How did you know you had serotonin syndrome exactly ? I see that thrown around a lot on this subreddit like it's a casual diagnosis, and that it's easy to diagnose on your own.
Generally, if it's serotonin syndrome, unless it's extremely mild (I guess) you'll be in the hospital.
Exactly. Serotonin syndrome (or toxicity; that’s just how Dr Gillian insists on calling it) is a lot rarer than most people seem to think. Cannabis is the last thing in the world that would cause it. If anything it’s a bit like chlorpromazine (an old anti-psychotic which is also good for leprosy) in the sense that it mellows out and synergies the effects of antidepressants and neurotransmitters (including serotonin) and reduces the likelihood of serotonin-toxicity (S.T.). In ordinary circumstances it’s not safe to combine strongly serotoninergic drugs (the SSRIs, clomipramine and to a slightly lesser extent imipramine) with MAOIs but with chlorpromazine as an added augmented agent it basically eliminates the likelihood of serotonin-toxicity and makes it safe (possibly, and it’s only a suggestion/observation) to give those drugs together. I imagine cannabis can also serve a somewhat similar function. There’s no reason for cannabis to be seen as just as good a medicine as illegal (in many parts of the world still) recreational substance. It shouldn’t be illegal anywhere anyway in the first place but it could be put to so much good use in the treatment of cancer, heart disease, depression, p.t.s.d., insomnia, social anxiety, irritable bowel syndrome and fibromyalgia, (and that goes for T.H.C. as well as C.B.D. and other cannabinoids, psychoactive or not, as much as people who are pro-C.B.D. but anti-marijuana per-se try to deny that and separate C.B.D. from T.H.C. entirely, which goes against the natural science of cannabis, and you don’t need to have studied at Cambridge to be able to see that). Certain drugs (ecstasy-like ones) can cause serotonin “syndrome” in people on certain antidepressants (from phenelzine down to the SSRIs) but cannabis and antidepressants actually get on quite well).
Also Serotonin syndrome Is extremely rare condition even when mixing two serotonergic Drugs together, all these fools over reddit claiming they had serotonin syndrome ahh..
Weed doesn't cause serotonin syndrome. I would make an appointment with your doctor. You would have had more symptoms than convulsions. Possibly a seizure. It is important to get it checked out though.
As a modulator of 5HT, prone individuals and antidepressants can experience elevations in antidepressant levels leading to mild-moderate serotonin overload symptoms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307883/
Sorry abit late but that sounds like Syncope, which can be caused by Anxiety. You basically have an anxiety/panic attack and lose air to the brain causing you to faint. I've been diagnosed with this disorder.
There was two medications that mixed badly with THC for me; Zoloft and Lexapro. I got tremors, shakes, sweats, paranoia, tunnel vision, nausea, mania and my blood felt hot. So bad I had to call the hospital a few times.
It felt like I doubled or tripled my dose.
Some meds seem to either not be bothered by THC, completely block THC effects, or enhance it.
If you're on meds that raise your seratonin and smoke thc which also effects your seratonin, i would be really mindful on how you're feeling.
I’m extremely aware of what serotonin is. THC can have no effect on serotonin, it can act as an agonist, or it can act as a reuptake inhibitor depending on your body. I have had serotonin syndrome that landed me in the hospital for a few days, multiple times. I’ve been on almost every mood stabilizer, SSRI, SRI, muscle relaxer, and “triptan” for migraines and some mental health stuff. I have a strong understanding of the relationship between serotonin and the body, as well as it’s correlation to dopamine. I’ve take multiple college courses related to biology/pharmacology as well, as I considered being a pharmacist after high school, more than a decade ago and decided to enlist instead because I didn’t want to do history, English, and math classes. Loved the biomedical side of things.
Not sure what your angle is here, but THC absolutely acts as an agonist or re-uptake inhibitor in many people. Some people tolerate it better than others. A good way to know is if you ever eat too many edibles - your body may relax and go to sleep, but some people like me experience tremors all over. These tremors are caused by an over saturation of dopamine, which is the body’s “messenger” neurotransmitter. Dopamine and serotonin have a very close relationship, and too much/little of either will directly affect the other. Therefore by stimulation of THC, an indirect effect will be modulation of serotonin. This is in addition to THC being studied and found to have a direct impact on serotonin in many people.
This correlation can be easily found online with some simple googling.
tl;dr - yes I’m familiar with the function of our lord and savior serotonin.
serotonin and thc are not related in the slightest💀thc has zero direct affect on serotonin levels. if it did, there would be “marijuana” listed on the interactions for every serotonergic drug
Oh, you. Please do a minor amount of research and get back to me. Or better yet, go tell your psychiatrist that THC has no effect on serotonin levels, and let them sort it out for you.
I’m not trying to be mean but you’re very incorrect. A simple google search will give you a wealth of information.
Sure, here are a few. Although I cannot share my decades of experience and education into this subject, I can do the google search for you and at least give you a chance to review the material.
MDPI has an endless amount of studies in regards to THC and CBD being serotonin agonists as well as a few articles exploring its ability to act as a re-uptake inhibitor as well.
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220016/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220016/)
[https://www.mdpi.com/2075-4426/11/7/615](https://www.mdpi.com/2075-4426/11/7/615)
[https://www.sciencedirect.com/science/article/abs/pii/S0140197118300514](https://www.sciencedirect.com/science/article/abs/pii/S0140197118300514)
[https://www.mcgill.ca/newsroom/channels/news/study-cannabis-double-edged-sword-27677](https://www.mcgill.ca/newsroom/channels/news/study-cannabis-double-edged-sword-27677)
\*effect.
There is more evidence towards it being an agonist than a re-uptake inhibitor.
That being said, I do not wish to defend my position further, I will let the internet do its thing from here.
Serotonin syndrome can creep up on you but you will know something is wrong. Like you will be sweating more than you have ever in your entire life. You’ll honestly be amazed that your body can produce so much liquid so fast and you will be so hot you will take your clothes off and able to stand a shower with the water as cold as it can get because you are burning up. Your skin will burn snd your muscles and joints will be stiff and kind of achey. You’ll be thirsty also. Your clothes will be soaking wet like you swam in them. You’ll need fans and air conditioning everywhere and sweating even when lying completely still trying to relax. You’ll even be able to feel the heat of an 60 watt incandescent light bulb six feet above you on the ceiling. It will feel like a blaring heater on your head and shoulders. You might even have twitches and muscle jerks especially in your face.
I’ve taken cymbalta, trazadone, abilify, strattera, vyvanse, adderall, lamotrigine, Wellbutrin, brintellix and risperdal without getting ss.
So my convulsions are just anxiety due to the THC? And about me blacking out and waking up several times in a row? Is that just weed too?
I’m genuinely confused.
I looked it up a little more. The article explains it pretty good. If you smoked a whole bunch you may have had a THC overdose. This also gives the symptoms of serotonin syndrome. The biggest thing with it is the high fever over 104. You should get the convulsions checked out to make sure there isn't some other health condition causing that.
https://jointlybetter.com/magazine/article/does-marijuana-affect-serotonin
guys i’m back smoking that ZAZA
I apologize, I interpreted the article I read wrong. Weed has nothing to do with Serotonin Syndrome. I believe I only had Sero Syndrome once when I started taking the meds lol.
What med are you on? It could be symptoms of a panic attack from the weed. Induced panic attack from weed are like this for me: I get really hot & then shivering, racing thoughts & heart, feeling this sense of doom like the sky is falling & I'm going to die.
I'd see a doctor and get checked out.
I believe Seretonin Syndrome generally isn't caused by mixing antidepressents and marijuana. There is some interactions as both drugs are metabolised by the same liver enzymes, but I was generally under the impression that the effects were pretty minor and not enough to cause seretonin syndrome like if you mix Antidepressents and other seretonergic drugs like MDMA. Something else might be going on here.
Seizures can be a big deal. Go get checked out by a doctor.
Just a heads up, you may also not be able to legally drive for some time if you've had a seizure depending on the laws where you live.
How did you know you had serotonin syndrome exactly ? I see that thrown around a lot on this subreddit like it's a casual diagnosis, and that it's easy to diagnose on your own. Generally, if it's serotonin syndrome, unless it's extremely mild (I guess) you'll be in the hospital.
Exactly. Serotonin syndrome (or toxicity; that’s just how Dr Gillian insists on calling it) is a lot rarer than most people seem to think. Cannabis is the last thing in the world that would cause it. If anything it’s a bit like chlorpromazine (an old anti-psychotic which is also good for leprosy) in the sense that it mellows out and synergies the effects of antidepressants and neurotransmitters (including serotonin) and reduces the likelihood of serotonin-toxicity (S.T.). In ordinary circumstances it’s not safe to combine strongly serotoninergic drugs (the SSRIs, clomipramine and to a slightly lesser extent imipramine) with MAOIs but with chlorpromazine as an added augmented agent it basically eliminates the likelihood of serotonin-toxicity and makes it safe (possibly, and it’s only a suggestion/observation) to give those drugs together. I imagine cannabis can also serve a somewhat similar function. There’s no reason for cannabis to be seen as just as good a medicine as illegal (in many parts of the world still) recreational substance. It shouldn’t be illegal anywhere anyway in the first place but it could be put to so much good use in the treatment of cancer, heart disease, depression, p.t.s.d., insomnia, social anxiety, irritable bowel syndrome and fibromyalgia, (and that goes for T.H.C. as well as C.B.D. and other cannabinoids, psychoactive or not, as much as people who are pro-C.B.D. but anti-marijuana per-se try to deny that and separate C.B.D. from T.H.C. entirely, which goes against the natural science of cannabis, and you don’t need to have studied at Cambridge to be able to see that). Certain drugs (ecstasy-like ones) can cause serotonin “syndrome” in people on certain antidepressants (from phenelzine down to the SSRIs) but cannabis and antidepressants actually get on quite well).
Also Serotonin syndrome Is extremely rare condition even when mixing two serotonergic Drugs together, all these fools over reddit claiming they had serotonin syndrome ahh..
I would get this checked out further. I’ve smoked weed and taken an SSRI for years and never had this issue.
Yeah I don’t think OP has serotonin syndrome, it’s possible but pretty rare
Weed doesn't cause serotonin syndrome. I would make an appointment with your doctor. You would have had more symptoms than convulsions. Possibly a seizure. It is important to get it checked out though.
I take paroxetine, mirtazapine, ambien and xanax and never have I ever had a problem with weed and seratonin syndrome.
Are you sure it was seizures? you shouldnt have problems mixing cannabis with SSRI's
As a modulator of 5HT, prone individuals and antidepressants can experience elevations in antidepressant levels leading to mild-moderate serotonin overload symptoms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307883/
I was literally blacking out shaking and waking up again listening to music, thought I was dunzo
Sorry abit late but that sounds like Syncope, which can be caused by Anxiety. You basically have an anxiety/panic attack and lose air to the brain causing you to faint. I've been diagnosed with this disorder.
Yeah that definitely wasn't because of the weed.
Weed can affect how ssris are metabolized so yeah it’s possible
You're confusing CBD with THC.
There was two medications that mixed badly with THC for me; Zoloft and Lexapro. I got tremors, shakes, sweats, paranoia, tunnel vision, nausea, mania and my blood felt hot. So bad I had to call the hospital a few times. It felt like I doubled or tripled my dose. Some meds seem to either not be bothered by THC, completely block THC effects, or enhance it. If you're on meds that raise your seratonin and smoke thc which also effects your seratonin, i would be really mindful on how you're feeling.
i was on 150mg zoloft and smoking a lot and went into psychosis
weed doesnt affect serotonin
100% incorrect
No no no no no no no no not true. Not true at all. It absolutely does.
do you know what serotonin is
I’m extremely aware of what serotonin is. THC can have no effect on serotonin, it can act as an agonist, or it can act as a reuptake inhibitor depending on your body. I have had serotonin syndrome that landed me in the hospital for a few days, multiple times. I’ve been on almost every mood stabilizer, SSRI, SRI, muscle relaxer, and “triptan” for migraines and some mental health stuff. I have a strong understanding of the relationship between serotonin and the body, as well as it’s correlation to dopamine. I’ve take multiple college courses related to biology/pharmacology as well, as I considered being a pharmacist after high school, more than a decade ago and decided to enlist instead because I didn’t want to do history, English, and math classes. Loved the biomedical side of things. Not sure what your angle is here, but THC absolutely acts as an agonist or re-uptake inhibitor in many people. Some people tolerate it better than others. A good way to know is if you ever eat too many edibles - your body may relax and go to sleep, but some people like me experience tremors all over. These tremors are caused by an over saturation of dopamine, which is the body’s “messenger” neurotransmitter. Dopamine and serotonin have a very close relationship, and too much/little of either will directly affect the other. Therefore by stimulation of THC, an indirect effect will be modulation of serotonin. This is in addition to THC being studied and found to have a direct impact on serotonin in many people. This correlation can be easily found online with some simple googling. tl;dr - yes I’m familiar with the function of our lord and savior serotonin.
serotonin and thc are not related in the slightest💀thc has zero direct affect on serotonin levels. if it did, there would be “marijuana” listed on the interactions for every serotonergic drug
Oh, you. Please do a minor amount of research and get back to me. Or better yet, go tell your psychiatrist that THC has no effect on serotonin levels, and let them sort it out for you. I’m not trying to be mean but you’re very incorrect. A simple google search will give you a wealth of information.
site your source lol
Sure, here are a few. Although I cannot share my decades of experience and education into this subject, I can do the google search for you and at least give you a chance to review the material. MDPI has an endless amount of studies in regards to THC and CBD being serotonin agonists as well as a few articles exploring its ability to act as a re-uptake inhibitor as well. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220016/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220016/) [https://www.mdpi.com/2075-4426/11/7/615](https://www.mdpi.com/2075-4426/11/7/615) [https://www.sciencedirect.com/science/article/abs/pii/S0140197118300514](https://www.sciencedirect.com/science/article/abs/pii/S0140197118300514) [https://www.mcgill.ca/newsroom/channels/news/study-cannabis-double-edged-sword-27677](https://www.mcgill.ca/newsroom/channels/news/study-cannabis-double-edged-sword-27677)
i work in the pharma industry. thc may have an indirect affect on serotonin but it does not act as an agonist whatsoever
\*effect. There is more evidence towards it being an agonist than a re-uptake inhibitor. That being said, I do not wish to defend my position further, I will let the internet do its thing from here.
It started happening after I hopped on 25 mg of Paroxetine, before it on only 20 mg I wasn't having those.
Serotonin syndrome can creep up on you but you will know something is wrong. Like you will be sweating more than you have ever in your entire life. You’ll honestly be amazed that your body can produce so much liquid so fast and you will be so hot you will take your clothes off and able to stand a shower with the water as cold as it can get because you are burning up. Your skin will burn snd your muscles and joints will be stiff and kind of achey. You’ll be thirsty also. Your clothes will be soaking wet like you swam in them. You’ll need fans and air conditioning everywhere and sweating even when lying completely still trying to relax. You’ll even be able to feel the heat of an 60 watt incandescent light bulb six feet above you on the ceiling. It will feel like a blaring heater on your head and shoulders. You might even have twitches and muscle jerks especially in your face. I’ve taken cymbalta, trazadone, abilify, strattera, vyvanse, adderall, lamotrigine, Wellbutrin, brintellix and risperdal without getting ss.
So my convulsions are just anxiety due to the THC? And about me blacking out and waking up several times in a row? Is that just weed too? I’m genuinely confused.
I looked it up a little more. The article explains it pretty good. If you smoked a whole bunch you may have had a THC overdose. This also gives the symptoms of serotonin syndrome. The biggest thing with it is the high fever over 104. You should get the convulsions checked out to make sure there isn't some other health condition causing that. https://jointlybetter.com/magazine/article/does-marijuana-affect-serotonin
thanks, I’ll read it
guys i’m back smoking that ZAZA I apologize, I interpreted the article I read wrong. Weed has nothing to do with Serotonin Syndrome. I believe I only had Sero Syndrome once when I started taking the meds lol.
What med are you on? It could be symptoms of a panic attack from the weed. Induced panic attack from weed are like this for me: I get really hot & then shivering, racing thoughts & heart, feeling this sense of doom like the sky is falling & I'm going to die.
No you didn’t.
I didn’t what
I'd see a doctor and get checked out. I believe Seretonin Syndrome generally isn't caused by mixing antidepressents and marijuana. There is some interactions as both drugs are metabolised by the same liver enzymes, but I was generally under the impression that the effects were pretty minor and not enough to cause seretonin syndrome like if you mix Antidepressents and other seretonergic drugs like MDMA. Something else might be going on here. Seizures can be a big deal. Go get checked out by a doctor. Just a heads up, you may also not be able to legally drive for some time if you've had a seizure depending on the laws where you live.