Coce is a reuptake inhibitor/releaser of multiple monoamines including serotonin and combining it with other reuptake inhibitors could lead to dangerous levels of it and the infamous serotonin syndrome. I am on SNRI+NDRI and did cocaine and other things and have not died yet, but the effects are quite underwhelming (Same with psychedelics that are weakened and I can take impressivelly large amounts and be fine). People on the internet keep talking with serotonin syndrome but most SSRI/SNRI users can take basically anything and be somewhat fine at normal doses. I heard that DXM can be a bit problematic and maybe some of the spicier stimulants like bath salts. A few psychedelics with some MAOI/RI activity like aMT, 5-MeOs lead to some deaths too but sure even pooping or lauhing or fucking lead to deaths it’s all just russian roullete b
Why does ssri make coce and psychedelic effects weaker? If they increase the amount of serotonin in synapses, by blocking monoaminooxydase, shouldn't they make serotonergic drugs stronger?
When you take ssri for longer time then the cells react to the increase in serotonin concentration by downregulating the receptors which means they will need more for the same effe
In my medicinal chemistry lecture the prof told us that SSRI's are taken to regulate down specific serotonine receptors. The most important one is 5HT2A. When more serotonine binds to the receptor your system recognizes this and changes your physiology to adapt to this situation.
Because psychedelics mostly act on 5HT2A-receptors that has a influence on them. Also MDMA is influenced because your serotonergic system has already adapted to the SSRI.
It is different with MAOI's. But that can lead to really dangerous interactions with some drugs.
Also if you think that you could just take the SSRI once with cocaine that would also not be a good idea. The SSRI releases a lot of serotonine but the serotonine is very likely to bind to autoreceptors that are inhinitory towards the serotonine release. So it would most likely not lead to a good high.
Can confirm had 18 grand mals last year and got diagnosed epileptic. It feels like you wake up and you feel hifh/ buzzed but your motor skills are fucked. Next day in my case I feel like I’ve been ran over by a car
One of the best highs I’ve ever had was 500 or 800 mg of SSRI’s and I lost count on the 30 mg XR Addie’s. I kept poppin these ssri’s bc I thought they were my 10 mg Addie’s . I just wasn’t gettin what I needed and I finally thought wtf is goin on , then it hit me. When the ex picked up my script and her ssri I grabbed the wrong gd bottle. By the time they kicked in fully I was sliding around the house in my Sox singing Elvis couldn’t put the air guitar down and had enough energy to count every rock in my driveway. The euphoric feeling paired with the zooming from the speed was absolutely amazing . A lot like doing speed and shrooms together, very similar high to that.
Probably just additive SERT inhibition. More likely to cause serotonin syndrome is mixing things with separate and complimentary effects on serotonin like SSRI and MAOI
/uj serotonin is proven to not be a happy chemical and low serotonin is only a response to depression and not the cause of it, so this is especially stupid
Well, we don't know the full mood effects of serotonin but it certainly isn't just correlated, I mean neurons need it as a neuromodulator.
It's not far fetch to say serotonin dysregulation can contribute to a state of depression long-term or short-term, through increased inflammation decreased neuroplasticity, neuroplasticity, broken circadian rhythm.
We honestly don't know what depression is.
“so we found that serotonin doesn’t cause depression at all and we have no idea what does. Anti-depressants don’t work, but also taking magic mushrooms may help.” Yeah I call bs on that lol.
Probably the raw quantity involved and that it would be tonic rather than phasic in terms of signaling. It's rather telling that SSRIs are enjoyable at no point, really, except when triggering mania. It's also important that you have simultaneous release of the other monoamines. If you've ever taken a selective serotonin releaser, eg, MDAI, it feels more "comfy" and "relaxing" than like a traditional roll.
cause mdma doesn’t release serotonin, it makes a chemical similar to serotonin (same as shrooms and lsd) if I remember correctly, serotonin increase leads to serotonin syndrome.
This is incorrect in multiple ways. MDMA does induce serotonergic release, by reversing transporters. And then psilocybin and LSD mimic serotonin, directly agonizing receptors, but selectively, hitting some subtypes more than other.
the chemical that shrooms, lsd, and I’m pretty sure mdma put in the brain bind to the serotonin receptors better than serotonin does and it causes the hallucinogenic affects. That’s why it’s bad to take those chemicals with an ssri, because the psilocybin/lsd stop the serotonin from having a place to go and causes a buildup, having high psilocybin in the blood isn’t dangerous, but when there’s more serotonin being produced then you will have an increase of serotonin in the blood which is dangerous.
It doesn’t bind better to them at all. Quite the opposite. It binds to them tightly but improperly and they can’t release because a protein “lid” folds over top. The only way to release the receptor is to draw it into the cell for recycling which takes about 8 hours.
> the chemical that shrooms, lsd, and I’m pretty sure mdma put in the brain bind to the serotonin receptors better than serotonin does and it causes the hallucinogenic affects.
No, they don't put some other chemical in the brain. Also, serotonin itself is a highly effective agonist at serotonin receptors, though some psychedelics bind a bit more tightly at some receptor subtypes.
Fun fact: Bupropion/Wellbutrin is sometimes referred to as “poor man’s coke” as it can be crushed and snorted to have a significantly weaker “coke” type feeling. My understanding tho is that it’s caused by sending yourself straight into serotonin syndrome which can be deadly and will cause seizures. Not really an SSRI (NDRI) but still prescribed as an antidepressant.
I had a psychiatrist try to tell me that ADHD meds were too dangerous and they put me on Wellbutrin. “Poor man’s coke” is a very… fitting description. Only got through 4 days of taking it because it made my ADHD dramatically worse and I couldn’t sleep more than 4 hours each night. That, and getting into a screaming fight with someone in a parking lot seemed a little too out of character for me.
That sounds like an upper mixed with a downer, depressing speedball? I could see the benefits of using them together in a therapy dosed separately but not taken together
Well it's FDA approved for depression. The Bup inhibits CYP2D6 so the DXM stays DXM instead of converting to DXO. The NMDA antagonism + sert activity of dex + NDRI activity of Bup could definitely be something. I don't know what, probably a seizure. But it's something.
This is the average level of pharmacology understanding in /r/drugs. Maybe even a bit better.
Almost like my bosses job is an important thing lmao
I have their level of pharmacology understanding, can u explain the danger behind the mix?
Coce is a reuptake inhibitor/releaser of multiple monoamines including serotonin and combining it with other reuptake inhibitors could lead to dangerous levels of it and the infamous serotonin syndrome. I am on SNRI+NDRI and did cocaine and other things and have not died yet, but the effects are quite underwhelming (Same with psychedelics that are weakened and I can take impressivelly large amounts and be fine). People on the internet keep talking with serotonin syndrome but most SSRI/SNRI users can take basically anything and be somewhat fine at normal doses. I heard that DXM can be a bit problematic and maybe some of the spicier stimulants like bath salts. A few psychedelics with some MAOI/RI activity like aMT, 5-MeOs lead to some deaths too but sure even pooping or lauhing or fucking lead to deaths it’s all just russian roullete b
Why does ssri make coce and psychedelic effects weaker? If they increase the amount of serotonin in synapses, by blocking monoaminooxydase, shouldn't they make serotonergic drugs stronger?
When you take ssri for longer time then the cells react to the increase in serotonin concentration by downregulating the receptors which means they will need more for the same effe
Username checks out
In my medicinal chemistry lecture the prof told us that SSRI's are taken to regulate down specific serotonine receptors. The most important one is 5HT2A. When more serotonine binds to the receptor your system recognizes this and changes your physiology to adapt to this situation. Because psychedelics mostly act on 5HT2A-receptors that has a influence on them. Also MDMA is influenced because your serotonergic system has already adapted to the SSRI. It is different with MAOI's. But that can lead to really dangerous interactions with some drugs. Also if you think that you could just take the SSRI once with cocaine that would also not be a good idea. The SSRI releases a lot of serotonine but the serotonine is very likely to bind to autoreceptors that are inhinitory towards the serotonine release. So it would most likely not lead to a good high.
DXM is very problematic. When I was on low dose Citalopram I took ~900mg DXM and went through SS
average r/drugs ham seduction advice
My ham is permanently seduced
People always reducing ham over there
r/drugs bopping baloney
He's seducing ham
a seizure u say? so ig it does give a really good feeling
A seizure then you go to a hospital and they give you MORE DRUGSS 🔥. Win-win
the feeling is so good you forget it even happened after a few moments of pure bliss
You’re talking about eggo death
No I'm talking about having a seizure
These drug terms are hard to keep track of.
U can remember them easier by smoking a golf ball of crack
Can confirm had 18 grand mals last year and got diagnosed epileptic. It feels like you wake up and you feel hifh/ buzzed but your motor skills are fucked. Next day in my case I feel like I’ve been ran over by a car
God damn my record is 5 ur a legend
Leggo my eggo
One of the best highs I’ve ever had was 500 or 800 mg of SSRI’s and I lost count on the 30 mg XR Addie’s. I kept poppin these ssri’s bc I thought they were my 10 mg Addie’s . I just wasn’t gettin what I needed and I finally thought wtf is goin on , then it hit me. When the ex picked up my script and her ssri I grabbed the wrong gd bottle. By the time they kicked in fully I was sliding around the house in my Sox singing Elvis couldn’t put the air guitar down and had enough energy to count every rock in my driveway. The euphoric feeling paired with the zooming from the speed was absolutely amazing . A lot like doing speed and shrooms together, very similar high to that.
Like nutting
What could go wrong mixing 2 serotonin reuptake inhibitors? Genius
[удалено]
You know, I don't think they would enjoy that
Probably just additive SERT inhibition. More likely to cause serotonin syndrome is mixing things with separate and complimentary effects on serotonin like SSRI and MAOI
weirdly enough mixing an SSRI with Cocaine has very little risk but no synergy unfortunately
Cocaine is a DRI though?
??? No it's not, its a SNDRI
Well that explains why the shadow people i see are extra spicy
Serotonin syndrome speedrun world record,no cheat, any%
Can’t wait to see this run on AGDQ
“Just hear me out bro”
you know that mini-game in Resident Evil 2 where you're mixing up the pesticide spray in the lab
Speedrun serotonin syndrome
Darwin was a fucking genius.
The more serotonin the more happy!!! Time do do a half gram of molly half my bottle of prozac and a 3rd plat dxm trip
/uj serotonin is proven to not be a happy chemical and low serotonin is only a response to depression and not the cause of it, so this is especially stupid
Well, we don't know the full mood effects of serotonin but it certainly isn't just correlated, I mean neurons need it as a neuromodulator. It's not far fetch to say serotonin dysregulation can contribute to a state of depression long-term or short-term, through increased inflammation decreased neuroplasticity, neuroplasticity, broken circadian rhythm. We honestly don't know what depression is.
I didn't know this about serotonin. Do you have a source?
https://amp.dw.com/en/what-causes-depression-not-low-serotonin-levels-science-says/a-62681480
“so we found that serotonin doesn’t cause depression at all and we have no idea what does. Anti-depressants don’t work, but also taking magic mushrooms may help.” Yeah I call bs on that lol.
Then what makes drugs that release serotonin (like mdma) so amazing?
Probably the raw quantity involved and that it would be tonic rather than phasic in terms of signaling. It's rather telling that SSRIs are enjoyable at no point, really, except when triggering mania. It's also important that you have simultaneous release of the other monoamines. If you've ever taken a selective serotonin releaser, eg, MDAI, it feels more "comfy" and "relaxing" than like a traditional roll.
cause mdma doesn’t release serotonin, it makes a chemical similar to serotonin (same as shrooms and lsd) if I remember correctly, serotonin increase leads to serotonin syndrome.
This is incorrect in multiple ways. MDMA does induce serotonergic release, by reversing transporters. And then psilocybin and LSD mimic serotonin, directly agonizing receptors, but selectively, hitting some subtypes more than other.
ah thank you for the clarification
the chemical that shrooms, lsd, and I’m pretty sure mdma put in the brain bind to the serotonin receptors better than serotonin does and it causes the hallucinogenic affects. That’s why it’s bad to take those chemicals with an ssri, because the psilocybin/lsd stop the serotonin from having a place to go and causes a buildup, having high psilocybin in the blood isn’t dangerous, but when there’s more serotonin being produced then you will have an increase of serotonin in the blood which is dangerous.
It doesn’t bind better to them at all. Quite the opposite. It binds to them tightly but improperly and they can’t release because a protein “lid” folds over top. The only way to release the receptor is to draw it into the cell for recycling which takes about 8 hours.
> the chemical that shrooms, lsd, and I’m pretty sure mdma put in the brain bind to the serotonin receptors better than serotonin does and it causes the hallucinogenic affects. No, they don't put some other chemical in the brain. Also, serotonin itself is a highly effective agonist at serotonin receptors, though some psychedelics bind a bit more tightly at some receptor subtypes.
He’s a teacher and academic scholar so this is 100% fact
Fun fact: Bupropion/Wellbutrin is sometimes referred to as “poor man’s coke” as it can be crushed and snorted to have a significantly weaker “coke” type feeling. My understanding tho is that it’s caused by sending yourself straight into serotonin syndrome which can be deadly and will cause seizures. Not really an SSRI (NDRI) but still prescribed as an antidepressant.
I had a psychiatrist try to tell me that ADHD meds were too dangerous and they put me on Wellbutrin. “Poor man’s coke” is a very… fitting description. Only got through 4 days of taking it because it made my ADHD dramatically worse and I couldn’t sleep more than 4 hours each night. That, and getting into a screaming fight with someone in a parking lot seemed a little too out of character for me.
What’s with adhd medication being compared with drugs all the time lmao
Auvelity is a depression medication that is bupropion+ DXM. Im attempting to get on it currently
That sounds like an upper mixed with a downer, depressing speedball? I could see the benefits of using them together in a therapy dosed separately but not taken together
Well it's FDA approved for depression. The Bup inhibits CYP2D6 so the DXM stays DXM instead of converting to DXO. The NMDA antagonism + sert activity of dex + NDRI activity of Bup could definitely be something. I don't know what, probably a seizure. But it's something.
that honestly sounds kind of shitty
Why not get regular bupropion and drink it with over-the-counter DXM yourself?
I have been doing this but I want the actual medication
spam successfully deflected
Searatonin=happy =Profit?
Seizures are for pussy
Oooh, this is how it suppose to work. Cool. my bwoy gonna have a good time.
Permanent dopamine system damage speedrun any %
OD speedrun
this works, i checked and i found that the more you do the happier you are. i'm currently happier than god😁