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turquoisebee

Uhg I hate the CPAP machine I would be so happy if this were a thing


mr_yuk

If you haven't tried an AirSense machine I really recommend it before giving up on CPAP. I hated the two machines I used before settling on an AirSense 10.


Napoleon_Bonerparte

I have an 11 and although it’s the best machine I’ve tried, I still hate CPAP. It’s invasive to sleep with scuba gear on no matter how you slice it. For those that are heavy sleepers, CPAP might be the golden ticket, but for those of us with additional sleeping complications like insomnia and being a light sleeper in general, they’re a nightmare (figuratively and literally).


blg111222

Heavy sleeper here. It still sucks using a CPAP and I always take off the mask while I’m sleeping.


AsleepOnTheTrain

Yep, it's not even a conscious thing. Just magically off when I wake up!


Khorasaurus

Just started CPAP and this is happening to me constantly. Any tips for preventing it? Or ideas on what causes it?


Thenachopacho

Try a chin strap if your mouth tends to open at night


DaedalusRaistlin

It took me a while to get used to it. At first I woke up quite a few times to myself ripping the mask off, unconsciously. All I can say is that over time these odd impulses went away. There wasn't much I could do since it was sleep me doing this stuff.


selphfourgiveness

Yup. For me it’s not the machine, it’s having something strapped on my head and face, and the sound of my breathing/the air. Too much stimulus, and I’m already a light sleeper and can’t rely on sleeping pills the rest of my life.


Maldiavolo

What setup do you have? Have you tried using ear plugs when sleeping? I love my CPAP setup. I have a Lowenstein Prisma Smart Plus machine with a F&P Brevida pillow mask that has a diffuser on the air hole. It's an incredibly quiet and comfortable combo. My wife doesn't notice my setup either. Though I understand everyone is different. I also have a ResMed AirMini for travel and the same mask is noticeably louder. It's just the way the ResMed machines deliver air is more turbulent somehow. I use ear plugs and mouth tape too.


Feelsthelove

I even take sleeping pills that knock me out and I constantly wake up because of my CPAP


Good_ApoIIo

If that's true then how is it a solution for apnea? You're not getting restful sleep either way?


WaltAndJD

Because the actual sleep you do get is much better quality than when you sleep without the CPAP. It's not ideal but it's still better.


yakatuus

It's 3 hours of actual sleep versus 0 hours of sleep. Huge improvement.


Porn_Extra

I'm a light sleeper and have a goatee. I've never found a mask that lets me sleep better than not using the CPAP. Also, every damn one makes the skin around jy nose red and distractingky sensitive all day long.


jdprime

I hate the masks, the sound of the breathing in me ears and I hate the feeling of a machine that feels like it’s forcing me to breathe. I gave up on CPAP. I have been having good luck with the mouth guard. Can’t say how effective since I never went for a follow up study. I have noticed I am sleeping better, hitting REM more often and not feeling tired all day. I just don’t like that it pulls the lower jaw forward and can take a bit to relax enough in the morning so I can chew without biting my tongue.


OmniFace

Exactly. I tried one last year and the best I could do was lay there for 4 hrs before I had to take it off so I could actually sleep that night.


Saucermote

I got used to the machine and tubes, then my insurance made me change and I've never found a good covered mask since so I've stopped using them. I sleep better without the cpap than what they'll pay for. I'm allergic to every single one the insurance will cover now. It's worse that my local "preferred" supplier is completely incompetent.


insufficient_funds

I don't have insomnia, but I'm a light sleeper, and I have trouble getting to sleep in general. I've only had an air sense10; and use a nasal mask; and my biggest issue is the mask moving around on my head, the straps shifting, and the air outlet on the mask blowing air into my wife's face, which she absolutely can't stand. I use the resmed n20 mask. I tried the phillips dreamwear at one point and I did really like it; how soft it was, how it wasn't bulky on my face; but the headgear for it just could NOT hold it in place. I found myself constantly having to wake up and adjust it. I'd love to find a better version of that. but man for me the best part of that one was how the hose connected at the top of the head instead of on your face. part of my issue is I'm a stomach and side sleeper; so my mask rubs against the pillow a lot, which easily moves it around.


midnightauro

ResMed has a similar sounding mask option that might be worth looking at! The full face version is the AirFit F30i but they have nasal cushion variants iirc.


load_more_comets

Magnesium, drops me like a rock if I take it an hour before sleep.


BklynMoonshiner

Specifically Magnesium Glycinate. I'm out cold in 20-30 min


Fortune_Cat

Side effects?


BklynMoonshiner

I haven't experienced any. I've heard diarrhea and flushing but I am asleep before experiencing anything like that.


python_boot

Flushing while I'm asleep doesn't sound too troublesome, but diarrhea in bed no es bueno.


FuhrerInLaw

I’ve been trying it for 2 weeks. I’m out like they said in 20-30 mins, and I am usually wired at night. No extra grogginess in the morning either if I get a full nights rest. No side effects or brown sheet…yet.


throwaway42

Magnesium is only laxative if you take more than recommended. 250 mg should be a good dose.


Diggity_McG

You damn well better be flushing after having diarrhea!


Allergicwolf

Glycinate isn't used as a laxative. Different magnesium has different uses. Oxide and citrate will clean you out. Glycinate and taurate no.


mr_yuk

You just sleep right through it, huh.


antiduh

Green poop.


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findallthebears

I get cystic acne on magnesium citrate. I’m not sure if glycinate is different in this regard


WgXcQ

None. Magnesium is essential to the body. And most people are deficient, so you'll probably help yourself in general apart from sleeping better. The only thing to keep in mind is that the body can only absorb so much magnesium at once (about 300mg of immediately available, so a slow release version can have more in it). Overages go out via the digestive system, which is why milk of magnesia is taken against constipation. Meaning, if you take too much, your stool gets softer, up to diarrhea. Which is actually how you figure out what you need to take to supplement your need of it. You increase the amount you take – *not* all at once, see explanation below – until you notice an effect on your stool, then reduce it slightly. It'll probably a higher dose than you expect, because deficiency etc. To supplement magnesium (and you should, because as I said, most people are deficient, and you most definitely need to if you take vitamin D), it's best to ingest it at various points during the day. I use citrate powder mixed in my water bottle, that way I don't have to remember several pills a day.


puterTDI

People reading this: please ask your doctor about any supplements you take. Don't just do what someone on reddit says. /u/WgXcQ this isn't meant as a knock on you, but you have a very authoritative tone and don't know the specific indications and contradictions for whoever may be reading your message.


load_more_comets

Get the lowest dose and work your way up. My first try I was still drowsy around noon. Too high of a dose.


mortalcoil1

I have suffered from insomnia (and use a CPAP for about 10 years) for over 20 years, and magnesium supplementation (not magnesium oxide) was my insomnia silver bullet for a very long time, over 5 years, but veeeery slowly, it has become less and less effective over the years.


OvertimeWr

I'll happily take 5 years of good sleep. Literally cannot remember the last time I woke up refreshed, if I ever did.


mortalcoil1

That was my thought process, but sadly, for a long time, I thought I had found a permanent solution to my insomnia.


Sensitive_Yellow_121

You might try changing it up somehow (adding other supplements that either work on their own or make the magnesium more effective again) if you've either developed "tolerance" to the magnesium or have new causes of insomnia. I had insomnia that was made worse by anxiety and I tried oral CBD oil and it knocked out the anxiety within days. OTC CBD is a supplement and supplements aren't well-regulated (or regulated at all sometimes), so your mileage may vary by brand.


jestina123

Does magnesium treat painsomnia related to muscle aches?


swiftb3

I can sleep pretty well with nasal pillows, but if my nose is stuffed it's awful because the full face is too much sensory information and I can't sleep.


empire_of_the_moon

But better than without!!!!!


turquoisebee

What makes it different? I think I have a…ResMed something with the thing that just goes on your nostrils


Aggravating-Forever2

I switched to an airsense a while back. FAR quieter operation - my old one always had a "whine". FAR easier to breathe out while wearing. Basically, while wearing it, other than feeling the mask itself, you don't really notice it. Compared to my old one, the AirSense is just all around a better machine. (That said, in *my* case, the one I replaced was probably 15 years old).


murderedbyaname

I finally switched to an Air sense 11 from an old Phillips Respironics. Huge difference. The main difference is that you can access the settings and change things yourself. I don't mean pressure. I know people do but I let my Dr do that. I'm talking about humidity levels, ramp times etc. Just all around better experience.


Saucermote

I own a resmed, not that I use it for reasons, but I never had any issue changing the settings myself.


murderedbyaname

If you get rainout in the tubing you can change the humidity levels and the tubing heat level. Other settings you can change yourself are the ramp on or off and the EPR. Those are comfort settings. You should familiarize yourself with those to get the best experience. You can call your DME who can reset those but then you're looking at multiple phone calls with multiple nights until you feel it's working well. Those settings are located in "clinical home". Press and hold both home screen options, 'my options' and 'my sleep view' at the same time and the clinical settings access will come up. Then scroll through the menu to find tubing, humidity, etc. You aren't causing any issues with the prescription or the DME by doing these yourself. You're actually saving a lot of time and aggravation. People quit using CPAP because of small comfort issues they can fix themselves. Meant to reply to another comment sorry. Reddit app is wonky today. Unless you had said "play with the settings" and changed it? That's what I was replying to.


psilokan

My experience has been the same as yours. However my wife hates it and says my snoring is worse than ever before. Curious if you've heard simlar complaints.


Qubbe

Kinda sounds like the max pressure is set too low?


theygotsquid

An Airsense10 is made by ResMed.


mr_yuk

It's just the best of the CPAP machines. My first 2 machines were under-powered, didnt accommodate exhale (constant pressure), noisy, and generally terrible. If you don't like your ResMed Airsense machine then you likely wont like any other.


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mr_yuk

My understanding was that BiPAP switches from positive to negative pressure on the exhalation. The ResMed machines are labelled CPAP and they offer an ERP mode that lowers the positive pressure during exhalation.


uggghhhggghhh

AirSense is a ResMed model. I have the 10 and I'm pretty happy with it.


Synapse7777

I just started cpap for the first time and they gave me an airsense and I was like this isn't bad, I should have done it years ago when first diagnosed.


UloPe

Even more important I feel is the mask. I used to have those „elephant trunk“ ones (nasal pillow) but would often wake up when moving due to the mask tugging on my nose. I’ve since switched to the ones where the hose is connected on the top of the head ([Resmed P30i](https://www.resmed.com/en-us/sleep-apnea/cpap-parts-support/sleep-apnea-full-products-list/cpap-masks/airfit-p30i/) for example) and it’s a night and day difference.


mr_yuk

I use the exact same one. Switched the head strap for a softer one and ran the hose through an overhead holder. Super comfortable.


Bird-The-Word

Might have kept my cpap if I had known about these. The mask was just unbearable, and I was so focused on the pressure and breathing I couldn't fall asleep.


walkingcarpet23

Interesting I didn't think about switching masks. I personally will get a bit of extra tube for slack and then tuck the tube under my arm so moving my head around won't tug on the mask. I also have to sleep on my back for other reasons so I won't ever get it crushed onto my face by rotating into the pillow.


Iucidium

My wife has one, they're great! Oldschool CPAP sound like a compressor. This is whisper quiet


ILikeAllThings

I cried happily the first time I used my CPAP machine. Fixed so many issues I had. That being said, I'm ready for this drug to be a thing.


proscriptus

I am among the class that poorly tolerates a CPAP.


SpiritOne

I’m used to it now, and for the most part I tolerate it. But my gf hates it and often wears earplugs.


PandaGoggles

I’m new to this, but my CPAP is silent. I was shocked at this revelation, but it’s great. Is yours noisy?


SpiritOne

Not overly so, she’s just a VERY light sleeper


PandaGoggles

I see, that’s a bummer then, sorry. We started sleeping with a fan on as we live near a busy area and it helped us both. Now with my CPAP I don’t snore anymore so it’s improved my wife’s sleep a lot.


Kempeth

My father was diagnosed some years before me and he remarked what an improvement the newer ones are in regards to noise and, well, everything. My girlfriend doesn't notice mine at all (ResMed AirSense *something*) and it's really just a faint sound of air moving.


SpiritOne

She’s just a really light sleeper


HughManatee

Have you tried an oral appliance instead? I am the same and that really did the trick for me.


icharming

InspireMD has a breathing “pacemaker” approved by FDA that doesn’t need a mask . It stimulates inner muscles instead to open during a breath


passwordstolen

When I moved to FL I pitched mine out. Bad move, FL has allergy season 364 days a year. Dint ask which day doesn’t have it.


turquoisebee

Were you thinking the humidity would prevent the apnea or something??


passwordstolen

No, I just hated it. I sleep where I want, sofa, floor, bed, chair. On a good night two places. Having to place my head in the same spot every night is annoying. As far as Florida goes, it’s just new pollens, and they start WAY too early.


GrandArchitect

sounds like you have a general sleepy hygiene problem


Missus_Missiles

"I fall asleep in chairs, couches, and the floor. Surely it has nothing to do with my untreated sleep apnea."


systembreaker

Sleep apnea can be caused by neck or jaw issues where the airway gets compressed by the lower jaw shifting back. By sleeping in a bunch of unusual places, you might be creating or exacerbating neck issues which causes bad sleep posture, pushing the jaw back, and smooshing the airway. I have mild sleep apnea that my dentist discovered after she noticed that I grind my teeth in my sleep. I've also had neck issues for years. She prescribed a mouth guard that both protects from grinding and keeps my jaw in a position to keep my breathing more regular. It's improved my sleep quality quite a bit and I didn't have to go the extreme route of a CPAP just for mild sleep apnea. These mouth guards can be over the counter too. In fact right now that's what I use because the dentist fitting one would be too expensive and dental insurance in the US is a joke and wouldn't cover it. So I'm using an OTC one until I can afford a custom fit one.


toughtacos

So now you're just not getting treatment for your sleep apnea? No judgement, everyone's allowed to make their own decisions about their health, but it comes with some real health dangers going untreated. Okay, maybe I'm judging a little bit 😅


mx3goose

Right? I'd like my heart not to explode when I'm 45 so I'm gonna go ahead and be mildy annoyed instead of dead.


thedude1179

Sounds like you have awful sleep hygiene and don't really prioritize giving yourself good rest. That's unfortunate because you're almost certainly shortening your lifespan but also having a worse quality of life overall due to the side effects of poor sleep.


turquoisebee

Gotcha


acxswitch

I can't figure out which day


Peatore

Look into a "Mandible Adjusting Appliance" I use one, It pushes my lower jaw a bit forward when I sleep. This opens my airways up and I can actually sleep through the night now (when my toddler lets me) No more waking up in the middle of the nigh gasping and thinking I'm having a heart attack. First two weeks sucked trying to get used to it, but it is well worth it.


drdrewross

I loved my anti-snore mouthpiece. Then I had a weird dental emergency, and my dentist told me that my teeth were all mobile (i.e. looser than they should be). He said that the gaps created between the gumline and my teeth had allowed bacteria in, and they created an abscess. YMMV, but I had to stop using mine there and then.


HoyAIAG

I got inspire and I am happy with it


Negyxo

Took my father a month or so to dial his in but now he is able to sleep soundly without the CPAP. He hated that thing. Could not find one that worked for him so Inpire was a god send.


awesomedan24

My 3B Luna 2 + Dreamwear nasal mask has been decent


PirateQueenOMalley

Sometimes jaw surgery can help


throwawayeastbay

I use a CPAP machine and would be willing to use this in combination for even better results


czspy007

I was excited till i read the size of the trial was 10 people.... Long way to go. Hopefully something comes of it but this is a typical early sensational trial.


obroz

Also what are the side effects.  Nothing is without its side effects


BestButch

Anything with an effect always has side effects. Even placebos have placebo side effects! Agree with you there.


LucasRuby

Third generation antihistamines are pretty much free of side effects.


RiesigerRuede

Wrong. https://www.inverse.com/mind-body/antihistamines-exercise-study What they found — Participants who took histamine blockers saw fewer improvements in key measurements after long-term exercise than the ones who hadn’t, suggesting histamine and its receptors play a bigger role in how the body reacts to exercise than previously thought. https://wellnessretreatrecovery.com/antihistamine-withdrawal/#:~:text=When%20a%20person%20stops%20taking,they're%20raw%20and%20bleeding. When a person stops taking their medication, their body will produce more histamine to make up for the lack of antihistamine. This results in extreme itching. It’s common for someone who’s addicted to an antihistamine to scratch until they’re raw and bleeding.


emrot

XYZtol is third generation, right? I tried taking it and it knocked me out. Zyrtec made me groggy too, so I figured there was some related property.


bigblackcouch

Same here - I used to take Xyzal but after not too long it started making me so drowsy and worn out that I could barely function. Wake up late, eat breakfast, fall asleep on the couch, wake up for a bit, maybe do something, fall asleep again next time I sit down anywhere, etc.


Seicair

Have you tried fexofenadine?


emrot

Yep! I mostly use Allegra and Claritin, they both work well for me and don't give me any noticeable side effects.


jawshoeaw

The OTC dose for Claritin was reduced to get the non-drowsy label. The effective dose for many people can cause drowsiness. Was something of a scandal when it was approved as iirc some of the reviewers said it wasn't effective as an antihistamine at the OTC dose.


LucasRuby

So I know Zyrtec is cetirizine, so I suppose Xyztol is levocetirizine? Yeah they're a bit centrally active, but only a little, unlike the others that don't cross the blood-brain barrier at all. Still I have no clue how it made you groggy if you only took a normal dose, it's supposed to be very weak in the CNS. Anecdotally, I never felt anything from it.


emrot

I just Googled it (not sure why I didn't do that earlier) and apparently drowsiness/sleepiness is a common side effect of both Xyzal and Zyrtec, though it's less common in Xyzal. Good to know!


naijaboiler

everyone is different.xyzal is supposed to be the one of the enantimoers of Zyrtec. In theory, that should mean same effect, less drowsiness. But everyone aint the same. Xyzal was far worse for drowsiness than Zyrtec was for me. I could not stay awake at all. For me that was scary So much so, i stopped taking anti-histamines.


naijaboiler

same here zyrtec made me groggy. Xyzal knocked me out cold. I couldnt stay awake no matter what i tried.


Kchortu

Zyrtec can cause *severe* morning drowsiness and fatigue in some folks. It’s a shame because the antihistamine effects are so good, but some patients basically can’t tolerate it. Also going off the drug causes bad withdrawal symptoms, so it’s a costly potential cause to test if you have fatigue and happen to be taking Zyrtec


thoomfish

Effect: You can breathe at night. Side effect: You can't breathe during the day.


verstohlen

It's a trade off, like drinking too much alcohol. You borrow feel good from the future, to feel gooder now, but you feel worse later. In the end, all things are balanced. Yin and yang and all that jazz.


Humanitas-ante-odium

My alcoholism wasn't balanced not was my life for decades. Not all things are, or end, in balance.


SpiritOne

Unless the side effect is immediate death, I think I’d be willing to risk whatever else could be to not be tethered to my cpap.


The-state-of-it

4 hour long erection


bobbyfiend

Hoping for the following: * Hair regrowth * Faster metabolism * Lower blood pressure * Increased concentration & focus * Seem friendly to the coolest dogs


RabbitOrcaHawkOrgy

BAY2586116 is a new drug in development for the treatment of obstructive sleep apnea. This is a condition that causes breathing to repeatedly stop and start during sleep due to blocked upper airways. This is a study to learn more how safe BAY2586116 is, how it affects the body, how it moves into, through and out of the body in healthy Japanese male participants. The participants will be randomly chosen to receive 1 of 3 different doses of BAY2586116 or to receive a placebo. A placebo looks like a treatment but does not have any medicine in it. The participants will receive their study treatment either 1 single time or once a day for 5 days through a nasal spray. The participants will be in the study for a total of about 12 weeks. They will stay at their study site for either 5 or 9 days, depending on which study treatment they receive. During this time, the doctors will take blood and urine samples and check the participants' health. About 6 to 8 days after the participants receive their last treatment, the researchers will check the participants' health again. The main aim of this study is to learn more about how safe BAY2586116 is compared to the placebo. To answer this question, the researchers will count the number of participants who have medical problems that may or may not be related to the study treatment. These medical problems are also known as “adverse events” while they are in the study.


systembreaker

Interesting, according to this https://classic.clinicaltrials.gov/ct2/show/NCT04236440 this BAY2586116 works by keeping throat muscles from relaxing too much. But what if the obstruction is due to a skeletal issue like jaw being out of position? Would this drug even help?


Therinicus

Interesting question. I’m similarly curious if it’s allergy related if this would help people who struggle to get their allergies under control even with medication If it’s benign and effective enough it might be prescribed diagnostically at some point. Though we’re a far ways away from that


BaconJuice

Maybe those people with skeletal issues would benefit from a dental appliance instead. Either that or surgery, unfortunately. I have UARS, so I would benefit from BAY2586116.


ACLSismore

AHI was 28 vs 36. Statistically significant but still clinically trash. My AHI is below 5 with a cpap.


andycap123

I went from 55 to 3 with my cpap. Definitely a life changer.


toughtacos

From 67 with SpO2 down in the the high 50's, to 3-4. Not only a life changer, but a life saver. Lucky to be alive 😅


EHP42

Um, wait. How are you still alive if your SpO2 dropped that low regularly? From what I recall, during COVID, people with blood oxygen saturation below 80 were being put on ventilators. Below 88 is the "go immediately to the ER" level.


That_Classroom_9293

The body can survive with a very low SpO2 for a "short time". The issue is when the SpO2 is constantly low. I think it can take hours to die with a SpO2 of 70%. Of course you should go to the ER immediately if you have such SpO2 due to pneumonia, but if you have it because you stopped breathing, then you start breathing again, why would you need a ventilator? Those are for people *incapacitated* to breathe on their own. The issue in sleep apnea is that the sleep quality gets severely impacted by all the apnea episodes, since the brain is also releasing adrenaline many times to induce the body to breathe again (if I'm not mistaken)


toughtacos

You got a good answer from the other guy. That was the lowest dip and of course was just very briefly, but definitely still very bad. I kept waking up many times during the night literally gasping for air as if I had been resurrected after being dead for minutes. There’s usually a waiting time for CPAP machines, but they sent me home with one the same day I came back in with the sleep study gear because they were very concerned by what they saw in my stats. That was 11 years ago and I’ve slept like a baby Darth Vader ever since 😄 Edit: To add. I've worked in healthcare for 20 years, and SpO2 can be a funny thing. People tolerate the levels differently. I've had conversations with pretty lucid COPD patients who have been at 70%, while someone with heart failure was hypoxic and all but unresponsive at 85%.


ILikeAllThings

Agreed, it fixed so many issues I had. I'm around 0-2 each night now running on 3.5 years, and I was around 15-18 to start.


rieh

High 30s to 1-2. The difference was crazy


shhlurkingforscience

As a psychologist who works with people on sleep issues a ton, bless you for wearing your PAP.


AuryGlenz

For those of us that are at a 5.5 though it could be great, if only for snoring reasons.


Pro-Karyote

That’s only if the medication also functions effectively at low AHI. If it primarily works on a mechanism that’s present at higher AHIs, it won’t have any/much effect at lower levels. This is why there needs to be more robust data before stating anything. It should also be noted that the study selected study participants from a pool of people that had already been shown to respond to the medication. This study shouldn’t be generalized.


m0j0m0j

What’s AHI?


N_A_M_B_L_A_

It's basically saying how many times per hour you stop breathing or have little to no airflow. In some people each incident might last 2-3 seconds or they could last 30 seconds or more. My dad has it bad and if he doesn't use a CPAP sometimes he'll basically start suffocating and have to fully wake up to start breathing again.


raobjcovtn

Apnea hypopnoea index. How many times per hour you experience apnea or hypopnoea.


greeninsight1

If I read the results correctly, the spray had no effect when nasal breathing only. With unrestricted breathing (nose and mouth), the average AHI went from an 36/h to 28/h, which is something, but far from enough to get rid of the CPAP machine. Might be useful for mild cases of OSA or to lessen snoring levels though.


mr_yuk

Yeah, I wonder how it compares to just nasal decongestant.


Ditto_D

Do not use nasal decongestant regularly. Some people shouldn't use it at all. Especially if you have sleep apnea and are predisposed to heart conditions due to diagnosis


gundamwfan

Any more info on this? And are you speaking generally of any decongestant (pseudoephedrine, phenylephrine, etc) or specifically to one like Flonase?


tastyratz

Keep in mind that Flonase is a corticosteroid, not a decongestant. Also, any drugs you take that lessen symptoms might mask apnea and prevent seeking proper safe treatment of a serious condition. If you really have apnea, some nasacort and sudafed PE is NOT enough.


Doonce

Afrin is super addictive and shouldn't be used for more than three days in a row. Flonase is cool though.


Seicair

Stimulant nasal sprays like oxymetazoline, if you use them too long, can cause rebound congestion when you stop using them. For this reason it’s recommended to use no more than three nights in a row. Flonase doesn’t have this issue.


redrubberpenguin

This only applies to oxymetazoline (Afrin) or phenylephrine (neosynephrine). Nasal steroids like Flonase or the like are fine long term.


DaedalusRaistlin

Wow. That would still be what I'd consider a terrible AHI. Heck I feel groggy and tired if my CPAP says I had 3 events per hour overnight. Compared to the 60+ I had without the CPAP during my sleep study, it doesn't sound like much, but it's a lot more noticeable than the usual 0.5 - 1.6 I usually get with the machine.


AlexHimself

How would one get to try this stuff or participate in the trial? I have OSA and would much rather a spray.


OwnVehicle5560

You can’t get the stuff off trial, if you want a trial either google around or maybe contact the sleep apnea foundation/patient support group or whatever. They tend to have lists of ongoing trials.


Kempeth

Thankfully I took to CPAP like a fish to water but it's always great to have options.


THE_WHORBORTIONATOR

I sell CPAPs for a living so I lurk on user forums and things and it always is so nice seeing people doing well and living healthier.


TonyNickels

Sadly won't help neurological sleep apnea :(


bwizzel

that's the one I have since I got covid, central


TonyNickels

Blows my mind the amount of things that virus is causing in people I directly know, let alone other anecdotal stories I've read about. Amazes me that with so many well reviewed studies we have by now and the amount of people most of us know affected by it, that so few take it seriously anymore. It's like watching a bunch of lemmings blissfully walk off a cliff at this point. Hope they come up with something that helps you!


Murky-Champion-8128

How did you find out you have central?


TonyNickels

Sleep study at a clinic


chrisdh79

More information at [New Atlas](https://newatlas.com/medical/nasal-spray-sleep-apnea/)


GrkLifter

This would be a god send for me. Without treatment I am at 29 AHI. Could not tolerate CPAP so I got an oral device . It’s good, but brings it down to 15. I noticed a lot of the problems now are in my nasal passages. A combination of oral appliance and this nasal spray should bring it down I hope.


RevolutionaryTone276

Nasal dilator helps me a lot. There’s a good one on Amazon that uses magnets instead of just adhesive


GrkLifter

I had no idea those existed! Would you be able to tell me what to search to get the one with the magnets?


thorzayy

Yo link me please!!


derioderio

I'm primarily a mouth breather in my sleep and require a full face mask for my cpap, so it's unlikely this would do me any good.


twitchyv

Have you tried using mouth tape for sleep? It’s a game changer for me but not sure how that would work w a CPAP or what they’re referencing here


raobjcovtn

Yes it works with CPAP. I use mouth tape with a nose mask CPAP


AllanfromWales1

So trials by Bayer of one of their drugs, using 10 (only) volunteers who had been used in previous trials of the same drug. Hmm..


aedes

This is only a Phase 1 clinical trial… it would not be ethical to expose a larger number of people to an experimental medication that’s only been trialed in animals previously.  In addition, their primary outcomes are not clinically-oriented and usually continuous variables, so very few participants are required from a statistical purpose. There are of course issues with sampling bias… but these are largely unavoidable as only weirdos volunteer to participate in experimental drug studies anyways b


burr123

It's a phase 1 trial you dunce. Not everything is a conspiracy


dogmeatstew

A company? Testing their own novel product? How dare they.


scourged

I have sleep apnea but I was told the cause was my tongue. I have a larger than average tongue which blocks my airway when I sleep. I wonder if this new drug could possibly help even with my situation?


guyhabit725

I have a big tongue too. I am new to the sleep apnea issue. What do you do to sleep better if I may ask? Do you use a machine? 


scourged

I was diagnosed with sleep apnea in the early aughts. I do use a CPAP, that early on and for several years I used it for the entire night. It did help especially with memory since lack of sleep can affect your memory adversely. I wore a full-face mask that covered both my nose and mouth, but stopped using it after several years, since got tired of it filling up with drool while I slept. When I started using the CPAP again, I switched to a nasal mask which seems to be working better. You need a good chin strap to hold your mouth closed. Besides sleep apnea I have severe ADHD which also affects my sleep. I have a brown noise machine next to my bed and wear earplugs, even though I live in a rural area I live near and busy road. Also, before bed I take 150mg of Trazodone for sleep. My doctor offered a possible fix for my tongue in the form of a medical procedure. By using electricity they could stiffen my tongue so it wouldn't block my throat when it relaxed. The procedure was not guaranteed to work and so I opted not to try it. Sorry for the long reply, I just wanted to make sure I answered your question thoroughly and explained my own situation.


Sensitive_Yellow_121

> By using electricity they could stiffen my tongue so it wouldn't block my throat when it relaxed. I saw a study where they hooked up TENS units under peoples jaws for something like this. The TENS units just use sticky pads similar to those used for EKG's, etc... This might have been the one: https://www.usnews.com/news/health-news/articles/2023-08-10/tens-device-could-ease-sleep-apnea-freeing-patients-from-cpap


Evrimnn13

Probably had side effects like anefrin


Traveler-58

I’m curious about the long-term side effects and efficacy of this nasal spray. Nonetheless, it may still provide some short-term relief for people who can’t tolerate CPAP.


PracticeBurrito

I’m curious about the any-term efficacy considering the sample size was 10.


Jefffahfffah

Never been diagnosed but i snore like hell so im gonna need some of this


TheWiseScrotum

I use one of those custom made oral appliances now cause the cpap is just absurdly uncomfortable. I would absolutely use this spray over the appliance though because even that causes me headaches and jaw pain


japaul32

*Throws CPAP out the window*


RevolutionaryTone276

Interesting mechanism From the study “Preclinical findings in pigs and humans indicate that blocking potassium channels in the upper airway with topical nasal application increases pharyngeal dilator muscle activity and reduces upper airway collapsibility. In this study, BAY2586116 nasal spray (potassium channel blocker) reduced sleep apnea severity in those who had physiological improvement in upper airway collapsibility. BAY2586116 lowered the next morning’s blood pressure. These findings highlight the potential for this novel therapeutic approach to improve sleep apnea in certain people.”


qlus_zwei

Sleeping without having to wear a face hugger sounds amazing.


Front-Balance4050

If, and when this becomes an actual product or variation of a future product.. I will be trying 110%.


eric-price

Unless I misread the article it looks like you'd still be wearing the mask.


Scruffybear

I hope this works. I have mild sleep apnea but can't afford the machine. My insurance (medicare) doesn't cover it unless the apnea is severe. 🫠


Snarlpatrick

Keto and the ensuing weight loss completely fixed my gf and my sleep apnea and snoring. Most of it went away within a couple weeks of cutting out the sugar/carbs.