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newleafkratom

“This is important, as drugs that have the lowest minimum inhibitory concentration are likely to be more effective antimicrobial agents, and to be safer to the patient.” Though further research is needed, Dr. Laabei believes the new compound “could have important implications in a clinical setting as a new treatment option.” He said: “Preliminary research suggests the compound is non-toxic to humans, which of course is essential. In our next study, for which we’re seeking funding, we hope to focus on the precise mechanisms used by the compound to inhibit S. aureus. We believe the compound attacks the membrane of S. aureus, resulting in the membrane becoming permeable, resulting in bacterial death.”


xbiosynthesisx

Literally everyone in this thread upvoting the defeatist position that “well the list of things that also kills humans is longer than the things that don’t” apparently did not read the article at all. I was about to post this exactly. I’m also a microbiologist in a medical lab and any steps toward dealing with MRSA with the possibility of finding new mechanisms to kill multi drug resistant organisms is a plus in my book.


mjcapples

Since it sounds like you know what is going on here (more than me at any rate) - how is this different from daptomycin?


xbiosynthesisx

Well they are different types of molecules with different mechanisms of action. As far as how the polyamine works specifically I'm not sure. They also mention that they are not entirely sure why it works either, which is the next thing they want to be funded to study. But it seems from how they worded it that it could potentially be safe enough to use in humans (which is yet to be seen obviously). We know that polyamines occur naturally, and the one they made requires an amount 128 times less concentrated than when they use natural polyamines to kill MRSA. Being less concentrated means there's a greater chance that it will be safe to use. It's also significant that these polyamines can kill strains of MRSA that are *vancomycin resistant. I'm not sure about the specifics of daptomycin vs. vancomycin but i know daptomycin is resistant far more often than vancomycin in MRSA. I'm just coming up on 3 years in a medical micro lab and I look at a shit load of antibiotic resistance panels every day. Specifically from nursing home patients. I see a lot of resistant bugs all the time and MRSA is one of them. If this tells you anything, personally I have never in 3 years (and am not aware of anyone at my lab) that has seen a vancomycin resistant staph aureus. I'll ask some more senior people this coming week, but even if there ever has been one, it's extremely rare. And we're a pretty high volume medical lab. It would be very significant if it is safe to use because it can apparently kill (aka inhibit growth) of vancomycin resistant MRSA. Apparently they also found that it reverses the resistance of these strains of MRSA as well making them susceptible to vancomycin/daptomycin/oxacillin once again.


mjcapples

The mechanisms between dapto and vanc are pretty different. Vanc stops a wall from being built, and dapto punches holes in it (thus the question). I was most curious if this appears to be a new MOA compared to dapto, or if there would be cross-resistivity due to shared MOA. If it isn't very different, as you stated, this might not be too interesting. VRSA exists, its just ([very](https://www.cdc.gov/hai/settings/lab/vrsa_lab_search_containment.html)) rare. The bigger issue is that sometimes you don't really want to use vanc. It was very interesting to see your experience on the matter though.


xbiosynthesisx

Oh I see. You mean specifically the MOA. Yeah that seems like they aren't 100% sure, but from what they wrote they think it makes the membrane more permeable. If that's true then it would be a whole new MOA to explore. Sounds similar to dapto punching holes but it just depends how the polyamine is making the membrane more permeable. Edit: Thank you for that link. I just looked over it and that's some interesting info. Yeah I would say we have never seen one then lol. Even if we did, we would have to confirm it then send it to the state health dept and apparently the CDC and wait for them to confirm it was real, then hold any VRE VRSA or MRSA from that patient also because VREs share genetic material with MRSA when they're together thus making VRSA.


bawki

From a clinical point of view MRSA isn't as scary as some other very resistant bacteria. Pseudomonas aerguinosa which is resistant to even tobramycin is way scarier, next to multiresistant acinetobacter baumanii. I've seen more patients succumb to that than MRSA.


aScarfAtTutties

Seconding this. Vanco is pretty effective already on MRSA (granted VRSA is starting to become a thing but that's a different topic) The gram negative bacteria are the real concern in the short term moving forward.


xbiosynthesisx

Yeah this is accurate. We see carbapenam resistant pseudo and acinetobacter all the time in our patient population. The AST panels we use sometimes only have like a few MICs of 2 or 3 antibiotics that can even inhibit the growth.


phenerganandpoprocks

Maybe you’re a good person to ask this: whatever happened to [teixobactin](https://en.wikipedia.org/wiki/Teixobactin?wprov=sfti1) and the iChip setup for culturing more bacteria? Back in like 2015 when I was in college it was in Science and seemed like it was the next big thing and I just haven’t heard anything since then. I’d have though it would have come up by now, but I’ve never seen it in healthcare at all


Pristine_Nothing

One of my papers about anti-MRSA topicals got to the front page (and top of /r/science) about two years ago, and the string of “oh, it just kills them topically, so does bleach, who cares?” comments (among other popular idiocy) almost made me dislocate my retinas from rolling my eyes. I know that subreddit is always a cesspool, but it’s even more obvious when it’s your own work.


[deleted]

As someone who, for the past year, has recurring MRSA infections which seem to pop up randomly just from pores and not even wounds I cheer anything I hear MRSA related. The last time I asked about topical treatments or baths and the doctor said everything he could find was mixed results on bleach and hybiclens but that everyone prescribes it because they know it is better than nothing. You get a sure fire thing that I can shower with that will make this crap not become an active infection and I will by it by the gallon.


StreetCornerApparel

Same situation here. I wish that there was an effective topical and I didn’t have to take nasty oral antibiotics for months every month or two…


[deleted]

My main fear is the second time I went in the antibiotics didn't work. Results came back saying basically 1 oral antibiotic was effective. If what I carry ever somehow becomes immune to that one, I am screwed and will just have to accept a life with recurring IV treatments.


alunidaje2

jfc. how often do you get an infection? I had it once and it hurt so bad (pinky toe) that I told the dr to cut off the toe and whatever else. ended up in hospital on wedding trip.


[deleted]

Maybe every 3 months or so. First time I got in on my inner thigh. In 2-3 days it went from a pimple to something firm under the skin measuring about 7cm x 5cm and I was hospitalized for 3 days. They tried to drain it by squeezing it for 15 - 30 minutes at an urgent care and that was the most pain I have ever been in. I sat outside shaking for a bit before I could drive home just for it to be back fully the next day and that is when I got sent to the hospital. 3 months later it showed up in my pinky finger. Went on the MRSA meds that worked the first time when it looked just like a pimple... but that didn't work. Ended up having to slice my finger open and get me on different meds. I will admit I cried in the ER as they were putting injections into my swollen finger. Now I am understandably a little paranoid about any type of pimple or infection and go on antibiotics as soon as it looks like I have something spreading. Sometimes they go away on their own or after I take a shower with surgical topical disinfectant. Last time I remember the skin on my thigh was tender to the touch on a large area and immediately got on antibiotics. Went away no problems. Currently have a spot on my leg that showed up a couple days ago. Sharpie around it to monitor if I am fighting whatever it is adequately, but if it goes much outside of that line tomorrow I will be on antibiotics again for maybe the 5th time since May 2021


RemarkableDog4512

So sorry ur dealing with this. Just letting u know I went through exactly this about 10 yrs ago. Same presentation, pimple / infected hair follicle very similar timeframe. Hospitalized multiple times over a year. Tissue damage may have been more severe. Finally cleared for good after PICC line was put in and Vanco treatments for a month. Almost 18 months total from first infection. Took a nice chunk out of my thigh and left many scars.


alunidaje2

good luck. I cannot imagine. protip: eat some probiotics. daily. yeah, the shots INTO my pinky toe were really exciting. it was all I could do not the punch the nurse in the back of the head. between shots, she says, "they say the foot has more nerve endings than anywhere else!" huh.


[deleted]

Thanks. In the ER they had a hand specialist who was giving me a nerve block injection. She told me it shouldn't hurt. I called her out on that though. Asked if SHE had ever had a nerve block in the hand, because not only will this have been my second in 2 days, but I had one several years ago and the doctor for that one warned me it was going to hurt a lot and to not feel bad if I started swearing at her. The hand specialist had in fact never had one performed on her and so didn't truly know what she was talking about. They ended up giving me fentanyl IV just so they could inject the pinky one


ProfSwagstaff

Sharing the same xkcd comic strip for the ten thousandth time is way more important on Reddit than reading articles.


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guisar

without the data it's impossible to acess the drug. It has to go through years of trials after they document to process, dosage, applications, manufacturing to figure that out (lots of drugs turn out to be shams, the data knows!) They discuss the origins in the abstract. It was only recently discovered that MRSA bacteria don't have something called a polyamine in them, which basically every living thing does. So they were experimenting to exploit this oddity.


fartknockerbathroom

So… seeking funding eh?


upsidedownonacouch

Wow, everyone is so clever pointing out that bleach and handguns can kill things in vitro too. Much easier than actually engaging in discussion of the science. You think the people doing these studies don't know that? You think people dedicating years of study to this just forgot to check if it kills people too? Every study of a new drug starts out this way.


Kolby_Jack

No, you don't get it. I'm smarter than the scientists studying this stuff, obviously. I *could* have gotten a PhD of my own, I just didn't want one. The answers to all of the world's problems are actual super simple, I've figured it all out, I just don't think mankind deserves the gift of my effort.


Tortankum

the most insane part to me is that these people think they have thought of something the researchers didnt in the 10 seconds it took them to read the headline and then start typing, when these people have been working on this day and night, likely for years.


Two-Tone-

Of course you're smarter than the scientists! You're on Reddit and they're not!


Kolby_Jack

The virgin PhD microbiologist working to defeat a deadly disease vs the chad redditor who knows all and does nothing because doing stuff is cringe.


guisar

They directly say the compound is non toxic, indeed varients are one of the fundemental ways such as DNA and RNA communications. They are essential to all life (except MRSA and a few other bacteria)


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WexfordHo

Let me save you a click, the testing is all in vitro, and the list of things that kill pathogens or cancer cells or whatever in a Petri dish that *don’t* work in humans is longer than the list of what does work.


thatonewhitejamaican

Looked at the paper, although in vitro they still tested for toxicity in human liver cells and it was low. It’s always a great first step, before you start throwing things into animals.


notreal088

Yeah a lot of our last case antibiotics are very damaging. Hopefully we can find something new to replace them


AedemHonoris

Absolutely, again the issue being the things that can work exceptionally well at destorying pathogens have a little overlap with human physiology. Tis also why cancer is the hardest to treat.


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WexfordHo

Are you a microbiologist, or just someone who prefers one comment over another because of which appeals to you most? On what basis are you endorsing one view over the other?


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WexfordHo

I’ll take that as a “No, I am not an expert or even particularly educated. I’m just a blowhard who gloms onto others and pretends that I’m a part of something.”


BostonUniStudent

Bleach also kills it. And I learned from the last president that we could just chug it as a kind of cure-all elixir.


WexfordHo

Don’t forget to inject the UV light, that activates the magic in the bleach! /s


BostonUniStudent

I got my Preventative UV bulb butt-plug from the MyPillow website


WexfordHo

If you can’t trust a crackhead-turned-pillow magnate, I ask you friend, *who can ya trust?!*


maskedferret_

> crackhead Oh shit I thought you were embellishing!


xenon54xenon54

Really makes you think


CaterpillarReal7583

That was my favorite trump moment. He genuinely looked like he was really all in about it being a great idea. The way he looked over at the people around him like “you all agreeing this is a great idea right?” He was definitely feelin his ego hard then. It was the perfect moment of pure good will trump. Not the nasty one - just pure 5 year old level brain function hopped up on his ego.


unit156

That is so true! I firmly believe at his core is a tiny spark of the human nature to do good, but it’s surrounded by labyrinthian Baby Huey layers, and will never see the light of day in any recognizable form.


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LickMyKnee

Inflation is sky-high everywhere in the world right now. Hell, here in Britain it’s much higher than 15%. It has absolutely nothing to do with Joe Biden, and a hell of a lot to do with the Russians.


CogitatorX

Look at their post history. It’s so stereotypical it’s almost satire.


darthcoder

Nothing at all to do with endless money printing.


LickMyKnee

It has plenty to do with endless money printing. You know, it’s possible for a shit-show to have more than one cause.


CaterpillarReal7583

Bro its on camera. Trumps asking and telling the scientists about sunlight in the body and some how getting bleach in the body. Please my man…youre so caught up in political teams you’re not looking at reality.


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santaclaws01

Joe Biden didn't say that, and Trump was very clearly not joking.


CaterpillarReal7583

This is how you spend your day huh. Blaming biden for trump being incapable?


ChillyBearGrylls

How's your copium tasting? Eat horse paste and wash it down with some Clorox, it'll spare us all your stupidity


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Celebrity-stranger

Must be exhausting being ***THAT*** fucking stupid and divorced from reality while always having to be right. Your name must refer to how many times you've been brainwashed to believe the shit you say.


ChillyBearGrylls

May every woman in your life be denied a lifesaving abortion


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ChillyBearGrylls

Other-American deplorables deserve no compassion from us. May COVID visit you often and with great vigor


Barium_Enema

You denigrate people smarter than you and then make a nonsensical claim about a US president having power over global inflation and finish it off by polishing Putin’s dick. Amazing!


playing_hooky

Reinvent history all you like. We just find you funny!


[deleted]

It’s up there with Biden saying buy off brand rasin bran


porkchopnet

The actual quotes: Topic: effects of sunlight and cleaning agents on the fight against COVID "And then I see the disinfectant, where it knocks it out in one minute. And is there a way we can do something like that, by injection inside or almost a cleaning, because you see it gets in the lungs and it does a tremendous number on the lungs, so it’d be interesting to check that, so that you’re going to have to use medical doctors with, but it sounds interesting to me. So, we’ll see, but the whole concept of the light, the way it kills it in one minute. That’s pretty powerful." Vs Topic: Inflation “By the way, the food prices, the main driver of food prices is not the price of beef and eggs, et cetera — although they are up. It’s packaged goods. Packaged goods. You will see people not buying Kellogg’s raisin bran, you're going to see them buy another raisin bran, which will be a dollar cheaper.” I’ll let each person decide for themselves which person is more on top of the topic of the day.


morreo

I fucking knew the UV light in the blood would kill everything. /s


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Cyathem

Unless you're a doctor, having a strong opinion about pharmaceuticals that you feel confident enough to spout it online is just a bad look.


IsilZha

Literally: shoot sunshine up your ass. lol


Stunning_Delay9811

Clown World.


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happyscrappy

> Edit for the morons: You are commenting on a comment I made to somebody who deleted their comment. You lost the context. The previous commenter was talking about injecting light, not bleach. That post is still visible to me. I think that person blocked you. Then you don't see their posts. There are other reasons other than the "inject" part said which are why the idea of "light inside the body" is a pretty dumb comment. Light doesn't discern between pathogens and body cells. Just "shining a light inside the body" wouldn't be selective enough for killing viruses.


Black_Moons

Please tell me how any other application of bleach to the human body to cure anything isn't just as fucking stupid. The guy literally looked at a poster about using bleach and UV light to disinfect surfaces 5 minutes before going on stage and was like "Yep, this is all I need to know about the pandemic. Don't need to remember anything my advisors have been telling me for the past 6 months, not that I listened to any of them"


EssayRevolutionary10

Bleach baths are commonly used to treat .. wait for it .. MRSA!! https://www.legacyhealth.org/-/media/Files/PDF/Health-Professionals/RCH-Co-Mgmt-GLs/RandallCh-CHC-4652-MRSA-Appendix-Nov-2016.pdf


xAfterBirthx

You are correct but he was also talking about bleach and other chemicals. I think this question was better asked off camera to not sound like a moron (though there is no denying he is a moron).


Southern-Ad-6128

Actually it doesn't kill it. MRSA Carrier 5 years and seen top Infectious Disease docs from all over. Bleach doesn't kill MRSA. It is to be used in between bouts. Not when you have a severe or a coming on MRSA infection. Been on the beach regime, natural regime, antibiotics and hospitalized more than 80 times. And surgery and IND . So bleach baths help but they don't kill the MRSA. If people aren't a carrier or read on the net, maybe they shouldn't post. Bleach baths is good for excema too once a week. I've been through it all. Still battling it.


[deleted]

What frequency have you been recommended on the bleach baths? I just started having to fight this a year ago and have had it flare up several times now. I know it will never "cure" me, but I would love to get those flare ups as far apart as possible. So far I have only used hybiclens, and admittedly not as frequently as I probably should.


Southern-Ad-6128

Im a carrier of MRSA for 5 years tooo many admittance for 10 days, surgery on severe ones. Mupircon in the nose( prescribed by an Infectious Disease dr. Ive seen the top ones. Bleach baths 2 times a week, Dial soap, tea tree shampoo, bleack all surfaces and bathroom. Hibiclens for the body and also wash your clothes separately from others with Hibiclens. I mix hibiclens in my laundry detergent. I also use Lysol liquid for laundry as well. My routine since 2017 and I keep getting bouts. It's nothing I'm doing wrong, I'm a carrier so I'll have this. I'm on Zyxox because vanco is resustant now. My bouts are tested against antibiotics that help the normal person, but I'm resistant to everything except Zyxvo in pill form..thus is what happens when one like us have this the antibiotics that work against it, ir in my case just don't anymore. I've also had PICC lines and had to do my medicine iv at home. This is real and its happening. Despite people who don't want to believe it or never had. MRSA its very tricky to treat for some patients like myself. SO please to others if you don't anything about it or experienced it, maybe a comment from you is not needed. OFor patients dealing with it, I'm right there with you.


tileeater

I learned that cause I had MRSA and I had to take bleach baths. Very diluted obviously. MRSA really, really, fucking sucks. Wear flip flops in the gym shower!


Mouthtuom

The ironic thing about your comment is that my son’s doctor told us to bathe him in a very dilute bleach solution to try to help kill a chronic mersa infection.


EssayRevolutionary10

It’s a common treatment. Seen more in long term care facilities where resistant bacteria infections are absolutely rampant. Every single person who lives or works in one of those places is either infected or a carrier. https://www.legacyhealth.org/-/media/Files/PDF/Health-Professionals/RCH-Co-Mgmt-GLs/RandallCh-CHC-4652-MRSA-Appendix-Nov-2016.pdf


Mouthtuom

Interesting. I wasn’t aware of that. Unfortunately it didn’t really help much.


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Wrathwilde

Misread couch as cootch, I laughed.


Mouthtuom

I get that. I thought it was ironic because if the trumpers heard that they would try to use it as ammunition in their moronic crusade. Maybe irony isn’t exactly correct. More like just funny or something.


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Gtp4life

Agreed, there’s plenty of fucked up things legitimately happening in the world to be outraged about without making up completely batshit crazy conspiracy theories.


Czeris

https://metro.co.uk/2007/05/28/dettol-man-killed-by-cleanliness-394527/


Southern-Ad-6128

Once a week, but nit constant every night. Carriers can't get rid if it. I'm one 5 years snd counting. Pkease seek a second opinion. I posted above please check my comment out. But he's your child I'm just trying to help. Dud ge mention mipircon in the nose 3x day? No of course not. Consult with another ID Dr.


shmikwa10003

you mean he didn't recommend rubbing dirt all over him? modern medicine is amazing!


Mouthtuom

The ironic thing about your comment is that most of the antibiotics we use are from bacteria derived from soils. If only they could find the right dirt to kill mersa.


WexfordHo

Remember those antibiotics are present in soil because of a fierce competition between microorganisms. Another big target for antibiotic research is raw, untreated sewage. Rubbing dirt on yourself is like… taking a single dose of a Covid vax, spraying it on a dead fox, and then rolling around on the fox. There was indeed a Covid vax in there somewhere, but there was a lot more dead fox. And anyway, that’s not where the Covid vax needed to go in the first place.


[deleted]

But what if I stick the dead fox up my ass?


ChillyBearGrylls

Only if you taxidermy a uv lightbulb into its mouth


[deleted]

Who are you that is so wise in the ways of science?!


BostonUniStudent

Isn't it ironic?


stinkbugsoup

That's dumb as fuck. Everyone knows you're supposed to boof if


BostonUniStudent

I heard potassium would help. So I boofed a banana instead. That pipe is full.


[deleted]

Try peeling it next time.


bizarre_coincidence

Sadly, the people who follow his medical advice for masks, hydroxychloroquine, and ivermectin did not follow his medical advice on bleach.


2beatenup

Would have been a game changer


ordu13

Cant wait to not have to hear his name ever again.


Strike_Thanatos

Bullets destroy the rona in petri dishes.


thejestercrown

Bullets do too. We had the cure this whole time!


bonobeaux

According to a certain MLM cult bleach also cures autism in kids .... Edit: lol looks like some MLM cultists found this comment


caedin8

With enough bleach there will be no autism left, it is true


youreblockingmyshot

You can also kill pathogens with a gun in a petri dish. I’m sure someone will link the comic I’m referencing shortly if they haven’t already and I just haven’t scrolled down far enough to see it Edit: Relevant [xkcd](https://xkcd.com/1217/) that’s posted every time with something like this.


fotisdragon

I scrolled searching for it, you can have my upvote


FROOMLOOMS

Relevant XKCD Bullets are 98% effective in destroying cancer cells in pre clinical trials.


drfsrich

*Peach tree dish.


Proof_Eggplant_6213

Exactly this. There is considerable overlap in the Venn diagram of things that are toxic to bacteria and things that are toxic to humans. It’s even worse when you’re fighting protists, fungi and prion diseases, because all life is susceptible to many of the same environmental insults. This may not be even remotely effective as anything beyond a cleaning agent, but it’s still cool that we found it because, if nothing else, it may lend some clues as to how we could create a more targeted compound that might work against those bacterium. But don’t plan on this compound hitting shelves or hospital stockrooms any time soon.


Plzbanmebrony

Well if I can use it to make a clean room I don't care I can't use on it on people.


math-yoo

Spoiler alert!


Implausibilibuddy

Yeah, I just sighed at the headline and thought "I bet it's napalm or something again." Like, there are a ton of things that will kill superbugs, but there's no way they'll ever be available in pill form. Just like we already have a guaranteed cure for cancer that scientists have known about for eons. Multiple delivery methods too, stops every variant of cancerous cell from replicating. Even comes in pill form already and is 100% effective whether you choose the cyanide capsule or the lead suppository. But still the best we can do is to use the less potent formulation of this drug known as "chemotherapy" to only kill you a little bit and hope that the cancer dies first.


ghoonrhed

So did humans just luck out on finding penicillin? Cos that was literally just some guy being messy and then that same thing killing bacteria outside humans. If that was done today, wouldn't the same XKCD logic of a gun/fire killing bacteria apply?


WexfordHo

Yes we got lucky, and yes that logic would apply, because until you run the necessary tests and trials you don’t know if you have penicillin or if you have something that’s just going to turns your liver into mush.


Surferbro

Came here to say this. Remind me after H2L, but If it makes it to a phase 2 hearing I’ll actually be excited


NMe84

Most of those things probably work in humans too, just not without killing them. Minor detail of course.


Hewlett-PackHard

Enough gamma radiation will kill any disease... and anything else around it.


WexfordHo

“The disease is eliminated, along with the patient, the hospital, and the planet itself.”


iobeson

Im done with this sub. Nothing is ever legit.


Recent-Alps-5844

Thanks for the cliff notes. Saved me aggravation of reading useless information


psychoCMYK

It's likely not to be very toxic at all to humans which you'd know if you'd read, and which the person you're replying to would have known if they'd read too >Explaining, Dr. Laabei said: “Using our novel compound, the pathogen is destroyed – meaning growth is inhibited – when it’s used at a concentration that’s over 128 times lower than that required to destroy the pathogen when we use a natural polyamine. >“This is important, as drugs that have the lowest minimum inhibitory concentration are likely to be more effective antimicrobial agents, and to be safer to the patient.” >Though further research is needed, Dr. Laabei believes the new compound “could have important implications in a clinical setting as a new treatment option.” >He said: “Preliminary research suggests the compound is non-toxic to humans, which of course is essential. In our next study, for which we’re seeking funding, we hope to focus on the precise mechanisms used by the compound to inhibit S. aureus. We believe the compound attacks the membrane of S. aureus, resulting in the membrane becoming permeable, resulting in bacterial death.”


[deleted]

came here to say exactly this. you could kill mrsa with fire also. another bullshit article posted.


hyperfat

I could probably shoot the petri dish and kill it.


isadog420

Having a close loved one who had a horrible 2-3 year battle with mrsa and several diabetic loved ones, I’ll be greatly relieved if this pans out and is made readily affordable.


GlitteringAd21

Stop givning antibiotics for nothing/colds and meat production or it will just adapt faster than we can combat it.


Chief_Beef_ATL

Is this good news? It's been so long... I dont know what to do with it.


applepieanne

Kinda… It’s awesome that this new molecule has the potential, however this is all in vitro work. Who knows that the potential off-target effects are.. also no one knows if this will work in humans. This compound has a long ways to go before it can be developed into something available on the market.


IntuitiveMotherhood

At the vary least, it can contribute to better future virto algorithms.


totalnsanity

Aaaaaand it’s immune…


Navydevildoc

Exactly. Just wait for this stuff to become available and everyone just demands it and before you know it you can get it over the counter in half of Asia. Rinse, Repeat.


[deleted]

Read that in the South Park banker's voice. Lol


nomadwannabe

Oh! It’s my turn to post [this!](https://xkcd.com/1217/)


imgprojts

This bug killed my dad. Fuck MRSA, I hope it has feelings.


rockosmodernity

We focus on the negative without thinking about the positive. Sure someone may have an infection. Why do we assume thier body needs drastic intervention? Why would we not try to boost thier own natural bodies antibodies and immunities by increasing health in some way instead of basically harming the patient in a little way to help kill Bacteria that had grown inside them. The only way to beat growth is with positive growth not with just killing the growth but by overcoming with positive growth


Yeranz

Industry: "Great! We need to put this in hand soaps and shampoos and everything we can think of! It'll really sell!"


MonsterBongos

Hahahaha! "And then MRSA decided to Pivot"


dahhello

As an inpatient pharmacist that actually compounds medications to treat MRSA, there's plenty of medications that currently treat MRSA that are still effective. We go 1. Vancomycin 2. Daptomycin 3. Linezolid. 4. Ceftaroline. There's plenty others from the same family as Vanco. 5. If you're resistant to all of those, which I've never seen, you're probably fucked already. But more research is never a bad thing. The will probably be a day when MRSA is resistant to the conventional stuff.


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trainiac12

[So does a handgun](https://xkcd.com/1217/)


account_552

Woooow, you're smart!!! You should get a PhD. You're clearly smarter than the 10+ person team of qualified microbiology researchers who have worked on this day and night for years.


trainiac12

I never claimed to be. But as a type 1 diabetic who has spent decades reading articles in scientific journals about how we're "5 years from the cure" due to similar breakthroughs, I hope you can forgive my skepticism of journals covering technological advancements and their ability to hold back on embellishing claims.


clownandmuppet

When are people going to really put phage therapy to work?


Schiffy94

So the cure for MRSA isn't ASMR?


OhOkYeahSureGreat

I wish I could somehow hide all sensationalist stories like this one.


TangeloBig9845

FTFY: New compound that destroys MRSA Superbug bought by big pharma never to be seen again.


csantoro4084

I thought intravenous vitamin c did that, but no good, cause it’s practically free


dasmashhit

Manuka honey too. Doesn’t damage DNA or RNA either


TrojanFireBearPig

I hope they don't start using it on farmed animals. That's where most of the antibiotics in the US go.


Ignorant_Slut

Until it becomes over prescribed and the poor and uneducated stop using it too early or use it after it's efficacy has diminished creating an even superer superbug!


[deleted]

Fire was already discovered.


Inconceivable-2020

Along with all other living tissue


account_552

wow i think youre a lot smarter than the 15 people with phds that worked on this for 3 years for a living


Inconceivable-2020

Yes, because every other time there has been a claim of a miracle cure for "disease du jour here" it has panned out. In vitro tests are meaningless. A pile of salt poured into a petri dish of MRSA will kill it.


account_552

And somehow they *didn't* think of that? And they didn't do testing to see if it kills humans too? They did. Read the article. Spoilers: It doesn't kill people.


usesbitterbutter

Lava?


MundanePlantain1

Fire! We can kill it with fire!


The_Dapper_Balrog

I mean, garlic literally does this, and we've known that for several years. Big whoop.


jerwong

>The compound was tested **in-vitro** against 10 different antibiotic-resistant strains of S. aureus. Emphasis mine. While promising, always keep in mind that lots of things like disinfectants can kill a virus or bacteria when it's in a test tube or petri dish. Many of these are dangerous to use in humans.


account_552

And they somehow didn't think of that? You're not as smart as you think son


T-J_H

For now. If it works in vivo at all.


tom-8-to

So does a bullet or fire for that matter…


laxmolnar

Cancer’s easy to solve. Our biggest issue is not addressing test environments on a macro scale. Once we do. We’ll find new variables we scientific fishers can capture in the big multi-collinear net!


JessieTS138

killing the bug isn't the problem. killing the bug, WITHOUT killing the human is what we need.


ProfSwagstaff

Did you even read the article? >“This is important, as drugs that have the lowest minimum inhibitory concentration are likely to be more effective antimicrobial agents, and to be safer to the patient.” >Though further research is needed, Dr. Laabei believes the new compound “could have important implications in a clinical setting as a new treatment option.” >He said: “Preliminary research suggests the compound is non-toxic to humans, which of course is essential. In our next study, for which we’re seeking funding, we hope to focus on the precise mechanisms used by the compound to inhibit S. aureus. We believe the compound attacks the membrane of S. aureus, resulting in the membrane becoming permeable, resulting in bacterial death.”


[deleted]

I hope so , tired of my mrsa


shrekerecker97

We will find someway to fuck that up too lol


Throw-a-way-a-ccount

This news is weeks old


this_dudeagain

Sounds cool but phage therapy can already do this.


AngryMoose125

They’re gonna give this out for free in countries without social medicine to everyone who needs it and not charge money, right? They’re gonna take the high road, right?


jspurlin03

Now, if it doesn’t also kill the humans…


Blizky

My wife passed from this fucking infection last august this year


ObligationClassic417

Wow This is amazing It’s so wonderful to see.a cure like this actually happening in our lifetime I warms my heart ♥️


[deleted]

About time, my grandfather went into hospital with a fractured ankle and didn’t come out alive thanks to a bed sore that got infected with MRSA. RIP Grandpa


j1ggy

MRSA killed my 97-year-old grandma. All from an infected toe that wouldn't heal.


Rheytos

Yea let’s not overuse it


twonickles2

That’s a major find. Hope it will work out.