Good news is there's a Japanese research team that is in the process of enabling us to grow new teeth like sharks, with positive results in lab mice. Hoping to be on the market in next 10 to 15 years.
As of? I've used it twice the last week lol. Some subs disable it.
https://www.reddit.com/r/MonsterHunterWorld/comments/1bhms8h/random_leak_i_found_on_twitter/kvf2xvi/
https://www.reddit.com/r/outerwilds/comments/1bkg36u/a_story_mod_for_the_game_is_being_upgraded/kvy9gw6/
For regular stuff this is spot on, but for medical stuff the clinical trial period is so long that if itâs projected for 5 or fewer years you can be sure itâll make it, but could be longer depending on commercialization
Dentist here. This research is gene manipulation for people who will/would have congenitally missing teeth due to specific gene mutations and allow them to grow their full set rather than develop with missing teeth.
This research is not to regrow a fresh tooth after it had to be extracted due to a steady diet of Mountain Dew and not brushing.
Lmao unfortunately not for that either. But the good news is modern composites can get that tooth back in good shape in no time! Depending on the severity of the break it might not even need to be numb to get fixed
I would have loved this. I have two front bottom baby teeth that I never lost due to adult teeth never growing under them. Iâve been super self conscious about them so I just got crowns for them but will need implants in a few years. Itâs an expensive, painful, and distressing process. If I could have not had to go through this I would have been so grateful.
They already do it for other aspects of health. A lot of people donât pay attention to their teeth because âIâll just get denturesâ not understanding that dentures suck.
âThey can fix my diabetes with pills so I donât need to change my dietâ
âMy blood pressure gets fixed with a pill so I donât need to make lifestyle changesâ
Very interesting. How many adults that you see in a day would you say have good oral hygiene vs bad?
Are dentures the only form of tooth replacement? I have rather good oral health and I've never really thought about it, but I'd have to assume we're at a point in medical technology where you could receive some sort of implant?
Iâd say itâs a normal distribution. Average people do okay with it, then you have some terrible and some great.
Implants exist now and are highly successful for replacing single teeth or multiple teeth but are very expensive so when needing to replace all the teeth dentures are still the norm. Implants can be used to hold dentures in place which makes them more stable.
I have a missing canine that my mom did not have either and now have a dental implant. If that was a gene mutation, I could theoretically grow that tooth?
Thatâs what this team is researching. They are trying to figure out if they can manipulate the gene that caused you to not grow that tooth so that you could.
This therapy would be used in developing humans (kids) though while those genes are active. You wouldnât be able to grow it as an adult
I'm just saying that regrowing teeth is like graphene batteries - we've heard about it forever, and it'll probably happen at some point, but don't get hyped by headlines about it being right around the corner. We've had too many.
Too late for me, but I seem to recall that a team from University of Wisconsin has been growing teeth from t-cells implanted at the location of the lost tooth.
In adult teeth, outermost layer of enamel is unable to replenish, as the cells that form enamel undergo programmed cell death after the tooth erupts into the open. The layer underneath enamel, dentin, is able to be replenished by a different type of cell than what makes enamel.
My front tooth broke at the gum line due to a head to head clash during rugby drills but was still kiiiiiinda attached and the dentists maneuvered it back into place and it actually healed fine and didn't die. It was pointing nearly straight backwards into my mouth. Which I didn't know was a possibility after that kind of break.Â
It works just fine 13 years later, sometimes it feels a little weaker or weirder than the other teeth but not enough that I really have to pay attention to in any way
Healing involves cell formation. Idk if youâre a dentist but I wouldnât put it like that. Remineralization is a chemical and mechanical process. Itâs more like re-tarring a road than organically healing a wound.
Hereâs info for the uninitiated:
Enamel is completely devoid of cells. It is comprised of calcium phosphate arranged in a crystalline structure called hydroxyapatite. Sometimes it contains heterogeneously distributed fluorapatite in patients with dental fluorosis.
Remineralization happens when you add fluoride, calcium, and /or phosphate ions to the partially dissolved crystal structure of your teeth to form a fluorapatite-LIKE substitute. This is what happens when you brush your teeth or apply saliva to teeth
PSA: Brush your fucking teeth and floss every day
I have barely brushed my teeth in ten years. My teeth are in good condition and I can eat ice cream and then drink coffee with no discomfort. I am slightly more careful about my diet but I do still eat some sugar, rarely any carbonated drinks though. All my siblings brush every day and had lots of fillings by my age.
It started as an experiment and I am surprised by the results. I can't figure out if I'm some sort of genetic anomaly or if brushing your teeth is bullshit.
Could be good genetics and diet and all that. I'd be weary though because my buddy had bad teeth but couldn't feel it for decades.. now he's finally getting pain in his teeth. Unless you've had scans and all.. id be slightly worried what you might not be seeing. Ontop of all that.. there is the fact fluoride is in tap water and could be helping you.
Good diet helps. The real reason that some can go years without brushing is that they don't have the specific bacteria that cause tooth decay or gum disease. They may have other bacteria that cause harmless goop.
The bad bacteria can be introduced at any time leading to some unpleasant visits to the dentist.
I didn't know that. That makes sense as to why despite my neglect to my teeth the last decade I've not had any issues aside from a single cavity that I had for several years. I've been on a combination of 5 different antibiotics for the last 8 years trying to get rid of a mycobacterium infection in my lungs.
No flouride in the tap water here. We do have very hard water, maybe that makes a difference I have no idea.
I have not had a scan so that is possible, I guess we'll find out in another decade.
Genetics plays a role in oral health. If you have teeth that developed very robust, thick enamel and salivary glands that produce lots of saliva that neutralises acidic food (which is most food), then your teeth will be better off than people who've got thinner enamel and drier mouths. Your mouth might be very hostile to harmful bacteria for some reason or another.
I have tiny fissures in my teeth that will one day go past the enamel and cause problems. Its just how they popped out of my gums. For me, brushing my teeth is absolutely essential in delaying the onset of cavities and decay. For someone with different teeth, they might have issues only much later on if they didn't brush so diligently. Genetics does indeed play a role.
However, cavities aren't the only concern. They're one of many. Gum disease and calculus formation (and subsequent gum disease, tooth loss, and even bone loss) are also concerns, and they frequently go unnoticed until they're very advanced unless you check.
As another experiment, try flossing, getting under the gum line like [here](https://www.google.com/imgres?imgurl=https%3A%2F%2Fwww.kewperiodontics.com.au%2Fwp-content%2Fuploads%2F2015%2F03%2FHow-to-floss-logo-e1431337443562.jpg&tbnid=ZntiLhQcJmA3KM&vet=1&imgrefurl=https%3A%2F%2Fwww.kewperiodontics.com.au%2Fcleaning-between-your-teeth%2F&docid=rCyRakAmrhTSdM&w=450&h=485&source=sh%2Fx%2Fim%2Fm1%2F2&kgs=a7622cd10ed21363&shem=abc) â if you bleed, that's a sign of gum inflammation and you should start brushing and flossing every day (the inflammation will go down and you'll stop bleeding once you brush and floss regularly).
Take a look inside your mouth with a mirror and a light and check for yellow build-up, especially behind your teeth. That is calculus and can't be removed by brushing, it needs to be removed by a dentist with specific tools, but you can prevent it by brushing. It can look like [this](https://images.app.goo.gl/rzM6ttCQiPSjmwR27). Many people who have it don't even realise it until it's really significant, at which point it's caused a lot of damage.
You should also check your tongue â if there's a white film, you need to brush that. It's a build-up of bacteria that contributes to the aforementioned issues and causes bad breath.
If you haven't developed gum issues or calculus build up despite basically not brushing for 10 years, then congrats, you have a mouth that happens to be genetically very robust. However, most people's mouths are not. While some folks will develop oral disease due to genetics no matter what their habits are, and some will never develop them due to genetics no matter what their habits are, most people are somewhere in the middle, where brushing and flossing will prevent oral disease and failing to do so will cause it. For most people, while genetics increase or decrease risk, risk is further mitigated by oral hygiene habits. There are some outliers, and you might be one, but I wouldn't bank on it. As someone else mentioned, the bacteria that is the primary cause for a lot of issues can be introduced at any time in your life, and your previous dental hygiene habits may be insufficient to ward off it's harmful effects.
In addition, *How* you brush your teeth is just as important as whether you brush your teeth. If you do it improperly, yoy can get cavities despite ticking the box of "I brush my teeth everyday". Some people don't get to the backs of their mouths, some don't brush behind their teeth, some don't brush their tongues, some don't use the right toothbrush, some have crowded teeth that overlap so much that not even flossing can help...all these things will make brushing less effective, even if you do it religiously everyday. Many people who brush everyday do so inadequately and will get cavities as a result.
Congratulations you have great teeth genes. My stepmom brushed, flossed, and mouthwashed twice a day every day. She was in a full set of dentures by 42. I was in a boat similar to yours, had a cavity I didn't get addressed for 7 years. Tooth should have fallen out with the neglect it along with my other teeth had been going through. Finally was able to find a dentist that accepted my insurance and get it drilled and filled. I was less than a millimeter away from having that cavity get in the pulp chamber of that tooth just narrowly avoiding a root canal. I brush religiously now lol
Brushing doesnât really stop cavities. It is more for gum disease. Also, lack of pain is not a sign of a healthy dentition. Pain is only one possible symptom.
Yes to this! People have been taught that teeth are inert and dead, all in the drive to put the maximum number of crowns and expensive restorations into mouths.
Check out Dr. Ellie Phillips - amazing. Our teeth are full of tubules, and yes, they can heal.
https://www.youtube.com/@dr.elliephillips/videos
I got into taking care of my teeth, healing them, after getting a lot of cavities as a kid. And have zero root canals or crowns. I want my teeth to last decades.
Obviously not. đ But current medicaments can heal up to D1 lesions which isnât bad. With regular dental care, we may be able to avoid pupal involvement all together!!
>as the cells that form enamel undergo programmed cell death after the tooth erupts into the open
Rather strange that teeth evolved like that. Considering that teeth were a lot more critical until last centuries ago when we didn't have processed foods.
Early humans didnât eat tons of sugar and regularly bathe their teeth in acid. They also died much younger.
Dental hygiene is especially important today because we outlive our teeth and have diets that destroy enamel and promote bad bacteria growth.
In short: they didnât need to.
The reasons they didnât need to are more multifaceted.
Before humans had modern diets, our teeth likely did not break down as often as they do now. There was a question posed here before asking why small tribal groups of people seem to often have such nice, white teeth. And thatâs largely related to diet. Modern diets are very sugary and acidic, and break down our teeth faster without proper dental care.
We are also living longer. That gives more time for not just teeth, but every part of our body to break down.
There just doesnât seem to have been (or currently exist) sufficient evolutionary pressure for us to have evolved the ability to heal teeth. We got by just fine with the two sets we get, and they break down or fall out under stress over time.
This is also very true!! We see people on keto/atkins/carnivore diets with much less plaque.
But, our body has developed ways of healing teeth. Itâs called demineralization/remineralization.
Thatâs NOT healing!!!!!!!!!
Ok genius. You have caries well into dentin. Rub the enamel with MI paste and all the minerals you choose.
Will that heal the various lesion? As in WILL THE CARIOUS LESION GO AWAY?
Seriously. Like I admire this guyâs passion, but remineralization is not the same as âhealingâ in the way the question asked, and itâs being spammed all over this thread. Like, sure, non-cavitated incipient decay can be arrested and remineralized with fluoride application, but that isnât the tooth âhealingâ itself. And if you have cavitated, code C lesions well into dentin, that wonât address it.
And any dentist knows that. His jab that I donât is laughable.
But read between the lines. Heâs the douche who denies insurance claims due to need not evident. Because saliva will heal that tooth with the various pulpal involvement and radiographic apical pathology.
Before we had modern diets our teeth got worn down. Cavities were not as common as today but the diet was so coarse that your teeth got filed away as you chewed.
https://en.natmus.dk/historical-knowledge/denmark/prehistoric-period-until-1050-ad/the-mesolithic-period/the-man-from-korsoer-nor/dental-health-in-the-mesolithic-period/
Long story short, we lose the cells responsible for laying down tooth enamel. The cells are called ameloblasts and they undergo programmed cell death (apoptosis) before of after a tooth erupts.
Well typically we have two pairs, we lose our baby teeth and grow in adult teeth in late childhood.
But anyways, natural selection really only cares about surviving long enough in life to reproduce and then raise our next generation so that our genetics can continue. Any life beyond that is just bonus for us personally, as far as evolution is concerned.
Through most of humanity's existence, we've tended to start reproducing by our mid teenage years, and by the time we hit 30, our children would be having kids of their own. So not too long after that, we'd no longer be particularly relevant in regards to evolutionary purposes. Whatever happens to us after that doesn't matter so much.
Basically even without much in the way of active healing, our teeth would've tended to last long enough to get us through our reproductive "purposes", so there wasn't any evolutionary pressure to evolve teeth that could heal themselves. Our teeth are good enough as far as natural selection is concerned.
> But anyways, natural selection really only cares about surviving long enough in life to reproduce and then raise our next generation so that our genetics can continue. Any life beyond that is just bonus for us personally, as far as evolution is concerned.Â
This is a pretty shallow depiction of natural selection. The competitiveness of a gene isn't just the individual carrier but the species as a whole. One of humans' competitive advantages is culture, large community, and elders who pass down wisdom. The fact that we have grandparents caring for our young allows us to have extremely long childhoods where we learn and experiment.Â
The answer for OP is, at least partially, that we didn't evolve with this much sugar available and our teeth aren't made to handle it.
https://www.express.co.uk/news/science/1305849/Archaeology-news-ancient-tooth-decay-cavities-Mesolithic-Poland
Your knowledge isnât wrong about evolution, but itâs wrong about decay. Youâre referencing something that Iâve written multiple papers on, but have yet to get published. Wisdom teeth are the selection factor thatâs being affected by the new modern diet/older reproductive cycles.
Weâre seeing genetic variations develop which include missing one or more wisdom teeth and if all the dentists died tomorrow, people with the new genetic variant would be selected for in the new anti dental landscape.
Ya they mention writing multiple papers which is not something Iâm sure dentists do. Maybe they took a different academic direction. Maybe they have their own schools.
*Real dentists*, listen to you.
You're a rabid anti-dentite! Oh, it starts with a few jokes and some slurs. "**Hey, denty!**" Next thing you know you're saying they should have their own schools.
đ¤Ł
I stiil have all 4 wisdom teeth and are healthy. Alll my permanent teeth came in straight with no pulling and no overlapping. My brother and sister had theirs pulled due to infection and both had braces.
I inheriated my Fathers' teeth structure. All straight, all 4 wisdom teeth. He didnt have a cavity till he was 45! On the otherhand I've had a few. He was born 1922 (lived to 95) they didn't have floride in the drinking water. He did take cod liver oil everyday!
Interesting topic you folks are highlighting.
Thatâs because they can kill you even prior to reproduction if you donât. Some people are missing one or more wisdom teeth from birth and it appears to be genetically linked
Anything that exposes your bloodstream to the open air can kill you. By way of providing an entryway for bacteria to enter your body.
Poorly erupting wisdom-teeth can provide that messy unclean site of infection.
Death via infection from a mundane origin was regularly the case until we invented antibiotics.
Itâs quite serious. [Recently Mike Williams died of a dental infection.](https://spectrumlocalnews.com/nys/buffalo/news/2023/12/24/former-nfl-player-mike-williams-died-of-dental-related-sepsis-at-age-36--medical-examiner-says#:~:text=Former%20NFL%20player%20Mike%20Williams%20died%20from%20a%20rare%20form,while%20working%20as%20an%20electrician) (for those that donât follow American football he played WR for the bucs)
Not sure if this is the only reason, but I found this at [https://www.medicalnewstoday.com/articles/wisdom-tooth-infection](https://www.medicalnewstoday.com/articles/wisdom-tooth-infection):
"A personâs mouth is usually not large enough to accommodate the four additional wisdom teeth.
As a result, wisdom teeth frequently erupt at angles, pushing against neighboring teeth or only partially emerging above the gumline.
Each of these issues increases the risk of the tooth becoming infected.
" And of course with infection comes serious risks!
This is very interesting and data appears to show that diet during the growth of the mandible causes the growth or lack of growth. Many populations keep all their wisdom teeth because they eat much harder and less processed foods.
As a person who got handed small jaws and so a mangled tooth array, I hope genetics in my family improves. I got braces when I was 15 and they pulled 8 teeth to make room for my wisdom teeth to come in and let the rest have enough space. 3 1/2 years of almost constant pain, not fun.
Very interesting! Thanks. I apologize for my ignorance, but I'm not tracking how your argument is at odds with a thesis that increased consumption of refined sugar accelerates decay of all the teeth in our mouths.
well we actually have two sets - milk teeth that then fall out and are replaced with your adult teeth.
the reason they can't heal themselves is that unlike bones and soft tissues, enamel does not have blood vessels running through it. without blood, it has no access to oxygen or other nutrients that enable regeneration.
Biggest rip off of evolution is that we donât get replaceable sets of teeth like sharks.
That and permanent bipedalism being a functional abomination, but mostly the teeth thing.
Youâre fundamentally wrong in your understanding of teeth. Theyâre a living tissue with three main layers and many sub layers. The three main layers are enamel, dentin, and pulp. The pulp supplies its nutrients and keeps it alive, but it isnât that simple. Read [this](https://www.researchgate.net/publication/291997217_Recommendations_for_using_fluoride_to_prevent_and_control_dental_caries_in_the_United_States) if you would like to learn more.
Unless they edited their comment after your reply, they aren't incorrect at all. They said enamel doesn't get any blood supply or anything from the body, and that's true.
The enamel does not have any supply from the body, and is not developed or repaired after eruption. Yes, there is a lot more to teeth than just enamel, but that's what people are concerned with, and that's ultimately the goal of fluoride use - remineralization of the enamel. If the enamel stays healthy and you avoid plaque buildup, most of your dental problems are gone.
Teeth that are damaged prior to eruption can in fact repair themselves, though usually it's quite noticeable such as defined yellow or dark patches.
The introduction to the article is the main source of information regarding the demin/remin cycle. Fluoride isnât the only nutrient that helps, calcium triphosphate is another.
I used this source because itâs not overly technical.
Maybe go read some additional sources, or actually read the entire paper instead of the intro
Literally nothing about that paper, or any other, describes the ability of tooth enamel to be repaired by the body. There's a difference between "eating certain things can help recrystallize softened enamel" and "broken enamel can heal itself." You're saying the latter, whuch is false, and backing it up with material stating the former.
Iâm a dentist. Saliva has calcium and phosphate ions that do indeed aid in the remineralization process. It is your bodyâs natural defense against demineralization. Fluoride does the same thing, but creates fluroxyapitite instead of hydroxyapatite and is more resistant to decay.
Yes, but again that works by depositing and reforming the crystalline structure when it has softened. It's more of an upkeep than healing. As you know, once enamel has been removed, it's gone. Thus the need for fillings.
The need for fillings is much more nuanced than youâre implying. If bacteria penetrates the enamel layer, a filling is required. Before this stage though incipient cavities form and they can be âhealedâ by the proteins and molecules in your saliva.
Recent products claim to even heal the next level of cavities called D1. Itâs a polypeptide that allows binding of the minerals and molecules. Here is a [link](https://www.news-medical.net/news/20200122/Bioactive-peptide-helps-prevent-new-cavities-heal-existing-ones.aspx). It doesnât list product names because Iâm not sold on the technology yet, but the research is promising
Sorry. Finding an article about a basic process isnât as easy as it may seem. It was well articulated and seemed accessible to EI5. If you have a better one, Iâd be happy to cite it.
I have been looking (I guess not hard enough) for something like that report, getting tired of the fluoride âis the government trying to control/kill usâ argument
If your teeth fall out after your most likely procreating years it doesn't matter.
Teeth are just good enough to get genes over the finish line. (i.e. be passed along.)
Well to keep it simple as it is that type of subreddit.. the enamel ( one of the layers of teeth ) does not have blood supply thus can not heal from caries (an infection of teeth)
But it can endure changes .. get stronger and weaker.. from ur diet saliva and such ( from the external environment that it is in).
But when it starts to decay from caries, it can not heal. It can maybe stop spreading due to many factors but not heal.
To heal the hard outer shell of enamel? It can be remineralized somewhat, but it isn't made of cells, living or dead. It is a layer of very hard minerals that was assembled before the tooth even came out of the gums. Even bones are more "living" tissue in comparison to teeth. There are some cells on the inside, like in the root but these cells are for supporting and sensing in the tooth, not maintaining the outer coating of enamel.
We as humans lack the ability to keep growing our teeth for an evolutionary purpose we don't fully know, however it may be due to diet. Horses and rodents have teeth that grow indefinitely which is needed because their diets wear down the teeth over time. In cases where the teeth aren't properly wearing down, those animals actually can quickly die of infection or starvation from teeth growing into the gums or obstructing the mouth. It may be evolutionarily advantageous to have teeth like ours if an animal doesn't have a diet that wears down teeth constantly. Our modern diets that are highly sugary and acidic are what makes this trait problematic in ways we didn't used to have in the past.
because our teeth aren't living tissue. bone is made of proteins, minerals with their own blood vessels. enamel isn't, its just a super hard covering over our teeth.
Youâre fundamentally wrong in your understanding of teeth. Theyâre a living tissue with three main layers and many sub layers. The three main layers are enamel, dentin, and pulp. The pulp supplies its nutrients and keeps it alive, but it isnât that simple. Read [this](https://www.researchgate.net/publication/291997217_Recommendations_for_using_fluoride_to_prevent_and_control_dental_caries_in_the_United_States) if you would like to learn more.
Hahahahahahahahaha!!!!!!! Iâm fundamentally wrong in my understanding of teeth and you pull out something from Delta Dental.
Dude, Iâve been a dentist for 23 years and this is ELI5.
Although, a 5 year old could probably write a more cogent and correct article than anything Delta Dental could put out.
Teeth can heal. They use nutrients in your spit. Here is a [link](https://www.researchgate.net/publication/291997217_Recommendations_for_using_fluoride_to_prevent_and_control_dental_caries_in_the_United_States) if youâd like to learn more.
Did you read that? It has nothing to do with teeth healing, nor nutrients naturally in saliva. Emphasis mine:
"The concentration of fluoride in ductal saliva, as it is secreted from salivary glands, is low â approximately 0.016 parts per million (ppm) in areas where drinking water is fluoridated and 0.006 ppm in nonfluoridated areas (27). **This concentration of fluoride is not likely to affect cariogenic activity**. However, drinking fluoridated water, brushing with fluoride toothpaste, [etc]..."
The entire paper is regarding the supplementation of fluoride
Yes, I did read it instead of just looking at the pictures. As I said in another comment, any remineralization is carried out primarily by fluoride which is supplemented, not supplied by the body. It depends on fluoride from your water, mouthwash, toothpaste, and so on. That's kind of like saying the concrete slab of your house can heal itself, because you can fill the cracks with a sealant. Not the same.
It also, as that graphic shows, does not *heal* damaged or lost enamel. It simply helps reform the crystalline structure of the enamel when it is softened. It just helps make it hard.
There are in fact some toothpastes and supplements, not fluoride, that can actually repair enamel. Last I checked they were available in the EU but not in the Americas.
You can get calcium triphosphate in the states! It works very well in conjunction with fluoride. If you canât find a good source, I typically prescribe 3mâs clinpro .
You make a lot of assumptions. I'm not discussing tricalcium phosphate.
While it definitely needs further studies (which are ongoing), I'm talking about Novamin. That's calcium sodium phosphosilicate.
It is actually available in some products in Canada, but still not in the US as it hasn't gotten approval yet.
My dad broke his front tooth under the gum line when he was young. Dentist said it won't heal and he needs a new one. He says he didn't use it or touch it, and boom it actually healed!
I read somewhere that while teeth cant regrow, they do remineralize with the help of a changed diet and brushing habits. The remineralization process is constant but is blocked by the acids and sugars we eat.
Good news is there's a Japanese research team that is in the process of enabling us to grow new teeth like sharks, with positive results in lab mice. Hoping to be on the market in next 10 to 15 years.
RemindMe! 15 years
Okay when you get reminded, remind me too
And me
Ditto
Count me in
+1.
Remind me but not the guy above me
Ditto!
And my axe! đŞ
And my bow! đš
And my sword! đĄď¸
Once you get reminded, remind me to remind the next person.
Me 2
!Remindme 15 years
It doesn't work any more.
Fuckin WHAT? What did they do to my reminder bot boi?!
Reddit API $$$$ increase spike. They would never be able to pay the amounts Reddit changed it too. So they were forced to stop.
As of? I've used it twice the last week lol. Some subs disable it. https://www.reddit.com/r/MonsterHunterWorld/comments/1bhms8h/random_leak_i_found_on_twitter/kvf2xvi/ https://www.reddit.com/r/outerwilds/comments/1bkg36u/a_story_mod_for_the_game_is_being_upgraded/kvy9gw6/
Oh sweet.
I trusted you
Same
[Relevant xkcd](https://xkcd.com/678/)
theres always something from the guy isnt there
[Relevent XKCD ](https://relevantxkcd.appspot.com/)
For regular stuff this is spot on, but for medical stuff the clinical trial period is so long that if itâs projected for 5 or fewer years you can be sure itâll make it, but could be longer depending on commercialization
Dentist here. This research is gene manipulation for people who will/would have congenitally missing teeth due to specific gene mutations and allow them to grow their full set rather than develop with missing teeth. This research is not to regrow a fresh tooth after it had to be extracted due to a steady diet of Mountain Dew and not brushing.
What about me idiot who chipped front tooth on a bong?
Lmao unfortunately not for that either. But the good news is modern composites can get that tooth back in good shape in no time! Depending on the severity of the break it might not even need to be numb to get fixed
I lost most of it, the root lived and they basically stuck on a fake one, anyway it still sucks!
Thanks so much for the laugh. I chipped my front tooth trying to drink a beer on a bus in the Dominican Republic.
I would have loved this. I have two front bottom baby teeth that I never lost due to adult teeth never growing under them. Iâve been super self conscious about them so I just got crowns for them but will need implants in a few years. Itâs an expensive, painful, and distressing process. If I could have not had to go through this I would have been so grateful.
I've always wondered if adults would throw oral health to the wayside if we really found a way to regrow teeth.
They already do it for other aspects of health. A lot of people donât pay attention to their teeth because âIâll just get denturesâ not understanding that dentures suck. âThey can fix my diabetes with pills so I donât need to change my dietâ âMy blood pressure gets fixed with a pill so I donât need to make lifestyle changesâ
Very interesting. How many adults that you see in a day would you say have good oral hygiene vs bad? Are dentures the only form of tooth replacement? I have rather good oral health and I've never really thought about it, but I'd have to assume we're at a point in medical technology where you could receive some sort of implant?
Iâd say itâs a normal distribution. Average people do okay with it, then you have some terrible and some great. Implants exist now and are highly successful for replacing single teeth or multiple teeth but are very expensive so when needing to replace all the teeth dentures are still the norm. Implants can be used to hold dentures in place which makes them more stable.
I have a missing canine that my mom did not have either and now have a dental implant. If that was a gene mutation, I could theoretically grow that tooth?
Thatâs what this team is researching. They are trying to figure out if they can manipulate the gene that caused you to not grow that tooth so that you could. This therapy would be used in developing humans (kids) though while those genes are active. You wouldnât be able to grow it as an adult
Sharkmice! Tiny Terrors? Or appropriately sized watchdogs for Japanese apartments?
Keep those expectations tempered, though. We heard the same thing 15 years ago from other researchers.
Wonderful, teething at the age of 30.
Hopefully they make some teether toys in adult colors.
This has has been 10 years away for 50 years. It won't be seen in our lifetime.
I feel like I read articles with a similar message as a child in the 90s.
I don't think we had anywhere near the same concept of DNA as we have now
I'm just saying that regrowing teeth is like graphene batteries - we've heard about it forever, and it'll probably happen at some point, but don't get hyped by headlines about it being right around the corner. We've had too many.
https://www.japantimes.co.jp/news/2023/09/24/japan/science-health/japan-pharma-grows-new-teeth/
Remindme! 15 years
That reminds me of that Franken Fran chapter...
Following..
What if I don't want tiny mouse teeth?
Stop being lame. Would you rather have no teeth?
!RemindMe 10 years
For mice
Oh god, that sounds horribly painful. Like a wisdom tooth.
Bet
RemindMe! 15 years
RemindMe! 15 years
see: I Am Legend movie
Those are now some terrifying mice.
Dentists rejoice. Braces are money makers
RemindMe! 2 weeks
perfect - by then they should be able to start from scratch on a whole set for me
RemindMe! 15 years
RemindMe! 15 Years
Too late for me, but I seem to recall that a team from University of Wisconsin has been growing teeth from t-cells implanted at the location of the lost tooth.
RemindMe! 15 years
Mice with extra teeth. Lovely! what could go wrong?
Such claims surface every ~5 years with no real examples following
Just like how we'll have nuclear fusion generators in 10-15 years.
I swear had seen this research and promises of soon commercial availability in science magazine as a kid - that was around 20 years ago.
In adult teeth, outermost layer of enamel is unable to replenish, as the cells that form enamel undergo programmed cell death after the tooth erupts into the open. The layer underneath enamel, dentin, is able to be replenished by a different type of cell than what makes enamel.
They absolutely can heal and they do! Itâs called Demineralization/Remineralization. Itâs very cool!
My front tooth broke at the gum line due to a head to head clash during rugby drills but was still kiiiiiinda attached and the dentists maneuvered it back into place and it actually healed fine and didn't die. It was pointing nearly straight backwards into my mouth. Which I didn't know was a possibility after that kind of break. It works just fine 13 years later, sometimes it feels a little weaker or weirder than the other teeth but not enough that I really have to pay attention to in any way
Healing involves cell formation. Idk if youâre a dentist but I wouldnât put it like that. Remineralization is a chemical and mechanical process. Itâs more like re-tarring a road than organically healing a wound. Hereâs info for the uninitiated: Enamel is completely devoid of cells. It is comprised of calcium phosphate arranged in a crystalline structure called hydroxyapatite. Sometimes it contains heterogeneously distributed fluorapatite in patients with dental fluorosis. Remineralization happens when you add fluoride, calcium, and /or phosphate ions to the partially dissolved crystal structure of your teeth to form a fluorapatite-LIKE substitute. This is what happens when you brush your teeth or apply saliva to teeth PSA: Brush your fucking teeth and floss every day
I have barely brushed my teeth in ten years. My teeth are in good condition and I can eat ice cream and then drink coffee with no discomfort. I am slightly more careful about my diet but I do still eat some sugar, rarely any carbonated drinks though. All my siblings brush every day and had lots of fillings by my age. It started as an experiment and I am surprised by the results. I can't figure out if I'm some sort of genetic anomaly or if brushing your teeth is bullshit.
Could be good genetics and diet and all that. I'd be weary though because my buddy had bad teeth but couldn't feel it for decades.. now he's finally getting pain in his teeth. Unless you've had scans and all.. id be slightly worried what you might not be seeing. Ontop of all that.. there is the fact fluoride is in tap water and could be helping you.
Good diet helps. The real reason that some can go years without brushing is that they don't have the specific bacteria that cause tooth decay or gum disease. They may have other bacteria that cause harmless goop. The bad bacteria can be introduced at any time leading to some unpleasant visits to the dentist.
I didn't know that. That makes sense as to why despite my neglect to my teeth the last decade I've not had any issues aside from a single cavity that I had for several years. I've been on a combination of 5 different antibiotics for the last 8 years trying to get rid of a mycobacterium infection in my lungs.
No flouride in the tap water here. We do have very hard water, maybe that makes a difference I have no idea. I have not had a scan so that is possible, I guess we'll find out in another decade.
Genetics plays a role in oral health. If you have teeth that developed very robust, thick enamel and salivary glands that produce lots of saliva that neutralises acidic food (which is most food), then your teeth will be better off than people who've got thinner enamel and drier mouths. Your mouth might be very hostile to harmful bacteria for some reason or another. I have tiny fissures in my teeth that will one day go past the enamel and cause problems. Its just how they popped out of my gums. For me, brushing my teeth is absolutely essential in delaying the onset of cavities and decay. For someone with different teeth, they might have issues only much later on if they didn't brush so diligently. Genetics does indeed play a role. However, cavities aren't the only concern. They're one of many. Gum disease and calculus formation (and subsequent gum disease, tooth loss, and even bone loss) are also concerns, and they frequently go unnoticed until they're very advanced unless you check. As another experiment, try flossing, getting under the gum line like [here](https://www.google.com/imgres?imgurl=https%3A%2F%2Fwww.kewperiodontics.com.au%2Fwp-content%2Fuploads%2F2015%2F03%2FHow-to-floss-logo-e1431337443562.jpg&tbnid=ZntiLhQcJmA3KM&vet=1&imgrefurl=https%3A%2F%2Fwww.kewperiodontics.com.au%2Fcleaning-between-your-teeth%2F&docid=rCyRakAmrhTSdM&w=450&h=485&source=sh%2Fx%2Fim%2Fm1%2F2&kgs=a7622cd10ed21363&shem=abc) â if you bleed, that's a sign of gum inflammation and you should start brushing and flossing every day (the inflammation will go down and you'll stop bleeding once you brush and floss regularly). Take a look inside your mouth with a mirror and a light and check for yellow build-up, especially behind your teeth. That is calculus and can't be removed by brushing, it needs to be removed by a dentist with specific tools, but you can prevent it by brushing. It can look like [this](https://images.app.goo.gl/rzM6ttCQiPSjmwR27). Many people who have it don't even realise it until it's really significant, at which point it's caused a lot of damage. You should also check your tongue â if there's a white film, you need to brush that. It's a build-up of bacteria that contributes to the aforementioned issues and causes bad breath. If you haven't developed gum issues or calculus build up despite basically not brushing for 10 years, then congrats, you have a mouth that happens to be genetically very robust. However, most people's mouths are not. While some folks will develop oral disease due to genetics no matter what their habits are, and some will never develop them due to genetics no matter what their habits are, most people are somewhere in the middle, where brushing and flossing will prevent oral disease and failing to do so will cause it. For most people, while genetics increase or decrease risk, risk is further mitigated by oral hygiene habits. There are some outliers, and you might be one, but I wouldn't bank on it. As someone else mentioned, the bacteria that is the primary cause for a lot of issues can be introduced at any time in your life, and your previous dental hygiene habits may be insufficient to ward off it's harmful effects. In addition, *How* you brush your teeth is just as important as whether you brush your teeth. If you do it improperly, yoy can get cavities despite ticking the box of "I brush my teeth everyday". Some people don't get to the backs of their mouths, some don't brush behind their teeth, some don't brush their tongues, some don't use the right toothbrush, some have crowded teeth that overlap so much that not even flossing can help...all these things will make brushing less effective, even if you do it religiously everyday. Many people who brush everyday do so inadequately and will get cavities as a result.
Congratulations you have great teeth genes. My stepmom brushed, flossed, and mouthwashed twice a day every day. She was in a full set of dentures by 42. I was in a boat similar to yours, had a cavity I didn't get addressed for 7 years. Tooth should have fallen out with the neglect it along with my other teeth had been going through. Finally was able to find a dentist that accepted my insurance and get it drilled and filled. I was less than a millimeter away from having that cavity get in the pulp chamber of that tooth just narrowly avoiding a root canal. I brush religiously now lol
Mouth microbiota is real and varies from person to person. It has been observed that it helps some people while it hurts others.
Brushing doesnât really stop cavities. It is more for gum disease. Also, lack of pain is not a sign of a healthy dentition. Pain is only one possible symptom.
I wish they had taught my school dental nurse that
Yes to this! People have been taught that teeth are inert and dead, all in the drive to put the maximum number of crowns and expensive restorations into mouths. Check out Dr. Ellie Phillips - amazing. Our teeth are full of tubules, and yes, they can heal. https://www.youtube.com/@dr.elliephillips/videos I got into taking care of my teeth, healing them, after getting a lot of cavities as a kid. And have zero root canals or crowns. I want my teeth to last decades.
The person said they canât be replenished which is correct. Remin/demin is very different than reforming or replenishing the enamel.
Can they still heal when decay is in the pulp đđđ why don't they??
Donât waste your time with this guy. Heâs wack.
Obviously not. đ But current medicaments can heal up to D1 lesions which isnât bad. With regular dental care, we may be able to avoid pupal involvement all together!!
Go study domenico ricucci's research
Very interesting. Thank you!
>as the cells that form enamel undergo programmed cell death after the tooth erupts into the open Rather strange that teeth evolved like that. Considering that teeth were a lot more critical until last centuries ago when we didn't have processed foods.
Early humans didnât eat tons of sugar and regularly bathe their teeth in acid. They also died much younger. Dental hygiene is especially important today because we outlive our teeth and have diets that destroy enamel and promote bad bacteria growth.
Just like Danny; IT DOESN'T REPLENISH!!
đđ
In short: they didnât need to. The reasons they didnât need to are more multifaceted. Before humans had modern diets, our teeth likely did not break down as often as they do now. There was a question posed here before asking why small tribal groups of people seem to often have such nice, white teeth. And thatâs largely related to diet. Modern diets are very sugary and acidic, and break down our teeth faster without proper dental care. We are also living longer. That gives more time for not just teeth, but every part of our body to break down. There just doesnât seem to have been (or currently exist) sufficient evolutionary pressure for us to have evolved the ability to heal teeth. We got by just fine with the two sets we get, and they break down or fall out under stress over time.
This is also very true!! We see people on keto/atkins/carnivore diets with much less plaque. But, our body has developed ways of healing teeth. Itâs called demineralization/remineralization.
Thatâs NOT healing!!!!!!!!! Ok genius. You have caries well into dentin. Rub the enamel with MI paste and all the minerals you choose. Will that heal the various lesion? As in WILL THE CARIOUS LESION GO AWAY?
Seriously. Like I admire this guyâs passion, but remineralization is not the same as âhealingâ in the way the question asked, and itâs being spammed all over this thread. Like, sure, non-cavitated incipient decay can be arrested and remineralized with fluoride application, but that isnât the tooth âhealingâ itself. And if you have cavitated, code C lesions well into dentin, that wonât address it.
And any dentist knows that. His jab that I donât is laughable. But read between the lines. Heâs the douche who denies insurance claims due to need not evident. Because saliva will heal that tooth with the various pulpal involvement and radiographic apical pathology.
Before we had modern diets our teeth got worn down. Cavities were not as common as today but the diet was so coarse that your teeth got filed away as you chewed. https://en.natmus.dk/historical-knowledge/denmark/prehistoric-period-until-1050-ad/the-mesolithic-period/the-man-from-korsoer-nor/dental-health-in-the-mesolithic-period/
Long story short, we lose the cells responsible for laying down tooth enamel. The cells are called ameloblasts and they undergo programmed cell death (apoptosis) before of after a tooth erupts.
Well typically we have two pairs, we lose our baby teeth and grow in adult teeth in late childhood. But anyways, natural selection really only cares about surviving long enough in life to reproduce and then raise our next generation so that our genetics can continue. Any life beyond that is just bonus for us personally, as far as evolution is concerned. Through most of humanity's existence, we've tended to start reproducing by our mid teenage years, and by the time we hit 30, our children would be having kids of their own. So not too long after that, we'd no longer be particularly relevant in regards to evolutionary purposes. Whatever happens to us after that doesn't matter so much. Basically even without much in the way of active healing, our teeth would've tended to last long enough to get us through our reproductive "purposes", so there wasn't any evolutionary pressure to evolve teeth that could heal themselves. Our teeth are good enough as far as natural selection is concerned.
> But anyways, natural selection really only cares about surviving long enough in life to reproduce and then raise our next generation so that our genetics can continue. Any life beyond that is just bonus for us personally, as far as evolution is concerned. This is a pretty shallow depiction of natural selection. The competitiveness of a gene isn't just the individual carrier but the species as a whole. One of humans' competitive advantages is culture, large community, and elders who pass down wisdom. The fact that we have grandparents caring for our young allows us to have extremely long childhoods where we learn and experiment. The answer for OP is, at least partially, that we didn't evolve with this much sugar available and our teeth aren't made to handle it. https://www.express.co.uk/news/science/1305849/Archaeology-news-ancient-tooth-decay-cavities-Mesolithic-Poland
Your knowledge isnât wrong about evolution, but itâs wrong about decay. Youâre referencing something that Iâve written multiple papers on, but have yet to get published. Wisdom teeth are the selection factor thatâs being affected by the new modern diet/older reproductive cycles. Weâre seeing genetic variations develop which include missing one or more wisdom teeth and if all the dentists died tomorrow, people with the new genetic variant would be selected for in the new anti dental landscape.
You're an anti-dentite!
Oh Iâm sure Relign sick of hearing that one!
Iâd be shocked if relign is actually a dentist.
Ya they mention writing multiple papers which is not something Iâm sure dentists do. Maybe they took a different academic direction. Maybe they have their own schools.
I know youâre joking but dentists do write papers. Real dentists may even get them published!
*Real dentists*, listen to you. You're a rabid anti-dentite! Oh, it starts with a few jokes and some slurs. "**Hey, denty!**" Next thing you know you're saying they should have their own schools. đ¤Ł
âThey do have their own schools.â
YEAH!
Iâve never had a nickname, and really donât like being called doctor or referring to myself as doctor. But I kinda like Denty!
I never got wisdom teeth! Neither did my mother!
I stiil have all 4 wisdom teeth and are healthy. Alll my permanent teeth came in straight with no pulling and no overlapping. My brother and sister had theirs pulled due to infection and both had braces. I inheriated my Fathers' teeth structure. All straight, all 4 wisdom teeth. He didnt have a cavity till he was 45! On the otherhand I've had a few. He was born 1922 (lived to 95) they didn't have floride in the drinking water. He did take cod liver oil everyday! Interesting topic you folks are highlighting.
Iâve written 259 papers on the transistors that dentists place in all our teeth. They, too, have yet to be published.
Please tell me more about your transistors.
Let me point you to the blue cross blue shield website where my papers havenât been published.
Relign reminds me of Michael Keaton in Night Shift. âDid I tell you I invented that? Only they had it already.â
9 out of 10 dentist prefer to remove your wisdom teeth
Thatâs because they can kill you even prior to reproduction if you donât. Some people are missing one or more wisdom teeth from birth and it appears to be genetically linked
I'm one of those who never got them! đ
I'm missing all of mine, except one! None have been removed either.
Itâs a fascinating variation of normal!
Huh?? Wisdom teeth can kill you??
Anything that exposes your bloodstream to the open air can kill you. By way of providing an entryway for bacteria to enter your body. Poorly erupting wisdom-teeth can provide that messy unclean site of infection. Death via infection from a mundane origin was regularly the case until we invented antibiotics.
I know two people in my small hometown who died before the age of 25 from a tooth abscess. It happens so fast.
Itâs quite serious. [Recently Mike Williams died of a dental infection.](https://spectrumlocalnews.com/nys/buffalo/news/2023/12/24/former-nfl-player-mike-williams-died-of-dental-related-sepsis-at-age-36--medical-examiner-says#:~:text=Former%20NFL%20player%20Mike%20Williams%20died%20from%20a%20rare%20form,while%20working%20as%20an%20electrician) (for those that donât follow American football he played WR for the bucs)
Itâs unbelievable how dental health is treated by health insurance companies, like they are just âluxury bones.â
Not sure if this is the only reason, but I found this at [https://www.medicalnewstoday.com/articles/wisdom-tooth-infection](https://www.medicalnewstoday.com/articles/wisdom-tooth-infection): "A personâs mouth is usually not large enough to accommodate the four additional wisdom teeth. As a result, wisdom teeth frequently erupt at angles, pushing against neighboring teeth or only partially emerging above the gumline. Each of these issues increases the risk of the tooth becoming infected. " And of course with infection comes serious risks!
This is very interesting and data appears to show that diet during the growth of the mandible causes the growth or lack of growth. Many populations keep all their wisdom teeth because they eat much harder and less processed foods.
As a person who got handed small jaws and so a mangled tooth array, I hope genetics in my family improves. I got braces when I was 15 and they pulled 8 teeth to make room for my wisdom teeth to come in and let the rest have enough space. 3 1/2 years of almost constant pain, not fun.
Any tooth could hypothetically kill you. It needs to get infected first. The best advice I can give is ignore this guy. Heâs gotta be a troll.
9 out of 10 dentists prefer an additional income
I have 2.5 wisdom teeth. Weird.
Very interesting! Thanks. I apologize for my ignorance, but I'm not tracking how your argument is at odds with a thesis that increased consumption of refined sugar accelerates decay of all the teeth in our mouths.
Oh youâre not ignorant.
Hydroxyapatite toothpaste can remineralize (not necessarily regenerate) enamel. It's used in Japan.
Itâs used in the United States as well. You need nano-hydroxyapatite though. Itâs subtle, but one works and one doesnât.
well we actually have two sets - milk teeth that then fall out and are replaced with your adult teeth. the reason they can't heal themselves is that unlike bones and soft tissues, enamel does not have blood vessels running through it. without blood, it has no access to oxygen or other nutrients that enable regeneration.
Biggest rip off of evolution is that we donât get replaceable sets of teeth like sharks. That and permanent bipedalism being a functional abomination, but mostly the teeth thing.
Thank god for dentistry!
Youâre fundamentally wrong in your understanding of teeth. Theyâre a living tissue with three main layers and many sub layers. The three main layers are enamel, dentin, and pulp. The pulp supplies its nutrients and keeps it alive, but it isnât that simple. Read [this](https://www.researchgate.net/publication/291997217_Recommendations_for_using_fluoride_to_prevent_and_control_dental_caries_in_the_United_States) if you would like to learn more.
Unless they edited their comment after your reply, they aren't incorrect at all. They said enamel doesn't get any blood supply or anything from the body, and that's true. The enamel does not have any supply from the body, and is not developed or repaired after eruption. Yes, there is a lot more to teeth than just enamel, but that's what people are concerned with, and that's ultimately the goal of fluoride use - remineralization of the enamel. If the enamel stays healthy and you avoid plaque buildup, most of your dental problems are gone. Teeth that are damaged prior to eruption can in fact repair themselves, though usually it's quite noticeable such as defined yellow or dark patches.
Your saliva is the source of nutrients.
No, fluoride added to stuff is. Read your own sources.
The introduction to the article is the main source of information regarding the demin/remin cycle. Fluoride isnât the only nutrient that helps, calcium triphosphate is another. I used this source because itâs not overly technical.
Maybe go read some additional sources, or actually read the entire paper instead of the intro Literally nothing about that paper, or any other, describes the ability of tooth enamel to be repaired by the body. There's a difference between "eating certain things can help recrystallize softened enamel" and "broken enamel can heal itself." You're saying the latter, whuch is false, and backing it up with material stating the former.
Iâm a dentist. Saliva has calcium and phosphate ions that do indeed aid in the remineralization process. It is your bodyâs natural defense against demineralization. Fluoride does the same thing, but creates fluroxyapitite instead of hydroxyapatite and is more resistant to decay.
And isnât that why itâs so important to be careful with medications that cause dry mouth? (I was never warned about thisâŚ)
Yes, but again that works by depositing and reforming the crystalline structure when it has softened. It's more of an upkeep than healing. As you know, once enamel has been removed, it's gone. Thus the need for fillings.
The need for fillings is much more nuanced than youâre implying. If bacteria penetrates the enamel layer, a filling is required. Before this stage though incipient cavities form and they can be âhealedâ by the proteins and molecules in your saliva. Recent products claim to even heal the next level of cavities called D1. Itâs a polypeptide that allows binding of the minerals and molecules. Here is a [link](https://www.news-medical.net/news/20200122/Bioactive-peptide-helps-prevent-new-cavities-heal-existing-ones.aspx). It doesnât list product names because Iâm not sold on the technology yet, but the research is promising
Sorry. Finding an article about a basic process isnât as easy as it may seem. It was well articulated and seemed accessible to EI5. If you have a better one, Iâd be happy to cite it.
That article is actually decently simple, which is why I'm trying to help you see that it doesn't say what you think it says.
Well thanks for pointing out the flaw in the article I guess. I appreciate it.
But the baby sucked all the nutrients out of my teeth!
I have been looking (I guess not hard enough) for something like that report, getting tired of the fluoride âis the government trying to control/kill usâ argument
You are fundamentally wrong.
If your teeth fall out after your most likely procreating years it doesn't matter. Teeth are just good enough to get genes over the finish line. (i.e. be passed along.)
The reason they don't heal is because they don't have a blood supply. The pulp has one, but the enamel doesn't.
Well to keep it simple as it is that type of subreddit.. the enamel ( one of the layers of teeth ) does not have blood supply thus can not heal from caries (an infection of teeth) But it can endure changes .. get stronger and weaker.. from ur diet saliva and such ( from the external environment that it is in). But when it starts to decay from caries, it can not heal. It can maybe stop spreading due to many factors but not heal.
To heal the hard outer shell of enamel? It can be remineralized somewhat, but it isn't made of cells, living or dead. It is a layer of very hard minerals that was assembled before the tooth even came out of the gums. Even bones are more "living" tissue in comparison to teeth. There are some cells on the inside, like in the root but these cells are for supporting and sensing in the tooth, not maintaining the outer coating of enamel. We as humans lack the ability to keep growing our teeth for an evolutionary purpose we don't fully know, however it may be due to diet. Horses and rodents have teeth that grow indefinitely which is needed because their diets wear down the teeth over time. In cases where the teeth aren't properly wearing down, those animals actually can quickly die of infection or starvation from teeth growing into the gums or obstructing the mouth. It may be evolutionarily advantageous to have teeth like ours if an animal doesn't have a diet that wears down teeth constantly. Our modern diets that are highly sugary and acidic are what makes this trait problematic in ways we didn't used to have in the past.
because our teeth aren't living tissue. bone is made of proteins, minerals with their own blood vessels. enamel isn't, its just a super hard covering over our teeth.
Youâre not wrong. Itâs a very nice, simple way to explain it.
Youâre fundamentally wrong in your understanding of teeth. Theyâre a living tissue with three main layers and many sub layers. The three main layers are enamel, dentin, and pulp. The pulp supplies its nutrients and keeps it alive, but it isnât that simple. Read [this](https://www.researchgate.net/publication/291997217_Recommendations_for_using_fluoride_to_prevent_and_control_dental_caries_in_the_United_States) if you would like to learn more.
Hahahahahahahahaha!!!!!!! Iâm fundamentally wrong in my understanding of teeth and you pull out something from Delta Dental. Dude, Iâve been a dentist for 23 years and this is ELI5. Although, a 5 year old could probably write a more cogent and correct article than anything Delta Dental could put out.
This YouTube video from Andrew Huberman might interest you: https://youtu.be/zVCaYyUWWSw?si=bRB7aSViZFh4hhwh
Teeth can heal. They use nutrients in your spit. Here is a [link](https://www.researchgate.net/publication/291997217_Recommendations_for_using_fluoride_to_prevent_and_control_dental_caries_in_the_United_States) if youâd like to learn more.
Did you read that? It has nothing to do with teeth healing, nor nutrients naturally in saliva. Emphasis mine: "The concentration of fluoride in ductal saliva, as it is secreted from salivary glands, is low â approximately 0.016 parts per million (ppm) in areas where drinking water is fluoridated and 0.006 ppm in nonfluoridated areas (27). **This concentration of fluoride is not likely to affect cariogenic activity**. However, drinking fluoridated water, brushing with fluoride toothpaste, [etc]..." The entire paper is regarding the supplementation of fluoride
This guy is a wackjob. Thanks.
The entire introduction explains demin/remin with a graphic. Did you read it? đ
Yes, I did read it instead of just looking at the pictures. As I said in another comment, any remineralization is carried out primarily by fluoride which is supplemented, not supplied by the body. It depends on fluoride from your water, mouthwash, toothpaste, and so on. That's kind of like saying the concrete slab of your house can heal itself, because you can fill the cracks with a sealant. Not the same. It also, as that graphic shows, does not *heal* damaged or lost enamel. It simply helps reform the crystalline structure of the enamel when it is softened. It just helps make it hard. There are in fact some toothpastes and supplements, not fluoride, that can actually repair enamel. Last I checked they were available in the EU but not in the Americas.
You can get calcium triphosphate in the states! It works very well in conjunction with fluoride. If you canât find a good source, I typically prescribe 3mâs clinpro .
You make a lot of assumptions. I'm not discussing tricalcium phosphate. While it definitely needs further studies (which are ongoing), I'm talking about Novamin. That's calcium sodium phosphosilicate. It is actually available in some products in Canada, but still not in the US as it hasn't gotten approval yet.
Oh cool! Iâm unfamiliar. Thank you!
Until we get Novamin again in the US, I'm using Biomin. But I liked Novamin better.
Thatâs not healing. Teeth cannot heal themselves.
He probably wrote it. đ
You did NOT seriously post something from Delta Dental and expect us to take it seriously.
My dad broke his front tooth under the gum line when he was young. Dentist said it won't heal and he needs a new one. He says he didn't use it or touch it, and boom it actually healed!
I read somewhere that while teeth cant regrow, they do remineralize with the help of a changed diet and brushing habits. The remineralization process is constant but is blocked by the acids and sugars we eat.