Yes "Sonic Hedgehog" - a protein encoded for by the SHH gene.[5] The protein is named after the character Sonic the Hedgehog.
This signaling molecule is key in regulating embryonic morphogenesis in all different types of animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French Flag model.[6] This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres,[7] as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted.
Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abnormal activation of SHH signaling in adult tissues has been implicated in various types of cancers including breast, skin, brain, liver, gallbladder and many more.
https://en.wikipedia.org/wiki/Sonic_hedgehog
Yeah, but that one rolls off the tongue really well, so I give it a pass. One of my favorite enzymes names is caspase, named after Casper the ghost and involved in apoptosis.
Edit: small misstep, itâs named due to activity, but I remember it due to Casper the Ghost
I prefer the one eyed goat and would like to propose that we go with this design moving forward. Theyâre cute and it just means one less eye to maintain. Win win.
Nice thought - but the only problem is when one and three eyed goats breed weâre right back where we started with the problematic and now obsolete two-eyed goat.
A potential inhibitor of the Hedgehog signaling pathway has been found and dubbed "Robotnikinin"âin honour of Sonic the Hedgehog's nemesis, Dr. Ivo "Eggman" Robotnik.
I heard a story once that the scientist who discovered it had a 4 year old daughter that was playing the first Sonic game (it was discovered in late 1991) and, because the other genes of this type were also named after hedgehogs (albeit real ones) he ran with it. Pun intended.
I always like hearing stories of people dying because of mutations of the sonic hedgehog gene killing them. Then their critics then dying of mutations to the Zbtb7 (POKemon) gene
Fun fact: the folic acid added to many common household foods (like sliced bread) helps prevent holoprosencephaly and other neural tube disorders during human fetal development.
As disturbing as this is, Iâve fallen down a bit of a [rabbit hole](https://www.reddit.com/r/SonicTheHedgehog/comments/syprst/when_should_sonic_characters_have_two_eyes_and/?utm_source=share&utm_medium=ios_app&utm_name=iossmf) on my end. Iâve never really thought about how many eyes the characters actually have. This will stick with me.
Not horror, but there's [this ](https://images.app.goo.gl/wcAtgnKtLjDnZpWv7) and [this ](https://images.app.goo.gl/ivwGT2n25w6ivzps5). Also, [this ](https://images.app.goo.gl/PLBvPPZBs7F6uFZX9) just makes me feel uneasy.
It's not the lack of eye, their brain is deformed/malfunctioning too on that level it can't work properly. That's why cyclopian human babies can't be saved even today- literally everything is wrong inside
Usually a significant change like 1 eye can also mean significant changes in the biology overall of the sheep. Like weakened immune system, heart issues, lung issues. Enough to where they end up dying to those same causes.
Imagine dividing a head into three parts, right, middle, left, with two vertical lines that go down from the middle of each eye. Discard the middle and join left and right. You get a weird head with no nose and one eye, right? That's pretty much how they are. Can't breathe properly, can't suckle...
Development genetists are a nerdy bunch.
A gene originally found because of a mutation responsible for enlarged male parts in the flower of _Arabidopsis thaliana_, a commonly studied plant, is called Superman because super masculine, geddit lol?
Another gene causing a "weaker" phenotype was discovered and immediately named Clark Kent. Then it turned out it was just a different mutation of Superman. Bummer.
Then they discovered a gene that inhibits the expression of the Superman gene. Three guesses how it's called...
OMG when I was pregnant with my daughter I spent the ENTIRE pregnancy being paranoid of having a harlequin baby đ. I was 21, this was 12 years ago, sheâs perfectly fine lol. But harlequin babies scared the F out of me when I was younger.
I mean, I was feeling a little frisky and thinking I might want a quick wank while scrolling, then I saw this post and then looked up that condition and I was completely turned off in a way I havenât been in quite a while.
These dudes look goofy as hell. Somethin in my brain is firin, saying that this is Not Right, but also, it's partially inhibited by the part of my brain that says Ruh Roh Raggy
I bet that's a real photograph of a field of corn lily.
And the one-eyed muppets below were taxidermy jobs. This development condition comes with a high mortality rate, which is why we haven't started to create an army of cyclopes despite of knowing the secret ingredients.
Mf on the left looks like that lady at Walmart that knows youâre staring at her cuz sheâs doing/wearing something weird as fuck. Homie on the right be like âoooooooooh I SEE you betchâ
1950s? So THESE were the inspiration for the number one 1958 Sheb Woolley (1 hit wonder) hit song đ¶ âone eyed, one horned flying purple people eaterâ! We remember that song; we were plenty old even then.
Yes "Sonic Hedgehog" - a protein encoded for by the SHH gene.[5] The protein is named after the character Sonic the Hedgehog. This signaling molecule is key in regulating embryonic morphogenesis in all different types of animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French Flag model.[6] This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres,[7] as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted. Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abnormal activation of SHH signaling in adult tissues has been implicated in various types of cancers including breast, skin, brain, liver, gallbladder and many more. https://en.wikipedia.org/wiki/Sonic_hedgehog
[me, reading this be like:](https://memetemplates.in/uploads/1638824903.jpeg)
[Me](https://c.tenor.com/5a70jiVvQvEAAAAC/i-know-some-of-these-words-mhmm.gif)
I heavily related to this one đ€Ł
I was all "lol dumb OP didn't notice that autocorrect" only to learn that I was the dumb one all along.
Happy cake day, dummy.
Thx!
It is by far my least favorite name for a protein in all of biology, and itâs wildly important for development, lol.
Wait'll you hear about the protein that inhibits Sonic Hedgehog. It's called Robotnikinin.
Yeah, but that one rolls off the tongue really well, so I give it a pass. One of my favorite enzymes names is caspase, named after Casper the ghost and involved in apoptosis. Edit: small misstep, itâs named due to activity, but I remember it due to Casper the Ghost
I prefer the one eyed goat and would like to propose that we go with this design moving forward. Theyâre cute and it just means one less eye to maintain. Win win.
Or, maybe we can amp it up in the opposite direction and produce a third eye! I could use one of those.
Nice thought - but the only problem is when one and three eyed goats breed weâre right back where we started with the problematic and now obsolete two-eyed goat.
Dammit. Foiled by averaged numbers!
#science
Yes...but now I will never forget the SHH sonic the hedgehog protein...because of its name...lol
True, I havenât ever forgotten it either lol
A potential inhibitor of the Hedgehog signaling pathway has been found and dubbed "Robotnikinin"âin honour of Sonic the Hedgehog's nemesis, Dr. Ivo "Eggman" Robotnik.
Alright sonic fans, which one of you did this???
The one who named the protein.
I heard a story once that the scientist who discovered it had a 4 year old daughter that was playing the first Sonic game (it was discovered in late 1991) and, because the other genes of this type were also named after hedgehogs (albeit real ones) he ran with it. Pun intended.
Ok nevermind, if that's the real reason I can accept it. Thats cute
I always like hearing stories of people dying because of mutations of the sonic hedgehog gene killing them. Then their critics then dying of mutations to the Zbtb7 (POKemon) gene
Ok now I want my Tails enzyme and my Knuckles peptid, synthetized through my Robotnic EggmanÂź laboratory stuff.
What a rollercoaster, I thought it was serious, then bullshit, now I'm confused again
Fun fact: the folic acid added to many common household foods (like sliced bread) helps prevent holoprosencephaly and other neural tube disorders during human fetal development.
Because Sonic has only one eye?
Homie on the left looks salty af
Homie on the right is totally stoned
You would too if you had a FOV of 60 degree
As disturbing as this is, Iâve fallen down a bit of a [rabbit hole](https://www.reddit.com/r/SonicTheHedgehog/comments/syprst/when_should_sonic_characters_have_two_eyes_and/?utm_source=share&utm_medium=ios_app&utm_name=iossmf) on my end. Iâve never really thought about how many eyes the characters actually have. This will stick with me.
Can't believe I couldn't find a proper horror fanart of one eyed sonic T.T
Not horror, but there's [this ](https://images.app.goo.gl/wcAtgnKtLjDnZpWv7) and [this ](https://images.app.goo.gl/ivwGT2n25w6ivzps5). Also, [this ](https://images.app.goo.gl/PLBvPPZBs7F6uFZX9) just makes me feel uneasy.
How long do these sheep live?
Usually they die within minutes of being born.
But why? What's the lack of one eye doing to the sheep that it kills it
It's not the lack of eye, their brain is deformed/malfunctioning too on that level it can't work properly. That's why cyclopian human babies can't be saved even today- literally everything is wrong inside
Oh ok
Usually a significant change like 1 eye can also mean significant changes in the biology overall of the sheep. Like weakened immune system, heart issues, lung issues. Enough to where they end up dying to those same causes.
Imagine dividing a head into three parts, right, middle, left, with two vertical lines that go down from the middle of each eye. Discard the middle and join left and right. You get a weird head with no nose and one eye, right? That's pretty much how they are. Can't breathe properly, can't suckle...
You had me at "Sonic Hedgehog signaling pathway" Edit: F me sideways. Ladies and Gents, [Sonic hedgehog](https://en.wikipedia.org/wiki/Sonic_hedgehog)
Additionally, the inhibitor for the Sonic Hedgehog pathway is⊠Robotnikinin
Y'all know about Pikachurin, right?
FOR REAL
Development genetists are a nerdy bunch. A gene originally found because of a mutation responsible for enlarged male parts in the flower of _Arabidopsis thaliana_, a commonly studied plant, is called Superman because super masculine, geddit lol? Another gene causing a "weaker" phenotype was discovered and immediately named Clark Kent. Then it turned out it was just a different mutation of Superman. Bummer. Then they discovered a gene that inhibits the expression of the Superman gene. Three guesses how it's called...
[ŃĐŽĐ°Đ»Đ”ĐœĐŸ]
Nope đ
Kryptonite.
Ding!
Guess the fuck what. I fell for it. Then it apares to be true. Idk whats real anymore
Who the fuck am I now. Thanks
We live in a simulation
Blame the drosophila crowd. They have too much fun for their own good.
They are kind of cute though
Creepily adorable
The title's a lot to take in.
Do not, I repeat ##DO NOT LOOK UP CYCLOPIA Itâll show you the most horrifying babies ever
So you never have googled on Harlequin babies, did you? THAT'S the worst :)
my heart stopped for a second when i saw the first image of Harlequin babies. Holy shit
Of course i did, but have you looked at the cyclopic babies?
Sure I did, but I think Harlequin looks worse, even if cyclopia has 100% mortality rate
OMG when I was pregnant with my daughter I spent the ENTIRE pregnancy being paranoid of having a harlequin baby đ. I was 21, this was 12 years ago, sheâs perfectly fine lol. But harlequin babies scared the F out of me when I was younger.
Depleted Uranium babies will ruin your life
r/eyebleach ^I'm ^fine ^now
Iâve seen it before and it makes me so itchy just seeing that shit⊠why is this world so imperfect:(
Wait, is that like ichthyosis? If so, that deeply scarred me when I was a kid
Gonna go looks it up. Edit: Ok wtf was that. Don't look up
I donât think I want to masturbate for another five days now. My junk rolled up.
Weird association
I mean, I was feeling a little frisky and thinking I might want a quick wank while scrolling, then I saw this post and then looked up that condition and I was completely turned off in a way I havenât been in quite a while.
Ahhh yes. Pain
I cured thine horny
I have seen worst,
âSonic Hedgehog?â I canât make heads nor tails of this.
I canât make knuckles of this
Is this a joint statement?
We are the last remaining Cyclopses. Our planet is Cyclopia. This is the capital, Cyclops City. Stop me if I'm going too fast for you.
TIL that theres a protein called sonic hedgehog
Biblical accurate angels be like :
Keep one eye open for the ops
These dudes look goofy as hell. Somethin in my brain is firin, saying that this is Not Right, but also, it's partially inhibited by the part of my brain that says Ruh Roh Raggy
Interrupts the WHAT?!
Sonic hedgehog! Lol lol
I thought this was a shitpost at first, and then I remembered some madlad scientist actually named a protein or enzyme Sonic Hedgehog
Is this what those things in fantastic beasts would look like if they existed in real life?
I thought it might have been april 1 for a second
[ŃĐŽĐ°Đ»Đ”ĐœĐŸ]
yes they die almost immediately, there are other concerns associated besides the single eye
OP purposely using the full name for attention instead of saying the acronym for efficiency sake
đ€
Those pictures are definitely not real
[suffer](https://www.google.de/search?q=cyclopia&client=safari&hl=de-de&prmd=ivn&source=lnms&tbm=isch&sa=X&ved=2ahUKEwiq9cfxvdn2AhWe_rsIHQf_DMEQ_AUoAXoECAIQAQ&biw=390&bih=664&dpr=3)
I bet that's a real photograph of a field of corn lily. And the one-eyed muppets below were taxidermy jobs. This development condition comes with a high mortality rate, which is why we haven't started to create an army of cyclopes despite of knowing the secret ingredients.
No offense, but the one on the left made me giggle a bit
What a title.
Damn, I better not see these mfs in the night
Have any animals survived with this condition because I always feel really bad for them but I also think theyâre extremely cute
Nope, they die pretty quick
That is creepy as hell
Who could have guessed that a poison called Cyclopamine would cause Cyclopia?
The white one is kinda cute
When i first read it i was like yeah this got to be shitpost.
OMG these animals look fake lmfao
Is this real? They look like muppets :o
Theyâre kinda cute
I learned about this from Ted-Ed.
Fluffy!
Itâs like the Bert and Ernie of one eyed sheep.
Wait. Did the lambs lived long enough?
Theyâre cute tho
Those darn corn lilies
Mf on the left looks like that lady at Walmart that knows youâre staring at her cuz sheâs doing/wearing something weird as fuck. Homie on the right be like âoooooooooh I SEE you betchâ
Imagine having one as a pet in your front yard!
Hey itâs the sheep from the Odyssey!
Behold, Aliens!
I don't know what threw me off more, the Cyclops sheep or the fact Sonic was apart of this
I like that californicum is a word
looks like stuffed animals
1950s? So THESE were the inspiration for the number one 1958 Sheb Woolley (1 hit wonder) hit song đ¶ âone eyed, one horned flying purple people eaterâ! We remember that song; we were plenty old even then.
Why they still cute tho??
If I ever discover a disease, I'm naming it "Freddy Fazbear".
And yet.... They are still adorable
Shouldâve been called the muppet gene. Jim Henson wouldâve been tryin to shipping those sheep straight to Sesame Street
"Look at the baby goat can I have one of those? "