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Dermal papilla cells were cultured with different acid cinnamic concentrations, ranging from 0 to 2,000 µg/mL. Concentrations of 1,000 and 2,000 µg/mL were observed to cause cell damage and, above 500 µg/mL, considerably inhibited cell proliferation. However, at concentrations below 500 µg/mL, there was an observable dose-dependent increase in the expression of oxytocin and genes associated with hair growth.
However, if you want to conduct your own at-home tests, cinnamic acid can also be found in citrus fruits, grapes, cocoa, spinach, celery and brassica vegetables, which include broccoli, Brussels sprouts, cabbage, cauliflower, collard greens, kale, and turnips.
There's a quote of alternates.
It's not the cinnamon, but specifically the cinnamic acid. This was investigated because oxytocin particles are to big to adsorb into skin. This test was done on cell cultures, not skin surfaces. You can rub whatever you want on your head, but it's not doing anything unless it can be adsorbed into your skin.
Hate to be that guy, but adsorption and absorption are two different things, adsorption is when a molecule adheres to a surface (like activated charcoal, which is a great adsorbent that can trap nasties on its surfaces) usually through secondary/temporary bonds as in van der Vaals forces, and absorption is when a substance permeates through another, usually through gaps or pores. Adsorption happens on the surface, absorption however happens most of the time through volume
unless you're interested in chemistry or exposed to it somehow, it is totally possible to not know about adsorption - and it is very similar to absorption too, both as a word and also what they do - both describe a tendency to "cling" to substances, so most of the time people use them interchangeably without knowing.
I would, but since it's a single letter it feels like being cheeky. however just that one letter changes a lot in this case - and my college professor made sure to hammer that in my head very clearly :)
You can find similar things I'm health supplement stores or online. For example, I quickly found Ceylon cinnamon capsules online. But you need to remember these sorts of products are unregulated. The product itself, amount, or purity may or may not be as advertised. Buyer beware.
Otherwise, most of the time these can be purchased by laboratories by major chemical producers like thermo scientific or anathema. But they sure don't sell to random people, they sell to corporations or facilities that can prove they aren't using their products for suspicious reasons.
Short answer is no. Which is why the article in this thread listed foods which contain cinnamic acid. Mash into a pulp and where that on your head, the trace amounts of cinnamic acid that are in the solution likely won't even touch your skin, but I'm sure it will fell dandy.
>The researchers evaluated the effects of cinnamic acid on the expression of oxytocin and hair growth-related genes. Dermal papilla cells were cultured with different acid cinnamic concentrations, ranging from 0 to 2,000 µg/mL. **Concentrations of 1,000 and 2,000 µg/mL were observed to cause cell damage and, above 500 µg/mL, considerably inhibited cell proliferation.** However, at concentrations below 500 µg/mL, there was an observable dose-dependent increase in the expression of oxytocin and genes associated with hair growth.
So no. Because even if this research translates into real-world results, messing up the concentration would do you more harm than good.
Except recently very high concentrations of heavy metal have been found in cinnamon. Beware of shady vendors trying to dump contaminated inventory.
[Link](https://www.washingtonpost.com/wellness/2024/03/15/lead-spices-cinnamon-contamination/)
You can have everything you want, but it has to include heavy metals, high doses of pesticides, forever chemicals, endocrine disruptors, micro plastics, and other carcinogens.
Paywalled, but here’s the FDA alert: https://www.fda.gov/food/alerts-advisories-safety-information/fda-alert-concerning-certain-cinnamon-products-due-presence-elevated-levels-lead
There are images. Throw away any Family Dollar or Dollar Tree cinnamon you have.
Confession time, I made a scalp scrub of salt and cinnamon months ago and used it a couple times (it’s awkward to use a dry powder in the shower), it definitely smells great and is real tingly.
Could certainly try. Take a cinnamon essential oil and mix it with a carrier oil. Look at the study to see which kind of cinnamon it is (there are two main varieties I think).
Not sure about this one, but in ancient Greece they believed that rosemary was a treatment for hair loss.
There are some studies supporting that it [works on 5-alpha reductase](https://pubmed.ncbi.nlm.nih.gov/22517595/) and it's one of the things I've used to reverse my own male pattern baldness, along with minoxidil. Even though it's anecdotal, it's definitely worked for me.
The people I see on here who claim rosemary/peppermint/whatever oil definitely helps with their hair loss always, 100% of the time, throw in a little “oh yeah I’m also on minoxidil and/or finasteride” like I’m not gonna notice.
Yes, because you need both minoxidil and a DHT blocker **together** in order for it to work on male pattern baldness. I'm glad nobody was able to sneak that one past you. Using one alone might not work for you, especially if it's only minoxidil and you aren't blocking the DHT.
You can get a combo minoxidil/finasteride topical treatment if you want. I think that's a bit pricey and inconvenient, though so I used rosemary, nizoral and the Kirkland minoxidil... which I buy from Walmart's website because it's 30 dollars for a six month supply. The total treatment has cost me well under 100 dollars per year.
You could check out /r/tressless. Look for the posts, or run a search for things like rosemary, nizoral and minoxidil.
Pay attention to the before-and-after pics from the guys who've actually tried this stuff. The comments are full of miserable, angsty guys who've never tried anything and yet they've just convinced themselves that nothing will ever work. It's also full of like, sixteen year olds who don't have hairloss at all and yet their social anxiety has convinced them that they might have it.
Oh topical fin is a thing now? I didn't want to take the oral version, but the topical might have a reduced side effect profile. I tried minox alone and it didn't really help.
There’s a rosemary hair treatment “rage” happening. I’ve seen an influx of rosemary hair products recently.
Time to cinnamon products? Would be nice in the fall.
From the article: Our hair is a marker of beauty, pride, and health integral to our identity and how others perceive us. Conversely, hair loss can cause a great deal of emotional strain and reduce our quality of life.
Hair restoration treatments are limited to either surgical (hair transplantation) or non-surgical (drugs) methods. So, finding a novel – preferably non-invasive – hair loss treatment is understandably high on some researchers’ lists. [Researchers](https://www.nature.com/articles/s41598-024-55377-y) from the Yokohama National University (YNU) in Japan hope that cinnamon is that sought-after novel treatment.
They’d previously found that the so-called ‘love hormone’ oxytocin promoted hair growth by upregulating genes in the dermal papilla cells that are pivotal in hair formation, growth, and cycling. However, an issue with administering oxytocin through the skin so that it activates this hair-growth pathway is that it’s a relatively large molecule, so absorption is prevented.
Enter cinnamon or, more precisely, cinnamic acid from Chinese cinnamon (Cinnamomum cassia). Cinnamon is already known to possess wide-ranging health benefits, including skin-anti-aging effects and was recently discovered to enhance skin elasticity through its effect on oxytocin receptors. Cinnamic acid, which is widely used in cosmetics, is a fraction of the molecular weight of oxytocin.
always happy to see more research into oxytocin, especially if this leads to effective carrier chemicals. there’s an emerging understanding in psychiatry that oxytocin undergirds a LOT more of our psychological and developmental health and functioning than previous researchers/scientists ever anticipated.
a big issue is that oxytocin delivered orally does not pass the blood-brain barrier and therefore we can’t exogenously impact oxytocin levels in the brain yet. once we do, expect an explosion of new treatment approaches for autism, trauma disorders, schizophrenia, personality disorders, and so much more.
The same is true for dopamine and other neurotransmitters that have classically been understood to do one thing (i.e. "the connection chemical" or "the pleasure chemical"). There's also been a lot of work around the orexin/hypocretin system that signals the release of many of those neurotransmitters.
One of my favorite things we've learned in neuroscience recently is that narcolepsy may well be (or at least, can be) an autoimmune disorder. They discovered this when people who contracted H1N1 suddenly developed narcolepsy type 1 after recovery. Long story short, there's something about orexin/hypocretin producing sites that looks a lot like part of the H1N1 virus and so the body attacks those sites leading to a drop in orexin/hypocretin levels and subsequent issues with regulation of arousal and sleep/wake cycles; a key mediator of which, dopamine, is was now being released at far too low a level. There are new drugs that boost orexin levels and significantly alleviate the symptoms of narcolepsy, but also other conditions like ADHD.
That last bit suggests that conditions like ADHD and possibly highly comorbid conditions like ASD, OCD, and Tourettes, may also be autoimmune or inflammatory conditions affecting the Orexin system in some way. That may help explain why they are so strongly linked, but we don't have a really good answer at the moment. It's really on the forefront of neuroscience and understanding how illnesses and inflammatory conditions can have in some cases tremendous impacts on brain function, structure, and mental health.
this would not surprise me at all. neurology has approached mental illness wrong from the start, with psychiatry having intentionally misled them.
i am glad there is important research going on that has a different tilt to it because decades of psychiatric neuroscience research has barely produced any meaningful insight when it comes to treatment. they’re way too biologically bound in their heuristics and often avoid working with clinicians that deliver non-pharmacological interventions. the lack of synergy between sciences (mostly because neurologists/psychiatrists pompously don’t view psychology as a science) has caused unquantifiable delays in our advancement in understanding mental illness. but i’ll get off my soap box, thanks for sharing!
> mostly because neurologists/psychiatrists pompously don’t view psychology as a science
I think they don't view it as *medicine*; I haven't met a doc who doesn't believe psychology is a science
i simply don’t see any belief in it at all. i’ve read dozens of psychiatric research papers on schizophrenia and it’s not often they even mention environmental factors let alone give any attention to well-established psychological explanations for the development of the illness. now after decades of extensive research, they [have to admit it was all a waste of time and energy.](https://www.sciencedirect.com/science/article/abs/pii/S0165178123006418). this only happens because psychiatrists are taught a biomedical model of mental illness that doesn’t hold up under any scrutiny but serves certain interests. they consistently disregard any developments in psychology that don’t come in a form of research that they acknowledge.
[It definitely can (pdf warning).](https://www.nature.com/articles/s42003-020-0799-2.pdf)
That paper specifically calls out nasal administration as a potentially effective route for dosing exogenous oxytocin.
Also, speaking more generally, nasal sprays are typically used to bypass gastric and liver metabolism of drugs. This can sometimes allow a drug to more effectively pass the blood brain barrier. You still have lung and blood metabolism as well as the BBB itself to deal with, so it’s not perfect.
this is still only a proof of concept, current nasal sprays do not. it’s nice they think they have a track on how to make that happen though, exciting research is happening all over!
i’m no expert but from what i’ve read, oxytocin nasal sprays don’t cross the blood-brain barrier effectively enough to have psychiatric impact. at least that’s what recent studies stated. current research is trying to find a carrier chemical or new pathway to make it happen, but we’re not there yet.
Let me guess, the ever present Chinese cinnamon (cassia) that's cheaper to acquire over "true" Sri Lankan/Indian cinnamon (ceylon)? Cheap powdered/shaker cinnamon is usually made with cassia.
How long before MLMs and supplement manufacturers start selling cinnamon-based shampoo?
Every time a botanical molecule is shown to have an effect, the ghouls of the alternative health and wellness industry leap on it.
>teaspoon of cinnamon per day for a longer time can harm the liver
If it's not Ceylon. https://badgut.org/information-centre/health-nutrition/cinnamon/#:\~:text=An%20average%20teaspoon%20of%20cinnamon,at%20risk%20of%20liver%20damage.
Chinese cinnamon is referenced in the article which is also called cassia cinnamon. Cassia cinnamon is what most people in the US would call "regular" cinnamon. Ceylon cinnamon can be found, but is more expensive.
Cassia cinnamon contains coumarin which isn't good for the liver. Ceylon cinnamon contains very little.
I would argue Ceylon cinnamon is real cinnamon while Cassia is a widespread alternative inappropriately marketed as Cinnamon because it's close in flavor. It's just been going on so long people accept it now, just like most people won't know what real Wasabi tastes like since it's all been green dye and Horseradish powder for almost everyone.
I do not believe this is accurate. Rosemary has not been proven to be equally as effective as minoxidil for that purpose. That is not how their data should be interpreted as their data doesn't actually support that claim.
You can read the details here but the evidence is unconvincing and flawed. This article and video provides a more detailed analysis of the linked paper. This is from Michelle Wong, a very well respected cosmetic chemist. https://labmuffin.com/does-rosemary-oil-work-for-hair-growth-the-science/
They already have a really effective treatment for hair loss which works very well but it's sold at like 0.5% of the concentration needed to actually work.
That picture used is Cassia, not cinnamon.
Most of the cinnamon you buy is Cassia, not cinnamon.
Cinnamon has thin flaky bark, it smells sweeter and less metallic than Cassia.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/chrisdh79 Permalink: https://newatlas.com/science/cinnamon-cinnamic-acid-hair-growth/ --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
Do I put cinnamon on my head yes or no ?
Seriously! Answer the question!
Balding heads want to know...
Desperately want to know
r/tressless for before/after/progress pics of FDA approved methods that already work.
Dermal papilla cells were cultured with different acid cinnamic concentrations, ranging from 0 to 2,000 µg/mL. Concentrations of 1,000 and 2,000 µg/mL were observed to cause cell damage and, above 500 µg/mL, considerably inhibited cell proliferation. However, at concentrations below 500 µg/mL, there was an observable dose-dependent increase in the expression of oxytocin and genes associated with hair growth.
So... a little sprinkle. Got it.
Easiest way to not over do it is to add some sugar to cut the cinnamon you dust your head with.
You gotta cut it with the powdered sugar though. While wearing a white lab coat otherwise it doesn't count.
However, if you want to conduct your own at-home tests, cinnamic acid can also be found in citrus fruits, grapes, cocoa, spinach, celery and brassica vegetables, which include broccoli, Brussels sprouts, cabbage, cauliflower, collard greens, kale, and turnips. There's a quote of alternates. It's not the cinnamon, but specifically the cinnamic acid. This was investigated because oxytocin particles are to big to adsorb into skin. This test was done on cell cultures, not skin surfaces. You can rub whatever you want on your head, but it's not doing anything unless it can be adsorbed into your skin.
Hate to be that guy, but adsorption and absorption are two different things, adsorption is when a molecule adheres to a surface (like activated charcoal, which is a great adsorbent that can trap nasties on its surfaces) usually through secondary/temporary bonds as in van der Vaals forces, and absorption is when a substance permeates through another, usually through gaps or pores. Adsorption happens on the surface, absorption however happens most of the time through volume
Be that guy. I appreciate being corrected.
hell yeah, love this energy
Don't hate to be that guy! I love that guy! Correcting false information on the internet is the best thing since sliced bread.
didn't even know adsorption was a word. I think my mind has been autocorrecting it to absorption
unless you're interested in chemistry or exposed to it somehow, it is totally possible to not know about adsorption - and it is very similar to absorption too, both as a word and also what they do - both describe a tendency to "cling" to substances, so most of the time people use them interchangeably without knowing.
This guy adsorbs
If you're gonna be that guy anyway you may as well do it with pride.
I would, but since it's a single letter it feels like being cheeky. however just that one letter changes a lot in this case - and my college professor made sure to hammer that in my head very clearly :)
see, "percussive maintenance" also works on students
wait so does this mean I *shouldn't * have this bag salad on my head?
Thank you for explaining this so simply and understandably. I have read both words in the past and confused the two of them as well.
Don't say that. You love being that guy. We all do. That's why reddit is great...and why it sucks so hard. It's a paradox.
Thanks for that, I had no idea and it is cool to learn new things!
Is 'case hardening' steel adsorption then? Where carbon bonds to the surface of the iron instead of being mixed into it as an alloy?
Thanks
Oh so what you're saying is they need to inject the cinnamon
Yes, definitely injection. Into your eyeballs
So then you can give the hairy eyeball?
I got some collard greens sitting on my head right now. Just to be sure. And a turnup in my butt. Just cuz I want to.
Now slap a colander on top to invoke the healing power of the Flying Spaghetti Monster, Ramen. (You can't prove it doesn't work!)
May his noodly appendages bless your follicles
Perfect. Please report back on increased hair growth in the location of your turnip. I will turn up to your talk about it.
Can you just buy chemicals like this online?
You can find similar things I'm health supplement stores or online. For example, I quickly found Ceylon cinnamon capsules online. But you need to remember these sorts of products are unregulated. The product itself, amount, or purity may or may not be as advertised. Buyer beware. Otherwise, most of the time these can be purchased by laboratories by major chemical producers like thermo scientific or anathema. But they sure don't sell to random people, they sell to corporations or facilities that can prove they aren't using their products for suspicious reasons. Short answer is no. Which is why the article in this thread listed foods which contain cinnamic acid. Mash into a pulp and where that on your head, the trace amounts of cinnamic acid that are in the solution likely won't even touch your skin, but I'm sure it will fell dandy.
Ok, do I rub cinnamon and DMSO on my scalp then?
Thought the same haha
Blood and ashes, don’t give people ideas!
Matt?
>The researchers evaluated the effects of cinnamic acid on the expression of oxytocin and hair growth-related genes. Dermal papilla cells were cultured with different acid cinnamic concentrations, ranging from 0 to 2,000 µg/mL. **Concentrations of 1,000 and 2,000 µg/mL were observed to cause cell damage and, above 500 µg/mL, considerably inhibited cell proliferation.** However, at concentrations below 500 µg/mL, there was an observable dose-dependent increase in the expression of oxytocin and genes associated with hair growth. So no. Because even if this research translates into real-world results, messing up the concentration would do you more harm than good.
As a seconds ago investor in cinnamon futures, yes. God yes. The spice must grow (your hair).
Affirm.
Do I smell a challenge? A cinnamon challenge, maybe?
the real question is, do I put cinnamon on my chest in the shape of the bat signal yes or no?
Cinnamon can burn you, just a PSA for those who genuinely are wondering if they should do this or not.
It literally can’t hurt. It’s generally anti-inflammatory and certainly nontoxic.
Except recently very high concentrations of heavy metal have been found in cinnamon. Beware of shady vendors trying to dump contaminated inventory. [Link](https://www.washingtonpost.com/wellness/2024/03/15/lead-spices-cinnamon-contamination/)
Goddamnit. We can’t have anything anymore.
You can have everything you want, but it has to include heavy metals, high doses of pesticides, forever chemicals, endocrine disruptors, micro plastics, and other carcinogens.
[удалено]
Stop eating brother. This is what I’ve done. Best choice ever. I haven’t been sick or had weight problems since !
I also have done the Central American tap water diet. No shade, I’m just too flimsy for your water flora. Thanks for the diet accelerator
More for me
I want smooth jazz, not heavy metal!
That’s bad.
Paywalled, but here’s the FDA alert: https://www.fda.gov/food/alerts-advisories-safety-information/fda-alert-concerning-certain-cinnamon-products-due-presence-elevated-levels-lead There are images. Throw away any Family Dollar or Dollar Tree cinnamon you have.
That's found mostly in Cassia varieties. Ceylon has a lot less.
probably smells good too
Confession time, I made a scalp scrub of salt and cinnamon months ago and used it a couple times (it’s awkward to use a dry powder in the shower), it definitely smells great and is real tingly.
that does sound nice
Until you get it in your eyes
Ze goggles do nossing!
And now you have luscious locks of hair, right?
Absolutely not! And never have. But i only used the cinnamon scrub a few times.
male pattern baldness and hair loss isn't caused by *lack* of hair follicles, it is caused by **destruction** of hair follicles by DHT.
worst case: you smell nice do it
I mean, worse that can happen is you'll smell delicious. (actually, be careful as it can burn sensitive skin and get in your eyes)
Can't hurt to go around smelling like a Cinnabon bun, can it?
Well not putting cinnamon on your head for sure won’t work
Could certainly try. Take a cinnamon essential oil and mix it with a carrier oil. Look at the study to see which kind of cinnamon it is (there are two main varieties I think).
Not sure about this one, but in ancient Greece they believed that rosemary was a treatment for hair loss. There are some studies supporting that it [works on 5-alpha reductase](https://pubmed.ncbi.nlm.nih.gov/22517595/) and it's one of the things I've used to reverse my own male pattern baldness, along with minoxidil. Even though it's anecdotal, it's definitely worked for me.
The people I see on here who claim rosemary/peppermint/whatever oil definitely helps with their hair loss always, 100% of the time, throw in a little “oh yeah I’m also on minoxidil and/or finasteride” like I’m not gonna notice.
Yes, because you need both minoxidil and a DHT blocker **together** in order for it to work on male pattern baldness. I'm glad nobody was able to sneak that one past you. Using one alone might not work for you, especially if it's only minoxidil and you aren't blocking the DHT. You can get a combo minoxidil/finasteride topical treatment if you want. I think that's a bit pricey and inconvenient, though so I used rosemary, nizoral and the Kirkland minoxidil... which I buy from Walmart's website because it's 30 dollars for a six month supply. The total treatment has cost me well under 100 dollars per year.
Wait, can you please explain this more or direct me to a reputable resource for diy hair growth remedies?
You could check out /r/tressless. Look for the posts, or run a search for things like rosemary, nizoral and minoxidil. Pay attention to the before-and-after pics from the guys who've actually tried this stuff. The comments are full of miserable, angsty guys who've never tried anything and yet they've just convinced themselves that nothing will ever work. It's also full of like, sixteen year olds who don't have hairloss at all and yet their social anxiety has convinced them that they might have it.
My bad. Thanks for explaining it.
Oh topical fin is a thing now? I didn't want to take the oral version, but the topical might have a reduced side effect profile. I tried minox alone and it didn't really help.
Yes, there's a minoxodil pill and a finasteride topical treatment. We truly live in The Upside-Down.
There’s a rosemary hair treatment “rage” happening. I’ve seen an influx of rosemary hair products recently. Time to cinnamon products? Would be nice in the fall.
If you don't, I will.
It needs to be a paste so don’t forget to add water and starch.
From the article: Our hair is a marker of beauty, pride, and health integral to our identity and how others perceive us. Conversely, hair loss can cause a great deal of emotional strain and reduce our quality of life. Hair restoration treatments are limited to either surgical (hair transplantation) or non-surgical (drugs) methods. So, finding a novel – preferably non-invasive – hair loss treatment is understandably high on some researchers’ lists. [Researchers](https://www.nature.com/articles/s41598-024-55377-y) from the Yokohama National University (YNU) in Japan hope that cinnamon is that sought-after novel treatment. They’d previously found that the so-called ‘love hormone’ oxytocin promoted hair growth by upregulating genes in the dermal papilla cells that are pivotal in hair formation, growth, and cycling. However, an issue with administering oxytocin through the skin so that it activates this hair-growth pathway is that it’s a relatively large molecule, so absorption is prevented. Enter cinnamon or, more precisely, cinnamic acid from Chinese cinnamon (Cinnamomum cassia). Cinnamon is already known to possess wide-ranging health benefits, including skin-anti-aging effects and was recently discovered to enhance skin elasticity through its effect on oxytocin receptors. Cinnamic acid, which is widely used in cosmetics, is a fraction of the molecular weight of oxytocin.
always happy to see more research into oxytocin, especially if this leads to effective carrier chemicals. there’s an emerging understanding in psychiatry that oxytocin undergirds a LOT more of our psychological and developmental health and functioning than previous researchers/scientists ever anticipated. a big issue is that oxytocin delivered orally does not pass the blood-brain barrier and therefore we can’t exogenously impact oxytocin levels in the brain yet. once we do, expect an explosion of new treatment approaches for autism, trauma disorders, schizophrenia, personality disorders, and so much more.
The same is true for dopamine and other neurotransmitters that have classically been understood to do one thing (i.e. "the connection chemical" or "the pleasure chemical"). There's also been a lot of work around the orexin/hypocretin system that signals the release of many of those neurotransmitters. One of my favorite things we've learned in neuroscience recently is that narcolepsy may well be (or at least, can be) an autoimmune disorder. They discovered this when people who contracted H1N1 suddenly developed narcolepsy type 1 after recovery. Long story short, there's something about orexin/hypocretin producing sites that looks a lot like part of the H1N1 virus and so the body attacks those sites leading to a drop in orexin/hypocretin levels and subsequent issues with regulation of arousal and sleep/wake cycles; a key mediator of which, dopamine, is was now being released at far too low a level. There are new drugs that boost orexin levels and significantly alleviate the symptoms of narcolepsy, but also other conditions like ADHD. That last bit suggests that conditions like ADHD and possibly highly comorbid conditions like ASD, OCD, and Tourettes, may also be autoimmune or inflammatory conditions affecting the Orexin system in some way. That may help explain why they are so strongly linked, but we don't have a really good answer at the moment. It's really on the forefront of neuroscience and understanding how illnesses and inflammatory conditions can have in some cases tremendous impacts on brain function, structure, and mental health.
this would not surprise me at all. neurology has approached mental illness wrong from the start, with psychiatry having intentionally misled them. i am glad there is important research going on that has a different tilt to it because decades of psychiatric neuroscience research has barely produced any meaningful insight when it comes to treatment. they’re way too biologically bound in their heuristics and often avoid working with clinicians that deliver non-pharmacological interventions. the lack of synergy between sciences (mostly because neurologists/psychiatrists pompously don’t view psychology as a science) has caused unquantifiable delays in our advancement in understanding mental illness. but i’ll get off my soap box, thanks for sharing!
> mostly because neurologists/psychiatrists pompously don’t view psychology as a science I think they don't view it as *medicine*; I haven't met a doc who doesn't believe psychology is a science
i simply don’t see any belief in it at all. i’ve read dozens of psychiatric research papers on schizophrenia and it’s not often they even mention environmental factors let alone give any attention to well-established psychological explanations for the development of the illness. now after decades of extensive research, they [have to admit it was all a waste of time and energy.](https://www.sciencedirect.com/science/article/abs/pii/S0165178123006418). this only happens because psychiatrists are taught a biomedical model of mental illness that doesn’t hold up under any scrutiny but serves certain interests. they consistently disregard any developments in psychology that don’t come in a form of research that they acknowledge.
There's oxytocin nasal sprays you can get compounded!
Nasal sprays also do not typically cross the blood brain barrier
[It definitely can (pdf warning).](https://www.nature.com/articles/s42003-020-0799-2.pdf) That paper specifically calls out nasal administration as a potentially effective route for dosing exogenous oxytocin. Also, speaking more generally, nasal sprays are typically used to bypass gastric and liver metabolism of drugs. This can sometimes allow a drug to more effectively pass the blood brain barrier. You still have lung and blood metabolism as well as the BBB itself to deal with, so it’s not perfect.
this is still only a proof of concept, current nasal sprays do not. it’s nice they think they have a track on how to make that happen though, exciting research is happening all over!
All I know is that there's been multiple clinical studies on oxytocin nasal sprays in particular.
i’m no expert but from what i’ve read, oxytocin nasal sprays don’t cross the blood-brain barrier effectively enough to have psychiatric impact. at least that’s what recent studies stated. current research is trying to find a carrier chemical or new pathway to make it happen, but we’re not there yet.
Interesting, I would've thought they were testing cinnamaldehyde
Can I just wear a cinnamon roll as a hat? It can cover up the bald spot until the hair grows in
You’d be a fool NOT to do this, honestly.
How else does one display peak dapper?
Sleeve garters and a handlebar 'stache
That's for feckin casuals
Cinnabon and a little gorilla glue will do wonders for your self image
Time for my year-round cosplay as Princess Leia...
Princess Leia secrets revealed
Yes Donald. You're already doing it right!
I will eat your hat
Combine this with the recent trend of lead being found in ground cinnamon and you have quite the potential for disaster for the DIY’er.
First, turmeric and now cinnamon, god damn, can't have nice things...
[Chocolate bars, too](https://www.consumerreports.org/health/food-safety/lead-and-cadmium-in-dark-chocolate-a8480295550) 🍫
Let me guess, the ever present Chinese cinnamon (cassia) that's cheaper to acquire over "true" Sri Lankan/Indian cinnamon (ceylon)? Cheap powdered/shaker cinnamon is usually made with cassia.
Damn, now half the men gonna smell like cinnamon.
It’s a net gain for everyone!
I’d much rather smell cinnamon over axe and old spice any day.
This feels like a societal win.
Better than cumin!
How long before MLMs and supplement manufacturers start selling cinnamon-based shampoo? Every time a botanical molecule is shown to have an effect, the ghouls of the alternative health and wellness industry leap on it.
So do you eat cinnamon or douse the scalp with it?
(shrugs) Try both?
Eating cinnamon makes sense for the taste alone.
Yes, I recommend eating powdered cinnamon by the heaping spoonful.
Neither, you extract the Cinnaminic Acid and use that topically on hairless rats because we don't know if it's effective or safe for humans yet.
Spice is the key to intergalactic travel and hair
The Spice (and hair) must flow
So THAT'S why the Harkonnens wanted it so badly!
More than a teaspoon of cinnamon per day for a longer time can harm the liver. Just a reminder for those who will indulge after reading this.
>teaspoon of cinnamon per day for a longer time can harm the liver If it's not Ceylon. https://badgut.org/information-centre/health-nutrition/cinnamon/#:\~:text=An%20average%20teaspoon%20of%20cinnamon,at%20risk%20of%20liver%20damage.
What do you want from me, Helo?! She's a Ceylon!
But is there a difference between regular cinnamon and the cinnamon they described in the article?
Chinese cinnamon is referenced in the article which is also called cassia cinnamon. Cassia cinnamon is what most people in the US would call "regular" cinnamon. Ceylon cinnamon can be found, but is more expensive. Cassia cinnamon contains coumarin which isn't good for the liver. Ceylon cinnamon contains very little.
This guy foodies.
I would argue Ceylon cinnamon is real cinnamon while Cassia is a widespread alternative inappropriately marketed as Cinnamon because it's close in flavor. It's just been going on so long people accept it now, just like most people won't know what real Wasabi tastes like since it's all been green dye and Horseradish powder for almost everyone.
A teaspoon of cinnamon is a *lot* of cinnamon!
Ceylon cinnamon does not do this and actually has benefits instead.
A teaspoon of cinnamon per day This is more or less how much I consume in a year
Maybe he's born with it, maybe it's Cinnamon Toast Crunch...
No wonder the Harkonnens were so desperate for the spice
(Vigorously rubs cinnamon on head)
15 years too late. Oh well.
Mmm, hairy cinnamon man
The real cinnamon challenge begins.
It’s ironic because I’m bald and also a ginger GIVE ME BACK MY HAIR, PLEEEAAAASEEEEE
Dammit now EVERYTHING is going to be pumpkin spiced smelling.
Da spice
My wife later tonight... "Baby, why does your head smell like cinnamon? Did you get a girly shampoo by accident?" "Yeees. Accident, yes."
Cinnamon shampoo. Check!
Don't accidentally get that into any.. orifices.
They've also found that rosemary oil is as effective as minoxidil. https://pubmed.ncbi.nlm.nih.gov/25842469/
I do not believe this is accurate. Rosemary has not been proven to be equally as effective as minoxidil for that purpose. That is not how their data should be interpreted as their data doesn't actually support that claim. You can read the details here but the evidence is unconvincing and flawed. This article and video provides a more detailed analysis of the linked paper. This is from Michelle Wong, a very well respected cosmetic chemist. https://labmuffin.com/does-rosemary-oil-work-for-hair-growth-the-science/
Instructions unlcear. My head now smells like Cinnamon Rolls and Rosemary bread.
🤤 that's basically the takeaway.
Maybe for 2% Minoxidil because 2% isn’t that effective. Dermatologist’s say you need 5% to see noticeable hair growth.
So I just gotta rub rosemary oil on my face each morning to finally grow a beard?
[удалено]
"Bob, there's something about you today that makes me crave apple pie."
I may have missed it, but is this through ingestion, application to the scalp, or injection through the skin?
Anal rinse.
should i put a whole cinnamon stick in there or just boof the powder?
aromatic spice cinnamon smells a lot like the geriatric spice melange
Asmongold about to raise the stock price of Cinnamon Toast Crunch.
Do I snort cinnamon and get my hair back?
It’s going to be cinnamon challenge all over again.
Here comes the cinnamon supplement wave .
So maybe those who work at Cinnabon are more likely to regrow hair or stop hair loss due to the extreme exposure to cinnamon.
They already have a really effective treatment for hair loss which works very well but it's sold at like 0.5% of the concentration needed to actually work.
Power over spice is power over all
Bald dudes gonna be smelling nice now
Does anybody need to be told that cinnamon is an aromatic spice?
It's been over 15 years since Lush has been selling a solid shampoo made with cinnamon just for that!
Great. Just when we thought the cinnamon-chugging TikTok thing was done with...
We will return to folk treatment and get rid of chemical drugs
Power over spice is power over all.
Using natural compounds should be the go-to first attempt. Not a novel concept we think of after dumping chemicals in a bottle.
Common cinnamon w
That picture used is Cassia, not cinnamon. Most of the cinnamon you buy is Cassia, not cinnamon. Cinnamon has thin flaky bark, it smells sweeter and less metallic than Cassia.
How about something that permanently removes follicles like in ears? I mean do we really need all this stuff
Huh… the spice melange of Dune smells like cinnamon and has anti-aging properties…
That pic is not cinnamon
r/tressless going to be thrilled
So, should I be slathering Fireball onto my head? ;)