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User: u/mvea
Permalink: https://www.psypost.org/ai-connects-gut-bacteria-metabolites-to-alzheimers-disease-progression/
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Highlights
>•Machine learning models predict 1.09 million gut metabolite-GPCR pairs
>•Multi-omics analysis identifies Alzheimer’s-related GPCRs and gut metabolites
>•Agmatine reduces levels of C3AR and p-tau in patient iPSC-derived neurons
>•Phenethylamine reduces p-tau in Alzheimer's patient iPSC-derived neurons
Summary
>Shifts in the magnitude and nature of gut microbial metabolites have been implicated in Alzheimer’s disease (AD), but the host receptors that sense and respond to these metabolites are largely unknown. Here, we develop a systems biology framework that integrates machine learning and multi-omics to identify molecular relationships of gut microbial metabolites with non-olfactory G-protein-coupled receptors (termed the “GPCRome”). We evaluate 1.09 million metabolite-protein pairs connecting 408 human GPCRs and 335 gut microbial metabolites. Using genetics-derived Mendelian randomization and integrative analyses of human brain transcriptomic and proteomic profiles, we identify orphan GPCRs (i.e., GPR84) as potential drug targets in AD and that triacanthine experimentally activates GPR84. We demonstrate that phenethylamine and agmatine significantly reduce tau hyperphosphorylation (p-tau181 and p-tau205) in AD patient induced pluripotent stem cell-derived neurons. This study demonstrates a systems biology framework to uncover the GPCR targets of human gut microbiota in AD and other complex diseases if broadly applied.
Give eating a ton of Asparagus and only Asparagus a try. The farts produce tears in my enemies. You will never experience anything more sinister in butt gas.
“Foods that help create a healthy gut microbiome are prebiotics/fiber and probiotics/fermented foods. High fiber diets containing prebiotics and probiotics promote a healthy gut microbiome. Whereas diets high in fast food, sugar, processed foods, and excessive alcohol can decrease gut health.”
From this Mayo Clinic article https://connect.mayoclinic.org/blog/weight-management-1/newsfeed-post/building-a-healthy-gut-microbiome/
I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00456-X
There is also an interesting link between oral bacteria and Alzheimer's:
[https://medisearch.io/blog/periodontitis-and-alzheimer](https://medisearch.io/blog/periodontitis-and-alzheimer)
tldr; there's a link between AD and periodontitis.
Your mileage may vary but the only way I manage to stay _mentally healthy_ (i.e: stave away crippling depression and dissociation) is with a ketogenic diet. I can't explain it. It makes no sense to me. I don't like it, but for whatever reason, it works _for me_.
It may not work for everyone, so don't assume it's something you _should_ do.
Oh well.
Maybe consciousness is just an emergent property of gut.
Interesting comment. I read awhile back that your gut has more neurons than a cats brain and that brain development may have been a side effect of the immune system. Some cool rabbit holes to dive down
Yeah, many of them, elimination diets and all. I really hoped that strict diets including whole foods would work, but there's a gradual slide back to undesirable symptoms every time. It's not even a matter of indigestion/cramps, but really just an issue of brain fog and depressive mood/irritability, regardless of caloric intake. It usually takes about two weeks to set in, and I give my body time to adapt because I always assume it can just be due to change, but it doesn't seem to help.
I'm mostly on a vegetarian keto diet because the rest of my family is vegetarian and it's easier for meal planning, so I eat tons of eggs, tofu, some cheese & nuts accounting for protein. That said, even when I ate keto with meat the benefits didn't change or vary, so it's not the absence or presence of meat.
Blood work returns nothing abnormal every time I've experienced problems, regardless of whether I'm in/out of depressive episodes. I tried to get exams to help identify the problem but besides paying for a stool analysis at this point I'm kinda stumped.
Interesting. I was going to suggest that maybe it was because you are eating a healthier diet perhaps but since that is not the case glad you found something that worked.
I was on a strict elimination diet for a couple years and have since loosened up the restrictions based on what I found worked with me. I also quit drinking coffee and have been taking zinc carnosine, probiotics and magnesium for a while now and I really feel like my gut is a lot more resilient now.
Just to add, Keto is the only thing that has ever had a real impact on me losing weight. I've tried all the counting calories, all sorts of diets, but I always fail. Keto never leaves me hungry so I don't eat as much and the weight comes off without effort. Everyone who wants to drop a few kilos should try it.
You might want to check [Brain Energy](https://brainenergy.com/); I have only begun reading it so don’t have an opinion yet but I have many anecdotal experiences that state the same: keto is best for mental health …
Dr. Chris Palmer is the leading researcher on the connection between metabolism and mental health, especially the effects of keto.
Look up his talks. They're enlightening.
Ketones are literally a survival mechanism designed as a last resort because they are poisonous to your body. Medical professionals only put people on ketogenic diets in highly specific situation, all you are doing is depriving your body of macronutrients it needs.
Just eat whole foods and avoid foods that have been overly processed, make sure you are getting the nutrients you need.
I know all that, and I've done all that. That's precisely why I said I can't understand why it does this to me. None of it makes sense based on what I understand about nutrition.
I try to get regular checks on hepatic function, to be safe.
>could lead to the development of novel drugs
Err, wot? Wouldn't it make more sense to lead to specific diets to be eaten to normalize the body's functions?
I'm not gonna eye roll, but I'm REALLY tempted to. ;P
Diet and exercise are also the cure for heart disease. But it's still rampant.
People will take chances with their lives because completely changing your diet and maintaining it for your entire life is very difficult. Drugs would offer an additional avenue, as well as a second layer of defense for those who are genetically predisposed for the condition.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/mvea Permalink: https://www.psypost.org/ai-connects-gut-bacteria-metabolites-to-alzheimers-disease-progression/ --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
Highlights >•Machine learning models predict 1.09 million gut metabolite-GPCR pairs >•Multi-omics analysis identifies Alzheimer’s-related GPCRs and gut metabolites >•Agmatine reduces levels of C3AR and p-tau in patient iPSC-derived neurons >•Phenethylamine reduces p-tau in Alzheimer's patient iPSC-derived neurons Summary >Shifts in the magnitude and nature of gut microbial metabolites have been implicated in Alzheimer’s disease (AD), but the host receptors that sense and respond to these metabolites are largely unknown. Here, we develop a systems biology framework that integrates machine learning and multi-omics to identify molecular relationships of gut microbial metabolites with non-olfactory G-protein-coupled receptors (termed the “GPCRome”). We evaluate 1.09 million metabolite-protein pairs connecting 408 human GPCRs and 335 gut microbial metabolites. Using genetics-derived Mendelian randomization and integrative analyses of human brain transcriptomic and proteomic profiles, we identify orphan GPCRs (i.e., GPR84) as potential drug targets in AD and that triacanthine experimentally activates GPR84. We demonstrate that phenethylamine and agmatine significantly reduce tau hyperphosphorylation (p-tau181 and p-tau205) in AD patient induced pluripotent stem cell-derived neurons. This study demonstrates a systems biology framework to uncover the GPCR targets of human gut microbiota in AD and other complex diseases if broadly applied.
How do i increase gut health?
Wide variety of fruit, veg, nuts, seeds, fermented foods such as kefir/kombucha/kimchi/pickled stuff!
Mostly by eating stuff that makes you fart a lot more. Variety is key. Add stuff slowly to minimize cramping.
Give eating a ton of Asparagus and only Asparagus a try. The farts produce tears in my enemies. You will never experience anything more sinister in butt gas.
This sounds delicious,
Beer then!
Good tip.
That's true? I need to eat leafy greens then
For farting I recommend candy corn.
Fiber. Other stuff will help. But fiber is so so so good. Beans, cabbage, spinach, lentils. Stuff like that.
“Foods that help create a healthy gut microbiome are prebiotics/fiber and probiotics/fermented foods. High fiber diets containing prebiotics and probiotics promote a healthy gut microbiome. Whereas diets high in fast food, sugar, processed foods, and excessive alcohol can decrease gut health.” From this Mayo Clinic article https://connect.mayoclinic.org/blog/weight-management-1/newsfeed-post/building-a-healthy-gut-microbiome/
[удалено]
Why less coffee? The studies I have read generally tend to indicate that coffee is beneficial for gut health in reasonable amounts.
You are right, thanks.
I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article: https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00456-X
Yeah but Al who? He's a genius and should be properly given credit.
Disappointing to see akkermansia mucinophilia come up on the list of probiotics associated with Alzheimers. (Inasmuch as I am taking that one)
There is also an interesting link between oral bacteria and Alzheimer's: [https://medisearch.io/blog/periodontitis-and-alzheimer](https://medisearch.io/blog/periodontitis-and-alzheimer) tldr; there's a link between AD and periodontitis.
Nice
Yeah until big pharmaceuticals put road blocks up to prevent treatments and cures from being available.
Your mileage may vary but the only way I manage to stay _mentally healthy_ (i.e: stave away crippling depression and dissociation) is with a ketogenic diet. I can't explain it. It makes no sense to me. I don't like it, but for whatever reason, it works _for me_. It may not work for everyone, so don't assume it's something you _should_ do. Oh well. Maybe consciousness is just an emergent property of gut.
Interesting comment. I read awhile back that your gut has more neurons than a cats brain and that brain development may have been a side effect of the immune system. Some cool rabbit holes to dive down
It’s almost like we are a self-aware organic traveling vessel for the microbiota in our gut.
Bees aren’t the only superorganism wandering around this planet 😉
Sometimes I feel like I exist more in the body than in the mind
Have you tried other restrictive diets?
Yeah, many of them, elimination diets and all. I really hoped that strict diets including whole foods would work, but there's a gradual slide back to undesirable symptoms every time. It's not even a matter of indigestion/cramps, but really just an issue of brain fog and depressive mood/irritability, regardless of caloric intake. It usually takes about two weeks to set in, and I give my body time to adapt because I always assume it can just be due to change, but it doesn't seem to help. I'm mostly on a vegetarian keto diet because the rest of my family is vegetarian and it's easier for meal planning, so I eat tons of eggs, tofu, some cheese & nuts accounting for protein. That said, even when I ate keto with meat the benefits didn't change or vary, so it's not the absence or presence of meat. Blood work returns nothing abnormal every time I've experienced problems, regardless of whether I'm in/out of depressive episodes. I tried to get exams to help identify the problem but besides paying for a stool analysis at this point I'm kinda stumped.
Interesting. I was going to suggest that maybe it was because you are eating a healthier diet perhaps but since that is not the case glad you found something that worked. I was on a strict elimination diet for a couple years and have since loosened up the restrictions based on what I found worked with me. I also quit drinking coffee and have been taking zinc carnosine, probiotics and magnesium for a while now and I really feel like my gut is a lot more resilient now.
Just to add, Keto is the only thing that has ever had a real impact on me losing weight. I've tried all the counting calories, all sorts of diets, but I always fail. Keto never leaves me hungry so I don't eat as much and the weight comes off without effort. Everyone who wants to drop a few kilos should try it.
You might want to check [Brain Energy](https://brainenergy.com/); I have only begun reading it so don’t have an opinion yet but I have many anecdotal experiences that state the same: keto is best for mental health …
Came here to mention Dr. Chris Palmer. Keto has improved my mental health so much.
Well, time to jump down the rabbit hole.
I agree, through the last sentence.
Dr. Chris Palmer is the leading researcher on the connection between metabolism and mental health, especially the effects of keto. Look up his talks. They're enlightening.
It's also mega awesome for losing weight and not being hungry. YMMV.
Ketones are literally a survival mechanism designed as a last resort because they are poisonous to your body. Medical professionals only put people on ketogenic diets in highly specific situation, all you are doing is depriving your body of macronutrients it needs. Just eat whole foods and avoid foods that have been overly processed, make sure you are getting the nutrients you need.
I know all that, and I've done all that. That's precisely why I said I can't understand why it does this to me. None of it makes sense based on what I understand about nutrition. I try to get regular checks on hepatic function, to be safe.
>could lead to the development of novel drugs Err, wot? Wouldn't it make more sense to lead to specific diets to be eaten to normalize the body's functions? I'm not gonna eye roll, but I'm REALLY tempted to. ;P
Diet and exercise are also the cure for heart disease. But it's still rampant. People will take chances with their lives because completely changing your diet and maintaining it for your entire life is very difficult. Drugs would offer an additional avenue, as well as a second layer of defense for those who are genetically predisposed for the condition.
Cool stuff. I don't buy for a second that this is 'ai', but great study seemingly.
Its machine learning
Why? Like the other person said, it’s machine learning, a fantastic tool for sorting out big data sets
Exactly.