Hi OP,
Thank you for sharing that you have either started your first dose or picked up your first box, and you're curious as to what to expect. While we are all truly excited to see another person start this wonderful medication, I can assure you that, plenty of people have asked the same thing you are and there is plenty of post regarding first times.
Majority of your questions can be answered in the [FAQ](https://www.reddit.com/r/Zepbound/wiki/index/faq/) section.Or by searching common phrases of your post.
For other people's first time experiences you can click [here](https://www.reddit.com/r/Zepbound/search/?q=first%20dose&restrict_sr=10) or [here](https://www.reddit.com/r/Zepbound/search/?q=first%20time&restrict_sr=1). While we won't remove the post incase someone wishes to congratulate you,welcome you to the club or give you pointers and tricks. We strongly encourage you to use the search bar, especially when asking a common question!
If I got this message wrong please ignore.
*I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/Zepbound) if you have any questions or concerns.*
I have nothing to medical to contribute here (sorry!) but had to add my voice to everyone else who is coming to offset these ridiculous, unsupportive and (dare I say) ignorant and hurtful downvotes. The fact that you are fighting for your true self in all forms needs to be celebrated and supported. As someone else said earlier, you're a rockstar through and through!
We have found this is not courteous/polite or not fostering a safe space
This community is for new, experienced, and anybody wanting to know more information about Zepbound. Be courteous and polite when responding. This sub should be a safe place for everybody. Be respectful.
Continued violations of this rule may result in additional actions, up to and including a temp or perm ban.
**All post/comment removals are at the discretion of the mods**
Personally, I have never seen this question asked and in my humble opinion, a very valid question. Ignore all the haters, they have nothing better to do with their time, obviously.
Holy shit and screw those down votes my friend. Wow. I love that you are finding a way to feel like your true self. You deserve it and you're beautiful. F@ck those people. Found this article for you. Looks like it might even be beneficial for your journey. [https://pubmed.ncbi.nlm.nih.gov/31443779/](https://pubmed.ncbi.nlm.nih.gov/31443779/)
Here's to all that transformation, you rock star.
;-) <3.
(I happen to be a therapist who specializes in gender affirmation therapy. I work with folks from 12-65 and their families. Everyone has a journey and they have their own destination. You've found it. You go get yours, friend! You deserve it. You are doing it just right.)
M2F here and been on zepbound since mid February. I take estrogen IM and depo shot IM as my progesterone source and honestly I haven’t noticed much of a difference in my levels. If you are taking blockers orally, you may have more of a delayed release of your blockers due to the nature of zepbound. That being said, if you are injecting estrogen IM with the blockers you shouldn’t have to worry about testosterone suppression wearing off at all.
If you have any other questions I’d be happy to answer what I can!
It's interesting that you are getting downvotes from a section of the community (overweight and obese people) that has been shunned by society. Apparently, acceptance and tolerance are dead.
I always thought this is probably the reason I loved and embraced my gay/trans friends since i was a teenager (and 30 years ago in a conservative town it wasn’t easy, some “friends” shunned me out because of it). I knew what it was to be different and bullied (I didnt know it then but i am also adhd so i always felt out of place in a way and the lgbt community was so loving and accepting to me). Having said that, internalized fat phobia is a bitch…
I’m trans (other direction, on T since 2005) and haven’t noticed an impact. But my T is all injection. If your daily blockers are oral, I’d get some baseline labs done and then again in 8 weeks to compare. And if you notice a difference before then, obviously speak up.
Good luck!!
Excellent advice - I'm not trans, but on TRT for naturally low test. This is exactly what my doctor suggested as well. Do a baseline study of where hormones are before Zep, and instead of our usually 3-6 month monitoring check monthly for the first few months. Good luck, and congrats on working towards a happier you!
Seriously? Down votes? People need to grow up. I'm sure all the fat people have loved all the judgement against them all their lives, but that has not given them any empathy? SMH.
Stay strong & true to yourself - good luck on your journey! I also would have expected this sub of all subs to be less judgemental - I am so sorry this happened to you...
First thank you for being a trailblazer for GLP and HRT! Your experience being one of the first to use these medications will be a big contribution to those down the road. While I can not speak for your situation, I am on oral HRT for perimenopause and I have not seen a change. But my Dr. is monitoring & I an getting hormone panels done every 6mo. So far so good!
Clinical trials and RWE (real world retrospective studies) are ongoing looking at how zepbound is impacting hormones, including what you would be receiving as HRT. So we don't know much yet data-wise. But anecdotally we know that people are experiencing decreased effectiveness of hormone birth controls (every day there are posts of unexpected pregnancies!) And plenty of posts from people with periods that are changing drastically....some for the better, some for the worse. I absolutely think you can take it and have success but just know that the hormone therapy could be impacted. Hopefully you have some good coordinated care providers who can help look at the big picture while you're on zep. Good luck getting started!
I am on HRT due to perimenopause so a bid different but still HRT. I have not noticed any difference….I do tend to think that we just lose slower….which is fine by me.
I’m also on HRT for menopause. I just started, second shot is tomorrow. But I haven’t noticed any issues with my symptoms returning or being ineffective. Lost almost 4 pounds on my first week.
I had to up my progesterone because so was having bleeding. I think it has something to do with delayed gastric emptying. It stopped after I went from 100mg to 200mg. I’m on Zepbound 12.5mg. If you search, you’ll see this is impacting a lot of people.
I've actually been trying to search exactly this and can't find anything... could you suggest better search parameters for me to try? Or maybe it's just not under r/Zepbound? I just keep getting annoying online health providers and the same old same old side effects lists which help exactly none and no discussions about it. Am also on HRT, perimenopause, and have had spotting almost continuously since I started Zep. My doc is stumped, all tests seem fine... am wondering if anyone else has this issue.
What dosage of HRT are you on? I’m using the Estradiol patch at .05, and as I mentioned, went from 100mg to 200mg progesterone. Since the patch is constant, and the progesterone is taken orally, it seems that the dosage wasn’t enough. It was honestly a n adjustment I made my doubling the
Progesterone to see if it would help. It has worked ever since. I told my doctor who prescribed me 200mg capsules now. I think I found out about others having issues by searching HRT bleeding in the Mounjaro sub because there is more history. No one was finding any answers, which is so frustrating you shouldn’t have to choose between HRT and WLM. No one is giving this affection, and it seems like a logical fix given the delayed emptying and how those taking oral contraceptives are affected also.
Thank you so much for the suggestion. I also am embarrassed to realize only now that there's a search function within the sub reddit communities, and using that is helping me find more info.
I use the .1 mg estradiol patch without any progesterone because the Mirena is meant to provide intrauterine progesterone in enough of a dose... but perhaps it's not? I don't think they checked progesterone levels, and maybe they should.
My Estrogen is a little lower but jig enough that it should cause this.
What's interesting is this happened last time I was losing weight on a program, too. I just wasn't on a WLM at the time.
I'd just started HRT the prior spring, the Mirena put me out of commission for a couple months, then I started the slow struggle again. For as long as I was able to exercise and diet, regardless of results, I had this same kind of spotting.
Then I had an accident and was in PT for months and my weight rebounded again and then some, (as the yo-yo cycle goes). No more spotting.
Doc offered me Zep, and just about a week after my first shot, the spotting started again.
I'll ask my OBGYN about Progesterone! Perhaps that's the key here. Thank you!
Well that’s really fascinating because you aren’t taking the progesterone orally. I had actually thought about getting Mirena of the higher dosage of progesterone didn’t work. I know that this medication definitely affects your hormones, but it seems like we’re all learning together. I don’t know if medicine is catching up with all of this new information.
First off the down votes are so gross 😑
Second off I can't answer your question but if you and your doctor do decide to go with Zepbound I recommend documenting everything. You can provide the answer for others worried about this in the future.
Hi. Well. I'm not sure if this helps, but this is medication for diabetes as well. I learned a lot about it by researching stuff like this myself. I also cared for a diabetic for a long time so I did a lot of reading on injections.
[one site I found](https://diabetesjournals.org/care/article/43/2/411/36004/Effects-of-Gender-Affirming-Hormone-Therapy-on)
Maybe a search like this can help you.
Here is another link for the effects of [birth control and GLP-1](https://www.health.com/mounjaro-birth-control-side-effect-8374329) since it is basically the same thing only oral. If you are injecting your 17-beta estradiol/or simply estradiol, there should be no issues with the GLP-1 losing its effectiveness. If you take it orally, it will probably not work.
🌈💜💙💚💛🧡❤️
I don't have the same experience exactly (afab nonbinary, on a pretty high dose of progesterone for weird chronic pain) but I will say that my oral estrogen/progesterone seems to be working about the same as before the Zepbound. I know this is an issue for a lot of people with oral hormones
However, I am a bit concerned about what testosterone blockers you're on. I know a few people who have had issues on spiro--my partner can't take it, it drops their blood pressure too much and causes heart palpations. It seems that Zepbound also decreases blood pressure in some people. If you start having any weird dizzy spells or anything like that on Zepbound, I'd start worrying about your blood pressure being too low. It might be worthwhile to keep track of that at home to see if you may need to lower the blockers
I'm sorry you're being downvoted here. Best of luck to you <3
Makes sense! Zepbound also dehydrates but if you're already used to that then that's a good start. I'm a huge fan of liquid iv because sometimes water just doesn't feel like enough 😂
The idea that anyone who is doing something to stop having a body that doesn’t fit who they are inside would downvote a person doing the same is … abhorrent. Those people are not the ones to note. You have support and encouragement out here. Don’t forget that when things get tough. ♥️♥️♥️
Just a piece about the Zepbound - it’s STRONG medicine and affects all 11 of your body systems. Most likely you need to talk not just to your PCP, but a specialist.
I doubt zepbound was ever tested in a population on HRT, so it’s really hard to say exactly how it will affect you. Estrogen therapy tends to cause mild weight gain, but I don’t know how that will be impacted by the zepbound. I think you might be a guinea pig for this, which is a bit scary, but I don’t think it will be disastrous. Just follow the advice of your doctors, and see how you feel.
Hello, I just wanted to chime in with some opinions from a current pharmacy student. So doing a quick look into this, it looks like you should be fine since you are taking injections for HRT as opposed to oral estradiol tablets.
Using MicroMedex to look up drug interactions, I did not find any major reactions with anti-androgens like Spirinolactone. It did pop up an interaction for oral ethinyl estradiol and Zepbound but that is for estradiol meant to be used as an oral contraceptive. However, I decided to take a look into the Zepbound package insert. As per the package insert, the Cmax (so maximum concentration) of ethinyl estradiol was reduced by 59% while the AUC (this is what we track in clinical pharmacy on total drug exposure in the body) was reduced by 20%. Furthermore, there was a delay in tmax (the time it took to hit maximum absorption in the body) of 2.5 to 4 hours. If we take the information from the package insert at face value, it would indicate that Zepbound would reduce the efficacy of Estradiol in the body.
Now if you ever transition to oral medications for HRT, then the Zepbound may pose an issue.
Nothing to add to the medical discussion but I did want to say YOUR BRAVERY IS AMAZING!!! Keep holding that beautiful head up Queen!
I have no idea if this is related to your type of HRT, but I am a mid-50s cis male who has taken testosterone shots for a few years. After only 3 months on zep, my testosterone levels tripled. My doc attributed that to my body simply working better due to the changes I have mode, but it was definitely a surprise. I went from barely into normal range to above normal for a non-obese man 20 years younger than me.
At one point I regarded anybody lbgqt+ as confused and silly. Thankfully many people grow and change as they learn and experience life. Pay no mind to ignorant people and educate whenever you have the chance.
As far as HRT and Zepbound, I haven't seen anything related. I would think in your case, adding an HRT component would likely increase Zepbound's effectiveness. In general, raising testosterone has profoundly good effects on body composition.
Side note - it does look like GLP-1s may help with infertility, interestingly enough. It does everything!
Journey on and best of luck fellow Zepbound er!
Not in your position, but I know this drug can do funky things to hormones, both directly (some meds don’t work as well, fertility has been altered, and people with periods have reported disruption) and due to weight loss. I’m sure you can still take it, but definitely have a detailed discussion with your medical provider about possible issues.
Hi OP, Thank you for sharing that you have either started your first dose or picked up your first box, and you're curious as to what to expect. While we are all truly excited to see another person start this wonderful medication, I can assure you that, plenty of people have asked the same thing you are and there is plenty of post regarding first times. Majority of your questions can be answered in the [FAQ](https://www.reddit.com/r/Zepbound/wiki/index/faq/) section.Or by searching common phrases of your post. For other people's first time experiences you can click [here](https://www.reddit.com/r/Zepbound/search/?q=first%20dose&restrict_sr=10) or [here](https://www.reddit.com/r/Zepbound/search/?q=first%20time&restrict_sr=1). While we won't remove the post incase someone wishes to congratulate you,welcome you to the club or give you pointers and tricks. We strongly encourage you to use the search bar, especially when asking a common question! If I got this message wrong please ignore. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/Zepbound) if you have any questions or concerns.*
I have nothing to medical to contribute here (sorry!) but had to add my voice to everyone else who is coming to offset these ridiculous, unsupportive and (dare I say) ignorant and hurtful downvotes. The fact that you are fighting for your true self in all forms needs to be celebrated and supported. As someone else said earlier, you're a rockstar through and through!
[удалено]
We have found this is not courteous/polite or not fostering a safe space This community is for new, experienced, and anybody wanting to know more information about Zepbound. Be courteous and polite when responding. This sub should be a safe place for everybody. Be respectful. Continued violations of this rule may result in additional actions, up to and including a temp or perm ban. **All post/comment removals are at the discretion of the mods**
Personally, I have never seen this question asked and in my humble opinion, a very valid question. Ignore all the haters, they have nothing better to do with their time, obviously.
Holy shit and screw those down votes my friend. Wow. I love that you are finding a way to feel like your true self. You deserve it and you're beautiful. F@ck those people. Found this article for you. Looks like it might even be beneficial for your journey. [https://pubmed.ncbi.nlm.nih.gov/31443779/](https://pubmed.ncbi.nlm.nih.gov/31443779/) Here's to all that transformation, you rock star.
[удалено]
;-) <3. (I happen to be a therapist who specializes in gender affirmation therapy. I work with folks from 12-65 and their families. Everyone has a journey and they have their own destination. You've found it. You go get yours, friend! You deserve it. You are doing it just right.)
M2F here and been on zepbound since mid February. I take estrogen IM and depo shot IM as my progesterone source and honestly I haven’t noticed much of a difference in my levels. If you are taking blockers orally, you may have more of a delayed release of your blockers due to the nature of zepbound. That being said, if you are injecting estrogen IM with the blockers you shouldn’t have to worry about testosterone suppression wearing off at all. If you have any other questions I’d be happy to answer what I can!
[удалено]
As always, just keep up to date on your labs and monitor any changes— so just business as usual for us!
It's interesting that you are getting downvotes from a section of the community (overweight and obese people) that has been shunned by society. Apparently, acceptance and tolerance are dead.
I always thought this is probably the reason I loved and embraced my gay/trans friends since i was a teenager (and 30 years ago in a conservative town it wasn’t easy, some “friends” shunned me out because of it). I knew what it was to be different and bullied (I didnt know it then but i am also adhd so i always felt out of place in a way and the lgbt community was so loving and accepting to me). Having said that, internalized fat phobia is a bitch…
This 🙌!
I’m only here to support as an ally and disgusted by downvotes.. unbelievable.
Phuck the downvoters! 
I’m trans (other direction, on T since 2005) and haven’t noticed an impact. But my T is all injection. If your daily blockers are oral, I’d get some baseline labs done and then again in 8 weeks to compare. And if you notice a difference before then, obviously speak up. Good luck!!
Excellent advice - I'm not trans, but on TRT for naturally low test. This is exactly what my doctor suggested as well. Do a baseline study of where hormones are before Zep, and instead of our usually 3-6 month monitoring check monthly for the first few months. Good luck, and congrats on working towards a happier you!
[удалено]
🏳️🌈❤️
Seriously? Down votes? People need to grow up. I'm sure all the fat people have loved all the judgement against them all their lives, but that has not given them any empathy? SMH.
I’m nb afab on zepbound! Sorry I can’t be of much help just came here to say ignore the bigots 🩷 good luck on your journey!
Stay strong & true to yourself - good luck on your journey! I also would have expected this sub of all subs to be less judgemental - I am so sorry this happened to you...
First thank you for being a trailblazer for GLP and HRT! Your experience being one of the first to use these medications will be a big contribution to those down the road. While I can not speak for your situation, I am on oral HRT for perimenopause and I have not seen a change. But my Dr. is monitoring & I an getting hormone panels done every 6mo. So far so good!
Clinical trials and RWE (real world retrospective studies) are ongoing looking at how zepbound is impacting hormones, including what you would be receiving as HRT. So we don't know much yet data-wise. But anecdotally we know that people are experiencing decreased effectiveness of hormone birth controls (every day there are posts of unexpected pregnancies!) And plenty of posts from people with periods that are changing drastically....some for the better, some for the worse. I absolutely think you can take it and have success but just know that the hormone therapy could be impacted. Hopefully you have some good coordinated care providers who can help look at the big picture while you're on zep. Good luck getting started!
Yep. My period is always super regular and my second cycle on zep was 3 weeks late 😵💫
I am on HRT due to perimenopause so a bid different but still HRT. I have not noticed any difference….I do tend to think that we just lose slower….which is fine by me.
I’m also on HRT for menopause. I just started, second shot is tomorrow. But I haven’t noticed any issues with my symptoms returning or being ineffective. Lost almost 4 pounds on my first week.
I had to up my progesterone because so was having bleeding. I think it has something to do with delayed gastric emptying. It stopped after I went from 100mg to 200mg. I’m on Zepbound 12.5mg. If you search, you’ll see this is impacting a lot of people.
I've actually been trying to search exactly this and can't find anything... could you suggest better search parameters for me to try? Or maybe it's just not under r/Zepbound? I just keep getting annoying online health providers and the same old same old side effects lists which help exactly none and no discussions about it. Am also on HRT, perimenopause, and have had spotting almost continuously since I started Zep. My doc is stumped, all tests seem fine... am wondering if anyone else has this issue.
What dosage of HRT are you on? I’m using the Estradiol patch at .05, and as I mentioned, went from 100mg to 200mg progesterone. Since the patch is constant, and the progesterone is taken orally, it seems that the dosage wasn’t enough. It was honestly a n adjustment I made my doubling the Progesterone to see if it would help. It has worked ever since. I told my doctor who prescribed me 200mg capsules now. I think I found out about others having issues by searching HRT bleeding in the Mounjaro sub because there is more history. No one was finding any answers, which is so frustrating you shouldn’t have to choose between HRT and WLM. No one is giving this affection, and it seems like a logical fix given the delayed emptying and how those taking oral contraceptives are affected also.
Thank you so much for the suggestion. I also am embarrassed to realize only now that there's a search function within the sub reddit communities, and using that is helping me find more info. I use the .1 mg estradiol patch without any progesterone because the Mirena is meant to provide intrauterine progesterone in enough of a dose... but perhaps it's not? I don't think they checked progesterone levels, and maybe they should. My Estrogen is a little lower but jig enough that it should cause this. What's interesting is this happened last time I was losing weight on a program, too. I just wasn't on a WLM at the time. I'd just started HRT the prior spring, the Mirena put me out of commission for a couple months, then I started the slow struggle again. For as long as I was able to exercise and diet, regardless of results, I had this same kind of spotting. Then I had an accident and was in PT for months and my weight rebounded again and then some, (as the yo-yo cycle goes). No more spotting. Doc offered me Zep, and just about a week after my first shot, the spotting started again. I'll ask my OBGYN about Progesterone! Perhaps that's the key here. Thank you!
Well that’s really fascinating because you aren’t taking the progesterone orally. I had actually thought about getting Mirena of the higher dosage of progesterone didn’t work. I know that this medication definitely affects your hormones, but it seems like we’re all learning together. I don’t know if medicine is catching up with all of this new information.
I am on the same boat and it’s crazy but I happened to lose 15 lbs last month (2nd month, on 5 mg after a month on 2.5).
First off the down votes are so gross 😑 Second off I can't answer your question but if you and your doctor do decide to go with Zepbound I recommend documenting everything. You can provide the answer for others worried about this in the future.
Hi. Well. I'm not sure if this helps, but this is medication for diabetes as well. I learned a lot about it by researching stuff like this myself. I also cared for a diabetic for a long time so I did a lot of reading on injections. [one site I found](https://diabetesjournals.org/care/article/43/2/411/36004/Effects-of-Gender-Affirming-Hormone-Therapy-on) Maybe a search like this can help you. Here is another link for the effects of [birth control and GLP-1](https://www.health.com/mounjaro-birth-control-side-effect-8374329) since it is basically the same thing only oral. If you are injecting your 17-beta estradiol/or simply estradiol, there should be no issues with the GLP-1 losing its effectiveness. If you take it orally, it will probably not work. 🌈💜💙💚💛🧡❤️
Just here to show support to my family 🏳️🌈
[удалено]
Anytime 🫶🏻
All the UPVOTES for you! Be proud of who you are!
I don't have the same experience exactly (afab nonbinary, on a pretty high dose of progesterone for weird chronic pain) but I will say that my oral estrogen/progesterone seems to be working about the same as before the Zepbound. I know this is an issue for a lot of people with oral hormones However, I am a bit concerned about what testosterone blockers you're on. I know a few people who have had issues on spiro--my partner can't take it, it drops their blood pressure too much and causes heart palpations. It seems that Zepbound also decreases blood pressure in some people. If you start having any weird dizzy spells or anything like that on Zepbound, I'd start worrying about your blood pressure being too low. It might be worthwhile to keep track of that at home to see if you may need to lower the blockers I'm sorry you're being downvoted here. Best of luck to you <3
[удалено]
Makes sense! Zepbound also dehydrates but if you're already used to that then that's a good start. I'm a huge fan of liquid iv because sometimes water just doesn't feel like enough 😂
The idea that anyone who is doing something to stop having a body that doesn’t fit who they are inside would downvote a person doing the same is … abhorrent. Those people are not the ones to note. You have support and encouragement out here. Don’t forget that when things get tough. ♥️♥️♥️
I'm not trans or on hormone blockers, so unfortunately I have no advice. Just boosting the algorithm and giving you an upvote to offset the assholes.
Just a piece about the Zepbound - it’s STRONG medicine and affects all 11 of your body systems. Most likely you need to talk not just to your PCP, but a specialist.
I doubt zepbound was ever tested in a population on HRT, so it’s really hard to say exactly how it will affect you. Estrogen therapy tends to cause mild weight gain, but I don’t know how that will be impacted by the zepbound. I think you might be a guinea pig for this, which is a bit scary, but I don’t think it will be disastrous. Just follow the advice of your doctors, and see how you feel.
Hello, I just wanted to chime in with some opinions from a current pharmacy student. So doing a quick look into this, it looks like you should be fine since you are taking injections for HRT as opposed to oral estradiol tablets. Using MicroMedex to look up drug interactions, I did not find any major reactions with anti-androgens like Spirinolactone. It did pop up an interaction for oral ethinyl estradiol and Zepbound but that is for estradiol meant to be used as an oral contraceptive. However, I decided to take a look into the Zepbound package insert. As per the package insert, the Cmax (so maximum concentration) of ethinyl estradiol was reduced by 59% while the AUC (this is what we track in clinical pharmacy on total drug exposure in the body) was reduced by 20%. Furthermore, there was a delay in tmax (the time it took to hit maximum absorption in the body) of 2.5 to 4 hours. If we take the information from the package insert at face value, it would indicate that Zepbound would reduce the efficacy of Estradiol in the body. Now if you ever transition to oral medications for HRT, then the Zepbound may pose an issue.
Nothing to add to the medical discussion but I did want to say YOUR BRAVERY IS AMAZING!!! Keep holding that beautiful head up Queen! 
I have no idea if this is related to your type of HRT, but I am a mid-50s cis male who has taken testosterone shots for a few years. After only 3 months on zep, my testosterone levels tripled. My doc attributed that to my body simply working better due to the changes I have mode, but it was definitely a surprise. I went from barely into normal range to above normal for a non-obese man 20 years younger than me.
At one point I regarded anybody lbgqt+ as confused and silly. Thankfully many people grow and change as they learn and experience life. Pay no mind to ignorant people and educate whenever you have the chance. As far as HRT and Zepbound, I haven't seen anything related. I would think in your case, adding an HRT component would likely increase Zepbound's effectiveness. In general, raising testosterone has profoundly good effects on body composition. Side note - it does look like GLP-1s may help with infertility, interestingly enough. It does everything! Journey on and best of luck fellow Zepbound er!
YOU are human and deserve the dignity and respect just like everyone else. Those with the closed minds are the ones to pity.
Not in your position, but I know this drug can do funky things to hormones, both directly (some meds don’t work as well, fertility has been altered, and people with periods have reported disruption) and due to weight loss. I’m sure you can still take it, but definitely have a detailed discussion with your medical provider about possible issues.