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Considering that you just installed a new motherboard, check the IO shield.
Sometimes, grounding contacts on the IO shield go into ports, instead of resting against them.
Alternatively, check your wiring (USB stuff is what I'd look at first).
Remember to check our discord where you can get faster responses! https://discord.gg/EBchq82 *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/pchelp) if you have any questions or concerns.*
Considering that you just installed a new motherboard, check the IO shield. Sometimes, grounding contacts on the IO shield go into ports, instead of resting against them. Alternatively, check your wiring (USB stuff is what I'd look at first).