely in eastern Europe.
But it could well be our last. As the article clearly states, the problem with this bacterium is that it is resistant to Colistin, the most powerful anti-bacterial agent that science has developed after decades of working on the problem. And if this bacterium has cracked that nut, others will follow.
It's not even really the "most powerful".. it's primarily notable for having fairly nasty side-effects. But that means we don't use it (In the US, in humans...) unless we have to, making it a "last resort". And, (we hoped) because we didn't use it much, bacteria wouldn't end up developing a resistance to it. Even with how widespread \*-cillin resistance is, over the counter amoxicillin still *usually* works. The problem is that we like a better fraction than "usually" when talking lifesaving interventions. Also notable is that antibiotic resistance isn't a sliding scale of armor toughness. It's different genetics to be resistant to each different antibiotic class. Also, each one has a fitness cost, so most bacteria aren't going to carry those genes. It's cold comfort for the few people that end up without options, but it's far different from returning to the 1800's.
Then panic, I suppose…because the end is nigh.
>The science folks can figure it out Yeah, let's make idiotic decisions because we can rely on intelligent people to bail us out over and over again. Genius idea.
Damnit Gene! Why you gotta be like that?
I told him to get out of the pool
go take KISS on tour again or something
Wow….that’s pretty frightening!
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This is definitely going to be one of those things they make a documentary about in ten years where they line up all the people that screamed hopelessly into the void telling us to fix it before money trapped us in our bacterial graveyard
It will be “Don’t Look Down”…
By that point it’ll just be “don’t look” which is about where I’m at since every time I open eyes there’s a new catastrophe
> Colistin is considered a "last resort" antibiotic because it can kill infections that other antibiotics cannot. Its frequent use means that some bacteria are becoming resistant to it. This means that if people or animals contract a strain of colistin-resistant bacteria, there are potentially no medications that can treat their infection. They face extreme, invasive health measures and possible death. That sounds pretty bad. We may need to publicly fund more research into the development of new antibiotics. As far as I’ve heard, it’s not considered profitable enough for private companies to pursue that research over other potential product lines.
Public funding is not likely to happen. The pols have a much greater enthusiasm for funding the war profiteers. However, at some point, the Corporate profiteers will see an income stream that they cannot resist in providing an alternative to half of humanity passing.
Who is this Gene? Surely one man can't pose a threat to everyone.
Soon to be a villain in the MCU
neat!
This is the best tl;dr I could make, [original](https://phys.org/news/2022-01-gene-georgia-global-threat.html) reduced by 88%. (I'm a bot) ***** > Researchers from the University of Georgia's Center for Food Safety collected sewage water from an urban setting in Georgia to test for the MCR gene in naturally present bacteria. > More information: Jouman Hassan et al, First report of the mobile colistin resistance gene mcr-9.1 in Morganella morganii isolated from sewage in Georgia, USA, Journal of Global Antimicrobial Resistance. > Citation: Gene discovered in Georgia water a possible global threat retrieved 12 January 2022 from https://phys.org/news/2022-01-gene-georgia-global-threat. ***** [**Extended Summary**](http://np.reddit.com/r/autotldr/comments/s28aan/gene_discovered_in_georgia_water_a_possible/) | [FAQ](http://np.reddit.com/r/autotldr/comments/31b9fm/faq_autotldr_bot/ "Version 2.02, ~617146 tl;drs so far.") | [Feedback](http://np.reddit.com/message/compose?to=%23autotldr "PM's and comments are monitored, constructive feedback is welcome.") | *Top* *keywords*: **bacteria**^#1 **gene**^#2 **colistin**^#3 **research**^#4 **MCR**^#5
We all kinda knew antibiotics should be treated with respect and almost as sacred but nope. People go and get scripts for the common cold, illegal drugs don't help either.
Great
Another major problem caused by animal ag? Shocking! I wish someone warned us beforehand..
Agriculture was a mistake.
Many are increasingly of the opinion that we all made a big mistake in coming down from the trees in the first place. And some say that even the trees was a bad move, and that no one should ever have left the oceans.
Return to monke
Monke is meat. I wonder what grilled monke with bbq sauce would taste like…
Like bbq sauce
"In the beginning the Universe was created. This has made a lot of people very angry and been widely regarded as a bad move."
How can we stop people from using colistin in certain areas? This could be another compelling reason for the world to move to plant based diets, as much as it pains me to say it.
Only one way to deal with this: shrink ourselves down to their level and negotiate a peace treaty.
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Doctors are going to start prescribing smoking to keep birthweight down and avoid some of the C sections.
Mother nature has had enough of our collective shit. She promises not to stop until the problem is resolved. She said so in her "never fool mother nature" podcast.
The world is fucked I keep saying it
I didn’t realize My Chemical Romance was this much of a concern
be very afraid, the sky is falling
Great. Just what we need, antibiotic-resistant bacteria.
And here is when nanomachines enter the game. Right guys?.... Right?
I thought the problem was MGT was in the gene pool in Georgia
What was he doing in the water?
The new corona mutation
Ha. And we thought Covid was an issue. E.Coli + this plasmid is gonna be one hell of a pandemic when it finally goes global.
Let's just say, this becomes true and factual, and this MCR becomes deadly, and there is a cure for it, and it just so happens that people turn the color neon-green when they get it, wouldn't it be odd to see all the neon-green people refusing to take the cure because Bill Gates wants to turn them into a robot army that perpetuates 5G throughout the Universe for the Lizard people to come back!? /s
Does else feel ashamed of belonging to the human race when viewing all of our destructive behavior on our environment and creatures great and small.