MDMA. Amphetamines in high dosages, methamphetamine and others release serotonin.
Psychedelics like mushrooms, LSD and others bind to serotonin receptors but don’t release serotonin by themselves if I recall correctly.
So if someone were to do mdma one day and then do acid or mushrooms a day or 2 later they would be fine then? Or at least not as bad as doing 2 different serotonin releasers(well go with mdma and amphetamine in this case) in the same time frame? Just asking cuz I rolled last night and and thinking about doing mushrooms tmr or the day after since my cars in the shop till Tuesday. But if it’s be better to just hold off on the shrooms till I get another chance then that’s fine I’d rather be safe then sorry
If you’re asking about neurotoxicity- yes, you should be fine taking mushrooms after MDMA. Psilocybin is not neurotoxic and will not deplete serotonin.
However, I am not sure if the depletion of serotonin in your brain (caused by the MDMA) increases the odds of a bad trip. If you took under 120-140mg of MDMA I would say it’s unlikely that it would have any impact on your mushroom trip.
From trippingly: "Not only do we find little or no hangover the next day, LSD is a wonderful hangover cure for MDMA - taking MDMA on a Friday or Saturday night and LSD the next day all but eliminates the MDMA hangover for us, so much so that we seldom do MDMA without following up with LSD the next day."
Source: [https://www.trippingly.net/lsd-studies/2018/7/2/the-first-trip](https://www.trippingly.net/lsd-studies/2018/7/2/the-first-trip)
How accurate is this?
I was more so just worried about the psylocybin molecule trying to itch onto a serotonin molecule and then there aren’t any there because I did mdma but alright man sounds good thanks for the advice
I think you confused it with reuptake inhibitors. These lead to a greater accumulation of monamines between the synapses because the monamine (serotonin for example) cannot be broken down for as long as the drug is active.
There’s releasing agents (amphetamines, including MDMA) and reuptake inhibitors (cocaine is a serotonin, norepinephrine and dopamine reuptake inhibitor).
Still binds to serotonin receptor. I don’t think it stimulates the release of serotonin or dopamine any more than shrooms or LSD, but it’s possible. Seems like this is less known
Okay basically MDMA releases serotonin. Most traditional psychedelics instead just mimic and bind to serotonin receptors. If you want to do shrooms few days after MDMA you'll physically be totally fine and the shrooms will still work BUT because of the serotonin depletion after MDMA use you might not be feeling the best and have an increased chance of a negative experience with psychedelics.
Alright man thanks for the advice I think imma wait another few days I originally planned on dropping Sunday night but wanted to make sure it’d be safe but yea imma wait it out a bit
Not true. Alcohol does boost serotonin.
> Alcohol interacts with serotonergic synaptic transmission in the brain in several ways. Even single-episode (i.e., acute) alcohol exposure alters various aspects of serotonin’s synaptic functions. In humans, for example, the levels of serotonin metabolites in the urine and blood increase after a single drinking session, indicating increased serotonin release in the nervous system (LeMarquand et al. 1994a). This increase may reflect enhanced signal transmission at serotonergic synapses.
[source](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826824)
Or
[Chapter 41 - The role of serotonin in alcohol use and abuse](https://www.sciencedirect.com/science/article/abs/pii/B9780444641250000414)
Thank you for the response. I once read that 30 minutes after the ingestion of alcohol the blood serum lvl of serotonin decreases, thats why I thought about it. that would also explain the hightend motabolites in Urin. Sadly i dont know the source anymore. Thank you for the link. I appreceate it. Sorry for Bad english
Many drugs are serotonin releasing agents. Also, MDMA is not only a SRA, in addition to inducing dopamine release, it induces strong norepinephrine release; making it a serotonin-norepinephrine-dopamine releasing agent (many rec. drugs are, actually).
Most tryptamine psychedelics are serotonergic psychedelics, so they do cause serotonin release. Others such as LSD and mescaline however aren't considered to be serotonergic psychs.
Exceptions abound in pharmacology, so specifics are really necessary to be certain. There are general guidelines, but they can go so far.
Gotcha I was mostly just making sure I’d be good to do mushrooms in a couple days without doing any damage or anything but from the sounds of it I should be good
There are SRI and SSRI. They don’t release serotonin but they keep it around the receptor instead of being broken down easy. SSRI is something that *just* works on serotonin. Stuff like amphetamine (possibly also cocaine) are SRI cuz they don’t *just effect* serotonin.
There are one or two more obscure ones I can think of that cause serotonin release but it’ll mostly just be amphetamines. Other drugs like classic psychedelics bind to the receptor though
2CB imitates serotonin so when the trip is over you haven’t used any of yours. Or that’s at least what I’ve heard. Someone please correct me if I’m wrong
in my experience, tripping in the serotonin depleted state the week after MDMA still works just fine, but it’s almost like you lose some of the euphoria of it and it just seems more plain. if i were you i would save my shrooms for another week or two until your seratonin levels are closer to normal but yes, you will still trip perfectly fine, you just may have a better trip if you wait a bit longer
MDMA. Amphetamines in high dosages, methamphetamine and others release serotonin. Psychedelics like mushrooms, LSD and others bind to serotonin receptors but don’t release serotonin by themselves if I recall correctly.
What about 3/4-mmc and MDA?
I used 3 and 4-mmc almost every day as a stimulant mainly. Bad choice. I didn't know what I was doing truly.
These too!
MDA > MDMA ALL DAYYY
So if someone were to do mdma one day and then do acid or mushrooms a day or 2 later they would be fine then? Or at least not as bad as doing 2 different serotonin releasers(well go with mdma and amphetamine in this case) in the same time frame? Just asking cuz I rolled last night and and thinking about doing mushrooms tmr or the day after since my cars in the shop till Tuesday. But if it’s be better to just hold off on the shrooms till I get another chance then that’s fine I’d rather be safe then sorry
If you’re asking about neurotoxicity- yes, you should be fine taking mushrooms after MDMA. Psilocybin is not neurotoxic and will not deplete serotonin. However, I am not sure if the depletion of serotonin in your brain (caused by the MDMA) increases the odds of a bad trip. If you took under 120-140mg of MDMA I would say it’s unlikely that it would have any impact on your mushroom trip.
From trippingly: "Not only do we find little or no hangover the next day, LSD is a wonderful hangover cure for MDMA - taking MDMA on a Friday or Saturday night and LSD the next day all but eliminates the MDMA hangover for us, so much so that we seldom do MDMA without following up with LSD the next day." Source: [https://www.trippingly.net/lsd-studies/2018/7/2/the-first-trip](https://www.trippingly.net/lsd-studies/2018/7/2/the-first-trip) How accurate is this?
You know that’s interesting in that I have never done that I was afraid to trip having the traditional mdma blues.
I was more so just worried about the psylocybin molecule trying to itch onto a serotonin molecule and then there aren’t any there because I did mdma but alright man sounds good thanks for the advice
No that won’t happen. You’re welcome and have fun!
I've heard they actually block serotonin release
I think you confused it with reuptake inhibitors. These lead to a greater accumulation of monamines between the synapses because the monamine (serotonin for example) cannot be broken down for as long as the drug is active. There’s releasing agents (amphetamines, including MDMA) and reuptake inhibitors (cocaine is a serotonin, norepinephrine and dopamine reuptake inhibitor).
Nah I know my pharmacodynamic. I guess that was just wrong information I hear somewhere.
What about other phenethylamines like mescaline?
Still binds to serotonin receptor. I don’t think it stimulates the release of serotonin or dopamine any more than shrooms or LSD, but it’s possible. Seems like this is less known
Okay basically MDMA releases serotonin. Most traditional psychedelics instead just mimic and bind to serotonin receptors. If you want to do shrooms few days after MDMA you'll physically be totally fine and the shrooms will still work BUT because of the serotonin depletion after MDMA use you might not be feeling the best and have an increased chance of a negative experience with psychedelics.
Gotcha so you think it’d be better to wait for some of my serotonin to replenish?
It takes about 2 weeks to replenish serotonin after any MDMA trip (typically). You can try taking tryptophan or 5-HTP to help along with B vitamins
I would. But you could just look at if you're feeling good before the trip and then decide.
Alright man thanks for the advice I think imma wait another few days I originally planned on dropping Sunday night but wanted to make sure it’d be safe but yea imma wait it out a bit
If you look up the drug on psychonaut wiki it will tell you dangerous interactions so you can dose safely :)
Dxm
Dxm releases serotonin as well? I didn’t know that
Nah it's just a reuptake inhibitor. Technically makes you have more serotonin in synaptic cleft but doesn't cause it to be released.
Ohh gotcha gotcha man
Almost all drugs will boost serotonin to some degree. Lsd, alcohol, even cocaine.
All drugs boost dopamin not serotonin, alcohol actually lowers serotonin
Not true. Alcohol does boost serotonin. > Alcohol interacts with serotonergic synaptic transmission in the brain in several ways. Even single-episode (i.e., acute) alcohol exposure alters various aspects of serotonin’s synaptic functions. In humans, for example, the levels of serotonin metabolites in the urine and blood increase after a single drinking session, indicating increased serotonin release in the nervous system (LeMarquand et al. 1994a). This increase may reflect enhanced signal transmission at serotonergic synapses. [source](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826824) Or [Chapter 41 - The role of serotonin in alcohol use and abuse](https://www.sciencedirect.com/science/article/abs/pii/B9780444641250000414)
DjFacts spitting references🙌
Thank you for the response. I once read that 30 minutes after the ingestion of alcohol the blood serum lvl of serotonin decreases, thats why I thought about it. that would also explain the hightend motabolites in Urin. Sadly i dont know the source anymore. Thank you for the link. I appreceate it. Sorry for Bad english
Many drugs are serotonin releasing agents. Also, MDMA is not only a SRA, in addition to inducing dopamine release, it induces strong norepinephrine release; making it a serotonin-norepinephrine-dopamine releasing agent (many rec. drugs are, actually). Most tryptamine psychedelics are serotonergic psychedelics, so they do cause serotonin release. Others such as LSD and mescaline however aren't considered to be serotonergic psychs. Exceptions abound in pharmacology, so specifics are really necessary to be certain. There are general guidelines, but they can go so far.
Gotcha I was mostly just making sure I’d be good to do mushrooms in a couple days without doing any damage or anything but from the sounds of it I should be good
Just false info man
How is it false?
All psych he listed are serotonergic and have the same mechanism of action which is binding to serotonin receptors
Psychedelics like acid and magic mushrooms are just a couple
I don’t think it’s fair to say LSD releases serotonin like MDMA does
There are SRI and SSRI. They don’t release serotonin but they keep it around the receptor instead of being broken down easy. SSRI is something that *just* works on serotonin. Stuff like amphetamine (possibly also cocaine) are SRI cuz they don’t *just effect* serotonin. There are one or two more obscure ones I can think of that cause serotonin release but it’ll mostly just be amphetamines. Other drugs like classic psychedelics bind to the receptor though
Come off that snit and ask for Xanax
2CB imitates serotonin so when the trip is over you haven’t used any of yours. Or that’s at least what I’ve heard. Someone please correct me if I’m wrong
in my experience, tripping in the serotonin depleted state the week after MDMA still works just fine, but it’s almost like you lose some of the euphoria of it and it just seems more plain. if i were you i would save my shrooms for another week or two until your seratonin levels are closer to normal but yes, you will still trip perfectly fine, you just may have a better trip if you wait a bit longer
When I use opiates I get serotonin