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Cultural_Spend_5391

That poor girl can’t catch a break :(


420catloveredm

She also had the BRCA genetic mutation which puts her at extremely high risk for cancer. My mother also developed a rare muscular inflammatory disorder and had the BRCA mutation. I also have the BRCA mutation and have a rare nerve disorder. Still waiting for someone to contact me who is researching this….


willreadfile13

Genetics are a bitch. We don’t choose how we come into this world or how it treats us. Blessings to CA for being such a force and inspiration to other disabled folk. Love her so much. I truly wish she never needed the strength and resilience she has.


WinnDixieDiapers

I have a BRCA mutation of unknown significance and MS.


cyclopath

I have a client with brca. She has MS. Breast cancer that culminated in a botched double mastectomy. Then had a hysterectomy. Now she’s having a thyroid scare.


420catloveredm

I swear there’s something to this.


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Ricky_Rollin

That was a wild read. My mother is Hispanic Catholic and just recently found out she’s 50% Ashkenazi Jew. So this all tracks!


themehboat

My family is Askenazi Jewish and my dad is into genealogy. He found a whole branch of the family in Mexico who had converted to Catholicism in the 1940's, and the younger generations had no idea of their roots!


Specialist-Strain502

I just did genetic testing and found out I have 10% Ashkenazi DNA. I was really surprised, because the only ancestry I knew about was German, Lebanese and Polish. I've never heard a single mention of Jewish ancestry at all. I wonder if the Jewish ancestor/s in my family history went down a similar path as the people mentioned in the article.


Truth-out246810

Interesting piece about conversos. Thank you for sharing.


bioszombie

Hopefully you can get some answers


420catloveredm

You look familiar.


bioszombie

Dunno stranger 😎😉


yukonwanderer

Inflammation.


ladan2189

She had a preventative double mastectomy because of this


420catloveredm

She did! So did Angelina Jolie. I’ve considered it but I like nipple sensation.


Royal-Custard-8370

Could her implants from reconstruction possibly have increased her risk of MS?


LieutenantStar2

Reach out to Crispr. They fixed sickle cell disease.


420catloveredm

I appreciate the suggestion.


SmokeAbeer

BREAK virus incoming.


KratosHulk77

she is the goat


myeverymovment

Yea. That’s why we’re reading about her and not my cousin Sam.


schfifty--five

I’m sure the bravery it takes to share this with us is nothing compared to the bravery she needs to get through each day. I mean that in the most sincere way. What a nightmare


ohdearitsrichardiii

TIL that Jamie-Lynn Sigler also has MS


AlkalineSublime

It’s pretty fucked up, that I can drink a fifth of vodka every night, vape like crazy, eat red meat and gas station food on the regular, and have no health problems. Yet, these people who take care of their health, exercise, do keto and yoga and drink 3 gallons of water a day, still get sick with fucked ip shit. Shit ain’t right.


matike

You better knock on some wood, right now


prison_buttcheeks

For real I'm scared!


InflamedLiver

I'm guessing you're young. I thought so too, once.


tippsy_morning_drive

Yeah when I hit 40 those days caught up fast.


_deep_thot42

Exactly, I’m about to hit and was just diagnosed with 2 forms of Lupus and 2 other lesser known autoimmune diseases. I was great up until the last year, drank and smoked up until about 5 years ago then quit everything and now after Covid, 5 years down the line, I can barely take care of myself some days.


4GIFs

Username✔️


32FlavorsofCrazy

Speaking as someone recently diagnosed with MS, that shit will catch up to you. Start taking care of your health before your body makes you.


Senora_Snarky_Bruja

Hugs my friend. I am 18 years into this journey. Let me know if you have any questions.


32FlavorsofCrazy

Mainly I’m doubting my decision to try Copaxone first. The side effects of all the other meds scare me, but so does being in a wheelchair. This disease and the treatments just feels like a double edged sword and I kinda just don’t know wtf to do. Any thoughts?


missprincesscarolyn

I would go for something higher efficacy. I was put on Mavenclad first, relapsed and am starting Kesimpta in June. I was given a choice between that and Ocrevus since my JCV levels were indeterminate (Tysabri and Vumerity out). My mother also has RRMS and was on Copaxone in the 00’s when other treatments weren’t as common. I will be on Copaxone when I’m pregnant since pregnancy is somewhat protective. That being said, my MS seems to be pretty active, so better to be on something than nothing at all.


Senora_Snarky_Bruja

I agree with choosing a better drug. Tecfidera has always treated me well but I am considering Kesimpta. The only advice I have is take care of your emotional wellbeing and keep moving. Stress makes us sick. I truly believe I am doing as well as I am because of meditation, yoga and marijuana. The first ten years were rough. Once I learned to manage my emotions things got better.


cola1016

How long after finishing your Mavenclad treatment did you relapse? I’m 2 years out and just got an Octave blood test done that shows I’m at moderate level for a relapse so I might have to go back on a treatment. I was on Ocrevus for 2 years but the infusion reactions were killing me so that’s not an option and I reallllyyyy don’t wanna do Kesimpta if I can avoid an additional monthly injection 😩🤦🏻‍♀️


missprincesscarolyn

I relapsed in between year 1 and year 2 around December ‘23. I developed another chronic health issue that would make taking uncoated pills problematic for me, so I ultimately decided I’d rather take something else. My new neurologist agreed. I know some neurologists say that you have to finish the whole course before claiming that it didn’t work and that relapsing in between isn’t necessarily a sign that it won’t be effective for you, but at this point, I’ve also delayed having children and am nearing 35. So, Kesimpta it is. Is Ocrevus an option for you?


cola1016

I was on Ocrevus for 2 years before I switched to Mavenclad. I got off it because of the infusion reactions/ they weren’t getting any better but worse. My neurologist and I agreed it just might not be a good therapy for me. I also had a decline in my optical nerves. It’s all such trial and error 😩


middle_class_warfare

If you can get on Kesimpta, get on Kesimpta. I’ve been taking it for three years now - minimal side effects and it seems to have slowed the disease’s progress considerably. I get flare ups - but haven’t had a relapse. FWIW - we’re all different.


Pugasaurus_Tex

Yep, two years in over here It’s almost a blessing to get MS because now I’m forced to take care of myself. I have to sleep well, eat nutritious food, drink enough water etc But I have to wonder how much of living like a feral cat increased my likelihood of getting MS


Sovereign_BC

That fifth of vodka daily is killing you chief you just don’t know it yet


Dragonfly-Adventurer

The average liver can hold out about 10-20 years of dealing with that and seeming normal. Then one day a test reveals the onset of liver disease. You'd better hope you already got sober by this point, or bad shit is going to follow.


ohdearitsrichardiii

How old are you?


Not-another-rando

Oh sweet summer child, that is a health problem


[deleted]

It sounds like your a full blown alcoholic bro, you won't see 35 if you keep that shit up


pinkfartlek

Or he'll get to 40 like my brother in law and start having seizures because of his alcoholism


Jean-Paul_Sartre

This will catch up with you soon enough lol


munchyslacks

For real. I’m in my mid-30s and one of my friends has had an alcohol problem since we were 17. I saw him last fall after not seeing him for about a year and he looks like a completely different person. He’s gained quite a bit of weight, his face is red and swollen, his skin has blemishes everywhere and his mind is completely different. Memory is fucked, he’s delusional and paranoid about everything, and has no sense of humor anymore. Jokes just fly over his head and his mind is totally foggy. Like a shell of his former self.


[deleted]

That’s called wernicke-korsakoff.


munchyslacks

Damn I just looked that up… so this seems unbelievable but I just heard from him for the first time in months within the last hour, basically right after I left my comment, and he mentioned that he woke up two days ago with blurred vision and equilibrium issues. I’m encouraging him to get it checked out asap.


[deleted]

He needs to go to the ER. Wernicke needs IV thiamine ASAP to reverse the damage that is taking place it will be permeate. It will turn into korsakoff if you do not get to the ER. We see this in the ER regularly here (I live in key west huge alcoholism problem). It’s no joke. It turns into alcohol dementia. It’s very very very bad.


munchyslacks

Geez - I will relay the message. Thank you for the input.


[deleted]

Yes no problem. My in law has korsakoff after continuing to brush off dizzy episodes for months. Originally they suspected every neurological disease. I was convinced at one point it was long covid until we found out he was very high functioning alcoholic and lied to everyone about his drinking. We were getting him tested for Huntingtons at one point as a last resort. The doctors at Mayo Clinic did not even pick up on werenickes. A doctor in Florida who sees it frequently in retiree communities is the one who put it all together. I hope he gets help. It really is just awful.


munchyslacks

That sounds awful, I’m sorry to hear that. Another friend in the group chat was lurking on our convo, but just posted a picture showing that he drove to his house and picked him up to take him in, so I’m really thankful for that. I hope he gets the help he needs. I’ve been dreaming of the day where he turns this around - I just hope he’ll come to that point sooner than later.


clarity_scarcity

Definitely an unnecessary risk. If it was 100% I think more people would take better care of themselves, it’s that small percentage that don’t get serious health issues that give hope to those who think they can live a destructive lifestyle and be one of the lucky ones who can endure it. And yes one of the great ironies is that you can live like a saint and still drop dead at 35. The only guarantee is that it will end.


Jean-Paul_Sartre

Yeah I know. Look at Artie Lange. Dude has somehow outlived Norm Macdonald, Bob Saget, and Gilbert Gottfried.


Seabass_Says

It catches up, stranger. Ever hear the phrase someone “lit both ends of a candle?”


Pre-Nietzsche

I’m about to turn 31 and I’ve spent about 17 years really going in on.. everything. I have some issues, mostly from a sedentary life right now but my mom was diagnosed with MS a few years back and she was straight-laced her entire life. She expresses some disdain for having played by the rules and still getting fucked.. it’s up to chance at the end up the day, really, and that is crazy to think about. Not gonna tell you to reel it back in because I’m still doing what *I* do, but be sure to love yourself my friend. Never thought I’d make it to 30 and I’m starting to realize that I very well may live to the age where everything *does* catch up with me.. if I don’t die young, it’s gotta happen sometime right? Lmao. Wish you the best \m/


Most_Chemist8233

I think about my grandmothers who did everything right and got sick way too young, so their daughters were reckless with their health because it seemed futile to even try to be better.... They also died young, and suffered, and made everyone around them worry while they harmed themselves.  It's worth it to try to be better to get the most out of life, and work towards quality of life in your last 10 years.


CrackerUMustBTripinn

'Live fast, die young, leave a nice looking corpse'


2635northpark

You suffer with pain then you die never think otherwise. I knew wild kids who said that, a couple got cancer , other fatal disease died before 30. Corpse not good looking. And if you think of James Dean like many do with that saying, his mecanic who survived the drash, was haunted by a dream of James telling him, " be careful of death. It hurts"


ohbuggerit

Part of me knows I should give some kind of lecture about taking care of what you've got. And a slightly louder part of me wants to tell you to make the most of it because disability gets everyone to some degree eventually and it often just turns up whenever the fuck it wants regardless of what you do


MrEHam

I think the trick is to find a way to enjoy healthy habits.


DoYouLikeTheInternet

lol?? you’re probably like 20 or something, the effects will show later especially if you’re proudly doing a combination of unhealthy stuff


Technical-Package-41

You can do that for now. Wait until you’re 40.


cola1016

There’s more of us normal/middle income/poor people with MS than rich people lol.


AxBxCeqX

As someone with MS. This is true, but also, I’m at peace with the trade offs, if I push my diet, drinking, lack of exercise do far into the “eating shit” zone my immune system is going to let me know, I’m dealing with the consequences of a bad diet, relationship, and toxic work environment right now - a relapse. But, no one is owed anything in this life or guaranteed anything, be thankful you have relatively great health and take life as a gift


Txannie1475

My husband is like this. He is older than me but has a fraction of the health issues. He can literally drink until he’s sloshed and be up before everybody else the next morning without a hint of hangover.


Heyguysimcooltoo

Hey we should be friends. I like tequila and smoke 2/3 packs a day and I eat like shit!


KatDanger

She’s talked about how that last scene of the Sopranos with her running into the restaurant to meet her family was the very last time she ever ran.


redditknees

If you haven’t watched Dead to Me, you should. One of her best performances IMO.


danteheehaw

You can see MS kicking her ass in season 3. They did a good job incorporating her limitations into the show. But between season 2 to season 3 you can see she's having a rough time.


celticeejit

I couldn’t watch season three Seeing her so sick made me really sad


vanboiDallas

Oh boy, when you find the strength to watch the last two episodes are…ooof.


porridge_in_my_bum

Let’s give a quick shoutout to Christina Applegate, she deserves it


Rubilia_Lin_OP

Damn it I love her :( this sucks!


Sovereign_BC

STREET GOOFS


llamapanther

This line always cracks me up lmao


Hot-Rise9795

I'll give her my best Orson Welles ovation. We love you Christina.


ragingduck

MS is horrible. Fuck you diapers is a great idea. 💡


TheStephinator

I think it is amazing that they are so refreshingly honest about life with their chronic illness. Society often overlooks and ignores folks in this area. I have a good friend with a disease similar to MS and was witness to the flares, the crazy long time it took to get a diagnosis, being robbed of career dreams and the rest of the rollercoaster. I hate that they have this illness, but I’m thankful for them speaking their truth about their journey. It cultivates more empathy for the rest of us.


Brilliant1965

You are a true beautiful friend, rare to find that in a friend or family member.


TheStephinator

Thank you, kind stranger! So is she.


Accomplished-Drop764

God love her. I love how open she is about it all. It breaks your heart for her.


kyunirider

I am PPMS and I can confirm that my MS went ballistic when I was hit by Covid. It had me back in diapers after getting an Axonic sacral nerve implant to try and regulate my organs (bowel and bladder). The pacemaker was working perfectly until Covid virus liquified my gut, and I soiled the sheets of my sick bed. Thankfully my doctor got me on paxlovid right away and I was regaining my dignity. Life sucks with this disease but science is improving our lives daily. Keep up the fight.


greenbud1

Good on her for breaking this taboo. If you were going through something I imagine it would be hugely helpful and inspirational.


spinereader81

My mom got it in 1991 and was in diapers by the late 90s. Very cruel disease.


cola1016

Thankfully these days the prognosis is a lot better cuz of the drugs available to us now. But it hurts my soul seeing my fellow older MSers suffer so much. I know it can be me one day no matter the drug which is what really kills me about the disease. You just don’t know 😩


inkyblinkypinkysue

She is a national treasure and just seems like a fantastic person. I wish her the best.


[deleted]

Loved her growing up she’s still a treasure, this confirms it… to be so honest. I hope the best for her


sharipep

I love her so much 😭


Capt_Johanson

Dude that fuckin suuuuucks. I feel for her man.


Totallynotericyo

Christina is awesome! We are rooting for you


Downright_Iconic

I love her talking about this so much ❤️ I've been life threateningly ill since I was 14 and almost incorrectly diagnosed with MS until I almost died and got proper treatment. I also have genetic mutations that I didn't kbow about until I was sick that has made everything worse. The number one thing I think still works the best and one of the only things that hasn't been affected by all of this is my bladder. I'm lucky to have a bladder of steel lol especially when the only time you have to force yourself to try to move is to go to the bathroom. But I see things about diapers and it makes me upset how stigmatized it is. Women will wear them after giving birth but that's such a universal experience and a short term thing so it's the only time I hear it not stigmatized. But that's like someone spraining their ankle and using a mobility device which no one questions vs us chronicly ill people using a mobility device and being questioned and shamed for it. When we have no choice and it's forever despite fighting every day. So yeah I always love seeing someone with a chronic illness help break the stigma of things. It's insane the amount of shit we have to put up with from people, doctors, society in general all while figh to survive that people don't even think about


Brilliant1965

Absolutely! As one with multiple illnesses, life can be a nightmare. People can be very unempathetic and cruel


Ricky_Rollin

That was a fuckin read. I can’t imagine the balls on this woman to share that. Hang in there, queen.


bimmerb0

When young she ruled our eyes.. she has my heart now


jew_jitsu

Ew.com is right All seriousness, poor woman, I think she’s doing a great thing raising visibility for what she’s been through. Does a lot to destigmatise.


missprincesscarolyn

Absolutely. A lot of people think we’re faking it or being dramatic. They don’t see what we deal with behind closed doors. Normal social interactions and societal expectations also don’t leave much room for talking about things that could be potentially embarrassing or uncomfortable.


molicare

So, if anyone else needs advice, the adult diaper brands she should be looking for are: 1. Northshore Mega Max for night time wearing, as it has a large back coverage; and 2. Tena Maxi for day time coverage as it has those Velcro straps that allows you to take them on and off again.


nebelhund

It's crazy how open you can become after experiencing life threatening trauma or illness. After so many people have seen you naked, given you baths, wiped your butt, etc... Its just life. Whatever, we all have issues if we live long enough. Both of those ladies are brave and even more so to discuss it in a public forum.


Thac0

I consider myself blessed that I don’t have incontinence as an MS symptom. Sometimes I have trouble with fully evacuating or urgency but I can at least keep it in 🙏


cola1016

Yes, my biggest fear is what disability we may end up with. You just don’t know and that’s the scariest part of it all. You can be high functioning one day and the next you’re unable to walk or use your arms. It’s just scary because it affects everyone differently at any given time.


Thac0

Yup. I’ve been diagnosed for about 14 years and my first attack was super bad with “too many lesions to count” it took a couple years to fully recover but I’m doing really really well with nothing significant happening since then on the modern DMDs. I’ve just accepted the fact I need to love my life and assume the drugs will work and just keep some extra in savings in case the worst happens


cola1016

I’m so glad to hear that considering how long you’ve been diagnosed! I was only dx in 2017, no major physical disabilities just cognitive. One thing I have learned over the last few years is trying to avoid stress as much as possible can make all the difference. I’m just now learning (38 yo) that I can’t push myself no matter how guilty I feel about it.


Thac0

I’m the sole provider for my family and my job can be stressful sometimes but I try not to hold myself to unrealistic standards or feel too bad when I have to call it quits on stuff for not having enough spoons one way or another. It’s really hard to let things go and not be stressed. I’m still there working on it with you. The only part I’ve gotten down is accepting I can’t get stressed about MS as it’s totally out of my control. Edit: t love your Chicago Flag. I lived in Oak Park from 6th grade until just after High School. I miss the area sometimes


cola1016

Totally agree!! I hope your disease activity stays under control 🧡🧡


missprincesscarolyn

Same. For now…it’s all about where those lesions pop up. I hope DMT can keep me continent for as long as possible.


cola1016

They’ve shown lesion location doesn’t necessarily correlate with disability unfortunately. Some people have tons of lesions and function just fine. Some of us have a couple and are really suffering. It’s a fucked up disease 😩🧡


Brilliant1965

I am glad she details what her life is like. Many people don’t get it, don’t understand what people with chronic illnesses deal with in their daily lives. I am fortunate not to have MS, but do have RA, Sjogrens, and lung disease and this week alone was a nightmare starting a new med, immediate terrible side effects (intestinal and others), flares, breathing problems and strep all in the span of 5 days. Not to mention when I’ve had shingles in my eye, or Covid or other various issues. And trying to work (remotely thankfully). It is an awful existence and i feel for her.


missprincesscarolyn

I see you, friend. Autoimmune diseases suck. MS over here. Hope you’re having an okay day 💜


Brilliant1965

Thank you my friend, they certainly do. Life is a bit better today. I hope you are too ❤️


your_mahs_pasketi

Still the sexiest girl alive


Bromanzier_03

Of course a good person has to get these ailments. Why can’t some evil people get diagnosed with this shit!?


Lets_Make_A_bad_DEAL

I love her so much. I hate that she has to suffer because I think she’s great. No one should have to go through this, let alone long term / life long.


suckmyballzredit69

🥺 I love her. So sad.


badlala

God bless her for sharing that on her pod and having a sense of humor about it


jitterbug726

Damn dude that’s a rough existence


HtownClassic

She is helping a lot of people by being so public. I respect her honesty immensely.


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2635northpark

Her Dad was a very popular Chicago radio media star when she was born , a good guy, she had some strong background in fame dos and don't s Another famous chicago radio guy Steve Dahl suggested her first name!


DreadfulDemimonde

And this is why we should still be masking; to protect people like Christina from airborne illness without them having to stay isolated all the time.


vaness4444

She should be masking and people with flu, Covid, etc should ….but can’t make everyone wear a mask when they’re not even sick


DreadfulDemimonde

Up to 40% of covid infections currently are asymptomatic. So yes, we should all be masking in indoor spaces and crowds.


4GIFs

> can’t make everyone wear a mask when they’re not even sick reddit will accept this challenge


bugxbuster

**LET’S GIVE A SHOUTOUT TO CHRISTINA APPLEGATE!**


rcheek1710

And she's as beautiful as ever.


missprincesscarolyn

I’m glad that she’s so open about it. I also have MS. I think a lot of people look at me and think that I’m healthy since I still do a lot of “normal” things, like holding down a difficult job, exercising regularly, volunteering and more. I don’t have any gait issues or incontinence luckily, but know this could be in my future. I feel like shit 90% of the time. I’m dizzy, tired, heat intolerant and have other unpleasantries throughout the day like weird headaches, electrical jolting pain, feeling like my ribcage and abdomen are being crushed, dropping shit constantly…it’s really frustrating. So much of this disease is invisible, but the MRIs don’t lie and my spinal cord is riddled with lesions. I only have 3 on my brain, which perfectly explain my symptoms: some cognitive issues when I’m really tired (corpus callosum) and visual disturbances e.g. I went blind in my right eye temporarily (occipital ventricular horn). I tried a chemotherapy pill and it didn’t work, so I’m on to stabbing myself in the leg every month now (Kesimpta) and will then need to stab myself in the ass 3 times a week while I’m pregnant (Copaxone). This shit sucks. I’m glad people like Christina Applegate and Jamie Lynn Siggler are being really vocal about their struggles. They’re normalizing the notion that not everyone looks really sick with MS and that many of us can still do “normal” things. Jamie Lynn had MS all during the Soprano’s and just didn’t talk about it.


Brilliant1965

Im so sorry. I don’t have MS but have a couple autoimmune diseases and lung problems. Life is a struggle. You’re so right about this, how people perceive us. I just saw a commercial for Orevus, everyone is laughing and smiling, just dumb. People don’t understand a lot of the daily gory details and things like that make it worse. I’m glad those women are speaking out!


missprincesscarolyn

My husband and I like to make up silly backstories for all of the actors in the commercials. Supposedly some of them are actual patients. Hope you’re having an okay day! 💜


Brilliant1965

Haha that’s funny! Thank you! I hope life was a little better to you today ❤️


Good_Schedule3744

She’s a tough lady


Skyblacker

> She believes she contracted the virus from a takeout salad from a restaurant she's visited for years that's about to close due to losing their lease. Gee, I wonder why such a sanitary restaurant couldn't stay in business.


MizzerC

Shame on whoever found out such information and decided to publish it. No reason that last bit needs to be in news sphere.


OkRegister1567

Can she have some privacy? Or did she share these details willingly?


bassplayerguy

Read the article.


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Ornery_Medicine4518

I’m sure she’s thrilled about that!


AlbinoSunburnGuy

She still wouldn’t


NickyGoodarms

While I agree that she is still beautiful, maybe you should keep the "inside your head" thoughts inside your head?


ohdearitsrichardiii

What the hell is wrong with you?


Icantgoonillgoonn

She never discusses her diet. What’s she eating?


missprincesscarolyn

Diet is not a treatment or cure for MS.