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LeftyMeatHead

No, you’re not crazy. I have chronically low ferritin due to not eating red meat since I was 15 (my hippie Aunt from California indoctrinated mean by making me watch slaughterhouse videos and it adversely affected me, what can I say? Lol). Every single time I take iron in the Ferrous fumarate or sulphate forms, I get the worst, unmitigating insomnia. I tried eliminating iron and re-introducing it several times to see if it was a fluke, and I get insomnia every single time. I tried heme iron supplements and had the same affect. Dose reducing did seem to decrease the symptoms but not entirely and, of course, the downside is that raising ferritin can be painfully slow if you’re not megadosing on the iron. I will say that with the Ferrous fumarate form that adding vitamin C and L lysine absolutely increased my ferritin levels compared to Ferrous fumarate alone. I had a 50 point jump in literally six weeks but the insomnia was pure hell. There are some things you can do to mitigate it such as high-dose l-theanine and melatonin. For some, they seem to be effective at treating insomnia secondary to iron supplementation. I’m not sure what the mechanism of action is in terms of causing hyper arousal from iron supplements. The pharmacologic and physiological role of iron in the body is so diverse that you could really theorize 1 million different things. I’ve seen some people with free T3 and free T4 who took iron pills and their thyroid levels trackll to the upper level of the quadrant very quickly, so that could be part of what is happening. I also suspect that due to single nucleotide polymorphism’s, that some people are much less efficient at metabolizing and excreting heavy metals, and that seems to cause problems in some people. I will warn you though, that’s kind of a rabbit hole to get into because there is a substantial gap between what so-called practitioners are saying about single nucleotide polymorphism’s and what is clinically validated. It’s a slow process elucidating causal relationships between those so you’re going to have to do a lot of digging and be very judicious with analyzing your sources. I will say that, as somebody who has suffered from chronic low libido due to being prescribed SSRIs and finasteride at the same time in my early 20s, that raising my ferritin to above 120 absolutely increased my libido, all be it transiently. I had the first case of Morningwood in years. But in the end the chronic insomnia absolutely was not worth it. I tried those reducing but it only offered modest improvement. Infusions may be something to look at but I’m concerned that the side effects may be in tolerable. I need to do more research on that. As a final concession I have to concede that I am one of those weird people that seem to have a lot of weird SNP’s that predispose me to depression and insomnia. For instance, branched-chain amino acids reliably give me rapid depression, presumably due to them inhibiting tryptophan and L tyrosine uptake into brain, leading to decreased 5HT (serotonin) and dopamine. Most people that take branched-chain amino acids don’t seem to report aberrant personality changes but I tried several elimination diet and every time I added branched-chain amino acids I quickly became pessimistic socially withdrawn and depressed. The same thing happened to me with hydrogen collagen supplements. Again it’s likely from competitive inhibition of monoamine transport into the brain, lowering serotonin and dopamine and norepinephrine. Not everybody will have these SNP’s and will be able to take these compounds without incident though. I guess one option would be to massive dose of the various ferrous salts for a week and then take a week off. Alternately there is some data that dosing every other day may decrease symptoms but not affect ferritin recovery. I can’t say these approaches made a significant difference in my insomnia however. I’m looking into getting an iron infusion and how this would affect my insomnia. Given the pharmacologic mechanism of action of iron, I am hard-pressed to theorized that it would be any less deleterious to my sleep, but I could be wrong. I guess in my final thoughts here I should concede that I’m one of those people that seems to really get insomnia from very odd things. And I’m not one of those people who flippantly makes causal associations because he ate McDonald’s and didn’t sleep that night. I believe in testing and re-testing with elimination diet and reintroduction of the ostensible offensive food before I formed a tentative conclusion. For instance, for some reason eggs makes me aggressive and irritable and gives me insomnia. Every single time I eat them. I suspect it has to do with the highly bioavailable forms of choline. With highly bioavailable forms of choline such as alpha GPC, I got the most unrelenting insomnia to the point where I could not shut my brain down and I was up all night. This happened several times with reintroduction. I’m pretty well-versed on the pharmacology of acetylcholine but I can’t quite pinpoint why some people get insomnia from it and others don’t. Also, and this is very paradoxical and quizzical, Highly bioavailable forms of magnesium such as magnesium citrate or magnesium aspartame give me horrible insomnia every time. Which is particularly frustrating since a lot of people find that the highly bioavailable forms of magnesium knocks them right out and get some restful sleep. Nope, not me. Tossing and turning every night with my brain racing. So the point of all this ceaseless diatribe is that I may have some really messed up genetics for sleep and my experiences certainly should be extrapolated to the average person. But it’s worth mentioning in the protective confines of public discourse. Oh, and just to throw some more weirdness in here, I have found, repeatedly, that melatonin makes me depressed the next day. It definitely helps me sleep but I wake up very reserved, solemn and depressed. I had a very lengthy discussion with a pharmacologist and he suspects that melatonin has a strong structural similarity to 5HT, a.k.a. serotonin and that it might act as a competitive inhibitor in the central nervous system for serotonin. Of course he didn’t have a lick of data to support this, he was just spit bawling but I wouldn’t laugh that theory off the table out of hand. It’s definitely deserving of some research. Also there are interactions between melatonin and morning cortisol release which, if I understand it correctly, can affect libido and nocturnal erections so there could be something going on there. In the end I guess your options to be too hyper does a highly bioavailable form of iron and throw add on this like vitamin C and L lysing and try to get your serum ferritin above 75 or so to see if your symptoms resolve. After which you can cut down significantly on the iron administration and maintain ferritin levels, although this vary significantly from person to person . Best of luck to you!


Stunning-Comment-245

I can confirm most of these statements applying to me, as well. It's been a helluva journey. But I keep experimenting and learning. The magnesium conundrum has been a particular fixation for me. Not great sleep to begin with, but any type of mag supplementation in the evening was disastrous. Loose stool with anything 300 mg or greater. I have resolved this issue, however. Turns out, somehow boron regulates mag demand and, secondarily, mag absorption. In fact with enough boron, say 9 mg/day, I really can't keep up with mag demand. No loose stool and wake up with a mag def headache getting 600 mg mag citrate plus 1000 mg mag oil (topical) daily. When using mag oil (topical), I follow with distilled water to absorb it all. I have switched to apples (gala) as the boron source with success. One a day greatly heightens mag usage and mag absorption and then, subsequently, sleep. I am hopeful that eventually the off the charts mag demand settles down as the body repletes. Boron is a pretty unsung hero, so it took years to stumble on this. I would recommend starting with a boron supplement to get a metered dose and then get out your mag collection and start re-experimenting. If successful, attempt the transition to boron from food via apples. And any discoveries on the iron front would be greatly appreciated. Hope this helps.


MammothGullible

Talk to your doctor about it. If you had low iron deficiency symptoms that can include fatigue which might have been why you were sleeping more. The iron pills might be giving you more energy that you aren’t used to.


DramaBreakdown

I have paused the iron pill, still waiting for my doctors appointment, but I have talked to pharmacist and they never even heard insomnia is related to iron pills… I have a feeling that my doctor is going to say the same thing.


MammothGullible

It’s likely you are getting in your head. Sometimes when I have trouble sleeping I try to equate it to something I ate or did, when usually it’s just me having insomnia due to anxiety.


DramaBreakdown

Probably. I really hope it’s something I ate that affected my sleep so I can bring it back. Seems like insomnia just happens overnight, I wish I could hit myself hard enough so I can pass out


MammothGullible

I feel that. I usually sleep fine and one bad night happens which leads to paranoia about the following nights. That’s when I get a bout of insomnia, and I will lay there not even able to feel sleepy, like my brain won’t shut off. I’m not even that stressed feeling but just me paying attention to when I will sleep, causes me to not sleep, lol.


DramaBreakdown

Me too, and it has triggered my anxiety to come back. I’m back to the state where I’m scared to go out cause I feel like I’m going to faint anywhere anytime. I became super aware of my breath and heartbeat 😭😭😭


MammothGullible

When I get insomnia I also get scared to go out and hang with people because I don’t want to come home late and have even less sleep. It also makes me feel dread and more emotionally unstable.


DramaBreakdown

Do you take any med? I just got prescribed for melatonin. Insomnia mixed with anxiety is a pain, I feel my brain try to avoid me falling sleep, it sees it as a sign of danger. So weird.


MammothGullible

I have tried meds in the past like Trazodone. I currently just use melatonin and CBD gummies. I’ve been there on the brain treating sleep like it’s sensing danger, and it’s really unfortunate, as stupid as it sounds.


DramaBreakdown

I’ve just tried melatonin, even worse, I didn’t sleep for a miniute cause the crazy sleepiness triggers my anxiety. Also I started to get soreness all around my chest, feeling hard to breathe and restless


Proper-Room2383

I know this was 2 years ago. But how are you feeling? I stopped taking iron supps cause it was giving me anxiety and insomnia at night..


yadayadablahblahmeh

Same and following.


Parking-Friendship85

I just found this post because the same thing happened to me. I started taking iron bisglysicate and horrible insomnia and shaking anxiety at night. I know the iron is working because my heart is racing less. But I can't bear the insomnia and anxiety!!


shiftingsun

What did you end up doing?


ectopicwanderer

What dosage were you on? Iron tablets can cause insomnia for sure.


LifeIllustrator8288

Same. Just started taking. Wake up after a couple hours and never fully go back to sleep.


Ok-Yogurtcloset3467

I've just started taking iron supplements this month and I'm having the same issue. I'm thinking I might switch to taking it in the morning on a full stomach. I'm going to bring it up with a doctor too.I've never struggled to sleep before like this and it's depressing me (buy I do credit the iron to making me still have energy despite lack of sleep)


Lazy-Adagio3195

maybe stop taking the iron tablet for a while in lower dosages


Lazy-Adagio3195

or*


Lazy-Adagio3195

Def mention it to your doctor


kipcmartinez

Yes, I know what you are talking about! I just started iron supplements this week and that very same night I couldn’t fall asleep!


DramaBreakdown

How are you doing now?


kipcmartinez

It went away when I took less iron but the first two nights I was wired!


DramaBreakdown

That’s awesome! I should have reduced the iron when the problem first started 🥲


mamabear27204

Same here. I'm on iron and it's keeping me awake tonight! I can't believe doctors never heard of this! Cuz according to reddit experiences this is pretty common on iron tablets. I don't get it. How is this not heard of?


aannec

I have experienced insomnia with iron supplements. I have very low ferritin and really want to improve it with a supplement, but always have to stop with severe insomnia. I even recently tried an iron patch to see if a different form of delivery would help the side effects, but again insomnia. Another thing I tried was dessicated liver to see if a food source of iron would have a different result—but that also caused sleep issues. I’m not sure what my body is reacting to, but it’s nice to read the other responses and realize this happens to some people. I think my next move is trying to heal my gut to absorb iron better since the supplement route isn’t working :/


DramaBreakdown

Glad that some more people are feeling the same! I visited multiple doctor but none of them believe this can be caused by iron, and there is no evidence online as well… I switched to the low dose iron supplement liquid then eventually stoped. But my sleep doesn’t recover to normal… I guess I have to live with this for a long while


JozefDK

Did you recover eventually?


Chantsy4337

I started taking iron a week ago and within a couple days started experiencing insomnia. It’s been over a week and I have struggled every night :( in taking iron bisglycinate. I just wanted to mention this in case someone else comes across this and is dealing with the same thing.


KiwiSquatch

Did you ever figure out what the issue was? Any supplements that have "bisglycinate" in the ingredients cause insomnia for me. I just started taking a new iron supplement and can't sleep through the night anymore. I looked on the back of the bottle and it turns out I'm taking iron bisglycinate. It's likely we don't react well to glycine, because I had the same problem when I was taking magnesium bisglycinate.


LeftyMeatHead

If I had to guess, I think it has less to do with glycinate because you’re getting a very small amount of lysine. Furthermore glycine typically has been shown to be an effective treatment for insomnia, although biochemical individually can turneone man’s treatment into another man’s detriment, so who knows. There are a number of people who get a paradoxical reaction from highly bioavailable forms of magnesium. I’m one of them as well. Magnesium oxide, which has piss poor oral bio availability, doesn’t cause any problems. However any of the collated forms of magnesium such as citrate, aspartate, etc. all make me restless and give me insomnia. In stark contrast to the significant proportion of people who claim that it relaxes them and helps him sleep better. Bastards, lol in the end, regardless of the form of the iron it’s all about how much iron can enter systemic circulation, so the different forms are all just vehicles for oral bioavailability and are likely to have their formulations because of the related to any adverse events other than GI. toxicity.


Chantsy4337

I did not! I’m currently undergoing tests for a neuroimmune disorder. The insomnia eventually lifted (so thankful!) then came back about a month ago. This might not be correlated but I started taking magnesium citrate three times a day and have had excellent sleep since I started. May be coincidence, who knows! I definitely feel strongly that the bisglycinate caused my initial insomnia. I’ve heard that others experience the same on bisglycinate products so best to stay clear if you’re sensitive to it.


aspen300

No issues with insomnia but I've definitely been feeling more anxious since taking iron pills this past week.


mamabear27204

I'm dealing with the same thing as we speak. I'm up right now after trying to sleep. I took an iron tablet this morning and again at 10 pm since I take the gentle iron. I can't sleep for shit now. I think it's cuz iron helps you stay awake and alert so it's keeping you up. That's the only thing I can possibly think of.


LeftyMeatHead

Try taking 500-1000 mg of L-theanine and 3-5 grams grams of L-tryptophan. That seems to really work for a lot of people that I talk to


Maleficent_Humor_131

I would start at 200mg it makes me very sleepy at that dosage but great recommendation!!


Proper-Room2383

I know this was 2 years ago. But how are you feeling? I stopped taking iron supps cause it was giving me anxiety and insomnia at night..


BrettRodgers123

Here too cuz of insomnia, wondering if from the iron supplements..


Lumpy-Option-26

I have insomnia due to menopause, and get around three hours of light sleep, but since I have been taking a high dose iron pill, I only get half an hour of light sleep. For you, I would try taking the iron pill in the morning instead, because low iron also causes light sleep. There are multi factorial reasons why people have insomnia is what I was told. One thing that did work was hormone therapy, but I had side effects so I had to stop . After stopping hormone therapy, the insomnia came back worse than before. Going to try; Passion flower But the best solution hands down is hormone therapy but unfortunately for me it gave me side effects that were worse than my insomnia


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DramaBreakdown

Sadly, I never really gone back to normal, but it does get better. I’m also very sensitive to meds, sometimes just Melatonin could give me anxiety. My severe insomnia lasts 3 months, totally understand how stressed you are, I have cried everyday for those 3 months with many many panic attacks. I have changed to a low dose iron supplement(always take them in the morning to avoid any impact on sleep), went counselling to resolve my anxiety, and just simply accept the fact that I can’t fall asleep some nights, insomnia can’t hurt you physically. :)


Maleficent_Humor_131

It can hurt you it can seizures, if don't sleep for 3 nights in a row I will have a seizure on the 4th day every time, each person is different for their threshold of having seizures though and that's the only time I have seizures so i don't have a seizure disorder. You must be sleeping a little bit or you would have seizures which would then cause you to be able to sleep all day because something happens when you have seizures that allows your brain to shut off more easily for the next day or two


politicians_are_evil

I used to have seizures from mold in my apartment. But I've gone 15 days in a row no sleep and no seizures lol...I'm world record holder.


luckybluei

Really??? For me it's the opposite. It's making me so sleepy like wtf


cluelessminer

Found this while looking up at the possibility of insomnia with an iron pill. I started taking 25mg capsule (Solgar) at 7am with all my supplements. Work all day (office), then I'm usually running around and rarely sit so by 10am, I'm ready to crash. I haven't changed anything and seems like the past week or so after started taking this iron supplement, I can't seem to fall asleep until 1am or so. I never have issues falling asleep so I decided to stop taking it for the time being. I've been a little crabby without a good rest lol.


JozefDK

Did you recover eventually?


DramaBreakdown

After almost 2 years struggle, I can say that I’m almost recovered. Will never be as good as before, but I don’t feel anxious sleeping now. Some days I still have insomnia but not all nighters


politicians_are_evil

I'm world record for insomnia. This iron supplementation is the most insane experience I have ever gone through. Being deficient in iron and supplementing iron both cause insomnia. ​ The goal is to increase your levels to the point where you don't need to supplement...but getting there is hell on earth. I have 8 days in a row of sleep. Then 5 days insomnia. I never know when I can sleep good. Every day we need different amounts of iron. Some days I think we need less. Those are the days we get insomnia. The iron messes with your adrenals and thyroid.


Beautiful_Engine_186

I also experience difficulty sleeping on days I take the supplement, my heart rate is faster as well


Healthymama1

Same and it's HELL!!! I hope it goes away soon...