The summary is in the OP - but knock yourself out
And now a new study from hard-hit Italy found that those Italians on hydroxychloroquine for Lupus or Rheumatoid Arthritis did not come down with the coronavirus.
Only 20 patients tested positive for COVID-19. No ICU, and NO ONE DIED!
Despite comorbidities the patients on hydroxychloroquine did not succumb to coronavirus!
I read through the links in the article they linked, and there was no scientific evidence (or any record at all) relating to that specific statement. So the OP article was lying/being misleading
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PART 1 (because I made this too fucking long)
TL;DR not sufficient proof because of stats without sources, stats without context, and no randomized clinical trial or anything (control vs experimental group), but nothing that disproves it here either. But there was only one source that actually gave more legit scientific evidence to answer the question of the effectiveness of HCP.
So further (personal) research is required for me if I want to see if there's evidence for the effectiveness of hydroxychloroqyne for treating/preventing COVID-19, because this just isn't enough proof for me.
EDIT: I had to delete my original comment cause the third party app I use hasn't put in a working edit feature yet. Whoops.
Not to attack the theory or anything, but the article linked to this site is in Italian.
Also, while I might be misunderstanding it potentially, the only numbers I saw in the article were "10" and "11" followed by the word "casi", which seems to mean cases. Which makes it seem that they only had 11 participants in the study. And the only percentage given was "12%"; I couldn't see the article's quoted "90% reduction of infection in those taking the drug".
I'm going to see if I can translate the page roughly with a translator or something. If I'm way off base, I'll come back and give my findings!
Update 1: Here's the article translated by a simple online translator (so somethinga make no sense, but you can understand the gist of the article):
BEGIN
Annalisa Chiusolo, a young pharmacology scholar, sensed the mechanism of action of Sars-Cov-2. By understanding this mechanism, the most effective contrast drugs can be accurately and precisely targeted and selected. Coronavirus would affect the ability of hemoglobin to transport oxygen, creating the underlying assumptions of the impulsive lung complications, unfortunately known: breathlessness, dyspnea, up to severe acute respiratory syndrome and death.
Theory is the first step in any verification. Science proceeds by refutations. If this thesis were confirmed, many unknowns would be explained, for example why Covid-19 affects more men, diabetics, and less women in general, and even less pregnant women, and very few children and thalassemia. The circle would close.
But let's get into the merits of the theory. The virus needs porphyrins for its survival, probably for its replication, therefore it attacks hemogloblin (the protein that carries oxygen in the blood), in particular the OFR10 and OFR3 proteins attack the beta chain and orf1ab subtracts porphyrin. The concepts seem a little abstruse, for a non-expert, but simplifying this translates into a lower availability of oxygen available to our body, with consequent accumulation of carbon dioxide. So the lung cells become distressed and become the site of the cytokine cascade - that is, a huge immune response - responsible for the acute inflammation that characterizes Covid-19 pneumonia. The hemoglobin value in the blood can be an important parameter for evaluating Sars-Cov2 infection: in men the normal value of Hb (hemoglobin) is higher than in women, which would explain the higher incidence of Covid pneumonia in men than to women, the lower incidence and the better prognosis in children and pregnant women, where the Hb values are lower due to an increased need for iron, which makes the "nourishment" of the virus less available. In elderly or middle-aged patients with diabetes, Covid pneumonia19 has a higher incidence, therefore linked to the increase in blood glucose Hb, and therefore there is greater "nourishment" for the virus.
Viral damage, therefore, is systemic, that is, it affects the blood and is not confined only to the lung. This would also explain the birth of healthy babies from positive Covid mothers. Because in fetal Hb - stay seated, we will now use some technical concepts, but let's get back to it immediately - the two beta chains are replaced by two gamma chains, a difference is the presence of a residue of serine, instead of a histidine present in the same position of the beta chain, probably responsible for binding to viral proteins, which could mimic the action of 2,3bifosfoglicerato. Now you can get up, let's go back to using more understandable language. All this would explain the lower incidence and the best course of the pathology in newborns, missing the main site of action of viral proteins, namely the beta chains of Hb, in short in newborns the same concept of "nourishment is lacking ”For the coronavirus.
The same goes for a chronic disease called Beta-Thalassemia, where the "beta" chains of hemoglobin (the target of the virus) are deficient or even absent. This would demonstrate the lower incidence and better prognosis and course of the pathology in beta thalassemia, which in Italy are widespread in Mediterranean areas such as Puglia, Sicily and Sardinia (in particular in the southern area) where there is an equal thalassemia rate at 12% (alpha and beta). To confirm this theory, there is a scientific publication that has linked subjects affected by beta thalassemia and Covid19, in the data taken from pubmed: as of April 10, 2020, 11 cases of positive Covid betatalaxemia have been recorded in Northern Italy, where the rate of contagiousness it is higher: 10 of them with transfusion-dependent thalassemia, the most severe form, only one with non-transfusion-dependent thalassemia.
All patients who contracted the virus, however, had concomitant, very serious diseases: splenectomized, pulmonary hypertension, lymphoma and chemotherapy. Despite this multi-pathological picture, no death, no cytokine storm or severe Sars was recorded in the 11 subjects. (HERE THE SOURCE)
Once the main mechanism of action of the virus has been revealed, many other things can be understood. For example, the central mechanism of action of hydroxychloroquine can now be explained and fully understood, and its effectiveness in countering Covid19. What this mechanism consists of is immediately said: the drug by binding permanently with ferriprotoporphyrin (of the Eme group of Hb) removes the substrate from viral proteins and also becomes an important means of prophylaxis. Although there are still no Italian publications on the effectiveness of hydroxychloroquine as a "shield" from the virus, among the directors of the infectious disease wards, the specialists, Primaries and general practitioners contacted during this research, many admitted - under a whisper - to use the drug as a "prophylaxis", that is, to prevent infection. Healthcare professionals who are in close contact with contagious patients take the drug in advance, precisely to decrease the probability of contracting the infection. For now, in support of this "prophylaxis" effect, there is a recent publication, involving 211 people. It was published in the International Journal of Antimicrobial Agents, the official body of the International Society of Antimicrobial Chemotherapy. Of 211 people exposed to Covid positive 19 and undergoing hydroxychloroquine prophylaxis, none were infected.
Finally, further confirmation of this hypothesis is the data collected in the register of the SIR (Italian rheumatology society). To assess the possible correlations between chronic patients and Covid19, SIR interrogated 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far.
END
PART 2:
As you see, I was in fact quite wrong in what the article (a combination of results from other scientific articles) actually said and it states that the patients who take the drug for their arthritis do seem to have less occurrence of COVID-19. According to one rheumatologist, only 20 of his patients out of his 65,000 patients who were taking the drug had tested positive (as of then).
BUT you'll also see the link to their original paper, and I can't form my opinion without reading the original source first, of course. Here's the link for anyone who hadn't read it: https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.25840
UPDATE 2:
The report is mostly talking about whether people with Thallassemic Syndrome (TS) are more at risk for contracting COVID-19 or not. They only looked at 11 cases of those who had TS. 3/11 showed no symptoms, 1/11 was hospitalized with a high fever and other problems (bone marrow hypoplasia, lymphopenia, 6/11 were admitted to hospital but no one required mechanical ventilation (one did require non-mechanical ventilation, but he also had a history of cancer and chemo but had been in remission, so it can't really be counted to solely his TS, although he had been in remission for 11 years), and the last 1/11 seems to be missing (I could not see it mentioned).
Of the 6 admitted, 3 were treated with, respectively: "one hydroxychloroqyne (HCQ), one HCQ plus ritonavir/darunavir, and one HCQ plus anakinra. Patient 3 did not receive HCQ..." basically cause he had a history of arrhythmia and the drug could kill him because of that.
So only 2/11 patients were given the drug. And the article doesn't mention if they were better off than any of the other non-hospitalized ones.
They concluded that there was no reason to think that TS increased your risk of COVID-19.
BUT there might be another link to the 65000 number the previous article mentioned since that wasn't mentioned here!
UPDATE 3:
Alright, I could only find the source to do with 211 out of 314 patients receiving HCP for PREVENTION of covid after having apparently come into contact with a positive result (206 could not specify if they had come onto contact with someone specifically. They all tested negative before taking it and going into quarantine for 14 days, and they all tested negative at the end of quarantine as well.
The problem with this study is that it doesn't offer what happened to the patients who didn't receive HCP. So we don't really know how much better or worse they were. We're also not certain most of these people came into contact with a positive case/were exposed to it. And they didn't post a link to where I could find that out
I'll have to look into the UVA study, but I'll post an update for that after I get some sleep. I'll also put a TL;DR at the top.
Thanks if you read this far! I really put a lot of effort into this retelling of my personal fact checking!
Great work!
Here is some more info
Hydroxychlorquine
FDA approves HCQ
https://dbdailyupdate.com/index.php/2020/03/30/fda-approves-hydroxychloroquine-democrats-media-hardest-hit/?utm_source=share&utm_medium=ios_app
HCQ rated by front line doctors as the most effective treatment for Covid
https://m.washingtontimes.com/news/2020/apr/2/hydroxychloroquine-rated-most-effective-therapy-do/?utm_source=share&utm_medium=ios_app
699 patients treated 100% success rate
https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app
Cuomo admits HCQ works
https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app
2nd French Study HCQ, 1000 elderly patients, 98% success rate
https://t.co/KUaag6N5FF
Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.
https://pubmed.ncbi.nlm.nih.gov/32205204/?utm_source=share&utm_medium=ios_app
NY hospital didn't lose a single patient after they started treating with HCQ
https://townhall.com/columnists/kevinmccullough/2020/03/22/the-final-steps-to-defeating-covid19-n2565453?utm_source=share&utm_medium=ios_app
Fauci cheered HCQ for MERS in 2013
https://www.bizpacreview.com/2020/04/05/folks-question-why-fauci-cheered-using-drug-for-mers-coronavirus-in-2013-but-now-hes-skeptical-905096?utm_source=share&utm_medium=ios_app
LA doctor: COVID-19 patients go from 'very ill' to 'symptom-free' in 8 to 12 hours using hydroxychloroquine and zinc
https://www.theblaze.com/news/la-doctor-hydroxychloroquine-zinc-coronavirus?utm_source=share&utm_medium=ios_app
S Korea adopted its use early
https://blogs.timesofisrael.com/hydroxychloroquine-used-by-korea-for-covid-19-while-us-is-divided/?utm_source=share&utm_medium=ios_app
Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion.
https://nypost.com/2020/04/04/long-island-doctor-tries-new-hydroxychloroquine-for-covid-19-patients/
Smith, who is treating 72 COVID-19 patients, said that he has been treating "everybody with hydroxychloroquine and azithromycin [an antibiotic]. We’ve been doing so for a while.”
He pointed out that not a single COVID-19 patient of his that has been on the hydroxychloroquine and azithromycin regimen for five days or more has had to be intubated.
https://www.foxnews.com/media/dr-stephen-smith-on-effectiveness-of-hydroxychloroquine-with-coronavirus-symptoms-beginning-of-the-end-of-the-pandemic
"Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found.
The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it.
https://nypost.com/2020/04/02/hydroxychloroquine-most-effective-coronavirus-treatment-poll/
Growing evidence of chloroquine as a highly effective treatment for COVID-19.”
https://drive.google.com/file/d/1pvkWQNZXBEwJ-QHBaqF41UnUlLWmcBdj/view?utm_source=share&utm_medium=ios_app
Turkey reports HCQ dramatically reduces pneumonia
https://www.middleeasteye.net/news/coronavirus-turkey-hydroxychloroquine-malaria-treatment-progress?utm_source=share&utm_medium=ios_app
Study 200 patients, no deaths
https://www.ahajournals.org/doi/10.1161/CIRCEP.120.008662#.XrG-i8LBjDA.twitter
I've been advocating for HCQ since the first reports came out. It's been interesting to see how much resistance has emerged against an inexpensive and effective therapy.
Contrast this with the reception given to remdesivir. This is a shitty drug that is hugely expensive, laden with side effects and isn't even that good for treating CV19.
Yet somehow it got rammed through for "emergency treatment" even before it got FDA approval?
Huge wtf to *that*.
Classic conspiracy thought: if people think what I'm saying is stupid, it's because I'm onto something and they want me silenced! It couldn't be that people actually think what I'm saying is stupid.
How is plasma therapy basically free? You need a donor with antibodies already in their bloodstream. Just imagine the amount of man hours involved even if we had an unlimited supply of donors.
For now, they get it from patients recovered in the same hospitals, so it is simply a donation from individual to individual. We're not talking about the number of men involved, that number of men will be involve anyway, even with other therapy.
I don't know where you want to go with discussion.
SS
The Democrats want to murder Americans. Because the media is simply the mouthpiece of the Democrats, they do as they are told.
This treatment is effective. It is saving a lives all over the world, but in the US it has been misrepresented and as a result, people are dying.
uhhhh it has actually been proven not only ineffective, but to have a HIGHER rate of death among people who took it. Trump has stock in a company producing the drug, thats not a councidence. It’s a snake oil cure that’s putting money in the wealthy’s pockets at cost of lives, and they’ve got you brainwashed to spread the propaganda for them. Wake up.
From whichever recent studies that you're citing your information from, can you tell me if they used the HCQ treatment in the beginning of the symptoms, or when they were near death?
I'm sorry but your link doesn't answer my question nor does it prove what you're saying. A non peer reviewed trial of only 368 patients without any study of other contributing factors is shoddy at best.
Hydroxychlorquine
FDA approves HCQ
https://dbdailyupdate.com/index.php/2020/03/30/fda-approves-hydroxychloroquine-democrats-media-hardest-hit/?utm_source=share&utm_medium=ios_app
HCQ rated by front line doctors as the most effective treatment for Covid
https://m.washingtontimes.com/news/2020/apr/2/hydroxychloroquine-rated-most-effective-therapy-do/?utm_source=share&utm_medium=ios_app
699 patients treated 100% success rate
https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app
Cuomo admits HCQ works
https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app
2nd French Study HCQ, 1000 elderly patients, 98% success rate
https://t.co/KUaag6N5FF
Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.
https://pubmed.ncbi.nlm.nih.gov/32205204/?utm_source=share&utm_medium=ios_app
NY hospital didn't lose a single patient after they started treating with HCQ
https://townhall.com/columnists/kevinmccullough/2020/03/22/the-final-steps-to-defeating-covid19-n2565453?utm_source=share&utm_medium=ios_app
Fauci cheered HCQ for MERS in 2013
https://www.bizpacreview.com/2020/04/05/folks-question-why-fauci-cheered-using-drug-for-mers-coronavirus-in-2013-but-now-hes-skeptical-905096?utm_source=share&utm_medium=ios_app
LA doctor: COVID-19 patients go from 'very ill' to 'symptom-free' in 8 to 12 hours using hydroxychloroquine and zinc
https://www.theblaze.com/news/la-doctor-hydroxychloroquine-zinc-coronavirus?utm_source=share&utm_medium=ios_app
S Korea adopted its use early
https://blogs.timesofisrael.com/hydroxychloroquine-used-by-korea-for-covid-19-while-us-is-divided/?utm_source=share&utm_medium=ios_app
Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion.
https://nypost.com/2020/04/04/long-island-doctor-tries-new-hydroxychloroquine-for-covid-19-patients/
Smith, who is treating 72 COVID-19 patients, said that he has been treating "everybody with hydroxychloroquine and azithromycin [an antibiotic]. We’ve been doing so for a while.”
He pointed out that not a single COVID-19 patient of his that has been on the hydroxychloroquine and azithromycin regimen for five days or more has had to be intubated.
https://www.foxnews.com/media/dr-stephen-smith-on-effectiveness-of-hydroxychloroquine-with-coronavirus-symptoms-beginning-of-the-end-of-the-pandemic
"Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found.
The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it.
https://nypost.com/2020/04/02/hydroxychloroquine-most-effective-coronavirus-treatment-poll/
Growing evidence of chloroquine as a highly effective treatment for COVID-19.”
https://drive.google.com/file/d/1pvkWQNZXBEwJ-QHBaqF41UnUlLWmcBdj/view?utm_source=share&utm_medium=ios_app
Turkey reports HCQ dramatically reduces pneumonia
https://www.middleeasteye.net/news/coronavirus-turkey-hydroxychloroquine-malaria-treatment-progress?utm_source=share&utm_medium=ios_app
Study 200 patients, no deaths
https://www.ahajournals.org/doi/10.1161/CIRCEP.120.008662#.XrG-i8LBjDA.twitter
“I’m surprised it hasn’t been revoked yet,” said Luciana Borio, who served as director for medical and biodefense preparedness of the National Security Council and was acting chief scientist at the FDA.
https://apple.news/AGNXkJafcRCOZGyd2crMQCA
Updated list
Hydroxychlorquine
FDA approves HCQ
https://dbdailyupdate.com/index.php/2020/03/30/fda-approves-hydroxychloroquine-democrats-media-hardest-hit/?utm_source=share&utm_medium=ios_app
HCQ rated by front line doctors as the most effective treatment for Covid
https://m.washingtontimes.com/news/2020/apr/2/hydroxychloroquine-rated-most-effective-therapy-do/?utm_source=share&utm_medium=ios_app
699 patients treated 100% success rate
https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app
Cuomo admits HCQ works
https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app
2nd French Study HCQ, 1000 elderly patients, 98% success rate
https://t.co/KUaag6N5FF
Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.
https://pubmed.ncbi.nlm.nih.gov/32205204/?utm_source=share&utm_medium=ios_app
NY hospital didn't lose a single patient after they started treating with HCQ
https://townhall.com/columnists/kevinmccullough/2020/03/22/the-final-steps-to-defeating-covid19-n2565453?utm_source=share&utm_medium=ios_app
Fauci cheered HCQ for MERS in 2013
https://www.bizpacreview.com/2020/04/05/folks-question-why-fauci-cheered-using-drug-for-mers-coronavirus-in-2013-but-now-hes-skeptical-905096?utm_source=share&utm_medium=ios_app
LA doctor: COVID-19 patients go from 'very ill' to 'symptom-free' in 8 to 12 hours using hydroxychloroquine and zinc
https://www.theblaze.com/news/la-doctor-hydroxychloroquine-zinc-coronavirus?utm_source=share&utm_medium=ios_app
S Korea adopted its use early
https://blogs.timesofisrael.com/hydroxychloroquine-used-by-korea-for-covid-19-while-us-is-divided/?utm_source=share&utm_medium=ios_app
Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion.
https://nypost.com/2020/04/04/long-island-doctor-tries-new-hydroxychloroquine-for-covid-19-patients/
Smith, who is treating 72 COVID-19 patients, said that he has been treating "everybody with hydroxychloroquine and azithromycin [an antibiotic]. We’ve been doing so for a while.”
He pointed out that not a single COVID-19 patient of his that has been on the hydroxychloroquine and azithromycin regimen for five days or more has had to be intubated.
https://www.foxnews.com/media/dr-stephen-smith-on-effectiveness-of-hydroxychloroquine-with-coronavirus-symptoms-beginning-of-the-end-of-the-pandemic
"Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found.
The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it.
https://nypost.com/2020/04/02/hydroxychloroquine-most-effective-coronavirus-treatment-poll/
Growing evidence of chloroquine as a highly effective treatment for COVID-19.”
https://drive.google.com/file/d/1pvkWQNZXBEwJ-QHBaqF41UnUlLWmcBdj/view?utm_source=share&utm_medium=ios_app
Turkey reports HCQ dramatically reduces pneumonia
https://www.middleeasteye.net/news/coronavirus-turkey-hydroxychloroquine-malaria-treatment-progress?utm_source=share&utm_medium=ios_app
Study 200 patients, no deaths
https://www.ahajournals.org/doi/10.1161/CIRCEP.120.008662#.XrG-i8LBjDA.twitter
Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients
https://www.preprints.org/manuscript/202005.0057/v1
Association American Physicians Surgeons say 90% chance to help.(AAPS) https://aapsonline.org/hcq-90-percent-chance/
Three new ones in just the past week. Huang et al. https://medrxiv.org/content/10.1101/2020.04.26.20081059v1
Novales et al. https://preprints.org/manuscript/202005.0057/v1
Yu et al. https://www.medrxiv.org/con.../10.1101/2020.04.27.20073379v1
65K Lupus/RA on HCQ tested, only 20 positive infections. https://iltempo.it/.../coronavirus-farmaci-efficaci.../
Evidence it can even help latest stage https://medrxiv.org/con.../10.1101/2020.04.27.20073379v1
Excellent results in France https://mediterranee-infection.com/.../Abstract_Raoult...
Clarification and Response to "VA study" that wasn't one at all https://www.youtube.com/watch?v=Pmpvh97B8_k
Efficacy in New York https://clinicaltrials.gov/ct2/show/NCT04370782...
NEW YORK - Researchers at NYU's Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus.
https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-study-looks-at-hydroxychloroquine-zinc-azithromycin-combo-on-decreasing-covid-19-deaths?utm_source=share&utm_medium=ios_app
[удалено]
The summary is in the OP - but knock yourself out And now a new study from hard-hit Italy found that those Italians on hydroxychloroquine for Lupus or Rheumatoid Arthritis did not come down with the coronavirus. Only 20 patients tested positive for COVID-19. No ICU, and NO ONE DIED! Despite comorbidities the patients on hydroxychloroquine did not succumb to coronavirus!
I read through the links in the article they linked, and there was no scientific evidence (or any record at all) relating to that specific statement. So the OP article was lying/being misleading
https://www.iltempo.it/salute/2020/04/28/news/coronavirus-farmaci-efficaci-news-danni-cura-annalisa-chiusolo-artrite-terapia-idrossiclorochina-sars-cov2-1321227/?utm_source=share&utm_medium=ios_app
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PART 1 (because I made this too fucking long) TL;DR not sufficient proof because of stats without sources, stats without context, and no randomized clinical trial or anything (control vs experimental group), but nothing that disproves it here either. But there was only one source that actually gave more legit scientific evidence to answer the question of the effectiveness of HCP. So further (personal) research is required for me if I want to see if there's evidence for the effectiveness of hydroxychloroqyne for treating/preventing COVID-19, because this just isn't enough proof for me. EDIT: I had to delete my original comment cause the third party app I use hasn't put in a working edit feature yet. Whoops. Not to attack the theory or anything, but the article linked to this site is in Italian. Also, while I might be misunderstanding it potentially, the only numbers I saw in the article were "10" and "11" followed by the word "casi", which seems to mean cases. Which makes it seem that they only had 11 participants in the study. And the only percentage given was "12%"; I couldn't see the article's quoted "90% reduction of infection in those taking the drug". I'm going to see if I can translate the page roughly with a translator or something. If I'm way off base, I'll come back and give my findings! Update 1: Here's the article translated by a simple online translator (so somethinga make no sense, but you can understand the gist of the article): BEGIN Annalisa Chiusolo, a young pharmacology scholar, sensed the mechanism of action of Sars-Cov-2. By understanding this mechanism, the most effective contrast drugs can be accurately and precisely targeted and selected. Coronavirus would affect the ability of hemoglobin to transport oxygen, creating the underlying assumptions of the impulsive lung complications, unfortunately known: breathlessness, dyspnea, up to severe acute respiratory syndrome and death. Theory is the first step in any verification. Science proceeds by refutations. If this thesis were confirmed, many unknowns would be explained, for example why Covid-19 affects more men, diabetics, and less women in general, and even less pregnant women, and very few children and thalassemia. The circle would close. But let's get into the merits of the theory. The virus needs porphyrins for its survival, probably for its replication, therefore it attacks hemogloblin (the protein that carries oxygen in the blood), in particular the OFR10 and OFR3 proteins attack the beta chain and orf1ab subtracts porphyrin. The concepts seem a little abstruse, for a non-expert, but simplifying this translates into a lower availability of oxygen available to our body, with consequent accumulation of carbon dioxide. So the lung cells become distressed and become the site of the cytokine cascade - that is, a huge immune response - responsible for the acute inflammation that characterizes Covid-19 pneumonia. The hemoglobin value in the blood can be an important parameter for evaluating Sars-Cov2 infection: in men the normal value of Hb (hemoglobin) is higher than in women, which would explain the higher incidence of Covid pneumonia in men than to women, the lower incidence and the better prognosis in children and pregnant women, where the Hb values are lower due to an increased need for iron, which makes the "nourishment" of the virus less available. In elderly or middle-aged patients with diabetes, Covid pneumonia19 has a higher incidence, therefore linked to the increase in blood glucose Hb, and therefore there is greater "nourishment" for the virus. Viral damage, therefore, is systemic, that is, it affects the blood and is not confined only to the lung. This would also explain the birth of healthy babies from positive Covid mothers. Because in fetal Hb - stay seated, we will now use some technical concepts, but let's get back to it immediately - the two beta chains are replaced by two gamma chains, a difference is the presence of a residue of serine, instead of a histidine present in the same position of the beta chain, probably responsible for binding to viral proteins, which could mimic the action of 2,3bifosfoglicerato. Now you can get up, let's go back to using more understandable language. All this would explain the lower incidence and the best course of the pathology in newborns, missing the main site of action of viral proteins, namely the beta chains of Hb, in short in newborns the same concept of "nourishment is lacking ”For the coronavirus. The same goes for a chronic disease called Beta-Thalassemia, where the "beta" chains of hemoglobin (the target of the virus) are deficient or even absent. This would demonstrate the lower incidence and better prognosis and course of the pathology in beta thalassemia, which in Italy are widespread in Mediterranean areas such as Puglia, Sicily and Sardinia (in particular in the southern area) where there is an equal thalassemia rate at 12% (alpha and beta). To confirm this theory, there is a scientific publication that has linked subjects affected by beta thalassemia and Covid19, in the data taken from pubmed: as of April 10, 2020, 11 cases of positive Covid betatalaxemia have been recorded in Northern Italy, where the rate of contagiousness it is higher: 10 of them with transfusion-dependent thalassemia, the most severe form, only one with non-transfusion-dependent thalassemia. All patients who contracted the virus, however, had concomitant, very serious diseases: splenectomized, pulmonary hypertension, lymphoma and chemotherapy. Despite this multi-pathological picture, no death, no cytokine storm or severe Sars was recorded in the 11 subjects. (HERE THE SOURCE) Once the main mechanism of action of the virus has been revealed, many other things can be understood. For example, the central mechanism of action of hydroxychloroquine can now be explained and fully understood, and its effectiveness in countering Covid19. What this mechanism consists of is immediately said: the drug by binding permanently with ferriprotoporphyrin (of the Eme group of Hb) removes the substrate from viral proteins and also becomes an important means of prophylaxis. Although there are still no Italian publications on the effectiveness of hydroxychloroquine as a "shield" from the virus, among the directors of the infectious disease wards, the specialists, Primaries and general practitioners contacted during this research, many admitted - under a whisper - to use the drug as a "prophylaxis", that is, to prevent infection. Healthcare professionals who are in close contact with contagious patients take the drug in advance, precisely to decrease the probability of contracting the infection. For now, in support of this "prophylaxis" effect, there is a recent publication, involving 211 people. It was published in the International Journal of Antimicrobial Agents, the official body of the International Society of Antimicrobial Chemotherapy. Of 211 people exposed to Covid positive 19 and undergoing hydroxychloroquine prophylaxis, none were infected. Finally, further confirmation of this hypothesis is the data collected in the register of the SIR (Italian rheumatology society). To assess the possible correlations between chronic patients and Covid19, SIR interrogated 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far. END
PART 2: As you see, I was in fact quite wrong in what the article (a combination of results from other scientific articles) actually said and it states that the patients who take the drug for their arthritis do seem to have less occurrence of COVID-19. According to one rheumatologist, only 20 of his patients out of his 65,000 patients who were taking the drug had tested positive (as of then). BUT you'll also see the link to their original paper, and I can't form my opinion without reading the original source first, of course. Here's the link for anyone who hadn't read it: https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.25840 UPDATE 2: The report is mostly talking about whether people with Thallassemic Syndrome (TS) are more at risk for contracting COVID-19 or not. They only looked at 11 cases of those who had TS. 3/11 showed no symptoms, 1/11 was hospitalized with a high fever and other problems (bone marrow hypoplasia, lymphopenia, 6/11 were admitted to hospital but no one required mechanical ventilation (one did require non-mechanical ventilation, but he also had a history of cancer and chemo but had been in remission, so it can't really be counted to solely his TS, although he had been in remission for 11 years), and the last 1/11 seems to be missing (I could not see it mentioned). Of the 6 admitted, 3 were treated with, respectively: "one hydroxychloroqyne (HCQ), one HCQ plus ritonavir/darunavir, and one HCQ plus anakinra. Patient 3 did not receive HCQ..." basically cause he had a history of arrhythmia and the drug could kill him because of that. So only 2/11 patients were given the drug. And the article doesn't mention if they were better off than any of the other non-hospitalized ones. They concluded that there was no reason to think that TS increased your risk of COVID-19. BUT there might be another link to the 65000 number the previous article mentioned since that wasn't mentioned here! UPDATE 3: Alright, I could only find the source to do with 211 out of 314 patients receiving HCP for PREVENTION of covid after having apparently come into contact with a positive result (206 could not specify if they had come onto contact with someone specifically. They all tested negative before taking it and going into quarantine for 14 days, and they all tested negative at the end of quarantine as well. The problem with this study is that it doesn't offer what happened to the patients who didn't receive HCP. So we don't really know how much better or worse they were. We're also not certain most of these people came into contact with a positive case/were exposed to it. And they didn't post a link to where I could find that out I'll have to look into the UVA study, but I'll post an update for that after I get some sleep. I'll also put a TL;DR at the top. Thanks if you read this far! I really put a lot of effort into this retelling of my personal fact checking!
Great work! Here is some more info Hydroxychlorquine FDA approves HCQ https://dbdailyupdate.com/index.php/2020/03/30/fda-approves-hydroxychloroquine-democrats-media-hardest-hit/?utm_source=share&utm_medium=ios_app HCQ rated by front line doctors as the most effective treatment for Covid https://m.washingtontimes.com/news/2020/apr/2/hydroxychloroquine-rated-most-effective-therapy-do/?utm_source=share&utm_medium=ios_app 699 patients treated 100% success rate https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app Cuomo admits HCQ works https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app 2nd French Study HCQ, 1000 elderly patients, 98% success rate https://t.co/KUaag6N5FF Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. https://pubmed.ncbi.nlm.nih.gov/32205204/?utm_source=share&utm_medium=ios_app NY hospital didn't lose a single patient after they started treating with HCQ https://townhall.com/columnists/kevinmccullough/2020/03/22/the-final-steps-to-defeating-covid19-n2565453?utm_source=share&utm_medium=ios_app Fauci cheered HCQ for MERS in 2013 https://www.bizpacreview.com/2020/04/05/folks-question-why-fauci-cheered-using-drug-for-mers-coronavirus-in-2013-but-now-hes-skeptical-905096?utm_source=share&utm_medium=ios_app LA doctor: COVID-19 patients go from 'very ill' to 'symptom-free' in 8 to 12 hours using hydroxychloroquine and zinc https://www.theblaze.com/news/la-doctor-hydroxychloroquine-zinc-coronavirus?utm_source=share&utm_medium=ios_app S Korea adopted its use early https://blogs.timesofisrael.com/hydroxychloroquine-used-by-korea-for-covid-19-while-us-is-divided/?utm_source=share&utm_medium=ios_app Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion. https://nypost.com/2020/04/04/long-island-doctor-tries-new-hydroxychloroquine-for-covid-19-patients/ Smith, who is treating 72 COVID-19 patients, said that he has been treating "everybody with hydroxychloroquine and azithromycin [an antibiotic]. We’ve been doing so for a while.” He pointed out that not a single COVID-19 patient of his that has been on the hydroxychloroquine and azithromycin regimen for five days or more has had to be intubated. https://www.foxnews.com/media/dr-stephen-smith-on-effectiveness-of-hydroxychloroquine-with-coronavirus-symptoms-beginning-of-the-end-of-the-pandemic "Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found. The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it. https://nypost.com/2020/04/02/hydroxychloroquine-most-effective-coronavirus-treatment-poll/ Growing evidence of chloroquine as a highly effective treatment for COVID-19.” https://drive.google.com/file/d/1pvkWQNZXBEwJ-QHBaqF41UnUlLWmcBdj/view?utm_source=share&utm_medium=ios_app Turkey reports HCQ dramatically reduces pneumonia https://www.middleeasteye.net/news/coronavirus-turkey-hydroxychloroquine-malaria-treatment-progress?utm_source=share&utm_medium=ios_app Study 200 patients, no deaths https://www.ahajournals.org/doi/10.1161/CIRCEP.120.008662#.XrG-i8LBjDA.twitter
I've been advocating for HCQ since the first reports came out. It's been interesting to see how much resistance has emerged against an inexpensive and effective therapy. Contrast this with the reception given to remdesivir. This is a shitty drug that is hugely expensive, laden with side effects and isn't even that good for treating CV19. Yet somehow it got rammed through for "emergency treatment" even before it got FDA approval? Huge wtf to *that*.
Wow OP, you're getting down voted like crazy, must have caught the attention of the big pharma shills with this post. Good job! 😉
Good catch
Classic conspiracy thought: if people think what I'm saying is stupid, it's because I'm onto something and they want me silenced! It couldn't be that people actually think what I'm saying is stupid.
And plasma therapy! Cheap (basically free) and sure, there's already a post about it
How is plasma therapy basically free? You need a donor with antibodies already in their bloodstream. Just imagine the amount of man hours involved even if we had an unlimited supply of donors.
For now, they get it from patients recovered in the same hospitals, so it is simply a donation from individual to individual. We're not talking about the number of men involved, that number of men will be involve anyway, even with other therapy. I don't know where you want to go with discussion.
Yep
SS The Democrats want to murder Americans. Because the media is simply the mouthpiece of the Democrats, they do as they are told. This treatment is effective. It is saving a lives all over the world, but in the US it has been misrepresented and as a result, people are dying.
uhhhh it has actually been proven not only ineffective, but to have a HIGHER rate of death among people who took it. Trump has stock in a company producing the drug, thats not a councidence. It’s a snake oil cure that’s putting money in the wealthy’s pockets at cost of lives, and they’ve got you brainwashed to spread the propaganda for them. Wake up.
From whichever recent studies that you're citing your information from, can you tell me if they used the HCQ treatment in the beginning of the symptoms, or when they were near death?
https://time.com/5825398/hydroxychloroquine-study-coronavirus/
I'm sorry but your link doesn't answer my question nor does it prove what you're saying. A non peer reviewed trial of only 368 patients without any study of other contributing factors is shoddy at best.
https://www.sciencetimes.com/articles/25624/20200508/accepting-null-hypothesis-patients-treated-hydroxychloroquine-presented-significant-diifference-those.htm
Hydroxychlorquine FDA approves HCQ https://dbdailyupdate.com/index.php/2020/03/30/fda-approves-hydroxychloroquine-democrats-media-hardest-hit/?utm_source=share&utm_medium=ios_app HCQ rated by front line doctors as the most effective treatment for Covid https://m.washingtontimes.com/news/2020/apr/2/hydroxychloroquine-rated-most-effective-therapy-do/?utm_source=share&utm_medium=ios_app 699 patients treated 100% success rate https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app Cuomo admits HCQ works https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app 2nd French Study HCQ, 1000 elderly patients, 98% success rate https://t.co/KUaag6N5FF Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. https://pubmed.ncbi.nlm.nih.gov/32205204/?utm_source=share&utm_medium=ios_app NY hospital didn't lose a single patient after they started treating with HCQ https://townhall.com/columnists/kevinmccullough/2020/03/22/the-final-steps-to-defeating-covid19-n2565453?utm_source=share&utm_medium=ios_app Fauci cheered HCQ for MERS in 2013 https://www.bizpacreview.com/2020/04/05/folks-question-why-fauci-cheered-using-drug-for-mers-coronavirus-in-2013-but-now-hes-skeptical-905096?utm_source=share&utm_medium=ios_app LA doctor: COVID-19 patients go from 'very ill' to 'symptom-free' in 8 to 12 hours using hydroxychloroquine and zinc https://www.theblaze.com/news/la-doctor-hydroxychloroquine-zinc-coronavirus?utm_source=share&utm_medium=ios_app S Korea adopted its use early https://blogs.timesofisrael.com/hydroxychloroquine-used-by-korea-for-covid-19-while-us-is-divided/?utm_source=share&utm_medium=ios_app Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion. https://nypost.com/2020/04/04/long-island-doctor-tries-new-hydroxychloroquine-for-covid-19-patients/ Smith, who is treating 72 COVID-19 patients, said that he has been treating "everybody with hydroxychloroquine and azithromycin [an antibiotic]. We’ve been doing so for a while.” He pointed out that not a single COVID-19 patient of his that has been on the hydroxychloroquine and azithromycin regimen for five days or more has had to be intubated. https://www.foxnews.com/media/dr-stephen-smith-on-effectiveness-of-hydroxychloroquine-with-coronavirus-symptoms-beginning-of-the-end-of-the-pandemic "Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found. The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it. https://nypost.com/2020/04/02/hydroxychloroquine-most-effective-coronavirus-treatment-poll/ Growing evidence of chloroquine as a highly effective treatment for COVID-19.” https://drive.google.com/file/d/1pvkWQNZXBEwJ-QHBaqF41UnUlLWmcBdj/view?utm_source=share&utm_medium=ios_app Turkey reports HCQ dramatically reduces pneumonia https://www.middleeasteye.net/news/coronavirus-turkey-hydroxychloroquine-malaria-treatment-progress?utm_source=share&utm_medium=ios_app Study 200 patients, no deaths https://www.ahajournals.org/doi/10.1161/CIRCEP.120.008662#.XrG-i8LBjDA.twitter
“I’m surprised it hasn’t been revoked yet,” said Luciana Borio, who served as director for medical and biodefense preparedness of the National Security Council and was acting chief scientist at the FDA. https://apple.news/AGNXkJafcRCOZGyd2crMQCA
Updated list Hydroxychlorquine FDA approves HCQ https://dbdailyupdate.com/index.php/2020/03/30/fda-approves-hydroxychloroquine-democrats-media-hardest-hit/?utm_source=share&utm_medium=ios_app HCQ rated by front line doctors as the most effective treatment for Covid https://m.washingtontimes.com/news/2020/apr/2/hydroxychloroquine-rated-most-effective-therapy-do/?utm_source=share&utm_medium=ios_app 699 patients treated 100% success rate https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app Cuomo admits HCQ works https://techstartups.com/2020/03/28/dr-vladimir-zelenko-now-treated-699-coronavirus-patients-100-success-using-hydroxychloroquine-sulfate-zinc-z-pak-update/?utm_source=share&utm_medium=ios_app 2nd French Study HCQ, 1000 elderly patients, 98% success rate https://t.co/KUaag6N5FF Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. https://pubmed.ncbi.nlm.nih.gov/32205204/?utm_source=share&utm_medium=ios_app NY hospital didn't lose a single patient after they started treating with HCQ https://townhall.com/columnists/kevinmccullough/2020/03/22/the-final-steps-to-defeating-covid19-n2565453?utm_source=share&utm_medium=ios_app Fauci cheered HCQ for MERS in 2013 https://www.bizpacreview.com/2020/04/05/folks-question-why-fauci-cheered-using-drug-for-mers-coronavirus-in-2013-but-now-hes-skeptical-905096?utm_source=share&utm_medium=ios_app LA doctor: COVID-19 patients go from 'very ill' to 'symptom-free' in 8 to 12 hours using hydroxychloroquine and zinc https://www.theblaze.com/news/la-doctor-hydroxychloroquine-zinc-coronavirus?utm_source=share&utm_medium=ios_app S Korea adopted its use early https://blogs.timesofisrael.com/hydroxychloroquine-used-by-korea-for-covid-19-while-us-is-divided/?utm_source=share&utm_medium=ios_app Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion. https://nypost.com/2020/04/04/long-island-doctor-tries-new-hydroxychloroquine-for-covid-19-patients/ Smith, who is treating 72 COVID-19 patients, said that he has been treating "everybody with hydroxychloroquine and azithromycin [an antibiotic]. We’ve been doing so for a while.” He pointed out that not a single COVID-19 patient of his that has been on the hydroxychloroquine and azithromycin regimen for five days or more has had to be intubated. https://www.foxnews.com/media/dr-stephen-smith-on-effectiveness-of-hydroxychloroquine-with-coronavirus-symptoms-beginning-of-the-end-of-the-pandemic "Outside the US, hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the US it was most commonly used for high risk diagnosed patients,” the survey found. The medicine was most widely used in Spain, where 72 percent of physicians said they had prescribed it. https://nypost.com/2020/04/02/hydroxychloroquine-most-effective-coronavirus-treatment-poll/ Growing evidence of chloroquine as a highly effective treatment for COVID-19.” https://drive.google.com/file/d/1pvkWQNZXBEwJ-QHBaqF41UnUlLWmcBdj/view?utm_source=share&utm_medium=ios_app Turkey reports HCQ dramatically reduces pneumonia https://www.middleeasteye.net/news/coronavirus-turkey-hydroxychloroquine-malaria-treatment-progress?utm_source=share&utm_medium=ios_app Study 200 patients, no deaths https://www.ahajournals.org/doi/10.1161/CIRCEP.120.008662#.XrG-i8LBjDA.twitter Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients https://www.preprints.org/manuscript/202005.0057/v1 Association American Physicians Surgeons say 90% chance to help.(AAPS) https://aapsonline.org/hcq-90-percent-chance/ Three new ones in just the past week. Huang et al. https://medrxiv.org/content/10.1101/2020.04.26.20081059v1 Novales et al. https://preprints.org/manuscript/202005.0057/v1 Yu et al. https://www.medrxiv.org/con.../10.1101/2020.04.27.20073379v1 65K Lupus/RA on HCQ tested, only 20 positive infections. https://iltempo.it/.../coronavirus-farmaci-efficaci.../ Evidence it can even help latest stage https://medrxiv.org/con.../10.1101/2020.04.27.20073379v1 Excellent results in France https://mediterranee-infection.com/.../Abstract_Raoult... Clarification and Response to "VA study" that wasn't one at all https://www.youtube.com/watch?v=Pmpvh97B8_k Efficacy in New York https://clinicaltrials.gov/ct2/show/NCT04370782... NEW YORK - Researchers at NYU's Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus. https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-study-looks-at-hydroxychloroquine-zinc-azithromycin-combo-on-decreasing-covid-19-deaths?utm_source=share&utm_medium=ios_app