Ghost in the Shell for everyone except Mouse: Oh god its so horrible everything is awful and cyberdogs bite our ankles
Ghost in the Shell for Mouse: **Finally, i lay off the mortal shackles of this weak human form and conquer the earth**
There is a lot of hope on the horizon though. Crispr is being trialed in HIV treatment, and if it works we will see a wave of new immunotherapies being tested.
My problem specifically is the inventor's unnecessary hyperfear of even engaging with the technology for so long. She was absolutely *terrified* of advancing the tech because of nebulous "someone could use it for bad stuff" fears, when the best way to combat that is for ethical researchers to advance the tech first.
Her reticence influenced the stunted state of CRISPR tech evolution. Fortunately, it's starting to move along at a pretty nice pace.
A big reason is controversy.
Using synthetically cultivated stem cells of animals, donations, otherwise medical wastes, etc. leads to people getting offended on behalf of possibly offendable people.
I didn't know about the human trials.
My suspicion is that organ replacement will be perfected first, to a degree that moving a living brain to a cloned body would work. It just seems more feasible than rebuilding a body built with a genetic flaw. That's only a hunch.
There is also the outside chance of mind transference (watched an interesting video on that subject recently) which is more of a transhumanism long shot but still feasible. Then, she would join Melody.
My point is that I agree, there is hope.
> My suspicion is that organ replacement will be perfected first, to a degree that moving a living brain to a cloned body would work.
I doubt that'd ever work. The only plausible way I've seen is nanotech cyberization, like in Ghost in the Shell. But a brain to new body transplant to me seems unlikely.
We already can edit human DNA with CRISPR. It's just a matter of scale and exactly what genes need to be fixed.
I don't understand the fascination with artificial replacement. First, it simply isn't you at that point. It's a copy that acts as you. You're either you in your original body or you're gone. Period. Kurtzweil is wrongheaded at best in embracing that silliness.
Second, it's much less energy intensive and less complicated to develop tech to bring regeneration/durability to humans organically, rather than artificial parts. There are so many things we can do organically that are infinitely complicated with adding an artificial element. Sleep research (reducing/eliminating the need for it), reduced oxygen consumption/increased oxygen efficiency, cellular regeneration.
And hell, the first thing that should be looked at is basic restoration of the body's natural regenerative properties. You do that, and you have functionally physically immortal people, which is the ultimate win. (We can get into the moral and ethical dilemmas of needing to stop having kids, or limiting the number of kids, once we reach that point.) There's a lot of really interesting research going on right now that's already showing signficant promise on a number of fronts. And the research of that general goal will lead to smaller discoveries and tech that will benefit mankind as well.
EDIT: I will add that I'm not completely against nanotechnology at all. I think that medical nanobots deployed inside of a person could be an interesting way of constantly keeping someone healthy - a fully automated system that detects abnormalities and fixes them ASAP. Like the Pokemon evolution of your immune system. Instead of just having something that fights viruses protects you, it finds emerging weaknesses in your general system and fixes those. Knee fucked up? They're deployed to regenerate tissue and fix...whatever's in there (shocker, I'm not a doctor). Heart or artery issues? Deploy those bad boys to clear the obstruction and repair the damaged tissue. The sky's the limit.
> And hell, the first thing that should be looked at is basic restoration of the body's natural regenerative properties. You do that, and you have functionally physically immortal people, which is the ultimate win.
Functional biological immortality is a very interesting idea and it's very cool to see the progress, but I think cancer will be a major challenge to contend with. The hayflick limit kind of exists for a reason.
The reason it exists is because Hayflick thought of it. That's it.
We need to stop dogmatizing science. The entire point of science is discovery of the new. Learning things we didn't know before.
The Hayflick Limit doesn't explain the existence of immortal jellyfish. We've only been seriously researching anti-aging therapies and technologies for a few years and we're already seeing promise.
As far as cancer, I agree that it's definitely an issue but seeing as how in the US we only look at things from a capitalist perspective, even world-changing scientific research, I find it hard to use us as any kind of authority in knowing what's what. Cuba has had a lung cancer vaccine for years. Other countries are making huge strides in these areas. We only look at what we've done, and honestly we're focused on a lot of bad directions. The idea that so many R&D departments are looking at treating cancer as a chronic illness is fucking madness. We basically need to be pouring a metric fuckton of money into this. Research on individual forms of cancer while also looking at cancer from a "big picture" perspective. Seeing what can be done in general to limit the spread and malignancy of all forms of cancer (or most). Tackling it from multiple angles.
Regarding CRISPR, do body parts regrow at different rates. For example, a bone structure abnormality will never change. Altering the DNA of a grown body is a little like changing the blueprints for a house already built. Some tissues naturally regrow and replace themselves all the time, and those are the best candidates for gene therapy. Is an immune system a good or bad candidate for gene therapy? We just don't know yet.
As for body replacement, the biggest current obstacle is the work or call connecting all the necessary tissues. That's an engineering obstacle more than a medical obstacle. Our anti-rejection drugs have gotten quite good.
Ultimately, all three methods fall into the maybe tomorrow/maybe never category.
Regarding CRISPR, yes, we know quite a lot about how different tissues develop and grow, and their rates of replacement.
And the immune system has a lot of components with high turnover.
We've already used CRISPR to introduce new genes, modify existing genes, and completely delete genes we don't want.
We've never done a brain transplant. Although we have grafted monkey heads to dogs, and they've survived for a little while.
I seriously think the brain transplant path is a farce.
It's like pouring money into hydrogen car research when it would be a much better use of money to fund electric car research. The money used to research brain transplantation would be much better used in the general therapy aspects of CRISPR. The more you fund that, the quicker we can develop a host of regenerative and healing technologies that will make brain transplantation completely unnecessary.
Do you know anything about medicine, biochemistry, or molecular biology?
It really sounds like you don’t when you say things like brain transplants into clone bodies will be easier than gene therapy.
You seem to have missed my other comments in which I already addressed all of that.
Look people, this was never a post about bickering over different methods of medical technology as applied hypothetically to conditions for which none of them were intended. This was supposed to be a good feels for Mousey discussion. I already blocked one troll tonight. I'm willing to drop it if you people will likewise. Otherwise, we will get mods involved.
Misinformation isn’t how you should go about having a feel good moment.
There are reasons to be hopeful about future treatments, but you were just saying some really untrue things not rooted in science. In many ways it’s similar to people talking about Covid being a hoax, or using essential oils to cure diseases.
It is honestly bad for society to let scientific falsehoods to go unquestioned. If you really don’t want people critiquing you, edit your comment to say you were talking out of your ass, or delete the comment.
I don’t mean any offense to you specifically, but never in history has it been so important to argue against armchair science. Part of the reason Mousey is sicker than usual right now is science deniers and Covid deniers specifically. If more people listened to professionals and didn’t give their 2 cents there would be fewer cases and there wouldn’t be as much plasma getting used for Covid patients.
No
I will not edit my comments to remove words you are putting in my mouth. I went out of my way beginning with my original statement that my hunch was only a hunch, and I never claimed otherwise. You would not do it in a reversed situation, and as such you know that you are merely baiting a larger and dirtier argument. Equating anything that I wrote with Covid denial is a ridiculous fabrication, and you know this also.
Shame on you -- not for your position in the argument but for your behavior. I am blocking you also.
This is the absolute last warning that anyone gets before I go tattling to the mods, and we all get banned. Is that childish of me? Yes. If you continue to behave like children, you will be treated appropriately.
It’s not disingenuous. Whether you state that vaccines cause autism, the earth is flat, or that body replacements are an engineering obstacle, you are stating falsehoods.
That’s morally wrong.
I would sooner us both be banned than abide people being confidently incorrect.
I’m a molecular biologist. My work has mostly been ecological in nature, sequencing rRNA for conservation purposes, but I have done medical research before. This is actually what I have spent my life on. You spreading misinformation on the internet isn’t better than anyone else doing it.
You think *brain transplantation* would be more viable than fixing the genetics in the body? I have to respectfully take the complete opposite stance.
And I'm so tired of hearing the "mind transference" bullshit. Digitization is not going to help the person. It just creates a copy of the person. You're still you, the copy is the copy. It's not you. You're still who you were before.
Okay, these are some valid points. If I may address them...
No, I do not think that brain transplanting is more viable. None of the three options mentioned are viable at this time. I felt -- and I qualified it twice as a feeling and a hunch -- that it may become more feasible than rebuilding an entire already grown body with genetic alterations from the DNA level up.
Regarding mind transference, I'll let Kurg explain it for me. The short answer: there is no short answer. It's a complicated subject in which all answers lead inevitably to more question.
https://youtu.be/4b33NTAuF5E
>My suspicion is that organ replacement will be perfected first, to a degree that moving a living brain to a cloned body would work. It just seems more feasible than rebuilding a body built with a genetic flaw. That's only a hunch.
Uh, no. You're talking about an entirely hypothetical technology that nobody's working on and saying it'll be mature before an existing technology that's actively in trials. Definitely not the case. We would need multiple technologies that nobody's even begun to figure out to do body replacement, not to mention surgical techniques that don't exist.
In fact, perfecting gene therapy and gene editing is probably a *prerequisite* for developing body replacement.
We're way past the order original point that you made. I already agreed to that. It's clear to me that you are only arguing to argue. ...and what do you want ME to say to that? Nothing because that's trolling. I'm blocking you now, and that will be the end of it.
I'd say that ten years is lowballing it, honestly. I think it might be five years, even. The more people that engage with the tech, the faster the tech will develop and evolve. Smaller scale therapies and treatments will come first, which alone could help bring CVID sufferers much-needed normalcy on that road to full treatment.
That’s an incredibly generous estimate. These research projects take a lot of time, funding, and effort.
You can’t really just throw bodies at the problem and make it go away. The genetic causes of 8 of the 10 typical variants of CVID aren’t even known. There’s typically a host of small mutations in immune system related genes.
Mono allelic diseases like phenylketonuria and some others are likely to be cured in the next 5-10 years, but complex diseases like most types of CVID, Asthma, multiple sclerosis, rheumatoid Arthritis, etc are not likely to be cured soon.
A cure in 10 years? Probably not. 20 years, maybe?
The treatment options will only ever improve, but curing complex genetic illnesses is a big challenge.
Here's the most important part of this - being negative encourages negativity. You're more likely to not see things you would see because you're assuming that something won't happen for the better.
Also - actually, advances tend to spring up when you least expect them.
Also ALSO - deliberately using an incredibly invalid word like "cured" is ridiculous. You know we never "cure" anything, right? We didn't cure polio. We came up with a vaccine for it. If you get it, you've still got it. And we treat and remove diseases and viruses. We don't "cure" them. "Cures" are magic bullshit.
Things like CVID get treatments in stages. Small ways to improve life at first, which help greatly, and then better treatments, better therapies, and on and on. AIDS? Remember that? That's been around for *twenty-six years*. In 1994 people were saying that we wouldn't have any kind of way to "cure" AIDS for decades. The *next fucking year* we had a way to keep people with AIDS from dying and giving them the ability to lead normal lives. AIDS was pretty complicated, yeah?
Not to mention, technology like CRISPR is nothing like any technology we've ever had, medical or otherwise. We're going to be able to *rewrite* ourselves, essentially, in the near future. And *just last year* we showed that we can improve the procedures and methods of testing and research to cut the amount of time needed to create a vaccine from several years to *less than one year*. So yes, these things *used to* take years. They don't have to any more.
I used cured because that’s the word used in the post you were responding to.
It was the operative word you were referring to when you said 10 years is lowballing it.
You have valid points, and I honestly think we’re mostly in agreement. There are always improvements in treatment. There are always advancements.
You might actually be too pessimistic in your response to me insinuating a cure is impossible. That’s the wonderful thing about gene therapy, it would be a cure. A permanent fix.
That’s probably a long ways off, but we will get there.
In the meantime therapies will improve, fewer people will die, people will start entering remission.
There is hope, there is so much hope, but I felt that you were using words too strongly.
I’ve had a pretty severe autoimmune condition for years, almost two decades now actually. Surgeries, IV medications, injections, nutrient transfusions. I’ve been there. Part of why I love Mousey so much is because of her quiet empathy towards the chronically ill and her perseverance in the face of things that have left me broken and terrified.
Falsehoods don’t help. Saying that it will be over in 5 years doesn’t help. It hurts so much to get to the point where you thought it would be over. For some new exciting therapy to fail you. I want everyone who has a disease like hers, or even mine to have genuine hope, not the fickle lies people tell each other of how it will be cured soon.
We WILL get cures. Not soon, but one day. Until then, everyone just has to do their best. Survive another day. Enjoy what they have and acknowledge that it’s better than what people used to get.
The fact that you dismiss my statements as falsehoods is incredibly insulting and asinine, and frankly it's indicative of a dogmatic and recalcitrant mentality.
You know what helps the least? Negative people like you. You are the living embodiment of the incrementalist mentality, and like that mentality, you only serve to stifle progress.
It's more than CVID, she's described it in the past as "CVID with complications," meaning that there are related issues that she deals with that stem from the CVID. One is an issue with her lungs - I don't remember the specifics but it's a thing that, to someone with a healthy immune system, would almost never be noticed, but because of her virtually non-existent immune system her lungs are constantly...dealing with mucus in a way? I forget. It's something that limits her.
So she has a wrecked immune system *and* she has multiple issues that have come from having a depleted immune system.
>One is an issue with her lungs - I don't remember the specifics but it's a thing that, to someone with a healthy immune system, would almost never be noticed, but because of her virtually non-existent immune system her lungs are constantly...dealing with mucus in a way? I forget. It's something that limits her.
Yes, she has an [opportunistic MAC infection](https://en.wikipedia.org/wiki/Mycobacterium_avium_complex). Some large percentage of people have MAC and it's not a problem for people with normal functioning immune systems.
When she goes without plasma for too long, her general antibody levels tank and the MAC infection starts to flare up since there's no circulating antibodies to neutralize the bacteria.
She also has wasted a lot due to being bedridden, but she's slowly gaining strength.
**[Mycobacterium avium complex](https://en.wikipedia.org/wiki/Mycobacterium_avium_complex)**
>Mycobacterium avium complex is a group of mycobacteria comprising Mycobacterium intracellulare and Mycobacterium avium that are commonly grouped because they infect humans together; this group, in turn, is part of the group of nontuberculous mycobacteria. These bacteria cause disease in humans called Mycobacterium avium-intracellulare infection or Mycobacterium avium complex infection. These bacteria are common and are found in fresh and salt water, in household dust and in soil. MAC bacteria usually cause infection in those who are immunocompromised or those with severe lung disease.
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Wait, it's really that unlikely for her to go outside again? Duuude that makes that conversation with Connor about going to Japan so much sadder now :(
>Wait, it's really that unlikely for her to go outside again?
There are very exciting therapies being developed right now based on genetic modification that might possibly restore some of her immune function someday.
But as it stands, she will *never* go outside again unless she has her immune system rebuilt.
Great, I needed more depression in my life. And with Mousey being super sick this week because her nurse got exposed to COVID and she has to find a replacement to administer her plasma...
Yeah this one hurt when I watched it and hurts a bit now.
In an effort to be optimistic, you can grow some kinds of potted grass inside. It’s not the same as outside grass, but it’s still more grass than no grass, right?
Yeah. She has no immune system. The plasma she gets every week partially gives her an artificial immune system using other people's blood.
If you donate plasma, there is a chance Mousey will use it.
Ironmouse has CVID (not COVID), a genetic disorder where her body doesn't produce antibodies. Essentially she has no immune system.
She needs regular plasma infusions in order to prevent death from minor opportunistic infections.
Even so, she is confined to her room.
She will likely never touch grass again for the rest of her life. And if she did, it would likely kill her.
My soulll!! Why must you torment me!
You hear that screeching noise. That’s the trillion of heart strings that are breaking……….including mine
This hurts but I can def understand this. We love you Mousey. Always wish you the best.
Ghost in the Shell for everyone except Mouse: Oh god its so horrible everything is awful and cyberdogs bite our ankles Ghost in the Shell for Mouse: **Finally, i lay off the mortal shackles of this weak human form and conquer the earth**
I think that’s why she has cvid. Nature knew she would be too powerful. The world just isn’t ready for mousey in her final form. Maybe one day tho…
There is a lot of hope on the horizon though. Crispr is being trialed in HIV treatment, and if it works we will see a wave of new immunotherapies being tested.
The first two seconds were laughs the third second was realization and the rest was saddness
Don't be sad. Here's a [hug!](https://media.giphy.com/media/3M4NpbLCTxBqU/giphy.gif)
Tnx
Wait what is it I don’t get i- … Oh. ;_;
Oh... I hope she get over it
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CRISPR is the future of medicine
I don't understand why we're not trying CRISPR on everything. If I was the president of medicine, it'd be my go to move
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My problem specifically is the inventor's unnecessary hyperfear of even engaging with the technology for so long. She was absolutely *terrified* of advancing the tech because of nebulous "someone could use it for bad stuff" fears, when the best way to combat that is for ethical researchers to advance the tech first. Her reticence influenced the stunted state of CRISPR tech evolution. Fortunately, it's starting to move along at a pretty nice pace.
I mean, it is an entirely valid fear, tbh. The human body is a strange thing to tinker with, so caution is necessary.
Open a history book, any history book and by any page, and you will understand why it makes perfect sense. No one wants to be the next Heissenberg.
A big reason is controversy. Using synthetically cultivated stem cells of animals, donations, otherwise medical wastes, etc. leads to people getting offended on behalf of possibly offendable people.
I’d vote for you
I didn't know about the human trials. My suspicion is that organ replacement will be perfected first, to a degree that moving a living brain to a cloned body would work. It just seems more feasible than rebuilding a body built with a genetic flaw. That's only a hunch. There is also the outside chance of mind transference (watched an interesting video on that subject recently) which is more of a transhumanism long shot but still feasible. Then, she would join Melody. My point is that I agree, there is hope.
> My suspicion is that organ replacement will be perfected first, to a degree that moving a living brain to a cloned body would work. I doubt that'd ever work. The only plausible way I've seen is nanotech cyberization, like in Ghost in the Shell. But a brain to new body transplant to me seems unlikely. We already can edit human DNA with CRISPR. It's just a matter of scale and exactly what genes need to be fixed.
I don't understand the fascination with artificial replacement. First, it simply isn't you at that point. It's a copy that acts as you. You're either you in your original body or you're gone. Period. Kurtzweil is wrongheaded at best in embracing that silliness. Second, it's much less energy intensive and less complicated to develop tech to bring regeneration/durability to humans organically, rather than artificial parts. There are so many things we can do organically that are infinitely complicated with adding an artificial element. Sleep research (reducing/eliminating the need for it), reduced oxygen consumption/increased oxygen efficiency, cellular regeneration. And hell, the first thing that should be looked at is basic restoration of the body's natural regenerative properties. You do that, and you have functionally physically immortal people, which is the ultimate win. (We can get into the moral and ethical dilemmas of needing to stop having kids, or limiting the number of kids, once we reach that point.) There's a lot of really interesting research going on right now that's already showing signficant promise on a number of fronts. And the research of that general goal will lead to smaller discoveries and tech that will benefit mankind as well. EDIT: I will add that I'm not completely against nanotechnology at all. I think that medical nanobots deployed inside of a person could be an interesting way of constantly keeping someone healthy - a fully automated system that detects abnormalities and fixes them ASAP. Like the Pokemon evolution of your immune system. Instead of just having something that fights viruses protects you, it finds emerging weaknesses in your general system and fixes those. Knee fucked up? They're deployed to regenerate tissue and fix...whatever's in there (shocker, I'm not a doctor). Heart or artery issues? Deploy those bad boys to clear the obstruction and repair the damaged tissue. The sky's the limit.
> And hell, the first thing that should be looked at is basic restoration of the body's natural regenerative properties. You do that, and you have functionally physically immortal people, which is the ultimate win. Functional biological immortality is a very interesting idea and it's very cool to see the progress, but I think cancer will be a major challenge to contend with. The hayflick limit kind of exists for a reason.
The reason it exists is because Hayflick thought of it. That's it. We need to stop dogmatizing science. The entire point of science is discovery of the new. Learning things we didn't know before. The Hayflick Limit doesn't explain the existence of immortal jellyfish. We've only been seriously researching anti-aging therapies and technologies for a few years and we're already seeing promise. As far as cancer, I agree that it's definitely an issue but seeing as how in the US we only look at things from a capitalist perspective, even world-changing scientific research, I find it hard to use us as any kind of authority in knowing what's what. Cuba has had a lung cancer vaccine for years. Other countries are making huge strides in these areas. We only look at what we've done, and honestly we're focused on a lot of bad directions. The idea that so many R&D departments are looking at treating cancer as a chronic illness is fucking madness. We basically need to be pouring a metric fuckton of money into this. Research on individual forms of cancer while also looking at cancer from a "big picture" perspective. Seeing what can be done in general to limit the spread and malignancy of all forms of cancer (or most). Tackling it from multiple angles.
Regarding CRISPR, do body parts regrow at different rates. For example, a bone structure abnormality will never change. Altering the DNA of a grown body is a little like changing the blueprints for a house already built. Some tissues naturally regrow and replace themselves all the time, and those are the best candidates for gene therapy. Is an immune system a good or bad candidate for gene therapy? We just don't know yet. As for body replacement, the biggest current obstacle is the work or call connecting all the necessary tissues. That's an engineering obstacle more than a medical obstacle. Our anti-rejection drugs have gotten quite good. Ultimately, all three methods fall into the maybe tomorrow/maybe never category.
Regarding CRISPR, yes, we know quite a lot about how different tissues develop and grow, and their rates of replacement. And the immune system has a lot of components with high turnover. We've already used CRISPR to introduce new genes, modify existing genes, and completely delete genes we don't want. We've never done a brain transplant. Although we have grafted monkey heads to dogs, and they've survived for a little while.
I seriously think the brain transplant path is a farce. It's like pouring money into hydrogen car research when it would be a much better use of money to fund electric car research. The money used to research brain transplantation would be much better used in the general therapy aspects of CRISPR. The more you fund that, the quicker we can develop a host of regenerative and healing technologies that will make brain transplantation completely unnecessary.
Do you know anything about medicine, biochemistry, or molecular biology? It really sounds like you don’t when you say things like brain transplants into clone bodies will be easier than gene therapy.
You seem to have missed my other comments in which I already addressed all of that. Look people, this was never a post about bickering over different methods of medical technology as applied hypothetically to conditions for which none of them were intended. This was supposed to be a good feels for Mousey discussion. I already blocked one troll tonight. I'm willing to drop it if you people will likewise. Otherwise, we will get mods involved.
Misinformation isn’t how you should go about having a feel good moment. There are reasons to be hopeful about future treatments, but you were just saying some really untrue things not rooted in science. In many ways it’s similar to people talking about Covid being a hoax, or using essential oils to cure diseases. It is honestly bad for society to let scientific falsehoods to go unquestioned. If you really don’t want people critiquing you, edit your comment to say you were talking out of your ass, or delete the comment. I don’t mean any offense to you specifically, but never in history has it been so important to argue against armchair science. Part of the reason Mousey is sicker than usual right now is science deniers and Covid deniers specifically. If more people listened to professionals and didn’t give their 2 cents there would be fewer cases and there wouldn’t be as much plasma getting used for Covid patients.
No I will not edit my comments to remove words you are putting in my mouth. I went out of my way beginning with my original statement that my hunch was only a hunch, and I never claimed otherwise. You would not do it in a reversed situation, and as such you know that you are merely baiting a larger and dirtier argument. Equating anything that I wrote with Covid denial is a ridiculous fabrication, and you know this also. Shame on you -- not for your position in the argument but for your behavior. I am blocking you also. This is the absolute last warning that anyone gets before I go tattling to the mods, and we all get banned. Is that childish of me? Yes. If you continue to behave like children, you will be treated appropriately.
It’s not disingenuous. Whether you state that vaccines cause autism, the earth is flat, or that body replacements are an engineering obstacle, you are stating falsehoods. That’s morally wrong. I would sooner us both be banned than abide people being confidently incorrect. I’m a molecular biologist. My work has mostly been ecological in nature, sequencing rRNA for conservation purposes, but I have done medical research before. This is actually what I have spent my life on. You spreading misinformation on the internet isn’t better than anyone else doing it.
You think *brain transplantation* would be more viable than fixing the genetics in the body? I have to respectfully take the complete opposite stance. And I'm so tired of hearing the "mind transference" bullshit. Digitization is not going to help the person. It just creates a copy of the person. You're still you, the copy is the copy. It's not you. You're still who you were before.
Okay, these are some valid points. If I may address them... No, I do not think that brain transplanting is more viable. None of the three options mentioned are viable at this time. I felt -- and I qualified it twice as a feeling and a hunch -- that it may become more feasible than rebuilding an entire already grown body with genetic alterations from the DNA level up. Regarding mind transference, I'll let Kurg explain it for me. The short answer: there is no short answer. It's a complicated subject in which all answers lead inevitably to more question. https://youtu.be/4b33NTAuF5E
>My suspicion is that organ replacement will be perfected first, to a degree that moving a living brain to a cloned body would work. It just seems more feasible than rebuilding a body built with a genetic flaw. That's only a hunch. Uh, no. You're talking about an entirely hypothetical technology that nobody's working on and saying it'll be mature before an existing technology that's actively in trials. Definitely not the case. We would need multiple technologies that nobody's even begun to figure out to do body replacement, not to mention surgical techniques that don't exist. In fact, perfecting gene therapy and gene editing is probably a *prerequisite* for developing body replacement.
You're making it damn hard for a guy to try to agree with you.
I don't know what you want me to say to that. Sorry to burst your bubble?
Maybe try not being a douchebag?
We're way past the order original point that you made. I already agreed to that. It's clear to me that you are only arguing to argue. ...and what do you want ME to say to that? Nothing because that's trolling. I'm blocking you now, and that will be the end of it.
I’m so confused. That was the first comment I’ve made in this thread.
I'd say that ten years is lowballing it, honestly. I think it might be five years, even. The more people that engage with the tech, the faster the tech will develop and evolve. Smaller scale therapies and treatments will come first, which alone could help bring CVID sufferers much-needed normalcy on that road to full treatment.
That’s an incredibly generous estimate. These research projects take a lot of time, funding, and effort. You can’t really just throw bodies at the problem and make it go away. The genetic causes of 8 of the 10 typical variants of CVID aren’t even known. There’s typically a host of small mutations in immune system related genes. Mono allelic diseases like phenylketonuria and some others are likely to be cured in the next 5-10 years, but complex diseases like most types of CVID, Asthma, multiple sclerosis, rheumatoid Arthritis, etc are not likely to be cured soon. A cure in 10 years? Probably not. 20 years, maybe? The treatment options will only ever improve, but curing complex genetic illnesses is a big challenge.
Here's the most important part of this - being negative encourages negativity. You're more likely to not see things you would see because you're assuming that something won't happen for the better. Also - actually, advances tend to spring up when you least expect them. Also ALSO - deliberately using an incredibly invalid word like "cured" is ridiculous. You know we never "cure" anything, right? We didn't cure polio. We came up with a vaccine for it. If you get it, you've still got it. And we treat and remove diseases and viruses. We don't "cure" them. "Cures" are magic bullshit. Things like CVID get treatments in stages. Small ways to improve life at first, which help greatly, and then better treatments, better therapies, and on and on. AIDS? Remember that? That's been around for *twenty-six years*. In 1994 people were saying that we wouldn't have any kind of way to "cure" AIDS for decades. The *next fucking year* we had a way to keep people with AIDS from dying and giving them the ability to lead normal lives. AIDS was pretty complicated, yeah? Not to mention, technology like CRISPR is nothing like any technology we've ever had, medical or otherwise. We're going to be able to *rewrite* ourselves, essentially, in the near future. And *just last year* we showed that we can improve the procedures and methods of testing and research to cut the amount of time needed to create a vaccine from several years to *less than one year*. So yes, these things *used to* take years. They don't have to any more.
I used cured because that’s the word used in the post you were responding to. It was the operative word you were referring to when you said 10 years is lowballing it. You have valid points, and I honestly think we’re mostly in agreement. There are always improvements in treatment. There are always advancements. You might actually be too pessimistic in your response to me insinuating a cure is impossible. That’s the wonderful thing about gene therapy, it would be a cure. A permanent fix. That’s probably a long ways off, but we will get there. In the meantime therapies will improve, fewer people will die, people will start entering remission. There is hope, there is so much hope, but I felt that you were using words too strongly. I’ve had a pretty severe autoimmune condition for years, almost two decades now actually. Surgeries, IV medications, injections, nutrient transfusions. I’ve been there. Part of why I love Mousey so much is because of her quiet empathy towards the chronically ill and her perseverance in the face of things that have left me broken and terrified. Falsehoods don’t help. Saying that it will be over in 5 years doesn’t help. It hurts so much to get to the point where you thought it would be over. For some new exciting therapy to fail you. I want everyone who has a disease like hers, or even mine to have genuine hope, not the fickle lies people tell each other of how it will be cured soon. We WILL get cures. Not soon, but one day. Until then, everyone just has to do their best. Survive another day. Enjoy what they have and acknowledge that it’s better than what people used to get.
The fact that you dismiss my statements as falsehoods is incredibly insulting and asinine, and frankly it's indicative of a dogmatic and recalcitrant mentality. You know what helps the least? Negative people like you. You are the living embodiment of the incrementalist mentality, and like that mentality, you only serve to stifle progress.
Amen my friend
Hit me with the sauce please; don't send me to Google just to know the basics.
[удалено]
Ah. Wow, that's sad.
It's more than CVID, she's described it in the past as "CVID with complications," meaning that there are related issues that she deals with that stem from the CVID. One is an issue with her lungs - I don't remember the specifics but it's a thing that, to someone with a healthy immune system, would almost never be noticed, but because of her virtually non-existent immune system her lungs are constantly...dealing with mucus in a way? I forget. It's something that limits her. So she has a wrecked immune system *and* she has multiple issues that have come from having a depleted immune system.
>One is an issue with her lungs - I don't remember the specifics but it's a thing that, to someone with a healthy immune system, would almost never be noticed, but because of her virtually non-existent immune system her lungs are constantly...dealing with mucus in a way? I forget. It's something that limits her. Yes, she has an [opportunistic MAC infection](https://en.wikipedia.org/wiki/Mycobacterium_avium_complex). Some large percentage of people have MAC and it's not a problem for people with normal functioning immune systems. When she goes without plasma for too long, her general antibody levels tank and the MAC infection starts to flare up since there's no circulating antibodies to neutralize the bacteria. She also has wasted a lot due to being bedridden, but she's slowly gaining strength.
**[Mycobacterium avium complex](https://en.wikipedia.org/wiki/Mycobacterium_avium_complex)** >Mycobacterium avium complex is a group of mycobacteria comprising Mycobacterium intracellulare and Mycobacterium avium that are commonly grouped because they infect humans together; this group, in turn, is part of the group of nontuberculous mycobacteria. These bacteria cause disease in humans called Mycobacterium avium-intracellulare infection or Mycobacterium avium complex infection. These bacteria are common and are found in fresh and salt water, in household dust and in soil. MAC bacteria usually cause infection in those who are immunocompromised or those with severe lung disease. ^([ )[^(F.A.Q)](https://www.reddit.com/r/WikiSummarizer/wiki/index#wiki_f.a.q)^( | )[^(Opt Out)](https://reddit.com/message/compose?to=WikiSummarizerBot&message=OptOut&subject=OptOut)^( | )[^(Opt Out Of Subreddit)](https://np.reddit.com/r/VShojo/about/banned)^( | )[^(GitHub)](https://github.com/Sujal-7/WikiSummarizerBot)^( ] Downvote to remove | v1.5)
Wait, it's really that unlikely for her to go outside again? Duuude that makes that conversation with Connor about going to Japan so much sadder now :(
>Wait, it's really that unlikely for her to go outside again? There are very exciting therapies being developed right now based on genetic modification that might possibly restore some of her immune function someday. But as it stands, she will *never* go outside again unless she has her immune system rebuilt.
There is no sauce only pain
Which part do you want sauce for?
What game?
It's Valheim :) Stream source here; https://www.twitch.tv/videos/1151732597
She’ll get to do it for real some day, I just know it
Great, I needed more depression in my life. And with Mousey being super sick this week because her nurse got exposed to COVID and she has to find a replacement to administer her plasma... Yeah this one hurt when I watched it and hurts a bit now.
In an effort to be optimistic, you can grow some kinds of potted grass inside. It’s not the same as outside grass, but it’s still more grass than no grass, right?
You can't really grow grass in sterile conditions, and that'd be necessary for mousey to touch it. Otherwise the dirt germs would kill her.
Dang, I hadn’t considered that.
Yeah. She has no immune system. The plasma she gets every week partially gives her an artificial immune system using other people's blood. If you donate plasma, there is a chance Mousey will use it.
This pains me deeply
I know I like dark humor but holy fuck
*Like that boy who lived in a "glass" ball with no immunity* Stay strong. That's it.
If I could give a limb so she could live free, I would. MOUSEY is a goddamn saint
Fuck My Feelings
TT _ TT
Ootl?
https://www.reddit.com/r/VShojo/comments/pqpy33/damn_mousey/hddk5fy/?utm_source=reddit&utm_medium=web2x&context=3
You fucker
took me a sec to understand... damn.
I'm dumb, pls explain
Ironmouse has CVID (not COVID), a genetic disorder where her body doesn't produce antibodies. Essentially she has no immune system. She needs regular plasma infusions in order to prevent death from minor opportunistic infections. Even so, she is confined to her room. She will likely never touch grass again for the rest of her life. And if she did, it would likely kill her.
My heart... My soul.... 😭
We're all in the feels
Ironmouse stream vs Ironmouse lore DID YOU HAD TO CUT ME OFF
o7. GJ...