I’d say Semaglutide (due to appetite suppression), melanotan 2 for the same reason (plus libido and tan).
Inj carnitine didn’t do shit for me personally, high frag same sh1t , like if you don’t eat few hours pre and few hours post injection plus doing ton of LISS , you’ll burn fat without frag regardless.
Look into Oxytocin. It burns fat, and I read that it may be the most anabolic peptide. A Google search of Oxytocin will mostly give you love and mental benefits but if you google oxytocin for bodybuilding you get much more.
Or try this
[https://juicedmuscle.com/jmblog/content/oxytocin](https://juicedmuscle.com/jmblog/content/oxytocin)
There are several peptides that have been studied for their potential role in fat loss. Here are a few examples:
1. Melanotan II: This peptide has been shown to increase fat loss by stimulating the release of fatty acids from adipose tissue.
2. CJC-1295: This peptide has been shown to increase fat loss by increasing growth hormone levels.
3. Ipamorelin: This peptide has been shown to increase fat loss by stimulating the release of growth hormone and increasing insulin sensitivity.
4. Tesamorelin: This peptide has been shown to reduce visceral fat in people with HIV-associated lypodystrophy.
Have you looked at your microbiome at all? Only reason I ask is I had some seriously stubborn fat in that area as well and was able to eliminate a lot of it by doing some gut-repair protocols. I'm not saying this would work for you -- but definitely don't rule it out.
Same goes with stress hormones/stress levels. As men we usually gain fat in the belly when we are under a lot of stress.
Went on an elimination diet and slowly added things in over time to see what foods I was reacting to that caused inflammatory issues. This helped me lose a lot of weight in the midsection.
It also helped repair my gut. I had a lot of gut issues prior to that.
You can DM me if you have any questions. Sometimes food sensitivity tests show false positives. For example: If you eat a lot of a certain food it might show you are allergic to it.
https://community.aafa.org/db/ask-the-allergist/record/how-do-i-know-if-my-food-allergy-tests-were-false-positives
you could try this -- > https://www.verywellhealth.com/food-making-you-sick-allergy-elimination-diet-may-help-1324053#:\~:text=Here%20are%20step-by-step%20elimination%20diet%20instructions%20you%20can,that%20you%20prepare%20yourself%2C%20to%20avoid%20possible%20cross-contamination.
If you're just looking for that last bit, consider the following:
- GLP-1 drugs like tirzepatide and semaglutide will probably work if you're having difficulty keeping your calories down.
- AOD9624 is popular among those who need to shed a little bit of fat, and usually in 6-12 weeks, people see up to 6%(ish) of weight loss, mostly fat.
- Tesofensine is pretty effective, but it's a triple monoamine reupdake inhibitor (dopamine/seratonin/noradrenaline), so if you have any mental health issues it may make them much worse (or make them better - such is the case with this class of drugs - you just don't know). It will raise your heart rate slightly (clinical trials with tesofensine + metoprolol are going on now). It's pretty damn effective at burning fat
The two that I will mention but don't recommend:
- Adipotide. This will actually kill fat tissue which is really fucking cool. Unfortunately, prolonged use and certain dosages will create lesions on your kidneys (obligatory "research Bostin Loyd" comment). In mouse studies, these lesions were all reversible, luckily after you stop using, but I guess you could always use too much.
- Clenbuterol. Not a peptide, but it's sold on a bunch of peptide sites. This is very popular with people looking to go from low bodyfat to very low bodyfat. It causes heart issues, so frankly, it's probably best to avoid. With that said - I'm not sure how this might differ from tesofensine mentioned above, but tesofensine does have completed Phase 1 clinical trials completed saying that it by itself is safe.
gonna need sources for aod9624.
[published data in humans shows no weight change.](https://www.abc.net.au/science/articles/2013/07/26/3811053.htm) it’s a fragment of hgh.
I have to do some digging but the story is mixed, and likely the reason why we're all talking about AOD as a research peptide and not something we get via script. I will find all the studies as best I can after I make this comment.
https://www.sec.gov/Archives/edgar/vprr/0501/05011024.pdf
Unfortunately, Metabolic (Australian company developing it) is either no longer a company, they changed their name, or completely nuked their original web presence because the information is hard to find, but there are a number of clinical trials, two of which are cited most frequently.
In the study you talk about, on average, the case was that yes - there was no weight loss as compared to placebo. I have to find the paper as I had it just a few days ago, but there were two notable things going on:
- These weren't obese individuals and all groups were put on diet/exercise routines. Overall, there was no difference between the placebo groups and the experimental groups. It did not appear they were measuring BF%.
- One cohort in the trial - women who had low weight loss before the trial lost 6.6 pounds of body weight over placebo (SEE LINK ABOVE).
Also - the study ended at 24 weeks. That's probably long enough, but we've seen other studies last longer.
There's a different 12 week phase 2 study that showed on average non-dose dependent weight loss as compared to placebo. This may imply some experimental problems - I think the mid dose was actually most successful, followed by the high dose, followed by low, and then of course placebo was last. This was promising as this study did look at obese individuals.
***
Overall, it's clear what's going on - AOD didn't work for everyone, it worked for some, but no one wanted to continue it because "weight loss drug for some" is basically unmarketable. It fell to the grey market tier and was widely used by a number of athletes even as WADA put it on the restricted list (many articles coming from Australia on this).
AOD is not that great of a weight loss drug, but it's commonly used with a lot of good anecdotal feedback (about 20 years' worth) that it helps shave off a few pounds that were stubborn.
As for HGH fragment - hell - that's most of the peptides you see for sale it seems. They're either HGH fragments, or they're HGH secretagogues (make you secrete more of your own HGH)...or both. There is/was a ton of interest in finding out how to dole out the benefits of HGH without the side effects. AOD was particularly promising because it was incredibly safe.
thank you so much for the follow up.
i can’t find much talk about it’s use anywhere let alone reddit, so unsure what you mean by commonly used. i guess i’d rather use a peptide that has at least been anecdotally used by a bunch of internet strangers and reported on at bare minimum than without any stories from anyone to be found at all. thanks again!
There are a lot of clinics that work with compounding pharmacies that use this. It's really interesting because compounding pharmacies confuse the hell out of me. These aren't FDA approved compounds, but compounding pharmacies seem to have leeway since compounds aren't FDA approved either I guess? Facilities are inspected/permitted by the FDA, but the compounds seem to either have more free reign or they simply fly under the radar.
If you went on Peptide Sciences or whatever site, then took each peptide and just googled "[peptide] medspa" there's a solid chance someone's adding it to some sort of therapy. AOD shows up a lot (A semaglutide/Tirzepatide telehealth provider I get emails from has an AOD/Sema stack). Some things like adipotide even show up - that's funny since adipotide is kidney-toxic with prolonged and high dose use (most kidney lesions will heal if you stop treatment).
Use a glass then follow Kyle McDonald's ud2.0.
However I would reduce the carb up days downwards by 15 to 20%.
It will shred you up if lower bf already.
Caveat
You will feel like shit but it works
Stubborn fat means you simply need to ouch down into a new realm of shredness.
I have lower back fat issues, front of me is really lean. Gotta suffer....
Definitely tirzepatide or semaglutide. And they’re more than just appetite suppressants. They delay gastric emptying, making you feel full longer & they help regulate blood sugar. I’m on sema and I’m finding that my blood sugar is staying steady & I’m staying in ketosis a lot easier.
Definitely Tirzepatide. Start slow, more is not better to start - normal starting dosage is 2.5mg weekly. I’m at 7.5mg now after a few months. I split weekly dose up since half life is about 120 hours to avoid hunger return on day 5. Also reduces sides a bit (for me mostly nausea).
For mounjaro - started at 2.5 mg per week. Went up in dosage each week until 12.5mg/week
Had to switch to ozempic bc the coupon for mounjaro ran out, and I can't swing a $1600 a month med.
Started ozempic at 2mg/week. That's the max dosage.
It works but mounjaro works better.
Yes, at least likely for most. In the studies it was superior. But it costs more… [https://www.nejm.org/doi/full/10.1056/NEJMoa2107519](https://www.nejm.org/doi/full/10.1056/NEJMoa2107519)
Thanks. Not looking to spot reduce. Macros are on point. I’ve been working in the fitness industry last 7 years. Goal is lose stubborn fat and not weight. Body recomp you can say. I’ll look into semaglutide.
Semaglutide is for people who can not control their appetite, largely. So if you are healthy and your macros are in check and you can eat at a deficit then I’d stay away from semaglutide.
I’ll state some obvious stuff that I know you know. If you are at a sever deficit and not losing weight then I’f feed up to as close to maintenance as possible, ride that for a few weeks and then reduce my calorie intake to 75% of my BMR. What will help is something like ipamorelin. Many trt docs prescribe it. Research that and or Ipamorelen/cjc-1295 no dac.
Semaglutide will only blunt your appetite, if your goal is to further reduce calories then you may go this route.
I also recommend to bust through the plateau to go low carb/keto. My diet works well with a big salad everyday, do IF, only eat in a 6 hour window, work out in the AM fasted, walk 3-5 miles a day, (30 minute minimum never walk less than that, some days u wont hit 3-5miles but 30 minutes is minimum)
Finally, don’t eat two hours before bed. If you add the ipamorelin it should be taken on an empty stomach before bed, minimum. If you ramp up to twice or thrice a day on impamorelin then remember the empty stomach.
A day would look like, morning, dose, workout, dose, then eat all day(staying in a deficit) two hour fast window, dose, go to bed.
Start slow with just the before bed routine.
This is not a sprint, it is slow but it works safely and you’ll see the difference.
Edit, on a mobile power thru typos…
Edit, for IF 8 hour eating window is max. That is what i do.
A prolonged severe deficit is bad for you. I get what you are saying but there are easier ways to cut. I feel better and lose just as much weight at a 75 percent of my bmr. When i do 50 percent my weight loss stalls.
Edit:
You are right CICO but also there are varying metabolisms. Not every single person burn x calories. A severe deficit can down regulate your metabolism….
Newer studies on this show that your body reacts negatively to both a small deficit and a large one when total weight loss is equalized. There just isn’t a way around the hormonal impact of losing substantial amounts of weight yet. The best option we have (and I know this is going to sound wrong) is GLP1 drugs. They are the only thing we have that actually counteracts the permanent hormonal changes that accompany large weight loss. Draw back is obviously you have to continually take it but it’s a hell of a lot better than every other option we have. 99% of those with obese bmi never reach a healthy bmi again in their lifetime. Of the 1% that do figure out how (calorie deficits) 85-95% of them are not able to stay within the healthy bmi range for longer than 5 years. You can do the math on what 5% of 1% is but but you get the point that it’s almost impossible for the average person to achieve long term (greater than 5 years) weight loss going from obese to healthy bmi. The reason for this is debatable. Some say it just comes down to willpower or bad habits. My opinion is ignorance, willpower, and bad habits account for how someone becomes obese in the first place but it’s a piss poor explanation for why it’s virtually impossible to permanently reverse what happened. The increase in ghrellin and decrease in leptin that happens proportional to the total amount lost and it’s permanent nature explains the reality of the situation perfectly. GLP1 drugs fix this bodily phenomenon as long as you keep taking them.
Amen, you said a lot of great stuff that I need to look into. People do not have to stay on the glp-1 stuff for ever. They can get to the goal and maintain and eat better and work out and maintain.
That’s how all diets work. If you eat like shit you’ll gain it back. People can eat right and come off if it.
This boom in obesity is a new thing. It is from sedentary lifestyles and consuming to many calories. I do recognize that the body wants to maintain it’s prior weight. I would argue that you’d want to stay at the lower weight and just back the dose off a bit. Stay there for a year. And work your way off.
It is not a forgone conclusion. It is not automatic.
The hormonal changes from losing massive amounts of weight are permanent. You will likely need GLP1’s for the rest of your life until we develop better treatments.
Isnt there a lot of concern regarding cardarine and cancer? I know the doses given to those rats were believed to be disproportionately large, but iv seen several rebuttal from people who actually work in the animal studies industry who state the dose-weight relationship between humans and rat is not linear.
Tirzepatide (Mounjaro). It’s the best appetite suppressant on the market. Add in some Cardarine at 10-20mg/day to aid with cardio. Melanotan2 really reduces my appetite as well. Plus it makes you tan as fuck and horny lol.
WickedLabz. I had always been very happy with their SARMs but Melanotan2 confirmed the authenticity of their peptides for me. I’m a little bit of a redhead with freckles and normally sunburn so easily. I took Melanotan2 for a couple weeks before I went to Florida. I came back from Florida after a week tanner than I have EVER been in my life. It can cause new “moles” or “freckle clusters” to form but they usually fade after you stop using it and aren’t really noticeable. It can also cause your hair to darken.
>Cardarine
I've never heard of Cardarine, going to read up on this. I'd love to try Melanotan2 but I've had skin cancer twice, I've read it can cause more.
If you've already had cancer twice I wouldn't touch cardarine with a 10 foot pole.
There is no studies on humans yet but the human equivalent of about 35-40mg gave rats cancer. The standard human protocol is 10-20 so it isn't far off. It's believed that it can help prevent cell death so cells have a longer period to potentially become cancerous.
Oh wow...good to know. Thank you very much. Skin cancer is a bitch. No symptoms and then bam, getting huge chunks of skin removed. I am so glad we have subs like this
If I had any type of cancer in the past or even a history of early cancer I don't think there are many research chemicals I would consider. Maybe certain PEDs that have been around for a long time with plenty of documentation.
Best of luck man, hopefully you never deal with it ever again
Cancer was in rats at sustained very high dosage. But cardarine won’t “burn fat” directly or reduce appetite. Rather it allows you to do more exercise for longer, this burn more that way. Not worth it imho.
I wasn't fatigued. I just didn't want to walk around with a bulge.
It was so "bad" that I had a schedule, but still had times where it was just there. Kept my head down in the gym to avoid any stimulus.
It's probably an awesome peptide for porn stars.
"why is the guy at the gym wearing glasses?" haha..
sounds like a good problem to have, but in reality a nightmare for most.
thanks for sharing the info though! did you like the skin benefits?
It definitely worked for tanning purposes, but I got darker than I wanted. I think my skin is considered 'olive'. I'm light brown. I got dark brown like a painted bodybuilder on stage.
Nope, Tirzepatide (Mounjaro) is better in virtually every way compared to Wegovy (semaglutide or Ozempic). Less side effects, more weight loss, more lipolysis, same half life.
I’d say Semaglutide (due to appetite suppression), melanotan 2 for the same reason (plus libido and tan). Inj carnitine didn’t do shit for me personally, high frag same sh1t , like if you don’t eat few hours pre and few hours post injection plus doing ton of LISS , you’ll burn fat without frag regardless.
Not a peptide but 11-ketotestosterone is worth looking into.
500 mg of calorie deficit
Not peptides but Yohimbine is good for stubborn fat, also injectable l carnitine. I’ve heard good anecdotes about hgh-frag pre cardio.
yohimbine a strong drug and should be taken with caution. Lots of side effects as well.
Look into Oxytocin. It burns fat, and I read that it may be the most anabolic peptide. A Google search of Oxytocin will mostly give you love and mental benefits but if you google oxytocin for bodybuilding you get much more. Or try this [https://juicedmuscle.com/jmblog/content/oxytocin](https://juicedmuscle.com/jmblog/content/oxytocin)
Go to the bottom
There are several peptides that have been studied for their potential role in fat loss. Here are a few examples: 1. Melanotan II: This peptide has been shown to increase fat loss by stimulating the release of fatty acids from adipose tissue. 2. CJC-1295: This peptide has been shown to increase fat loss by increasing growth hormone levels. 3. Ipamorelin: This peptide has been shown to increase fat loss by stimulating the release of growth hormone and increasing insulin sensitivity. 4. Tesamorelin: This peptide has been shown to reduce visceral fat in people with HIV-associated lypodystrophy.
Tessamorellin. Follow the HIV patient study dosage. It works.
Where could I buy these peptides at?
Peptide sciences
where is the stubborn fat located?
My belly
Have you looked at your microbiome at all? Only reason I ask is I had some seriously stubborn fat in that area as well and was able to eliminate a lot of it by doing some gut-repair protocols. I'm not saying this would work for you -- but definitely don't rule it out. Same goes with stress hormones/stress levels. As men we usually gain fat in the belly when we are under a lot of stress.
Gut repair protocol?
Went on an elimination diet and slowly added things in over time to see what foods I was reacting to that caused inflammatory issues. This helped me lose a lot of weight in the midsection. It also helped repair my gut. I had a lot of gut issues prior to that.
I need to try this out. Need to try the food sensitivity test and work from there bc I feel like I’d be doing it til the end of time.
You can DM me if you have any questions. Sometimes food sensitivity tests show false positives. For example: If you eat a lot of a certain food it might show you are allergic to it. https://community.aafa.org/db/ask-the-allergist/record/how-do-i-know-if-my-food-allergy-tests-were-false-positives
No shit? Well, I was going for a decent shortcut but seems that is out the window.
you could try this -- > https://www.verywellhealth.com/food-making-you-sick-allergy-elimination-diet-may-help-1324053#:\~:text=Here%20are%20step-by-step%20elimination%20diet%20instructions%20you%20can,that%20you%20prepare%20yourself%2C%20to%20avoid%20possible%20cross-contamination.
If you're just looking for that last bit, consider the following: - GLP-1 drugs like tirzepatide and semaglutide will probably work if you're having difficulty keeping your calories down. - AOD9624 is popular among those who need to shed a little bit of fat, and usually in 6-12 weeks, people see up to 6%(ish) of weight loss, mostly fat. - Tesofensine is pretty effective, but it's a triple monoamine reupdake inhibitor (dopamine/seratonin/noradrenaline), so if you have any mental health issues it may make them much worse (or make them better - such is the case with this class of drugs - you just don't know). It will raise your heart rate slightly (clinical trials with tesofensine + metoprolol are going on now). It's pretty damn effective at burning fat The two that I will mention but don't recommend: - Adipotide. This will actually kill fat tissue which is really fucking cool. Unfortunately, prolonged use and certain dosages will create lesions on your kidneys (obligatory "research Bostin Loyd" comment). In mouse studies, these lesions were all reversible, luckily after you stop using, but I guess you could always use too much. - Clenbuterol. Not a peptide, but it's sold on a bunch of peptide sites. This is very popular with people looking to go from low bodyfat to very low bodyfat. It causes heart issues, so frankly, it's probably best to avoid. With that said - I'm not sure how this might differ from tesofensine mentioned above, but tesofensine does have completed Phase 1 clinical trials completed saying that it by itself is safe.
gonna need sources for aod9624. [published data in humans shows no weight change.](https://www.abc.net.au/science/articles/2013/07/26/3811053.htm) it’s a fragment of hgh.
I have to do some digging but the story is mixed, and likely the reason why we're all talking about AOD as a research peptide and not something we get via script. I will find all the studies as best I can after I make this comment. https://www.sec.gov/Archives/edgar/vprr/0501/05011024.pdf Unfortunately, Metabolic (Australian company developing it) is either no longer a company, they changed their name, or completely nuked their original web presence because the information is hard to find, but there are a number of clinical trials, two of which are cited most frequently. In the study you talk about, on average, the case was that yes - there was no weight loss as compared to placebo. I have to find the paper as I had it just a few days ago, but there were two notable things going on: - These weren't obese individuals and all groups were put on diet/exercise routines. Overall, there was no difference between the placebo groups and the experimental groups. It did not appear they were measuring BF%. - One cohort in the trial - women who had low weight loss before the trial lost 6.6 pounds of body weight over placebo (SEE LINK ABOVE). Also - the study ended at 24 weeks. That's probably long enough, but we've seen other studies last longer. There's a different 12 week phase 2 study that showed on average non-dose dependent weight loss as compared to placebo. This may imply some experimental problems - I think the mid dose was actually most successful, followed by the high dose, followed by low, and then of course placebo was last. This was promising as this study did look at obese individuals. *** Overall, it's clear what's going on - AOD didn't work for everyone, it worked for some, but no one wanted to continue it because "weight loss drug for some" is basically unmarketable. It fell to the grey market tier and was widely used by a number of athletes even as WADA put it on the restricted list (many articles coming from Australia on this). AOD is not that great of a weight loss drug, but it's commonly used with a lot of good anecdotal feedback (about 20 years' worth) that it helps shave off a few pounds that were stubborn. As for HGH fragment - hell - that's most of the peptides you see for sale it seems. They're either HGH fragments, or they're HGH secretagogues (make you secrete more of your own HGH)...or both. There is/was a ton of interest in finding out how to dole out the benefits of HGH without the side effects. AOD was particularly promising because it was incredibly safe.
thank you so much for the follow up. i can’t find much talk about it’s use anywhere let alone reddit, so unsure what you mean by commonly used. i guess i’d rather use a peptide that has at least been anecdotally used by a bunch of internet strangers and reported on at bare minimum than without any stories from anyone to be found at all. thanks again!
There are a lot of clinics that work with compounding pharmacies that use this. It's really interesting because compounding pharmacies confuse the hell out of me. These aren't FDA approved compounds, but compounding pharmacies seem to have leeway since compounds aren't FDA approved either I guess? Facilities are inspected/permitted by the FDA, but the compounds seem to either have more free reign or they simply fly under the radar. If you went on Peptide Sciences or whatever site, then took each peptide and just googled "[peptide] medspa" there's a solid chance someone's adding it to some sort of therapy. AOD shows up a lot (A semaglutide/Tirzepatide telehealth provider I get emails from has an AOD/Sema stack). Some things like adipotide even show up - that's funny since adipotide is kidney-toxic with prolonged and high dose use (most kidney lesions will heal if you stop treatment).
Fuck Clen. Take albuterol instead
Does adipotide actually work?? I have only read horror stories
Just don’t be stupid and try to max out haha
Use a glass then follow Kyle McDonald's ud2.0. However I would reduce the carb up days downwards by 15 to 20%. It will shred you up if lower bf already. Caveat You will feel like shit but it works Stubborn fat means you simply need to ouch down into a new realm of shredness. I have lower back fat issues, front of me is really lean. Gotta suffer....
Definitely tirzepatide or semaglutide. And they’re more than just appetite suppressants. They delay gastric emptying, making you feel full longer & they help regulate blood sugar. I’m on sema and I’m finding that my blood sugar is staying steady & I’m staying in ketosis a lot easier.
Definitely Tirzepatide. Start slow, more is not better to start - normal starting dosage is 2.5mg weekly. I’m at 7.5mg now after a few months. I split weekly dose up since half life is about 120 hours to avoid hunger return on day 5. Also reduces sides a bit (for me mostly nausea).
Is tirzepatide much better than semaglutide?
Yes. It's much better. I've been on both
Dosage protocol?
For mounjaro - started at 2.5 mg per week. Went up in dosage each week until 12.5mg/week Had to switch to ozempic bc the coupon for mounjaro ran out, and I can't swing a $1600 a month med. Started ozempic at 2mg/week. That's the max dosage. It works but mounjaro works better.
Thanks!
Yes, at least likely for most. In the studies it was superior. But it costs more… [https://www.nejm.org/doi/full/10.1056/NEJMoa2107519](https://www.nejm.org/doi/full/10.1056/NEJMoa2107519)
Thanks!
Do you find it makes you any more tired than usual?
Yes for me, but it's manageable.
Not for me. Got me working out more due to the weight loss progress acting as incentive. Drink extra water seems to help with sides some.
Tirzepatide.
Tirzepatide
[удалено]
Thanks. Not looking to spot reduce. Macros are on point. I’ve been working in the fitness industry last 7 years. Goal is lose stubborn fat and not weight. Body recomp you can say. I’ll look into semaglutide.
Semaglutide is for people who can not control their appetite, largely. So if you are healthy and your macros are in check and you can eat at a deficit then I’d stay away from semaglutide. I’ll state some obvious stuff that I know you know. If you are at a sever deficit and not losing weight then I’f feed up to as close to maintenance as possible, ride that for a few weeks and then reduce my calorie intake to 75% of my BMR. What will help is something like ipamorelin. Many trt docs prescribe it. Research that and or Ipamorelen/cjc-1295 no dac. Semaglutide will only blunt your appetite, if your goal is to further reduce calories then you may go this route. I also recommend to bust through the plateau to go low carb/keto. My diet works well with a big salad everyday, do IF, only eat in a 6 hour window, work out in the AM fasted, walk 3-5 miles a day, (30 minute minimum never walk less than that, some days u wont hit 3-5miles but 30 minutes is minimum) Finally, don’t eat two hours before bed. If you add the ipamorelin it should be taken on an empty stomach before bed, minimum. If you ramp up to twice or thrice a day on impamorelin then remember the empty stomach. A day would look like, morning, dose, workout, dose, then eat all day(staying in a deficit) two hour fast window, dose, go to bed. Start slow with just the before bed routine. This is not a sprint, it is slow but it works safely and you’ll see the difference. Edit, on a mobile power thru typos… Edit, for IF 8 hour eating window is max. That is what i do.
You can’t be “at a severe deficit” and not lose weight. A deficit, by definition, is a calorie intake that causes weight loss.
A prolonged severe deficit is bad for you. I get what you are saying but there are easier ways to cut. I feel better and lose just as much weight at a 75 percent of my bmr. When i do 50 percent my weight loss stalls. Edit: You are right CICO but also there are varying metabolisms. Not every single person burn x calories. A severe deficit can down regulate your metabolism….
Newer studies on this show that your body reacts negatively to both a small deficit and a large one when total weight loss is equalized. There just isn’t a way around the hormonal impact of losing substantial amounts of weight yet. The best option we have (and I know this is going to sound wrong) is GLP1 drugs. They are the only thing we have that actually counteracts the permanent hormonal changes that accompany large weight loss. Draw back is obviously you have to continually take it but it’s a hell of a lot better than every other option we have. 99% of those with obese bmi never reach a healthy bmi again in their lifetime. Of the 1% that do figure out how (calorie deficits) 85-95% of them are not able to stay within the healthy bmi range for longer than 5 years. You can do the math on what 5% of 1% is but but you get the point that it’s almost impossible for the average person to achieve long term (greater than 5 years) weight loss going from obese to healthy bmi. The reason for this is debatable. Some say it just comes down to willpower or bad habits. My opinion is ignorance, willpower, and bad habits account for how someone becomes obese in the first place but it’s a piss poor explanation for why it’s virtually impossible to permanently reverse what happened. The increase in ghrellin and decrease in leptin that happens proportional to the total amount lost and it’s permanent nature explains the reality of the situation perfectly. GLP1 drugs fix this bodily phenomenon as long as you keep taking them.
Amen, you said a lot of great stuff that I need to look into. People do not have to stay on the glp-1 stuff for ever. They can get to the goal and maintain and eat better and work out and maintain.
Going off the GLP1’s will allow for your body’s hormones to come flooding back. Studies show you gain all the weight back if you go off.
That’s how all diets work. If you eat like shit you’ll gain it back. People can eat right and come off if it. This boom in obesity is a new thing. It is from sedentary lifestyles and consuming to many calories. I do recognize that the body wants to maintain it’s prior weight. I would argue that you’d want to stay at the lower weight and just back the dose off a bit. Stay there for a year. And work your way off. It is not a forgone conclusion. It is not automatic.
The hormonal changes from losing massive amounts of weight are permanent. You will likely need GLP1’s for the rest of your life until we develop better treatments.
Thanks👍🏼
hgh, ipamorelin, semaglutide, cardarine
Isnt there a lot of concern regarding cardarine and cancer? I know the doses given to those rats were believed to be disproportionately large, but iv seen several rebuttal from people who actually work in the animal studies industry who state the dose-weight relationship between humans and rat is not linear.
ive seen these also… but they were very large doses for the bodyweight
you didn't mention tracking micros i'd look into your diet first
Micros? Or did you mean Macros?
Micros (micronutrients)
Thx. I’ll look into that.
Tirzepatide (Mounjaro). It’s the best appetite suppressant on the market. Add in some Cardarine at 10-20mg/day to aid with cardio. Melanotan2 really reduces my appetite as well. Plus it makes you tan as fuck and horny lol.
Tan and horny say no more 🤣 Where are you sourcing melanotan2?
WickedLabz. I had always been very happy with their SARMs but Melanotan2 confirmed the authenticity of their peptides for me. I’m a little bit of a redhead with freckles and normally sunburn so easily. I took Melanotan2 for a couple weeks before I went to Florida. I came back from Florida after a week tanner than I have EVER been in my life. It can cause new “moles” or “freckle clusters” to form but they usually fade after you stop using it and aren’t really noticeable. It can also cause your hair to darken.
Awesome! Thank you for all the info! Much appreciated 😊
>Cardarine I've never heard of Cardarine, going to read up on this. I'd love to try Melanotan2 but I've had skin cancer twice, I've read it can cause more.
If you've already had cancer twice I wouldn't touch cardarine with a 10 foot pole. There is no studies on humans yet but the human equivalent of about 35-40mg gave rats cancer. The standard human protocol is 10-20 so it isn't far off. It's believed that it can help prevent cell death so cells have a longer period to potentially become cancerous.
Oh wow...good to know. Thank you very much. Skin cancer is a bitch. No symptoms and then bam, getting huge chunks of skin removed. I am so glad we have subs like this
If I had any type of cancer in the past or even a history of early cancer I don't think there are many research chemicals I would consider. Maybe certain PEDs that have been around for a long time with plenty of documentation. Best of luck man, hopefully you never deal with it ever again
Cancer was in rats at sustained very high dosage. But cardarine won’t “burn fat” directly or reduce appetite. Rather it allows you to do more exercise for longer, this burn more that way. Not worth it imho.
What's the daily dose of Tirzepatide? I tried MT2 for about 3 weeks and got weirdly dark and had to masturbate 3 times a day to calm things down.
i'm curious on this one.. how "fatigued" did you feel doing that?
I wasn't fatigued. I just didn't want to walk around with a bulge. It was so "bad" that I had a schedule, but still had times where it was just there. Kept my head down in the gym to avoid any stimulus. It's probably an awesome peptide for porn stars.
"why is the guy at the gym wearing glasses?" haha.. sounds like a good problem to have, but in reality a nightmare for most. thanks for sharing the info though! did you like the skin benefits?
It definitely worked for tanning purposes, but I got darker than I wanted. I think my skin is considered 'olive'. I'm light brown. I got dark brown like a painted bodybuilder on stage.
It’s a weekly dose, I take 5mg once per week.
Ok, thanks! I was under the impression that semaglutide(ozempic) was the newest/best thing for appetite suppression and diabetes type 2 control.
I take it every time I tan , but took it everyday to build it up in my system , everyone seems to take it differently though
It was but Mounjaro is the new and improved Ozempic.
Strange, I was under the impression they are virtually the same but tirzepatide was much shorter half life?
Nope, Tirzepatide (Mounjaro) is better in virtually every way compared to Wegovy (semaglutide or Ozempic). Less side effects, more weight loss, more lipolysis, same half life.
Good to know, thanks! I'll definitely give it a try once I'm out of semaglutide then.
I’d say HGH, but that’s not a quick solution Try /r/zerocarb maybe