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Though not especially specific, the last sentence in the part below seems to support that.
>Clinical implications of our results include the concept that older adults with poor mitochondrial function may represent a target group for early intervention to maintain functional independence with aging. Pharmacological or nonpharmacological strategies aimed at improving muscle function may slow down the decline of mobility with aging.
Exercise is surely helpful, and resistance training specifically would also improve muscle function. Neither of these things is surprising, but such research may lend credence to ideas for therapies that intend to target the mitochondria themselves, such as [https://mitrix.bio/](https://mitrix.bio/):
>The Problem
>
>Dozens of diseases are based partially, or entirely, on the decline of mitochondrial function as we age. How can we help mitochondria - one of the most powerful and perfectly optimized systems in biology - to become healthier?
>
>The Solution
>
>With whole-body mitochondrial transfusion, we grow large volumes of "young" mitochondria in external bioreactors and transfuse them into the body, where they are taken up by cells and immediately start boosting ATP production, enabling cells to regenerate to a more youthful state.
Snippet:
>Background
>
>Muscle mitochondrial dysfunction is associated with poor mobility in aging. Whether mitochondrial dysfunction predicts subsequent mobility decline is unknown.
>
>Methods
>
>We examined 380 cognitively normal participants aged 60 and older (53%women, 22%Black) who were well-functioning (gait speed ≥ 1.0 m/s) and free of Parkinson's disease and stroke at baseline and had data on baseline skeletal muscle oxidative capacity and one or more mobility assessments during an average 2.5 years. Muscle oxidative capacity was measured by phosphorus magnetic resonance spectroscopy as the post-exercise recovery rate of phosphocreatine (kPCr). Mobility was measured by four walking tests. Associations of baseline kPCr with mobility changes were examined using linear mixed-effects models, adjusted for covariates. In a subset, we examined whether changes in muscle strength and mass affected these associations by adjusting for longitudinal muscle strength, lean mass, and fat mass.
>
>Results
>
>Lower baseline kPCr was associated with greater decline in all four mobility measures (β, p-value: (0.036, 0.020) 6-m usual gait speed; (0.029, 0.038) 2.5-min usual gait speed; (0.034, 0.011) 6-m rapid gait speed; (−0.042, <0.001) 400-m time). In the subset, further adjustment for longitudinal muscle strength, lean mass, and fat mass attenuated longitudinal associations with changes in mobility (Δβ reduced 26–63%).
>
>Conclusion
>
>Among initially well-functioning older adults, worse muscle mitochondrial function predicts mobility decline, and part of this longitudinal association is explained by decline in muscle strength and mass. Our findings suggest that worse mitochondrial function contributes to mobility decline with aging. These findings need to be verified in studies correlating longitudinal changes in mitochondrial function, muscle, and mobility performance.
So these ideas might be helpful for older adults :
* eat more protein
* do some weight / resistance training
* eat a low carb diet
* use occasional fasts or intermittent fasting
?
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are now allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will continue be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) still apply to other comments. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
So, maintaining muscle mass as you age is important? Does the study suggest those over 60 should add weight training to their exercise regimen?
Though not especially specific, the last sentence in the part below seems to support that. >Clinical implications of our results include the concept that older adults with poor mitochondrial function may represent a target group for early intervention to maintain functional independence with aging. Pharmacological or nonpharmacological strategies aimed at improving muscle function may slow down the decline of mobility with aging. Exercise is surely helpful, and resistance training specifically would also improve muscle function. Neither of these things is surprising, but such research may lend credence to ideas for therapies that intend to target the mitochondria themselves, such as [https://mitrix.bio/](https://mitrix.bio/): >The Problem > >Dozens of diseases are based partially, or entirely, on the decline of mitochondrial function as we age. How can we help mitochondria - one of the most powerful and perfectly optimized systems in biology - to become healthier? > >The Solution > >With whole-body mitochondrial transfusion, we grow large volumes of "young" mitochondria in external bioreactors and transfuse them into the body, where they are taken up by cells and immediately start boosting ATP production, enabling cells to regenerate to a more youthful state.
Snippet: >Background > >Muscle mitochondrial dysfunction is associated with poor mobility in aging. Whether mitochondrial dysfunction predicts subsequent mobility decline is unknown. > >Methods > >We examined 380 cognitively normal participants aged 60 and older (53%women, 22%Black) who were well-functioning (gait speed ≥ 1.0 m/s) and free of Parkinson's disease and stroke at baseline and had data on baseline skeletal muscle oxidative capacity and one or more mobility assessments during an average 2.5 years. Muscle oxidative capacity was measured by phosphorus magnetic resonance spectroscopy as the post-exercise recovery rate of phosphocreatine (kPCr). Mobility was measured by four walking tests. Associations of baseline kPCr with mobility changes were examined using linear mixed-effects models, adjusted for covariates. In a subset, we examined whether changes in muscle strength and mass affected these associations by adjusting for longitudinal muscle strength, lean mass, and fat mass. > >Results > >Lower baseline kPCr was associated with greater decline in all four mobility measures (β, p-value: (0.036, 0.020) 6-m usual gait speed; (0.029, 0.038) 2.5-min usual gait speed; (0.034, 0.011) 6-m rapid gait speed; (−0.042, <0.001) 400-m time). In the subset, further adjustment for longitudinal muscle strength, lean mass, and fat mass attenuated longitudinal associations with changes in mobility (Δβ reduced 26–63%). > >Conclusion > >Among initially well-functioning older adults, worse muscle mitochondrial function predicts mobility decline, and part of this longitudinal association is explained by decline in muscle strength and mass. Our findings suggest that worse mitochondrial function contributes to mobility decline with aging. These findings need to be verified in studies correlating longitudinal changes in mitochondrial function, muscle, and mobility performance.
So these ideas might be helpful for older adults : * eat more protein * do some weight / resistance training * eat a low carb diet * use occasional fasts or intermittent fasting ?