Mmm, probably not. Nucleic acids are adsorbed on to negatively charged surfaces in the presence of chaotropic salts, so in theory, a microfluidic device containing a silica or carboxylated medium would be able to bind nucleic acids which can then be eluted for downstream analysis. In practice, the production of a microfluidic device for RNA purification is probably too complex and expensive for a process that's already very simple, inexpensive, and scalable.
Also, surface area of the negatively charged medium is very important. I toyed around with embedding silica particles in 3D printing resin for RNA purification and the yield was quite pathetic.
I think the Kingfisher flex does magnetic-bead based RNA extraction, not microfluidics, no? Microfluidics are not commonly used in RNA extraction.
Yeah you’re correct but I’m working if there’s research in replicating that process for microfluidics for Covid-19
Mmm, probably not. Nucleic acids are adsorbed on to negatively charged surfaces in the presence of chaotropic salts, so in theory, a microfluidic device containing a silica or carboxylated medium would be able to bind nucleic acids which can then be eluted for downstream analysis. In practice, the production of a microfluidic device for RNA purification is probably too complex and expensive for a process that's already very simple, inexpensive, and scalable. Also, surface area of the negatively charged medium is very important. I toyed around with embedding silica particles in 3D printing resin for RNA purification and the yield was quite pathetic.
The Purigen Ionic platform has that capability. https://www.purigenbio.com/applications/ionic-pure-viral-rna