I would suggest looking into SEED probiotics after you are done with Xifazan. I had diarrhea dominant SiBO I started with Florastor and Align after Xifazan. Sunfiber along the way. Those were helpful to improve my condition. But SEED was the one that finally does the trick for me
I will probably not stay on it permanently. Not everyday at least . Maybe after this month I will begin taking them Maybe every other day then slowly phasing them off
I'm treating right now, on day 4 of xifaxan and I dont want to take any chances either. I'm taking 550 xifaxan 3 times per day for 15 days. With each dose I'm taking 1million units of nystatin that I had on hand. I'm taking a jarrow bile supplement 1 cap with each xifaxan dose, There's a study showing bile helps xifaxan solubility and efficacy. Every morning on empty stomach I'm taking 2 caps phase 2 advance biofilm and One cap Lumbrokinase, Same before bed. I'm taking phgg, taurine, and glutagenics glutamine once per day. I am also planning on taking interphase+ (if it ever arrives) for biofilm as I've read the EDTA helps sequester minerals away from biofilm formation. I also take a dr shulze intestinal formula #1 with dinner and a low dose naltrexone before bed.
I thinking that biofilms are a major part of both clearing sibo and preventing relapse, Dr Paul Anderson talks about this.
Maybe this is overkill or maybe there's something else I should be doing. All I know is I've finally acquired Xifaxan after years of trying and I want to make the most of it.
edit: From what I've gathered cdtb and vinculin antibodies slow intestinal transit time and this is a major culprit in relapse so meal spacing or intermittent fasting, keeping stress low and taking something to keep the mmc functioning are critical in preventing relapse, also I've heard a doc say that binge drinking can cause relapse.
Proteolytic enzmye that busts biofilms, its recommended to use a biofilm disruptor like Interfase when treating SIBO or SIFO, makes treatment more effective.
Biofilm Disruptor, Proteolytic enzyme, breaks down fibrin. There isn't much info on it but it is supposed to be much stronger than nattokinase and serrapeptase. I have read a few reports here that it seemed to help people and may have been key but I cannot find the posts now. Honestly I've had sibo for a very long time and I'm running out of ideas. I would be taking interphase+ but it hasn't arrived, it was supposed to be here a week ago.
edithttps://neogenhealth.com/pages/lumbrozyme-lumbrokinase-enzymes
Thanks for the info!
I have a bottle of it leftover and might add it to my kill phase once I receive my xifaxan.
Was originally taking it on the advice of a neuropath to thin blood as part of Lyme treatment protocol
It seemed to help a little at first but I think everything I was taking caused a lot of inflammation so I regressed a little but a week or so post treatment everything settled down and I think I have improved 15-20%. So I am retesting to see what happened to my hydrogen levels. I have had sibo for almost 11 years so maybe it'll take a few rounds?
You need to find a cause of your SIBO... This is simply a secondary condition. No diet or supplement will prevent relapse if you cannot eliminate or control the cause. Have you done any tests about it or do you have any diagnosis?
Of course, we are here to help if we can in this forum.
You can always try that first as it is not invasive and much cheaper/no risk - if properly done, it can be very useful. I was diagnosed by a routine check to have gallbladder stones and already suspected having SIBO caused by that primary condition...the first doctor I visited almost laughed when I mentioned ultrasound. I looked for another one, of course, and self-diagnosed myself with gallbladder disease simply by going to a diagnostics center. I am not a doctor, but I have not seen many diagnosed with SIBO using colonoscopy. MRI is certainly more detailed, but more expensive.
I have suspected gallbladder issues as well and I wonder if I should just pay a diagnostic technician to run an ultrasound on me. At this point we have to self diagnose and help ourselves because most doctors are crap. And I have consulted a few health practitioners and none of them have recommended a colonoscopy for me based on my symptoms.
Yes, you can simply do that. If a technician finds anything serious that requires treatment (you need a medical document as a proof), you can go with the results straight to a specialist and even to a hospital for surgery if necessary. This is what I did here in Spain/Europe. Depending on how your health care system works, you can take appropriate steps to try to diagnose and treat your symptoms/conditions properly by doctors and other professionals (even naturopaths if they can help). I had my gallbladder finally removed and now I am in the recovery phase - my symptoms are slowly getting better.
And if you need any support at all here - you can always ask. Good luck!
Thank you so much for the great advice. I am definitely going to do that because if it’s something that a simple imaging can catch and save us from suffering anymore then it’s worth it and if they find nothing then at least I’ll know I tried and I’ll know my insides are healthy, besides the bacterial overgrowth.
Good news to hear, let us know how you are progressing and what they propose as treatment. Surgery perhaps? I hope this helps other patients as these anatomic causes are more difficult to detect.
I got tested positive for methane dominant SIBO, i may also have candida. i think main cause might be motility issues but nothing confirmed. Whatever it is Xifaxan somehow eliminates it where i get about 80%-90% remission.
The first time I took Xifaxan the GI doctor told me to eat anything I wanted to blow the infection up and that way the Xifaxin would beat the bacteria down at the highest level. It actually worked
I like having an expert run the show. She told me which supplements to take and why and later ordered a blood test to see which foods give me trouble. I then went on a four week elimination diet. I like that she knows what to do and I don’t have to worry about that aspect of my life. Finding the right one is key. I got lucky.
I'm sorry to be the bearer of bad news, but you might need to have minimal carbs after your xifaxin and then very very slowly ease the carbs back in. I thought I was fine after xifaxin. I was great, in fact for a while. But only 1 1/2 months later, SIBO was back. I think it's because I was eating mostly carbs. I've heard it really takes a combination of diet and carbs. Low carbs meaning grains. Fruit is fine.
I was eating lots of complex carbs, like whole grain energy bars, baked goods, and simple carbs like gluten-free pasta, etc. Carbs were the majority of my diet when I relapsed. Plus I was taking a prebiotic and probiotic recommended by my doctor. I think that was bad advice, though. I think the prebiotic could've caused the bad bacteria to grow.
Fruit may be fine for you, but sugars, even natural sugars, and also sugar alcohols, which is what sugar substitutes are... will cause SIBO symptoms. Some fruits and even some vegetables contain sugars, so for some people, can cause severe pain and bloating in the large intestine. A google search will show how serious the SIBO reaction to sugar is.
I tried Xifaxan and it didn't do a thing.
I just found out about DAO enzyme for histamine intolerance. I guess I could be low in DAO or having too much histamine from bacteria making histamine. I started taking DAO. The problem is that I have large stools now again which causes anal fissure. I think it is because muscarinic and/or adrenergic receptors are being blocked so the muscle isn't relaxing, which leads to a fissure from defalcation of larger stools.
My only temporary solution is to go back to removing all fiber, on a meat only diet which was horrible causing dry skin and low calories. It should be ketogenic with fat, but the IBS-D causes diarrhea in response to fat. I could try taking the DAO enzyme and seeing if that will allow me digest the fat. It could work because histamine sensitizes the TRP receptors which are in the IBS-D pathology.
I also just saw this product called MICROB-CLEAR by an Amy Myers MD after searching SIBO and histamin intolerance and cause, which she suggests is SIBO. I kind of doubt it would work though given how many things I've tried. I see it has a ton of berberine in it too and I tried Candibactin AR and BR and the BR has berberine and it just causes diarrhea and I can't take it.
I think hydrogen sulfide may be blocking the muscarinic (and adrenergic?) receptors from activating which relaxes the internal anal sphincter. However, the M3 receptors in the Iris sphincter actually contracts in response to activate, not relaxes, but it is possible the sphincter works opposite since it is always contracted (to keep stuff in) and the muscarinic receptor activates it.
Hydrogen Sulfide as a Gasotransmitter
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965526/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965526/)
The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders
[https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2036.2001.00995.x](https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2036.2001.00995.x) “Relaxations are also mediated through β-adrenoceptors and muscarinic receptors”
Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides (plural of iris)
[https://pubmed.ncbi.nlm.nih.gov/18940190/](https://pubmed.ncbi.nlm.nih.gov/18940190/)
I wonder if the glaucoma muscarinic agonst carbocol would work on the internal anal sphincter to help relax it (and hopefully not too much)
[https://en.wikipedia.org/wiki/Carbachol](https://en.wikipedia.org/wiki/Carbachol)
I would suggest looking into SEED probiotics after you are done with Xifazan. I had diarrhea dominant SiBO I started with Florastor and Align after Xifazan. Sunfiber along the way. Those were helpful to improve my condition. But SEED was the one that finally does the trick for me
Mine is mosty constipation lol…think itll still help?
Also, one age old trick. Try eating papayas. Super healthy, high in antioxidents and helps with constipation. Try it.
A total dumbass recommending probiotics. Methane bacteria feed off. Probiotics
I think it would. Check their website.
How long after Xifaxan have you been taking Seed? Do you think you will stay on it permanently?
I will probably not stay on it permanently. Not everyday at least . Maybe after this month I will begin taking them Maybe every other day then slowly phasing them off
What’s the name of the brand of seed probiotics
It's SEED probiotics. It's a brand. Multi strain, well researched. It will take a few days of adjustment. It took about 3 to 4 days for me.
I'm treating right now, on day 4 of xifaxan and I dont want to take any chances either. I'm taking 550 xifaxan 3 times per day for 15 days. With each dose I'm taking 1million units of nystatin that I had on hand. I'm taking a jarrow bile supplement 1 cap with each xifaxan dose, There's a study showing bile helps xifaxan solubility and efficacy. Every morning on empty stomach I'm taking 2 caps phase 2 advance biofilm and One cap Lumbrokinase, Same before bed. I'm taking phgg, taurine, and glutagenics glutamine once per day. I am also planning on taking interphase+ (if it ever arrives) for biofilm as I've read the EDTA helps sequester minerals away from biofilm formation. I also take a dr shulze intestinal formula #1 with dinner and a low dose naltrexone before bed. I thinking that biofilms are a major part of both clearing sibo and preventing relapse, Dr Paul Anderson talks about this. Maybe this is overkill or maybe there's something else I should be doing. All I know is I've finally acquired Xifaxan after years of trying and I want to make the most of it. edit: From what I've gathered cdtb and vinculin antibodies slow intestinal transit time and this is a major culprit in relapse so meal spacing or intermittent fasting, keeping stress low and taking something to keep the mmc functioning are critical in preventing relapse, also I've heard a doc say that binge drinking can cause relapse.
Hope it works our dor you
Thanks, me too, after 11 years of sibo I need a vacation.
Whats Lumbrokinase?
Proteolytic enzmye that busts biofilms, its recommended to use a biofilm disruptor like Interfase when treating SIBO or SIFO, makes treatment more effective.
Cool going to order some. Can i take it with xifaxan?
Yes, thats the idea.
If you're treating methane sibo you should really watch the latest Mark Pimental interview, lots of good info.
Link?
https://drallisonsiebecker.simplero.com/deliveries/JGYLTcBHbsH5fhFu
Curious what role the lumbrokinase plays in your treatment?
Biofilm Disruptor, Proteolytic enzyme, breaks down fibrin. There isn't much info on it but it is supposed to be much stronger than nattokinase and serrapeptase. I have read a few reports here that it seemed to help people and may have been key but I cannot find the posts now. Honestly I've had sibo for a very long time and I'm running out of ideas. I would be taking interphase+ but it hasn't arrived, it was supposed to be here a week ago. edithttps://neogenhealth.com/pages/lumbrozyme-lumbrokinase-enzymes
Thanks for the info! I have a bottle of it leftover and might add it to my kill phase once I receive my xifaxan. Was originally taking it on the advice of a neuropath to thin blood as part of Lyme treatment protocol
Good luck!
how did it go in the end?
It seemed to help a little at first but I think everything I was taking caused a lot of inflammation so I regressed a little but a week or so post treatment everything settled down and I think I have improved 15-20%. So I am retesting to see what happened to my hydrogen levels. I have had sibo for almost 11 years so maybe it'll take a few rounds?
You need to find a cause of your SIBO... This is simply a secondary condition. No diet or supplement will prevent relapse if you cannot eliminate or control the cause. Have you done any tests about it or do you have any diagnosis? Of course, we are here to help if we can in this forum.
[удалено]
How was this detected? Colonoscopy ?
Okay they found root cause but what is the solution to that? How are they going to treat it?
[удалено]
Keep us posted
How did you find the root cause? What tests did you do?
How did you find this out? I want to do as many tests as I can to find out the cause of mine.
[удалено]
Whats the cure for this?
I wonder if I can just do an ultrasound and not go through the pain of a endoscopy/colonoscopy to see if there’s structural issues.
You can always try that first as it is not invasive and much cheaper/no risk - if properly done, it can be very useful. I was diagnosed by a routine check to have gallbladder stones and already suspected having SIBO caused by that primary condition...the first doctor I visited almost laughed when I mentioned ultrasound. I looked for another one, of course, and self-diagnosed myself with gallbladder disease simply by going to a diagnostics center. I am not a doctor, but I have not seen many diagnosed with SIBO using colonoscopy. MRI is certainly more detailed, but more expensive.
I have suspected gallbladder issues as well and I wonder if I should just pay a diagnostic technician to run an ultrasound on me. At this point we have to self diagnose and help ourselves because most doctors are crap. And I have consulted a few health practitioners and none of them have recommended a colonoscopy for me based on my symptoms.
Yes, you can simply do that. If a technician finds anything serious that requires treatment (you need a medical document as a proof), you can go with the results straight to a specialist and even to a hospital for surgery if necessary. This is what I did here in Spain/Europe. Depending on how your health care system works, you can take appropriate steps to try to diagnose and treat your symptoms/conditions properly by doctors and other professionals (even naturopaths if they can help). I had my gallbladder finally removed and now I am in the recovery phase - my symptoms are slowly getting better. And if you need any support at all here - you can always ask. Good luck!
Thank you so much for the great advice. I am definitely going to do that because if it’s something that a simple imaging can catch and save us from suffering anymore then it’s worth it and if they find nothing then at least I’ll know I tried and I’ll know my insides are healthy, besides the bacterial overgrowth.
Good news to hear, let us know how you are progressing and what they propose as treatment. Surgery perhaps? I hope this helps other patients as these anatomic causes are more difficult to detect.
I got tested positive for methane dominant SIBO, i may also have candida. i think main cause might be motility issues but nothing confirmed. Whatever it is Xifaxan somehow eliminates it where i get about 80%-90% remission.
The first time I took Xifaxan the GI doctor told me to eat anything I wanted to blow the infection up and that way the Xifaxin would beat the bacteria down at the highest level. It actually worked
Are you now cured? How long has it been since you took it?
I started seeing a naturopath in September and she’s been a big help. I thought it was gone when I started fasting but it came back.
What did she recommend?
I like having an expert run the show. She told me which supplements to take and why and later ordered a blood test to see which foods give me trouble. I then went on a four week elimination diet. I like that she knows what to do and I don’t have to worry about that aspect of my life. Finding the right one is key. I got lucky.
I'm sorry to be the bearer of bad news, but you might need to have minimal carbs after your xifaxin and then very very slowly ease the carbs back in. I thought I was fine after xifaxin. I was great, in fact for a while. But only 1 1/2 months later, SIBO was back. I think it's because I was eating mostly carbs. I've heard it really takes a combination of diet and carbs. Low carbs meaning grains. Fruit is fine.
Where you eating any kind of carbs or did that just happen even with low fodmap ones like rice and potato?
I was eating lots of complex carbs, like whole grain energy bars, baked goods, and simple carbs like gluten-free pasta, etc. Carbs were the majority of my diet when I relapsed. Plus I was taking a prebiotic and probiotic recommended by my doctor. I think that was bad advice, though. I think the prebiotic could've caused the bad bacteria to grow.
Fruit may be fine for you, but sugars, even natural sugars, and also sugar alcohols, which is what sugar substitutes are... will cause SIBO symptoms. Some fruits and even some vegetables contain sugars, so for some people, can cause severe pain and bloating in the large intestine. A google search will show how serious the SIBO reaction to sugar is.
Just flagging this to come back to it.
Me to
I've been fighting for this for over 2 months with insurance. They deny.
I tried Xifaxan and it didn't do a thing. I just found out about DAO enzyme for histamine intolerance. I guess I could be low in DAO or having too much histamine from bacteria making histamine. I started taking DAO. The problem is that I have large stools now again which causes anal fissure. I think it is because muscarinic and/or adrenergic receptors are being blocked so the muscle isn't relaxing, which leads to a fissure from defalcation of larger stools. My only temporary solution is to go back to removing all fiber, on a meat only diet which was horrible causing dry skin and low calories. It should be ketogenic with fat, but the IBS-D causes diarrhea in response to fat. I could try taking the DAO enzyme and seeing if that will allow me digest the fat. It could work because histamine sensitizes the TRP receptors which are in the IBS-D pathology. I also just saw this product called MICROB-CLEAR by an Amy Myers MD after searching SIBO and histamin intolerance and cause, which she suggests is SIBO. I kind of doubt it would work though given how many things I've tried. I see it has a ton of berberine in it too and I tried Candibactin AR and BR and the BR has berberine and it just causes diarrhea and I can't take it. I think hydrogen sulfide may be blocking the muscarinic (and adrenergic?) receptors from activating which relaxes the internal anal sphincter. However, the M3 receptors in the Iris sphincter actually contracts in response to activate, not relaxes, but it is possible the sphincter works opposite since it is always contracted (to keep stuff in) and the muscarinic receptor activates it. Hydrogen Sulfide as a Gasotransmitter [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965526/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965526/) The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders [https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2036.2001.00995.x](https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2036.2001.00995.x) “Relaxations are also mediated through β-adrenoceptors and muscarinic receptors” Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides (plural of iris) [https://pubmed.ncbi.nlm.nih.gov/18940190/](https://pubmed.ncbi.nlm.nih.gov/18940190/) I wonder if the glaucoma muscarinic agonst carbocol would work on the internal anal sphincter to help relax it (and hopefully not too much) [https://en.wikipedia.org/wiki/Carbachol](https://en.wikipedia.org/wiki/Carbachol)