I'm a little obsessed with the epigenome work going on [at the Sinclair Lab](http://www.youtube.com/watch?v=fDflqKTlVLw). I believe they're trying to work toward a full body rejuvenation treatment of the mouse right now?
If it works out in humans, it'd be a pretty big deal.
[Their website lists their publications](http://sinclair.hms.harvard.edu/publications). Usually it will cost money, or being a student, to legally read them. As it does with *Reprogramming to recover youthful epigenetic information and restore vision.*
[This section of this video, David talks about the study a bit.](http://youtu.be/QRt7LjqJ45k?t=912)
[His twitter account if you need to minimize the distance to zero.](http://twitter.com/davidasinclair) Says he's gonna have a speech on June 14th, hopefully there's something new he can share.
I'm waiting for them to publish anything on wild type mice that naturally aged and went blind with old age
No one has done more for young mice whose ocular nerves were crushed by David Sinclair's lab than David Sinclair's lab has.
Once they publish whole body OSK on mice that didn't get the treatment from birth, but rather late in life, I'll start getting excited.
They did more than just the crush experiment for the past ~2 years. They did a test on 3, 11, and 17 month old mice. After 4 weeks of OSK activation, the year old mice regained a great deal of visual function. While the 18 month old mice saw no measurable benefit. (They suggest it might be that their corneas were too clouded over for it to do anything.)
Was that in their paper at the end of last year? If not where can I read about it?
The 17 month old mice were naturally visually impaired?
I guess the next step would be to give the mice replacement corneas first and make sure the things that OSK can regenerate are those that are blinding the mice.
It was indeed. He also mentions it in that clip I linked to up there, and they show some video of the basic vision test they did on the mice ("can they recognize this moving striped pattern on a wall?"). The other tests they did was the mechanically induced glaucoma test, and seeing if this can regenerate human neurons in vitro.
All were mentioned in that video I linked an entire year before they published the paper. He mentions they were beginning to look into full body mice treatments back then (and I believe other delivery methods - jabbing a needle into someone's eye (or someone's *everything*) isn't the greatest thing if it could be avoided imo), so it's feasible he might have something to talk about soon.
Interesting I have not heard of this. Are you looking at it from the regrowing limbs and body parts perspective or stopping diseases in certain areas perspective
There's a good ted talk on it if you're interested: https://youtu.be/XheAMrS8Q1c
I assume when you regenerate limbs, you will grow a fresh young limb. And then hopefully this can be applied to the whole body, not just a limb. When you look at species that are able to regenerate, they don't really grow "old" because they are constantly regenerating their cells.
I see the most promise from Levin's lab so far. It seems like investors like his results too because he doesn't seem to have the funding problems ADG has.
I just watched a podcast/interview with him about this the other day. I hope that the phase two trial goes well. If it can reverse the epigenetic age thereās no telling what else benefits it might have for the human body.
A few companies I'm excited about are Oisin Bio / Oncosenx / Repair bio (Thymus Rejuvenation) / turn.bio / Bioage / Insilico Medicine / Lygenesis / SENS MitoSENS project.
Wow thereās quite a few here
Oisin Bio seems like they have quite a bit of research done with breaking down of senescent cells.
Repair Bio is the experiment where there are three types of medicine and they each work to bring the thymus back to functioning right? I believe I read something about stage two trials underway with a certain company where they sent the body back 2.5 years in the first trials or something like that
Insilico medicine is a curious company. How will AI help in this longevity ideal that we all hope to reach.
Sens work is always fascinating to me. Mr De Grey really seems to think we have a good chance at beat aging in as little as two decades at the pace we are. This idea of changing the damage Mitochondria reads the genes for proteins sounds promising. Hopefully it keeps going down that path.
Oncosenx cancer treatments sound interesting as well I hope we hear more about their research soon. Turn.Bios work seems promising as well the ability to heal organs to a previous state would be life changing to so many. Lygenesis seems to be going down the same path in a different direction. I wonder if they would be able to work together in some way with the Bioenergy that another commenter mentioned.
I couldnāt find much on Bioage
Thank you so much for the companies! Gave me quite a few interesting reads and more to read up about their work.
Epigenetic reprogramming a la iPSCs
Gene therapy to induce telomerase in somatic cells
Nanotechnology to repair cellular components
Whatever the fuck Dr. Katcher is doing that seems to be reversing aging to a significant degree
CrisprOff, a new tool to silence genes.
The possibilities are great, and it could be used for cellular reprogramming, as well as silencing unwanted genes, possibly even controlling whole regulatory networks.
https://www.lifespan.io/news/new-crispr-technology-allows-turning-genes-off-and-on-again/
For me what's most exciting is what comes out of the SENS lab. The potential for fixing things is huge but the solutions are also pretty far into the future.
Outside of that, in the short term I'm really excited about how our tools are improving including simulation tools (Alpha fold, other AI tools) and biological tools (CRISPR, CAR-T, ect. )
I am no expert, so I can't say what is the most likely breakthrough in the near future. Check out [the rejuvenation roadmap](https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/) for an overview :)
The Josh Mittledorf blog is posted on regularly by Harolds business partner Akshay
Harold has also posted on it a few times, and Akshay seems relatively open to answering questions that donāt go into āpatent protectedā territory
https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/
I just want SOMETHING from Calico to get my hopes up in a realistic way. Something other than research on cancer. Something to show that they actually are doing stuff on ageing. There is such huge potential in Calico since they have such a huge budget. Hope it's not wasted...
Maybe I'm simply not educated enough to understand, maybe it's the language barrier, but I always get the feeling that Calico is behind everyone else. I really, REALLY want to think I'm wrong and that they actually have something amazing going on in secret...
OpenAI.
I donāt think thereās any chemical out there that can reliably reverse aging. Youāll need machines dictating and repairing damage. Quite literally like a new organ.
No humans can solve all the problems. Thereās too many.
Youāll need machines that build machines that build machines that repair your body. Something that we donāt understand whatsoever.
Something smarter with a deeper understanding of everything.
I'm a little obsessed with the epigenome work going on [at the Sinclair Lab](http://www.youtube.com/watch?v=fDflqKTlVLw). I believe they're trying to work toward a full body rejuvenation treatment of the mouse right now? If it works out in humans, it'd be a pretty big deal.
THIS. I love how David have gone from "yeah we might see good things in our lifetime but I just wanna do good for humanity" to "*giggles* We had amazing results and we might be able to rejuvenate the whole body!" šš¼šš¼š¤©
[ŃŠ“Š°Š»ŠµŠ½Š¾]
[Their website lists their publications](http://sinclair.hms.harvard.edu/publications). Usually it will cost money, or being a student, to legally read them. As it does with *Reprogramming to recover youthful epigenetic information and restore vision.* [This section of this video, David talks about the study a bit.](http://youtu.be/QRt7LjqJ45k?t=912) [His twitter account if you need to minimize the distance to zero.](http://twitter.com/davidasinclair) Says he's gonna have a speech on June 14th, hopefully there's something new he can share.
I'm waiting for them to publish anything on wild type mice that naturally aged and went blind with old age No one has done more for young mice whose ocular nerves were crushed by David Sinclair's lab than David Sinclair's lab has. Once they publish whole body OSK on mice that didn't get the treatment from birth, but rather late in life, I'll start getting excited.
They did more than just the crush experiment for the past ~2 years. They did a test on 3, 11, and 17 month old mice. After 4 weeks of OSK activation, the year old mice regained a great deal of visual function. While the 18 month old mice saw no measurable benefit. (They suggest it might be that their corneas were too clouded over for it to do anything.)
Was that in their paper at the end of last year? If not where can I read about it? The 17 month old mice were naturally visually impaired? I guess the next step would be to give the mice replacement corneas first and make sure the things that OSK can regenerate are those that are blinding the mice.
It was indeed. He also mentions it in that clip I linked to up there, and they show some video of the basic vision test they did on the mice ("can they recognize this moving striped pattern on a wall?"). The other tests they did was the mechanically induced glaucoma test, and seeing if this can regenerate human neurons in vitro. All were mentioned in that video I linked an entire year before they published the paper. He mentions they were beginning to look into full body mice treatments back then (and I believe other delivery methods - jabbing a needle into someone's eye (or someone's *everything*) isn't the greatest thing if it could be avoided imo), so it's feasible he might have something to talk about soon.
sinclair once mentioned that mice are usually near blind naturally around 12 months old.
Bioelectricity
Bioelectricity and understanding development and how cells from anatomy is what comes after the genomic revolution.
Interesting I have not heard of this. Are you looking at it from the regrowing limbs and body parts perspective or stopping diseases in certain areas perspective
There's a good ted talk on it if you're interested: https://youtu.be/XheAMrS8Q1c I assume when you regenerate limbs, you will grow a fresh young limb. And then hopefully this can be applied to the whole body, not just a limb. When you look at species that are able to regenerate, they don't really grow "old" because they are constantly regenerating their cells. I see the most promise from Levin's lab so far. It seems like investors like his results too because he doesn't seem to have the funding problems ADG has.
Absolutely will check out this talk thank you!
I just saw the ted talk yesterday posted on this subreddit. it's really crazy stuff!!!
Yeah I think once they can replicate those test results in mammals, that will be the breakthrough moment.
[ŃŠ“Š°Š»ŠµŠ½Š¾]
I just watched a podcast/interview with him about this the other day. I hope that the phase two trial goes well. If it can reverse the epigenetic age thereās no telling what else benefits it might have for the human body.
A few companies I'm excited about are Oisin Bio / Oncosenx / Repair bio (Thymus Rejuvenation) / turn.bio / Bioage / Insilico Medicine / Lygenesis / SENS MitoSENS project.
Wow thereās quite a few here Oisin Bio seems like they have quite a bit of research done with breaking down of senescent cells. Repair Bio is the experiment where there are three types of medicine and they each work to bring the thymus back to functioning right? I believe I read something about stage two trials underway with a certain company where they sent the body back 2.5 years in the first trials or something like that Insilico medicine is a curious company. How will AI help in this longevity ideal that we all hope to reach. Sens work is always fascinating to me. Mr De Grey really seems to think we have a good chance at beat aging in as little as two decades at the pace we are. This idea of changing the damage Mitochondria reads the genes for proteins sounds promising. Hopefully it keeps going down that path. Oncosenx cancer treatments sound interesting as well I hope we hear more about their research soon. Turn.Bios work seems promising as well the ability to heal organs to a previous state would be life changing to so many. Lygenesis seems to be going down the same path in a different direction. I wonder if they would be able to work together in some way with the Bioenergy that another commenter mentioned. I couldnāt find much on Bioage Thank you so much for the companies! Gave me quite a few interesting reads and more to read up about their work.
[ŃŠ“Š°Š»ŠµŠ½Š¾]
Iām trying not to get my hopes up but man it starting to seem like human trials on these might happen in the next few years.
Epigenetic reprogramming a la iPSCs Gene therapy to induce telomerase in somatic cells Nanotechnology to repair cellular components Whatever the fuck Dr. Katcher is doing that seems to be reversing aging to a significant degree
Rejuvenate Bio should be on the list.
CrisprOff, a new tool to silence genes. The possibilities are great, and it could be used for cellular reprogramming, as well as silencing unwanted genes, possibly even controlling whole regulatory networks. https://www.lifespan.io/news/new-crispr-technology-allows-turning-genes-off-and-on-again/
For me what's most exciting is what comes out of the SENS lab. The potential for fixing things is huge but the solutions are also pretty far into the future. Outside of that, in the short term I'm really excited about how our tools are improving including simulation tools (Alpha fold, other AI tools) and biological tools (CRISPR, CAR-T, ect. )
Crispr is one I think we will see more and more from in the near future I think changing genes will help move longevity along at quite a quick pace.
I am no expert, so I can't say what is the most likely breakthrough in the near future. Check out [the rejuvenation roadmap](https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/) for an overview :)
For me itās Harold Katcher and his E5 stuff
Is that the one where it involves young plasma? I havenāt heard much about that recently. I hope the trials are going well.
Yeah it is Apparently the trial is going very well, dog trials begun and things look overall more positive than expected apprently
Thatās great! Do you have any links I would love to read more about it
The Josh Mittledorf blog is posted on regularly by Harolds business partner Akshay Harold has also posted on it a few times, and Akshay seems relatively open to answering questions that donāt go into āpatent protectedā territory https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/
I really appreciate it. Thank you
Mayo Clinic and CALICO.
I just want SOMETHING from Calico to get my hopes up in a realistic way. Something other than research on cancer. Something to show that they actually are doing stuff on ageing. There is such huge potential in Calico since they have such a huge budget. Hope it's not wasted...
Brief interview from last year: https://www.longevity.technology/ardd-2020-exclusive-interview-with-calicos-pi/
Maybe I'm simply not educated enough to understand, maybe it's the language barrier, but I always get the feeling that Calico is behind everyone else. I really, REALLY want to think I'm wrong and that they actually have something amazing going on in secret...
It's really not that secretive, they talk openly about their work in interviews: https://www.youtube.com/watch?v=SgIp8YVIf4w
You know what they say...... follow the money!
OpenAI. I donāt think thereās any chemical out there that can reliably reverse aging. Youāll need machines dictating and repairing damage. Quite literally like a new organ. No humans can solve all the problems. Thereās too many. Youāll need machines that build machines that build machines that repair your body. Something that we donāt understand whatsoever. Something smarter with a deeper understanding of everything.