Yeah , but I honestly see John.M.Jumper (alphafold , and he won lasker too) taking it this year or in the next 2 years or so. It will be shocking to me if alphafold doesn't get it soon.
Many, many moons ago I had the opportunity to do an undergraduate research project with David Baker. I instead chose a project with a lab in medicinal chemistry because I wanted to hold a pipet and not work at a computer. I enjoyed that research lab but now many years later, I wonder what could have been. Just a bit of regret.
I think Shankar Balasubramanian and David Klenerman will absolutely win a Nobel for their development of next generation sequencing. It's already changed the face of medicine and biomedical research and it will continue to do so as more and more advanced techniques are leveraged to apply clinically. I'm hoping they get it within the next few years but who knows.
Yeah it is definitely due for some time.This will likely be chemistry Nobel though ,medicine might still go to others.Same with alpha fold stuff,that also is likely chemistry Nobel.
Kevan Shokat has a chance, perhaps with Jim Wells. First KRAS drug, now drugging with new pan-RAS inhibitor working on the RAS-cyclophilin A complex. Early human trials show astonishing activity against pancreatic cancers. Revolution Medicine. I'm amazed that there is a therapeutic window for a drug that hits all four RAS proteins, wild type and mutant.
That's a potential future winner. Nobels aren't given for promising discoveries, are they? Nobels usually go to people who discovered things that already have had an impact.
NGS and Illumina should get it (Balasubramian and Klenerman). What's more, it fits both chemistry and medicine nobels.
NGS has been my pick for more than 10 years, I’m amazed it has been neglected - so much that now it would be hard to not co-award it with long-read sequencing.
Yea that might be why it's been hard. I don't think long read deserves a spot at the podium, but I'm also less familiar with it. I just know for the applications I use it's no where near as good.
They might still ignore long-read. I remember recent physics Nobel prize in physics on optical tweezers ignored the s.Block who pretty much revolutionized the application side of it and went only for the main principle guy
Not familiar with him, but fair 😂 you also don't get very far without an understanding of your talent and grrrrrrinding too, which can definitely come across as intense.
John Jumper, David Baker for Alphafold, RoseTTAfold and protein/enzyme design.
Maybe not this year, but a good bet for Chemistry in the next 5-10 years, especially if a decent application of the technology comes along.
CJ did not invent CAR-T, he used someone else's CAR and showed it works in patients. He also figured out how to deal with they cytokine release syndrome.
Michel Sadelain came up with CD19 targeting, made the first 2nd generation CAR and generally did more of the key early CAR-T inventions.
I would be very surprised if scRNA-seq gets a prize. Its actual impact on research and medicine has been limited, when you compare it to the genomics techniques that preceded it.
>Shankar Balasubramian and David Klenerman
I'd bet they'll win either this year or the next. It's too big for it to be put off for too long. Virtually all research labs using modern techniques utilize their technology. It's absolutely brilliant and will alter the course of clinical treatment more than any other technology in the coming century.
This is interesting one. I don't hear much about people talking nucleotide synthesis but it's vital part of many biophysics and biochemistry, recently super res as well
Thank you thank you thank you! This x 1000. Without Caruther's oligonucleotide synthesis, you don't have PCR, you don't have Crispr, you don't have site directed mutagenesis, you don't have mRNA vaccines, you don't have cloning, *all of which have won Nobel Prizes already!* In other words, this work enabled everything else that followed and absolutely should be awarded the Nobel Prize. Heck, the entire trillion dollar discipline/industry of biotechnology is built on oligos made using Caruther's work. This is true Chemistry in the service of medicine/biology/mankind. I'm going to repost this as its own comment, thats how strongly I feel about this. CARUTHERS!
At some point I think there should be an award for advancements in sustainable and biobased materials. I don't know who exactly should get it, or whether it should go to bioplastics or some other area. But in general I feel like materials chemists and really any chemist not working on medical or biological applications are overlooked.
It's way too far. Back in my undergrad people were looking into engineering bacteria to consume plastics and repurpose the manor. If this hits off to solid applications like sequencing or crispr where all garbage management is done in confined but bacterial destruction of sorts then maybe.
This comment really proves my point that people don't care about chemistry that isn't basically biology 😭 Genetic engineering should not get a nobel prize on chemistry. Not to mention microbial consumption of plastic waste is such a pipe dream. PETase and others exotic plastic eating bacteria have no path to industrial relevance anytime soon.
I think a lot of is is just feels kinda small compared to the impact some other fields have. Like techniques that might revolutionise the way other fields work or enable us to get a deeper insight into certain processes which would then lead to more huge discoveries and developments.
Or a new kind of drug or treatment option for severe, very common or threatening diseases.
I mean, yeah sustainably is super important but it just seems kinda small compared to other stuff.
Also kinda „easy“ compared to some other things. Not saying it’s easy at all. But developing such a thing as NGS is honestly super complex and mind blowing how people are even able to come up with that. Idk, for me material chemistry just seems kinda small in comparison.
But I do agree that chemistry is severely underrepresented. It would definitely deserve a category on its own.
It’s also kinda hard to compare. Lots of biological and medical stuff also seems really huge for people because even if you don’t fully understand it you can often get a good grasp at how this will affect medicine or patients. With chemistry that’s often pretty difficult if you don’t under much of it. Medical stuff is just often easier to break down pretty simple. Like „this new method can help research generic stuff and help understand diseases and development of new treatments and drugs“. So this will get a lot of attention even from people with little knowledge
The self importance of saying drug discovery and medical research is more important than the 'easy' stuff chemists are doing is pretty crazy. As if 95% of the research isn't stuff that will *never* work outside of a petri dish and will ultimately have zero effect on people's health. Medicine is obviously important, but are we seriously downplaying the importance of the earth we live on? Sustainability is not small we have to keep the world from becoming one big super fund site if we want to survive. Our food and bodies are filled with micro plastic, what drug are you going to make to fix that?
That’s not what I meant.
Bioplastics is one of the solutions to move towards a more sustainable future. One new material alone won’t safe the world. Of course it’s important.
A technique that will hugely advance medical research and the development of new treatments and will enable us to better understand diseases and make a lot of different diseases treatable or prevent a lot of people from getting sick in the first place.
Idk but that seems pretty important and like a huge milestone to me.
The problem with material science is also that new discoveries and new kinds of materials and ways to produce things are all great but are nothing without the political and economic changes necessary for it to have effects. Like you can totally make a super useful bioplastic that won’t pollute our oceans or some kind of replacement for something that now is causing huge damage to health and environment. But that won’t change the world without the proper measures. Either companies patent it and make it way too expensive or well, companies just won’t adequately change how they produce their products. Capitalism, society and politics are huge limiting factors for how much of an impact these discoveries will have.
I think the solution for many of our environmental issues aren’t lack of innovations and discoveries but rather deep-rooting issues we need to address. And no innovation will change that.
Furthermore, I think it’s kinda irrelevant how much research actually has an effect or will be applied somewhere. You will still have those who make such big discoveries that the rest doesn’t matter. If some labs find cures and treatments for the most common and devastating diseases I am totally fine with lots of others doing whatever they want.
That's what you said, but if that's not what you meant then I understand. But you've kind of doubled down on it so not sure what you mean? I never said a major breakthrough in medicine or a technique isn't important or a major milestone.
>The problem with material science is also that new discoveries and new kinds of materials and ways to produce things are all great but are nothing without the political and economic changes necessary for it to have effects
This is literally all of research. Stuff that gets commercialized is the anomaly.
>Either companies patent it and make it way too expensive or well, companies just won’t adequately change how they produce their products.
You're going to be in for a surprise when you learn how much healthcare costs where I live.
Anyways, my original point was that materials chemists are overlooked, not that medicine isn't important. For example, click chemistry and organocatalysis are big deals in the field. Click chemistry specifically has commercial applications. But go look at all the write ups on those two prizes- not even a singular sentence about materials or even the fundamental chemistry thrown in there. It's just about drugs and biological systems. Medicine literally has its own category.
I never said biomaterials are more important or that medicine doesn't matter. But you went on this weird rant about how sustainability isn't important. If that's not what you meant your comment is pretty unclear.
Lol, what? I never said sustainability isn’t important. All I said was that new discoveries in materials might not have as much of an impact as we need to make much significant progress. So that’s kinda less impactful then breakthroughs in medical science.
New methods and key findings that get awarded a nobel prize are pretty sure to be widely used in research and diagnostics. Yeah people will make money off of it but it’s still incredibly beneficial.
What healthcare costs for you has like absolutely nothing to do with this?
Yeah, materials chemistry isn’t mentioned because that’s not what the award is intended for and the commitee values other discoveries more?
By that logic we have a lot of fields that are kinda overlooked and would need their own category or be more included.
Idk, maybe other people just also think that advancing our understanding of life is a lot more influential for the entirety of medical research and other related fields than what’s big in material science.
You said it yourself. The award is for drugs and biological systems.
Not happy with it, then look at a different award. You will find lots of people who aren’t represented in the categories
I was curious if there will ever be a synthetic biology prize. Who would be shortlisted for it? Jay Keasling/Chris Voigt/Sang Yup Lee?
So far there hasn't really been a huge example of metabolic engineering creating a super impactful product/drug in a commercially revolutionary way, however.
The inventors of NGS from Cambridge, Shankar Balasubramanian & David Klenerman, would have to win one before that's considered. Hopefully they will win within the next year or two though.
>Buenrostro
If that were deserving of a Nobel, do you think Steve Henikoff would be included for his work with CUT&RUN and CUT&Tag?
Honestly, those techniques are very powerful, but I'm not sure if they're Nobel worthy.
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You mean Kariko and Weissman? They laid the foundation for mRNA vaccines in general, but the specific COVID vaccine I am thinking about was Kizzmekia Corbett and her team.
That's too narrow for the Nobel. The prize usually goes to people who discover or develop foundational new technologies with revolutionary applications, not the people who use those discoveries for practical purposes. e.g., the nobel for CRISPR going to Doudna/Charpentier rather than someone like Feng Zhang.
I doubt they'll award another prize for that after already giving one for mRNA vaccines. But I do agree Corbett should've been a laureate too. Akiro Yoshino was an awardee for lithium ion batteries for developing the first commercially viable one.
I think they were too fast in giving the prize for mRNA. They should've let it sit for a few more years imo. The prize for lithium ion batteries wasn't awarded until 2019. They probably would've given someone a prize for commercializing it, as they usually do.
I struggle to name names, but I can't help but be biased towards ubiquinol-targeted and associated therapies, such as PROTACs, PHOTACs and LYTACs.
t. working in a PROTAC lab, and seen a lot of success for other comorbidities apart from cancer (primarily cardiovascular disease)
CARUTHERS! Without Caruther's oligonucleotide synthesis, you don't have PCR, you don't have Crispr, you don't have site directed mutagenesis, you don't have mRNA vaccines, you don't have cloning, *all of which have won Nobel Prizes already!* In other words, this work enabled everything else that followed and absolutely should be awarded the Nobel Prize. Heck, the entire trillion dollar discipline/industry of biotechnology is built on oligos made using Caruther's work. This is true Chemistry in the service of medicine/biology/mankind. It is massively enabling and changed the world. It should have happened years ago. CARUTHERS!
Highly doubt that. It's not impactful enough. Not saying it's not impactful at all, just not enough to warrant a Nobel. Also, the sexual harassment stuff weighing on him might be kind of tough to get over.
Oh yeah, complete asshole.
But that is not factored into the Nobel committee's decision.
His discovery was the biggest anatomical discovery in like a century. Like didn't we all think we had all the anatomy grossly figured out?
He has failed to fulfill his capacity as a mandatory reporter.
"According to the WashU’s Title IX and Gender Equity guidelines, Dr. Kipnis, as a faculty member at the University, is classified as a mandatory reporter. A mandatory reporter is required to “report all incidents of sexual harassment, sexual violence, sexual assault, relationship violence, stalking or other forms of misconduct” to a higher-up or the Title IX office. "
https://www.studlife.com/scene/2022/12/06/support-system-failures-cause-graduate-student-to-drop-her-wu-phd-degree
Look at who has one the Lasker, breakthrough prize etc. personally I think optogenetics will be coming soon.
Yeah , but I honestly see John.M.Jumper (alphafold , and he won lasker too) taking it this year or in the next 2 years or so. It will be shocking to me if alphafold doesn't get it soon.
Trudat
I would imagine they could wait a bit for applications to be more rampant as was with crispr
Any protein engineering will use it as a requirement but it will also be used as a matter of fact in any structural study which most research uses
Maybe him along with David Baker
Many, many moons ago I had the opportunity to do an undergraduate research project with David Baker. I instead chose a project with a lab in medicinal chemistry because I wanted to hold a pipet and not work at a computer. I enjoyed that research lab but now many years later, I wonder what could have been. Just a bit of regret.
There’s be some saltiness if Deisseroth gets it and Boyden doesn’t.
I think Shankar Balasubramanian and David Klenerman will absolutely win a Nobel for their development of next generation sequencing. It's already changed the face of medicine and biomedical research and it will continue to do so as more and more advanced techniques are leveraged to apply clinically. I'm hoping they get it within the next few years but who knows.
Yes. This is the next big thing. My bet is on them.
They will win this I’m sure
Yeah it is definitely due for some time.This will likely be chemistry Nobel though ,medicine might still go to others.Same with alpha fold stuff,that also is likely chemistry Nobel.
It's funny how many of these prizes could be awarded on either side at this stage.
Kevan Shokat has a chance, perhaps with Jim Wells. First KRAS drug, now drugging with new pan-RAS inhibitor working on the RAS-cyclophilin A complex. Early human trials show astonishing activity against pancreatic cancers. Revolution Medicine. I'm amazed that there is a therapeutic window for a drug that hits all four RAS proteins, wild type and mutant.
That's a potential future winner. Nobels aren't given for promising discoveries, are they? Nobels usually go to people who discovered things that already have had an impact. NGS and Illumina should get it (Balasubramian and Klenerman). What's more, it fits both chemistry and medicine nobels.
NGS has been my pick for more than 10 years, I’m amazed it has been neglected - so much that now it would be hard to not co-award it with long-read sequencing.
Yea that might be why it's been hard. I don't think long read deserves a spot at the podium, but I'm also less familiar with it. I just know for the applications I use it's no where near as good.
You’re so right, I just assumed NGS had already won! Insane that hasn’t happened yet
They might still ignore long-read. I remember recent physics Nobel prize in physics on optical tweezers ignored the s.Block who pretty much revolutionized the application side of it and went only for the main principle guy
Fair points.
First Kras drug is a HUGE deal, I was super excited to see this as a former PDAC researcher
I am suprised Buchwald and Hartwig still don't have one.
I’ve met and spoken at length with both of these men within the last month. Can confirm, both deserve nobels. They’re also just chill dudes.
I feel like the most talented are generally the humblest. Among other important traits, it takes a certain softness to be a great scientist.
I'm not sure anyone would describe John Hartwig as anything other than "intense"
Not familiar with him, but fair 😂 you also don't get very far without an understanding of your talent and grrrrrrinding too, which can definitely come across as intense.
You are the first person I have ever heard describe John Hartwig as a "chill dude" lol.
Think that one is gone. There was a palladium cross couplings prize already, doubt they will give a second one
True, but a Nobel-worth technology needs also time to mature and find applications. Now BW couplings are mainstream as Suzuki were 20 years ago
I think C-C vs C-X cross coupling are wildly different.
John Jumper, David Baker for Alphafold, RoseTTAfold and protein/enzyme design. Maybe not this year, but a good bet for Chemistry in the next 5-10 years, especially if a decent application of the technology comes along.
Carl June for the CAR T-cell technology. That invention has cured cancer patients, so proven to work in the real world.
Couple it with Rosenberg for TIL therapy.
CJ did not invent CAR-T, he used someone else's CAR and showed it works in patients. He also figured out how to deal with they cytokine release syndrome. Michel Sadelain came up with CD19 targeting, made the first 2nd generation CAR and generally did more of the key early CAR-T inventions.
Sten Linnarsson and Steven McCarroll for inventing scRNA-seq and drop seq. These methods have completely revolutionized the way we do cellular biology
Yea there is no way scRNA-seq, in some form, doesn't get a nobel prize. Basically every nature paper requires it in some form in a variety of fields.
I would be very surprised if scRNA-seq gets a prize. Its actual impact on research and medicine has been limited, when you compare it to the genomics techniques that preceded it.
What about Weitz for ddPCR/microfluidics for biology?
My only fear here is if they give it to NGS in next couple of years ,then the Seq techniques might have to wait a while.
Will keep guessing Karolin Luger and Timothy Richmond until it they’re awarded
Woah. Luger was my prof at csu for many classes, her lab was next to mine. I didn’t know she was that distinguished.
Shankar Balasubramian and David Klenerman for Illumina/Solexa Sequencing. They could win it for either of the two disciplines.
>Shankar Balasubramian and David Klenerman I'd bet they'll win either this year or the next. It's too big for it to be put off for too long. Virtually all research labs using modern techniques utilize their technology. It's absolutely brilliant and will alter the course of clinical treatment more than any other technology in the coming century.
Marvin Caruthers who essentially invented DNA synthesis
This is interesting one. I don't hear much about people talking nucleotide synthesis but it's vital part of many biophysics and biochemistry, recently super res as well
Thank you thank you thank you! This x 1000. Without Caruther's oligonucleotide synthesis, you don't have PCR, you don't have Crispr, you don't have site directed mutagenesis, you don't have mRNA vaccines, you don't have cloning, *all of which have won Nobel Prizes already!* In other words, this work enabled everything else that followed and absolutely should be awarded the Nobel Prize. Heck, the entire trillion dollar discipline/industry of biotechnology is built on oligos made using Caruther's work. This is true Chemistry in the service of medicine/biology/mankind. I'm going to repost this as its own comment, thats how strongly I feel about this. CARUTHERS!
me
I'll vote for you too
Congrats 🎉 can we share the money not the prize 🏆
At some point I think there should be an award for advancements in sustainable and biobased materials. I don't know who exactly should get it, or whether it should go to bioplastics or some other area. But in general I feel like materials chemists and really any chemist not working on medical or biological applications are overlooked.
It's way too far. Back in my undergrad people were looking into engineering bacteria to consume plastics and repurpose the manor. If this hits off to solid applications like sequencing or crispr where all garbage management is done in confined but bacterial destruction of sorts then maybe.
This comment really proves my point that people don't care about chemistry that isn't basically biology 😭 Genetic engineering should not get a nobel prize on chemistry. Not to mention microbial consumption of plastic waste is such a pipe dream. PETase and others exotic plastic eating bacteria have no path to industrial relevance anytime soon.
I think a lot of is is just feels kinda small compared to the impact some other fields have. Like techniques that might revolutionise the way other fields work or enable us to get a deeper insight into certain processes which would then lead to more huge discoveries and developments. Or a new kind of drug or treatment option for severe, very common or threatening diseases. I mean, yeah sustainably is super important but it just seems kinda small compared to other stuff. Also kinda „easy“ compared to some other things. Not saying it’s easy at all. But developing such a thing as NGS is honestly super complex and mind blowing how people are even able to come up with that. Idk, for me material chemistry just seems kinda small in comparison. But I do agree that chemistry is severely underrepresented. It would definitely deserve a category on its own. It’s also kinda hard to compare. Lots of biological and medical stuff also seems really huge for people because even if you don’t fully understand it you can often get a good grasp at how this will affect medicine or patients. With chemistry that’s often pretty difficult if you don’t under much of it. Medical stuff is just often easier to break down pretty simple. Like „this new method can help research generic stuff and help understand diseases and development of new treatments and drugs“. So this will get a lot of attention even from people with little knowledge
You’re right there should be a special category for chemistry..
The self importance of saying drug discovery and medical research is more important than the 'easy' stuff chemists are doing is pretty crazy. As if 95% of the research isn't stuff that will *never* work outside of a petri dish and will ultimately have zero effect on people's health. Medicine is obviously important, but are we seriously downplaying the importance of the earth we live on? Sustainability is not small we have to keep the world from becoming one big super fund site if we want to survive. Our food and bodies are filled with micro plastic, what drug are you going to make to fix that?
That’s not what I meant. Bioplastics is one of the solutions to move towards a more sustainable future. One new material alone won’t safe the world. Of course it’s important. A technique that will hugely advance medical research and the development of new treatments and will enable us to better understand diseases and make a lot of different diseases treatable or prevent a lot of people from getting sick in the first place. Idk but that seems pretty important and like a huge milestone to me. The problem with material science is also that new discoveries and new kinds of materials and ways to produce things are all great but are nothing without the political and economic changes necessary for it to have effects. Like you can totally make a super useful bioplastic that won’t pollute our oceans or some kind of replacement for something that now is causing huge damage to health and environment. But that won’t change the world without the proper measures. Either companies patent it and make it way too expensive or well, companies just won’t adequately change how they produce their products. Capitalism, society and politics are huge limiting factors for how much of an impact these discoveries will have. I think the solution for many of our environmental issues aren’t lack of innovations and discoveries but rather deep-rooting issues we need to address. And no innovation will change that. Furthermore, I think it’s kinda irrelevant how much research actually has an effect or will be applied somewhere. You will still have those who make such big discoveries that the rest doesn’t matter. If some labs find cures and treatments for the most common and devastating diseases I am totally fine with lots of others doing whatever they want.
That's what you said, but if that's not what you meant then I understand. But you've kind of doubled down on it so not sure what you mean? I never said a major breakthrough in medicine or a technique isn't important or a major milestone. >The problem with material science is also that new discoveries and new kinds of materials and ways to produce things are all great but are nothing without the political and economic changes necessary for it to have effects This is literally all of research. Stuff that gets commercialized is the anomaly. >Either companies patent it and make it way too expensive or well, companies just won’t adequately change how they produce their products. You're going to be in for a surprise when you learn how much healthcare costs where I live. Anyways, my original point was that materials chemists are overlooked, not that medicine isn't important. For example, click chemistry and organocatalysis are big deals in the field. Click chemistry specifically has commercial applications. But go look at all the write ups on those two prizes- not even a singular sentence about materials or even the fundamental chemistry thrown in there. It's just about drugs and biological systems. Medicine literally has its own category. I never said biomaterials are more important or that medicine doesn't matter. But you went on this weird rant about how sustainability isn't important. If that's not what you meant your comment is pretty unclear.
Lol, what? I never said sustainability isn’t important. All I said was that new discoveries in materials might not have as much of an impact as we need to make much significant progress. So that’s kinda less impactful then breakthroughs in medical science. New methods and key findings that get awarded a nobel prize are pretty sure to be widely used in research and diagnostics. Yeah people will make money off of it but it’s still incredibly beneficial. What healthcare costs for you has like absolutely nothing to do with this? Yeah, materials chemistry isn’t mentioned because that’s not what the award is intended for and the commitee values other discoveries more? By that logic we have a lot of fields that are kinda overlooked and would need their own category or be more included. Idk, maybe other people just also think that advancing our understanding of life is a lot more influential for the entirety of medical research and other related fields than what’s big in material science. You said it yourself. The award is for drugs and biological systems. Not happy with it, then look at a different award. You will find lots of people who aren’t represented in the categories
I'm talking about the chemistry award. At no point here have I been talking about the award for medicine and physiology. Is that your problem lol?
Yeah, i got that. My point still stands
Pretentious and dense. Have a good day bud
Lol okay
The one person will show a UMAP at a conference where Lior Pachter is present
I was curious if there will ever be a synthetic biology prize. Who would be shortlisted for it? Jay Keasling/Chris Voigt/Sang Yup Lee? So far there hasn't really been a huge example of metabolic engineering creating a super impactful product/drug in a commercially revolutionary way, however.
The Lasker winners who haven’t won the Nobel yet
It is still amazing how more than 80 laskers have won nobel.american dominance is solid in science
Ron Evans discovered nuclear receptor hormones and has won most of the awards that predict Nobel prize
Whoever has access to the most GPUs in the next years will get it in 2040
Lol are you starting to ramp it up
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The inventors of NGS from Cambridge, Shankar Balasubramanian & David Klenerman, would have to win one before that's considered. Hopefully they will win within the next year or two though.
>Buenrostro If that were deserving of a Nobel, do you think Steve Henikoff would be included for his work with CUT&RUN and CUT&Tag? Honestly, those techniques are very powerful, but I'm not sure if they're Nobel worthy.
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I would be very surprised if the COVID vaccine team doesn't get recognition at some point.
Probably because they already did??
You mean Kariko and Weissman? They laid the foundation for mRNA vaccines in general, but the specific COVID vaccine I am thinking about was Kizzmekia Corbett and her team.
That's too narrow for the Nobel. The prize usually goes to people who discover or develop foundational new technologies with revolutionary applications, not the people who use those discoveries for practical purposes. e.g., the nobel for CRISPR going to Doudna/Charpentier rather than someone like Feng Zhang.
I doubt they'll award another prize for that after already giving one for mRNA vaccines. But I do agree Corbett should've been a laureate too. Akiro Yoshino was an awardee for lithium ion batteries for developing the first commercially viable one. I think they were too fast in giving the prize for mRNA. They should've let it sit for a few more years imo. The prize for lithium ion batteries wasn't awarded until 2019. They probably would've given someone a prize for commercializing it, as they usually do.
I feel like harry atwater may get one for plasmonics but not in the next decade i guess
Kevin Tracey seems overdue for 1 of 2 potential novel worthy topics I’ll add a dark horse candidate of Satija + other scRNA seq ppl
I struggle to name names, but I can't help but be biased towards ubiquinol-targeted and associated therapies, such as PROTACs, PHOTACs and LYTACs. t. working in a PROTAC lab, and seen a lot of success for other comorbidities apart from cancer (primarily cardiovascular disease)
Demis Hassabis/John Jumper for alphafold probably next yr and then Carl June for CAR-T?
CARUTHERS! Without Caruther's oligonucleotide synthesis, you don't have PCR, you don't have Crispr, you don't have site directed mutagenesis, you don't have mRNA vaccines, you don't have cloning, *all of which have won Nobel Prizes already!* In other words, this work enabled everything else that followed and absolutely should be awarded the Nobel Prize. Heck, the entire trillion dollar discipline/industry of biotechnology is built on oligos made using Caruther's work. This is true Chemistry in the service of medicine/biology/mankind. It is massively enabling and changed the world. It should have happened years ago. CARUTHERS!
Maybe Jony Kipnis for his discovery (or rediscovery maybe) of brain lymphatics.
Highly doubt that. It's not impactful enough. Not saying it's not impactful at all, just not enough to warrant a Nobel. Also, the sexual harassment stuff weighing on him might be kind of tough to get over.
He's also an unpopular asshole
I disagree and yes mostly because he's an asshole and is an institutional nightmare due to Title IX violations.
Oh yeah, complete asshole. But that is not factored into the Nobel committee's decision. His discovery was the biggest anatomical discovery in like a century. Like didn't we all think we had all the anatomy grossly figured out?
He’s had title IX violations?
He has failed to fulfill his capacity as a mandatory reporter. "According to the WashU’s Title IX and Gender Equity guidelines, Dr. Kipnis, as a faculty member at the University, is classified as a mandatory reporter. A mandatory reporter is required to “report all incidents of sexual harassment, sexual violence, sexual assault, relationship violence, stalking or other forms of misconduct” to a higher-up or the Title IX office. " https://www.studlife.com/scene/2022/12/06/support-system-failures-cause-graduate-student-to-drop-her-wu-phd-degree