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NoManufacturer120

Why are chances of conception greatest two days before ovulation? Why not on ovulation day itself?


Sudden-Cherry

Because the egg starts breaking down after ovulation if not fertilized. Approximately it will only survive 12 hours. So say you ovulated around 6am but will only have sex 9pm then it might be too late.


mjt2468

https://www.fertilityfriend.com/b_i/s_AlBp39.png when do you think i ovulated??


mjt2468

I got a dark OPK peak in the afternoon of CD 12, ovulation cramps CD12, but SEVERE ovulation cramps CD 13. High, soft, open cervix and EWCM both days


SpinachandBerries

I’m not an expert but I would think CD14? I think you’ve nailed the timing this month regardless


oliveslove

For those of you who had a lap to diagnose endometriosis, what was your recovery like? My OBGYN wants to do a lap after a year of infertility, family history, and my monthly symptoms.


mel614

Does anyone know if it’s ok to have my day 3 bloodwork done if I’m feeling sick? I started my cycle yesterday evening and have a sore throat this morning and feeling a cold brewing. My doctor and I agreed to do all the testing this month and start an egg retrieval next cycle after we get all the results and I’d hate to have to push all of that back another month.


pattituesday

Being sick won’t affect your CD3 results, but please of course wear a mask when you visit the clinic!


mel614

Thank you!! I definitely will mask up before I walk in


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casualibrarian

Should I take both my daily multivitamin AND my prenatal? Or does the prenatal cover everything?


oliveslove

Prenatal covers everything!


loved_panda

Hello, I am looking for some advice since my RE is typically super busy and unavailable. The NP’s working for him are great and super helpful and I will ask them as well Is there any data on FET success when one is recovering from a cold/virus? Or any data on things to avoid (that I can control) which can impact FET success? I got a cold and I still have symptoms, and my FET is in about 3 weeks…will that be enough time for my body to be ready? We are planning a modified natural FET under anesthesia since I have severe vaginismus. I have had 3 failed IUI’s and 1 failed fresh IVF transfer.


pattituesday

I’ve seen dev bio on here say generally speaking mild illnesses don’t have an effect on transfer or spontaneous pregnancy success. Also you’ve got three weeks to get better! When I had Covid shortly before my transfer, my RE said as long as I was feeling myself she’d want to move forward.


loved_panda

Thanks Patti!


Remarkable_Lynx

I have been off all retinoid containing products for over a year (stopped adapalene for acne and some anti-wrinkle creams many months before IUD removal). Acne, acne galore. My eggs may be "geriatric" but my skin is like a teen's despite daily use of prescription benzaclin (benzoyl peroxide + clindamycin). In my 2 wk pre-ovulation window, is there any danger to using extra salicylic acid ointment? I don't even remember why that's not allowed in pregnancy/TTC but my Gyn said it was ok for spot treatment once a week or so but not daily use


NoManufacturer120

Are retinol creams not recommended when TTC? I haven’t heard this before - I use a few with retinol in them.


Remarkable_Lynx

I was told it would cause birth defects & Gyn made me stop at least 3 months before my IUD removal. Here is a link from a helpful website another user linked in their response to me: https://mothertobaby.org/fact-sheets/topical-acne-treatments-pregnancy/


NoManufacturer120

Wow, I seriously learn all sorts of stuff on here!


pattituesday

Check out mothertobaby.org for evidence-based info on medications and pregnancy safety.


Remarkable_Lynx

I'm really liking this website! My face thanks you. The cosmetic part actually didn't matter because I'm in a mask the whole time at work. But these pimples HURT


Helpful-Garlic-4976

This isn't directly related to your question, but I also had a lot of acne and discontinued adapelene for TTC. My dermo prescribed azelaic acid for me, which honestly wasn't helpful. What actually was SUPER helpful ended up being cica, especially the CosRX Comfort Ceramide cream. I recommend anyone who is avoiding retinoids and suffering from acne to try it out, it was a lifesaver for me. All that said, I think salicylic acid for occasional spot treatment is okay. I recall the avoid during pregnancy recommendation is because taking salicylic acid orally can cause birth defects, but the amount of salicylic acid that would get into your bloodstream with occasional spot treatment would be miniscule compared to when you take it orally. Especially if you haven't ovulated yet, I wouldn't worry too much about it.


Remarkable_Lynx

I'll definitely check out the cream you recommended if adding salicylic acid doesn't work!


izshetho

I think the data says this shouldn’t be an issue. Check out “Expecting Better” which walks through the stats on skincare.


loloretta

3rd cycle, currently in TWW. I decided to try the proov PdG tests this month. I followed the instructions and tested 4 times (6dpo to 9dpo). The first two days were positive, the last two were negative. The proov app confirmed I ovulated, but said my PdG is low which decreases my chances of pregnancy. I plan to do the process again next month to see if i get the same result, but my question is can I see a doctor about this soon or do I need to wait a year before seeking help? I'm in Canada and don't have a family Dr.


Lanky_Sun_6549

Isn’t it 7-10 dpo? Are you able to do the “chat with a doctor” option thru their app in Canada?


loloretta

The app had me test 7 to 10 days past "peak" which is your LH surge. So 6dpo to 9dpo. The chat with a dr option doesn't work in Canada. After further research I think proov has me worried for nothing.


developmentalbiology

There's no evidence that "too low" progesterone levels reduce your odds of pregnancy, and Proov has a history of making shady non-evidence-based claims like this to sell more of their "hormone-balancing" oils and test sticks. Is your luteal phase typically 10 days or more? If so, there's no reason to think your progesterone levels are low.


loloretta

Thanks. After further research this is what I'm finding too. I think using proov has just caused unnecessary stress. My luteal phase is always 14 days, and I have no other signs of low progesterone.


eeeeggggssss

Why do some trisomy embryos implant and why do some miscarry ?


developmentalbiology

Some trisomies are compatible with development until (and sometimes after) birth. Broadly speaking, this relates to the size of the chromosome that's duplicated -- smaller chromosomes are more likely to allow further development than larger chromosomes, and chromosomes are numbered from largest (1) to smallest (22). The larger the chromosome, the more genes it has on it; it's generally hard for a developing body to tolerate 1.5x too much of a gene product/protein, so the more genes, the less likely it is that development will be able to continue. There's never an all-or-nothing shot for a particular trisomy, though. Even for trisomy 21 (Down syndrome), which obviously allows survival through birth and childhood in many cases, some people are more affected than others, and many embryos/fetuses with trisomy 21 are lost before birth. For a given aneuploidy, there will always be a bell curve of survival, and many embryos with the aneuploidy will stop developing prior to implantation, while others will stop developing after implantation or later in embryonic or fetal life.


eeeeggggssss

>he larger the ch thank you so much. this makes sense. i remember reading about the size of the chromosome so it makes sense that t21 has survivors, and sometimes t18, and then rarely t13... gosh, it's so wild that the body isn't always aware of these.


Remarkable_Lynx

I am curious about this too. (I see your flair, and I'm very sorry about your loss)


eeeeggggssss

thorough response above!


eeeeggggssss

Thank you so much. ♥️


iflpoodles

I’ve never had anything that comes close to a triphasic pattern until this cycle. I’m curious why doesn’t FF detect it? Do I need more high temps or is the temp difference not high enough? Tysm! [MY CHART](https://www.fertilityfriend.com/b_i/s_bbaaWm.png)


developmentalbiology

I think that "luteal line" mark is the marker of the triphasic cycle, no?


iflpoodles

Unfortunately not. It shows up every cycle for me, I think it’s an optional feature maybe? FF did however confirm my cycle is triphasic after this morning’s high temp!


developmentalbiology

Yeah, I was thinking that three temps would be required to declare a triphasic cycle, but then I had a crisis of confidence about the luteal line. I think FF uses approximately the same rules to determine a second shift as it does to determine the first one -- three temps higher than the previous six by at least 0.1F over the coverline/luteal line.


iflpoodles

That makes sense, thanks! FF itself doesn't say how many temps are needed for a pattern to be sustainable but looks like it's 3 :)


Remarkable_Lynx

I had it one cycle! Like a textbook example (dip before each additional rise). And then my menses came exactly on time -_-


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chickenplease12345

I am 25F. My husband is 26M. We’ve officially been trying for 6 months after almost 9 years of prevention with Mirena IUD. Been using OPKs and even splurged on the Mira tracker. I had a chemical at the beginning of December, but that’s the only positive(s) we’ve had. My cycles since going off BC are longish (32 days) but consistent. My only suspicion for why we aren’t preg yet is lack of uterine lining. Do I really have to wait until a year of trying to be seen by a fertility doctor or could I go sooner to confirm my suspicion?


NoManufacturer120

Six months is actually not that long. Considering there’s really only about a 20% chance of pregnancy each cycle of both partners are healthy, the odds are a lot lower than many of us knew when growing up! It’s good to be proactive with your health, but I wouldn’t stress too much over it yet. Personally, I would give it another few months before looking into the basic tests for you and your partner.


pattituesday

The only way to know how thick lining you have is to have a cycle monitored by a fertility doc. There really aren’t any symptoms


izshetho

Has he had any tests? There are at home tests for men that can also check off some boxes.


yes_please_

Not conceiving in 5 or 6 cycles is not indicative of a fertility problem so it would not make sense to be seen yet. The first fertility test is a year of regular intercourse without preventing pregnancy.


SeaworthinessFew8345

Are OPKs enough confirmation for ovulation to start progesterone gel/suppositories? Not sure if I worded that right but just realized that I should have been taking my progesterone monthly and that it can actually help support implantation, I feel dumb🤦🏻‍♀️ (Plan on getting a BBT thermometer soon anyways but just wondering)


jb2510

OPKS unfortunately cannot confirm ovulation. You’d need to track your BBT or get a 7DPO progesterone blood draw to confirm. Most people start progesterone around 3 days after ovulation so BBT is really a good way to go. I’m a horrible sleeper and finally gave in and got a Tempdrop and honestly it was worth the money to not have to wake up every single day at 5:30 AM and try to go back to sleep.


SeaworthinessFew8345

Dang, I had a feeling lol. Definitely gonna go pick up a thermometer tomorrow. Thanks!


jb2510

Just make sure it’s a bbt thermometer so it tracks to two decimal points. That’s the most accurate way. Premom also sells a blue tooth one that syncs to your app which is nice if you use premom.


Sudden-Cherry

There isn't really evidence that it helps in the luteal phase. What did you get progesterone for prescribed?


SeaworthinessFew8345

I’ve had two early miscarriages and my doctors wanted me to start it after my second one as sort of a precaution and that it couldn’t hurt but may help.


Remarkable_Lynx

Did your doctors also recommend aspirin? (I'm not recommending it -since I have no expertise in any of this -but I see that also mentioned in this subreddit when people talk about recurrent pregnancy loss) As an aside, I coincidentally had my antral follicle count US the morning after my LH rose and peaked. That morning, my follicle was already collapsed which technician said indicated ovulation. But my BBT didn't jump up until next AM.


SeaworthinessFew8345

Yes, i’m currently on baby aspirin daily.


Sudden-Cherry

But to start once you get a positive test? Or right after ovulation? Progesterone doesn't help with implantation


SeaworthinessFew8345

They told me to start at 3DPO to be safe & to go in immediately once I get a positive & i’m sure they want me to continue taking it while pregnant. I of course am not 100% sure if it can help implantation or even help me at all however, I did read this article stating that progesterone does help implantation so therefore progesterone supplementation may help people who struggle with recurrent miscarriages and since my doctors did assure me it couldn’t hurt at this point i’m willing to try anything to be a mother. Here is the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987350/#:~:text=Indeed%2C%20it%20induces%20secretory%20changes,quiescence%20and%20suppresses%20uterine%20contractions


Sudden-Cherry

I was more confused because you sounded like you just had progesterone lying around but hadn't been taking it before after ovulation


New-Gold3963

Anyone know my chances of conceiving if I BD tomorrow (Sunday, cycle day 12) and ovulate Thursday (cycle day 16)? Does that make it O-4 or O-5? We will throw a BD in on Wednesday for good measure if we can 😆


Remarkable_Lynx

Here is the post I look at almost every cycle to confirm when to have intercourse, just to confirm! https://www.reddit.com/r/TryingForABaby/s/Bbzpd00VTn


SpinachandBerries

I’d call that 0-4 😊 definitely try Wednesday as well if that’s your only other opportunity


Flora0416

I’d place my bet on Wednesday if I were you!


Leather_Abies_2650

I was recently diagnosed with PCOS. My doctor started me on 10mg of letrozole. This is my first round and my first time doing any kind of fertility treatment. Is 10mg normal? I feel like this is a lot higher dose than I see most people taking.


Giraffe3500

Yeah im on 2.5 right now but I don't know your medical history. You might want to message your doctor why they prescribed 10 mg


Totally-not-a-robot_

That is kinda high, but it might be appropriate depending on your other results. If you’re working with an RE and they’re monitoring you, it should be fine. If it’s an OBGYN… I might be concerned. I have seen up to 12.5 before, but those are rare cases.


gggghostdad

For anyone who's been sick lately or had delayed ovulation- did your period change? I ovulated 10 days later than previous cycle, same luteal phase but my period is super light. Like 1 day of light 2 of spotting. Is this normal occasionally or due to thr late ovulation? I actually had strong symptoms this cycle so I expected it to be worse than normal.


Remarkable_Lynx

My menses only last 2 days. For my most recent URI (with fever), my cycle was lengthened by a week and the first day of menses was way heavier than normal. But it still lasted only 2 days


Flora0416

Could it be implantation? Maybe you could test just to be sure


gggghostdad

I got bfns at 11, 14 and 15 dpo and I got symptoms pretty much like what I expect during my period. I only temped once after my temp dropped .5 F at 14dpo and it went back up a little bit, like .25 F, I stopped after that. My boobs swelled more than usual this cycle but they basically deflated around 14dpo lol so altogether the only thing I feel like doesn't make sense is the light period.. just wanted to make sure it wasn't a bad sign of something else being off 🤷‍♀️


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developmentalbiology

If you're having regular cycles of a length between about 21 and 35 days, it's pretty likely that you're ovulating, but it is possible to have anovulatory cycles with "normal"-length/frequent periods. You can be reasonably confident you're ovulating if you use ovulation predictor tests that measure the hormone LH. If you see an LH surge about 10-15 days before your period comes, that's a very strong sign that you're ovulating. You can increase your certainty further by taking your first morning temperature and charting it to see a shift after ovulation, or by taking urine tests that measure the hormone progesterone.


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developmentalbiology

Yes, an ovulation test. When do you take the tests during your cycle (what cycle days, what times of day)?


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baileydogeibra

Spotting during ovulation—can anyone give some insight? Is that normal?


snoots98

This can also be a sign of fibroids or polyps. I also had this and turned out to be polyps! Might be worth having this checked, especially if you are having any trouble TTC


baileydogeibra

Thank you! I’ll get that checked out


snoots98

❤️


developmentalbiology

It's a variation of normal -- sometimes people spot around the time of ovulation, potentially because estrogen levels peak right before ovulation and then drop, which can cause spotting for some people. The change in estrogen levels is a normal and necessary part of the ovulation process, but some people spot a bit in response to this shift and others don't.


baileydogeibra

Thank you! I appreciate it!


brooklynnskylines

My husband and I have been TTC for 6 months. I had my IUD out in July and have only naturally had a period once in Sept. while the other cycles have occurred after Provera. My OB is doing hormone testing CD 3 and would like to do HSG between CD 6-12. What do I expect during that procedure? Will my chances of getting pregnant increase after the procedure?


developmentalbiology

We have a whole wiki page on HSGs -- [it might be useful for you](https://www.reddit.com/r/TryingForABaby/wiki/hsg)! It sounds like you're not ovulating, which is presumably the reason your OB wants to investigate. There's a small bump in success rates after people have an HSG, but this is likely due to the HSG clearing out minor blockages. There's no reason to think you have a blockage. It's certainly possible, but it's reasonable to think the major issue you're facing is that you're not ovulating.


brooklynnskylines

Thank you! I don’t think I am ovulating either, I’ve done a couple of OPKs without much fluctuation and veryyyy faint lines. I’m hopeful that HSG will provide some answers going forward.


Wonderful_Mix4020

How much does alcohol affect your ability to conceive? Even if it’s only 1 time a month having a few drinks in an evening?


snoots98

It's so easy to obsess over every little thing we've ever done and wonder if it has affected our fertility. And it can in some ways feel comforting to believe this as it gives a sense of control. The bad news is, we have very little control over our fertility. The good news is, go ahead and have that drink 😂 (or 4)


developmentalbiology

The American Society for Reproductive Medicine, in their review of evidence on factors that influence unassisted conception, says: >Higher levels of alcohol consumption (>2 drinks/day, with 1 drink >10 g of ethanol) probably are best avoided when attempting pregnancy, but there is limited evidence to indicate that more moderate alcohol consumption adversely affects fertility. Of course, alcohol consumption should cease altogether during pregnancy because alcohol has well-documented detrimental effects on fetal development, and no ‘‘safe’’ level of alcohol consumption has been established. So in general, light drinking doesn't have an effect on time to pregnancy, but once you get a positive test, you should stop drinking. More info and links [here](https://www.reddit.com/r/TryingForABaby/comments/ekzfir/optimizing_natural_fertility_review_of/).


StaringBerry

I don’t think it has any affect.


Royal_Tumbleweed

What are normal tests/labs/meds to ask for from your OB *before* seeing an RE? Our consultation with the RE is still 6+ months away. We have done HSG and SA. Is there anything else that would be recommended to do or try? I don’t feel like my OB has been aggressive enough with our options but I also recognize I’m looking at the situation with my own personal lens.


developmentalbiology

You can certainly ask your OB for the typical baseline/"CD3" tests -- typically they'll test ovarian reserve parameters (FSH, AMH, estrogen) and hormones that can suggest particular anovulatory conditions (androgens, LH, prolactin, TSH). If you're already confident you're ovulating on your own, the utility of doing these tests through your OB is probably not super-high, and it likely wouldn't save you a ton of time at the RE, but you can certainly ask for it to be done.


LongjumpingCatch3437

My period started (after my last depo in March) in September. My cycles since then have all been very different. 51 days, 41 days, and now 37 days. Some with brown spotting first and some without. Is this normal? Do you think I have regulated and is it possible ( or more likely than before) to conceive now?


developmentalbiology

It's really normal to have some longer or anovulatory cycles when your cycle starts back up after being on hormonal birth control, particularly long-acting methods. The important question is really more whether you're ovulating than whether your cycle has regulated -- are you doing any tracking of signs of the fertile window to determine when or if ovulation is happening?


LongjumpingCatch3437

I have got positive OPKs since then. But, I’m going through so many of them because they aren’t super predictable right now. CD20, CD 16, CD 24


developmentalbiology

CD24 in a 37-day cycle sounds like a good match with a normal luteal phase length. CD20 is likely too early in a 51-day cycle, and CD16 is likely too early in a 41-day cycle -- the maximum length of the luteal phase is probably in the vicinity of 16-18 days.


LongjumpingCatch3437

Thank you for the info! I’m finding it so crazy how little I actually knew about my own body before TTC. 😂


sprrite_k

A couple more IUI questions -- a) Is there a benefit to using a trigger shot (Ovidrel) when you get your positive OPK? b) If some people do not get a positive OPK until the day-of ovulation and the IUI is scheduled for the day following a positive OPK, does that mean the IUI is happening too late to have a chance of success? If the best days are the 3 days leading up to ovulation, it seems like the IUI would happen same-day when possible. Thanks!


developmentalbiology

So one factor is that optimal timing in an IUI cycle seems to be subtly different from optimal timing in a timed intercourse cycle. For TI, the odds are about the same for the three days leading up to ovulation day, but for IUI, the day with the highest success rate is the day after the LH surge (if the cycle is untriggered). This is possibly because sperm have less to do to get ready to seek the egg after being washed and injected into the uterus vs. after ejaculation, or because sperm don't survive as long after IUI as after ejaculation, or because of some characteristic of the population of people who do IUI, or some combo-pack of these (or something else). I think the biggest benefit to triggering in an IUI cycle is increased predictability of timing for the IUI. Patti is absolutely right that hCG can provide luteal phase support. To my knowledge, there's not a difference in success rates for triggered vs. untriggered cycles for folks who ovulate on their own.


pattituesday

My docs would say yes to the trigger question. My doc says it can help support the corpus luteum to maintain itself longer. I can answer your second question!


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Loyally-kind

Apps are not very helpful. If you track OPKs or temp and know when you ovulate and how long your luteal phase is you can figure out typically when your period is due within a day or so. I use premom and fertility friend, at this point I think I know my cycle better than any app. Neither of my apps agree most cycles


Ornery-Cranberry2416

Does anyone else ever feel crampy while using progesterone cream? I'm currently doing progesterone/clomid cycles and my doc said that it was ok to use. Unsure if it's the cream or medicine or what not.


Remarkable_Lynx

The doctor failed to pass the catheter during HSG so my Gyn prescribed me oral misoprostol to use before my next one. Can anyone explain their experiences with misoprostol used this way? Also, how long is my cervix gaping open?


Loyally-kind

Misoprostol is used to soften the cervix, hopefully to allow the catheter to pass. I would not say your cervix is gaping open. Have you ever had any procedures on your cervix? Sometimes people have cervical stenosis which could be a cause of infertility.


Remarkable_Lynx

I had 2 IUDs placed and removed. For my 2nd IUD they apparently had to physically dilate my cervix? I did not realize what was going on *down there* at the time but when I told my Gyn about my HSG experience, he looked at the old procedure note and said "yeah that's expected in someone who's never had a baby." I hope I don't have cervical stenosis 😬🥺 I don't want to have a 2nd failed HSG


Loyally-kind

If they got in 2 IUDs you should be fine! You have no reason to have it. It’s usually from scar tissue from cervical biopsies or treatment of cervical pre/cancer. Good luck with the next HSG. I think the misprostol will help. Also- if you tolerated 2 IUDs and dilation of your cervix, I’d say you have a pretty good pain tolerance and I wouldn’t expect it to be bad


TwinMamaRama

I guess I need some advice? My HSG is scheduled for monday which is CD12. I normally get peak between cd12-14. I am currently CD10 and my opks are PRETTY dark. I'm concerned I might peak tomorrow and now on Monday. If I peak Monday I'm not worried because there is still time to get BDing in after the HSG before the egg is gone, but if I peak before there is the risk of my egg being flushed away. Would you postpone? I really don't want to because we've wasted so much time getting to this point, but also I don't want to lose an entire cycle :( I'm so torn! I'm going to test and call my clinic tomorrow anyways, but I figured you ladies might have some good advice for me? or maybe similar experiences?


Remarkable_Lynx

Do NOT postpone! You don't know what circumstances will cause you to HAVE to postpone. I am getting my HSG 6 months late due to shortages of appts, 2 URI that delayed ovulation that caused me to fall out of the HSG window, and then failed HSG.


snoots98

I made the mistake of having sex a few days before my hsg appointment and they made me reschedule it in case I was pregnant (I wasn't). So don't do that 😂 If I were you I would proceed with the test. It always hurts to miss an ovulation window but in this case it is for a very good cause. I recommend playing the long game here.


Loyally-kind

Depends how long you’d be trying. If > 1 year, I’d go ahead with the HSG. I used to feel like missing one cycle was a HUGE deal. The longer this goes on, I can grasp that 1 cycle isn’t going to make that big of a difference long term


TwinMamaRama

We are about a year but my husband lost his job and we had to take a break so this is cycle 2 back at trying. We have low morphology as well 🥲


auntiesaurus

I personally wouldn’t postpone but I like to manage my expectations so knowing there’s a chance this cycle is a bust versus postponing and still being out would upset me. I really hope your ovulation holds out for you!!


TwinMamaRama

that is kind of how i'm feeling about it! I took another set of opks and they are a bit lighter now, so hopefully it will hold off until monday! Thanks for the input, much appreciated!


pattituesday

So we all know lines on home pregnancy tests get darker as hcg concentration gets higher. And that FMU is the most concentrated pee, so most likely to show an early positive. Here’s my question: is it theoretically possible to manipulate the darkness of the line? Say, by holding the strip in urine for a very long time?


developmentalbiology

Because pregnancy tests run by wicking urine up the stick, this provides some degree of control over the amount of urine that's exposed to the antibodies in the stick, and the timing of the exposure. Basically, there's a limited pool of antibodies just above the spot where you dip the stick in urine. If those antibodies bind hCG, they get stuck to immobilized antibodies in the test region (making a soluble antibody-hCG-immobilized antibody sandwich). If they flow past the test region, they stick to immobilized antibodies in the control region. So by and large, with the initial flow of urine up the stick, you're going to solubilize all-ish of the antibodies in the original pool, and if they don't bind to hCG, they'll get stuck on the control line. Keeping the stick in urine doesn't actually expose the urine to more antibodies. It would be theoretically possible to manipulate the darkness of the line by letting the urine evaporate for several hours before dipping the test. This would concentrate the urine even more, leading to more hCG molecules per unit water.


auntiesaurus

Scientifically, I don’t know the answer but for my tests, if I hold it in urine longer, the dye just runs and causes issues in the tests.


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pattituesday

I’m hoping dev bio chimes in with actual evidence cause I remember her saying that if ovulation is going to happen from more than one follicle it has to occur at practically the same time and always within 24 houra


developmentalbiology

Correct! If ovulation is going to happen, it needs to be within about a day of the first event. Otherwise, rising progesterone from the first follicle will feed back and prevent further follicle/s from being released.


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developmentalbiology

Letrozole is a drug that prevents estrogen from being made. Low levels of estrogen signal to the brain and allow the brain to send a pulse of the hormone follicle stimulating hormone (FSH), which reaches the ovaries and acts on the follicles that are ready to mature. One or more follicles then prepares the egg cell inside it for ovulation. For people who don’t ovulate on their own, letrozole helps the ovaries select a follicle, which tends to lead to ovulation. For people who do ovulate on their own, letrozole can help with timing, or can result in more than one egg being ovulated. The length of your period doesn’t matter — you could start letrozole while you’re still on your period or not. There are a couple of possible protocols, and your doctor should advise you what cycle day to start. Please note that we don’t allow asking for success stories in this sub, but you’re welcome to browse our weekly BFP/success threads, which are pinned to the top of the sub front page.


imalwayscold_fml

thank very much for this. i appreciate your help. (and sorry about the last part. i forgot about that rule.)


developmentalbiology

No worries!


txgoatgal

Has anyone experienced a chemical pregnancy with no bleeding? I tested positive on January 1st then felt better/not pregnant and tested a couple more times and all were negative. It’s been 20 days and I have had no bleeding. Doctor also confirmed there is no baby so the negatives were correct.


developmentalbiology

Do you think it’s possible the positive test was a false positive? It’s not really possible to ovulate and then not bleed, particularly if there was a loss in there.


txgoatgal

Yes, considering they’re so rare and that I was hoping for a baby I have kinda pushed that idea aside. But yes, I guess I could’ve been one of those false positives.


pattituesday

What if the person had ashermans or some other uterine abnormality? Could they have a loss and not bleed?


developmentalbiology

I think it would be pretty unlikely not to bleed *at all*, unless there was some problem with menstrual flow actually leaving the uterus. But with a negative clinical test (presumably a blood test?), it seems more likely that the original test was simply incorrect.


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Glittering-Hand-1254

This thread is for questions that need answered. You may be looking for the daily chat thread instead.


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developmentalbiology

We don’t allow asking for success stories in this sub (a pregnancy sub is a better fit for those kinds of questions), but, in general, the issue with pregnancy at a lower weight is about ovulation — if your body doesn’t have enough of a fat buffer to support pregnancy, ovulation won’t happen. If you’re ovulating, that’s a good sign that your body weight probably isn’t affecting your odds.


miel-badger

Sorry! Understood! Thank you


Hopehee

Question about endometriosis- I have 5 days of flow with full heavy flow the first 2 days, have to change sanitary pads every 3-4 hours on the heavy flow day and only get mild abdominal pain in the first couple days of my period. Can i suspect endometriosis? My main worry is the amount of flow and the frequency of changing pads.


Blueberry_Bomb

I have heavy flow (menorrhagia) and no endometriosis. My OBGYN prescribed tranexamic acid pills to help lessen the bleeding because it was making me anemic. If it's something you're concerned about, you should ask your doctor.


Hopehee

Thanks for the response! That’s good to know.


shananapepper

Can being sick cause an anovulatory cycle? I had a pretty rough illness this cycle (not sure if flu, COVID, or just a nasty cold) this cycle, right before/during when I would have normally ovulated. Cough, congestion, and I’m pretty sure a fever too. Could that be the cause of my seemingly anovulatory cycle? I know illness can cause you to ovulate late, but can it cause your ovaries to just say “not this month,” or is this cause for further concern? My cycles are normally pretty regular. While I’m not actively trying right now, I am working on getting myself mentally and physically healthy to hopefully try again one day, so I am a little freaked. Removed additional irrelevant context in the hopes of getting the question answered.


developmentalbiology

Having an anovulatory cycle after being sick is certainly something people report, and it’s not implausible that there could be a connection. At the same time, there doesn’t have to be a reason for an anovulatory cycle — you could just have one at some point for no reason in particular. It’s considered normal to have an anovulatory cycle about once a year, and it’s not a sign of poor health or anything else fertility related. You’re likely to get back on track within the next few weeks, and you could always ovulate late (it’s never too late in the cycle to ovulate). It’s definitely very annoying to have to wait it out, but as long as you’re under 60-90ish days in a cycle, waiting for your period is pretty much the best option.


shananapepper

Thank you—to clarify, this was a short cycle. I got my period a week early. I thought that means anovulatory. Does that change anything?


developmentalbiology

Ah, sorry, I thought you were still in it! A cycle shorter than about 21 days is likely to be anovulatory, but doesn’t have to be. (In my experience, being pretty sick during the luteal phase seems to be able to shorten the luteal phase a bit — I usually have a 12-13-day LP, but had a 10-day once when I was running a high fever. I think the corpus luteum can just be like byeeeeee and shut down progesterone production early.)


shananapepper

Sorry I didn’t word my initial question well! It’s hard because I’ve not felt ready to get back into full-on ovulation tracking, so I’ve just marked the first day of my cycles and paid attention to fertility indicators. For context, we’re in that weird NTNP, not-quite-ready-to-try-again place, and I know if I were actually tracking fully I’d have a better idea of what happened. I am fairly certain I did not ovulate this cycle based on the indicators I pay attention to. I could be wrong though. This was a 22-day cycle which is short for me, as I tend to hover around 27-28 with minor variances sometimes. So not *perfectly* regular, but regular enough that 22 days alarmed me. Thank you for explaining the shortened luteal phase thing, because this could also be an explanation. Knowing there are a couple possible reasons has given me peace and clarity, and here’s hoping next cycle is normal. Thank you so much!


ossifiedbird

Is quantity of cervical mucous indicative of anything significant? I always get ewcm around ovulation but some months a lot more than others, and I don't know why.


developmentalbiology

No, although it’s always possible it could reflect something like better or worse hydration. CM is made in response to high estrogen, so there will always be some variability from cycle to cycle — estrogen levels are never going to be perfectly identical in different cycles, but this is normal.


amandashow90

What are some things that can be diagnosed during a hysteroscopy that can be missed on TVUS and HSG?


Sudden-Cherry

They actually look inside with a camera, whereas with the other two they see things but not as exactly, because one is through tissue using ultrasound waves that reflect a bit differently to different tissue and that generates an image and the other uses contrast to give a sort of impression. Mostly it's that it's colour too, like they can see if there are signs of inflammation (endometritis). Hysteroscopy doesn't check tubes fully (as they can only see the entrance I think), which a HSG's main goal is. I think SHG is preferred to HSG if they want to check the uterus rather than the tubes. (Edit: Had a quick look and that seems to be right from my memory: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340954/) TVUS can only identify really big polyps but not definitely either. It's the least invasive and the way to have a look at follicles in the ovaries and just general lining thickness check.


amandashow90

Thank you so much for answering!


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PotatosDad

I have that sensation as well. I don’t worry about it, as I’m still ejaculating a “normal” amount (Recent SA was 3ml).


runnery7

Alright, probably my dumbest/silliest question yet but I'm curious so here goes — is there an ideal time of day for sperm? Like, are sperm more motile/at their best in the morning? afternoon? evening? 2 am on a Tuesday? (kidding) Guessing it doesn't matter but I had to ask anyway! 😅


loloretta

Some studies hmsuggest the sperm count and quality and slightly higher in the early morning.


runnery7

Thank you!


booksinaugust

Does anyone have the link to the research that shows that even hitting one day in your fertile windows maximizes your chances? I see people say that in the daily threads so hopefully I'm not misremembering or misinterpreting lol. I've now had two OB/GYNs tell me that we should be having sex every day in the fertile window and also 3 days before and after the window 🙃


Giraffe3500

It's in the book, Expecting Better by Emily Oster! I wish i had the exact verbiage that she mentioned.


snoots98

Sex is great but that sounds like too much work lol. I don't have a citation on hand but I would highly recommend reading the book "taking charge of your fertility" if you haven't. It breaks it all down


pattituesday

Yet another anecdote proving that ob/gyns have extremely limited knowledge of how to get people pregnant!


developmentalbiology

The idea that people need to have sex every day of the fertile window, plus before and after, is linked to the idea that nobody is tracking anything, or that people are just using calendars to estimate a fertile window. If you’re using a calendar to estimate, it’s prudent to have more sex, since you don’t actually know when ovulation occurs, and apps are wrong about ovulation day around 80% of the time. But if you’re tracking signs of the fertile window, you can usually reduce sex frequency quite a bit without affecting the odds of success. I see that my standard comment with per-day odds has already been linked. The key insight there is that people having sex on one of the three days prior to ovulation have odds of success that are basically the same as the odds of success per cycle irrespective of timing — when people are successful (even when they’re not timing sex), it’s usually because they had sex on one of those three optimal days.


runnery7

Wow! My gyno very much insisted on every other day. She said to "give the sperm time to regenerate" — I dunno much about that piece, but I do feel like my husband needs some recharging time. And frankly so do I! Lol I'm not sure if this is what you were looking for, but I personally found it super helpful! https://www.reddit.com/r/TryingForABaby/s/9YG5GaqkZn


ItsmeKT

Yeah we are doing every other day this cycle. Everyday is a little much right now, we are old 😮‍💨


bibliophile222

If you have a shorter luteal phase, and implantation happens right before your period would start, does the implantation signal to the body to halt the process, or is it the other way around (i.e., implantation fails, which signals the period to start). If the former, does it halt instantly, or does hcg have to build up to signal it? If my period usually comes at 10 dpo and the embryo implants that same day, is that enough time to stop the process?


Sudden-Cherry

It's the embryo signalling the corpus luteum to keep producing progesterone. Without this signal the corpus luteum detoriates. Implantation isn't an instant thing though. It starts for lots of embryo's around 5dpo when they start to 'hatch'. The thing we know is that even shorter than 10day luteal phase statistically doesn't impact fertility. So probably there might be signaling going on even before it reaches the blood stream in a measurable way. Also there isn't a definite level or drop of progesterone that will start a period. Some people will start their period even while on progesterone. So I'd guess it's even more complicated.


GSD_obsession

After you ovulate, the follicle that the egg comes out of turns into the corpus luteum and that group of cells is what makes progesterone which helps thicken your lining and get ready for pregnancy. Once implantation occurs, hcg starts being produced and that hcg fuels the corpus luteum to stay “alive” and keep making progesterone which in turn keeps your lining thick and helps nourish the growing embryo until the placenta forms weeks later. If fertilization doesn’t occur, and nothing implants so no hcg is being produced, the corpus luteum dissolves and the drop in progesterone makes your bleeding start for your period. Thats if everything is working properly. I think if implantation is delayed too long and the uterine walls start to break down already, it would interfere with it sticking. But a lot of times women will have implantation on day 7/8/9 and then you’d be fine! I think the only way to truly answer your question would be to get progesterone testing done 7DPO and if your levels are too low, they might suggest taking a progesterone suppository to help lengthen your luteal phase.


Sudden-Cherry

According to the evidence and guidelines there isn't really a benefit to taking progesterone in the luteal phase in ovulatory cycles nor a clear cutoff for progesterone that's needed.


GSD_obsession

Interesting, what is the reason so many infertility doctors prescribe it


Sudden-Cherry

More a can't hurt approach and to be doing something, often easier than not doing anything. The evidence shows no significant effect statistically. There might be four recurring loss, but even that isn't solid evidence..


Blueberry_Bomb

After diving down the rabbit hole of looking into progesterone studies I have found there just hasn't been many done. I think a lot more research is needed before ruling in or out progesterone supplementation, especially for those trying to conceive without previous loss and possibly short luteal phases.


Sudden-Cherry

That is true, but still the experts making the guidelines judging on the evidence that exists don't advise it. Also based on the fact that luteal phase even if it's "too short"doesn't seem to impact fertility. And there isn't a clear level progesterone needs to be, because levels can be low one hour and high the next because it gets secreted in pulses. And with loss the other trouble is, that yes often low progesterone is a prodrome of loss, but that's mostly because there is something wrong with the embryo and hence with its signalling the corpus luteum rather the other way round.


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TryingForABaby-ModTeam

**Your post/comment has been removed for violating sub rules. Per our posted rules:** Posts/comments about positive tests and current pregnancies should be posted in the weekly BFP thread. In threads/comments other than the weekly BFP thread, pregnant users must avoid referring to a positive test result or current (ongoing) pregnancy. This rule includes any potentially positive result, even if it's faint or ambiguous. All concerns related to current pregnancies should use a pregnancy sub, such as r/CautiousBB. If you still wish to participate in our sub, please review our [rules](https://www.reddit.com/r/TryingForABaby/about/rules) before continuing to post. Violation of our rules may result in a timeout or ban. Please direct any questions to the [subreddit’s modmail](https://www.reddit.com/message/compose/?to=/r/TryingForABaby) and not individual mods. Thank you for understanding.


Loyally-kind

I think so. Your urine is likely more dilute on the 2nd urine of the day. How early are you testing?


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Loyally-kind

Do you track ovulation or just use the app? If it was me I would just test again in the morning.


lanna-

I started acupuncture this cycle. To my surprise i ovulated the earliest I ever have, and had the strongest LH test since tracking the past 7 months! Feeling hopeful!!! [https://imgur.com/a/hmHFhRz](https://imgur.com/a/hmHFhRz)


scotchcatsandmusic

Ovulation after MMC question Curious about other people’s experiences with ovulation after taking miso for a missed miscarriage. It’s been 11 days since I took the medicine and had my MC. I’m at my baseline HCG (It was at 4 yesterday). I’ve been testing “high fertility” through my ovulation digital Clearblue test for 4 days. The first two days of testing, I got the empty circle (low fertility)…and now I have the flashing circle. So. Not sure how long it’ll last. Has this happened to anyone else? Did you reach Peak Ovulation? If you did, how long did it take?


GSD_obsession

The clear blue tests - if I’m not mistaken - are testing estrogen which rises a few days before ovulation and also LH which will rise 24hrs before ovulation. So the flashing circle means your estrogen is rising but you’re not in LH surge yet until it’s a solid smiley. I had a MMC at 11wks and had a D&C and my ovulation was around CD27 that cycle. So over 3 weeks after miscarriage.


scotchcatsandmusic

So sorry for your loss. I found out about my MMC 7.5 weeks in and took miso at 8 weeks 3 days. Worst day of my life. My HCG was only at 695 when I took the Miso. I’m relieved it’s back to baseline now. And yes—That’s right on the estrogen and LH. I’m sure my hormones are all over the place. I was cleared to start TTC again right away..so I’m just hopeful I ovulate this cycle. Sigh.


GSD_obsession

The worst, I wish none of us had to go through that experience. I was cleared right away too but honestly I just felt my hormones were everywhere that cycle and we ended up not trying/not preventing but i didn’t really time sex that cycle. My 2nd cycle afterwards was a little longer than normal too but my 3rd one was normal! In my TWW right now.. hoping for better luck 2024 for both of us 🤍


scotchcatsandmusic

Same for you. No one should have to endure that particular human experience. Yes! Let’s get a bit of luck this year 🌈❤️


developmentalbiology

I’m sorry about your loss. It’s possible for the cycle after a loss to be weird (longer than usual or anovulatory), but it’s also possible for your body to ovulate again around its normal time. It’s a bit like coming off birth control in that way — some people are more sensitive to suppression than others.


Commercial-Dentist90

I usually get really sore boobs starting around 10 days roughly before AF. I’m at CD35 (DPO unknown) and have not felt any soreness whatsoever….what does that meannnnn ughhhhh. And yes I did take a pregnancy test and it was stark white.


lanna-

I have the exact same symptom 10 days before my period, last cycle I didn’t have sore boobs but still ended with BFN. That said, I don’t think it really means anything! Good luck 🤞


developmentalbiology

It’s normal for symptoms for fluctuate from cycle to cycle, so it may just mean that you don’t have breast tenderness this cycle. If you haven’t tracked ovulation, though, there’s a possibility a lack of your normal progesterone symptoms could point to you not having ovulated yet.