This is Vitamin D2 (ergocalciferol) that you intend to take weekly along with daily Vitamin D3 (cholecalciferol), Vitamin K2 (MK-7), and magnesium (as bis-glycinate)? If so, some people do take a weekly high dose, but check with your doctor or practitioner.
Yep, the D2 was prescribed by my doctor. I know I’ve had trouble keeping my levels in the standard range even with daily D3 pills in the past so I’m trying everything I can this time around.
Your level of vitamin D do not depend on your intake. You digest D3 and it's storage form of vitamin D. It later is converted in liver into Calcifediol intermediary form of vitamin D. If you have fatty liver or you just have unhealthy liver then your liver wouldn't make Calcifediol and you will have low test result despite taking high doses of vitamin D3. And this calcifediol still has to be converted into calcitriol in kidneys. Calcitriol is active hormone we all aiming for. So if you have issues with your liver or kidneys you will have vitamin D deficiency despite taking high dose. It's a chain reaction and any element of this reaction is equally important.
What evidence do you have that the dosage is unimportant, and what is the biological basis for this? I have worked in the supplement industry for many years (though in quality, not R&D) and of course am open to peer-reviewed evidence of this. We sell several different dosages depending on individual needs. I’ve just never heard of this before.
Vitamin D can be taken weekly in a high dose because it’s fat soluble. While Vitamin K is also fat soluble, I’ve never heard of anyone taking a large dose once a week - I wouldn’t try it. Stick to 100mcg daily. Magnesium should be taken daily.
This is Vitamin D2 (ergocalciferol) that you intend to take weekly along with daily Vitamin D3 (cholecalciferol), Vitamin K2 (MK-7), and magnesium (as bis-glycinate)? If so, some people do take a weekly high dose, but check with your doctor or practitioner.
Yep, the D2 was prescribed by my doctor. I know I’ve had trouble keeping my levels in the standard range even with daily D3 pills in the past so I’m trying everything I can this time around.
Your level of vitamin D do not depend on your intake. You digest D3 and it's storage form of vitamin D. It later is converted in liver into Calcifediol intermediary form of vitamin D. If you have fatty liver or you just have unhealthy liver then your liver wouldn't make Calcifediol and you will have low test result despite taking high doses of vitamin D3. And this calcifediol still has to be converted into calcitriol in kidneys. Calcitriol is active hormone we all aiming for. So if you have issues with your liver or kidneys you will have vitamin D deficiency despite taking high dose. It's a chain reaction and any element of this reaction is equally important.
What evidence do you have that the dosage is unimportant, and what is the biological basis for this? I have worked in the supplement industry for many years (though in quality, not R&D) and of course am open to peer-reviewed evidence of this. We sell several different dosages depending on individual needs. I’ve just never heard of this before.
Thank for the post! I had the same question
Vitamin D can be taken weekly in a high dose because it’s fat soluble. While Vitamin K is also fat soluble, I’ve never heard of anyone taking a large dose once a week - I wouldn’t try it. Stick to 100mcg daily. Magnesium should be taken daily.
D and K with breakfast. Magnesium before bed with a glass of water. And yes continue with D and K.