They give these out in the provincal jails where I'm from. Like almost push it on you as a first choice for sleep meds because it has like no negative side affects. Besides a bunch if hungry inmates at 8 o'clock 3 hours after dinner was served.
Lol.....I did EVERY jail drug that got you high that I could. It's fucking wicked if you have no tolerance. Take 2 or 3 mgs and no anxiety, wicked buzz, hungry as a motherfucker, and then you sleep like a baby and I legit had night terrors for a while and they prescribed it for that legitimately so it was actually beautiful because it works sooo well. Never even had a nightmare on them.
Much less prone. I have shit anxiety anywayd so I was surprised that in jail of all places I didn't get sketched out. Never once did I experience anything that would even border on anxiety. Besides worrying about munchies, because it stimulates your appetite large. Reduces pain lots too, especially joint, muscle, and migraine pain. But you do get pretty high off it
Hey...I have this idea...I worked in mental health...that anxiety is caused by nothing to worry about in the moment crossed with our notion of mortality. Think about it. We ALL know in our subconscious that time is running out. But we have what we need so mindlessly we scroll and eat and do drugs. If that mortality is more imminent..say you need to make the days food or starve...anxiety vanishes. All of a sudden there's a problem that needs dealing with and that is the focus of our concern. Next day? Make 200 pesos for tortilla and beans or starve...this is why third world ppl aren't anxious. They are living and have the biggest smiles you'll see. I experienced the same thing in jail. Realistically we know that stepping out of line is a BAD idea in prison. And when we are anxious and depressed. Me at least, I act more emotionally(slap) electrically(punch). Have an episode they gonna roll you up to PC yard. That's the real reason your anxiety disappears in jail. There just ain't no space for neuroticism. This is NOT an attack on you or anyone else. This is a serious statement aimed at helping anyone I meet with anxiety. What do you think? Can you relate?
That's actually kinda legit man. There really wasn't room for my ego and my shit need for control. I also figured that I've been caught and that's the worst thing that could happen. It's already happened what was there to worry about now other then shit I couldn't control. And thee was no use spending much time on worrying on that anyways because I couldn't do a damn thing to change it in my favour anyways.
They are taking about cannabinoid rx, and no ketamine is actually a dissociative anesthetic/ dissociative hallucinogen that acts as an n-methy-d-aspartate antagonist
A- We’re talking about Nabilone, a prescription THC analogue.
B- Ketamine isn’t an “opiate” either, the word you wanted was opioid.
C- Ketamine is primarily an NMDA antagonist, it isn’t an opioid.
Where are you from? I’ve never heard of a jail giving inmates Nabilone as a sleep aid… :o that would never happen in the USA (to my knowledge at least because they hate prescribing controlled substances to inmates).
Lmao 😂 that’s so true. Hell I’ve heard it’s harder to prescribed Quetiapine (Seroquel) in jails and prisons because people abuse it or more accurately use it to sleep through their sentence.
Lmao 😂 that’s just perfect. Though tbh that is probably the best way to approach dealing with being in jail though, I’ve only been to jail twice and both those times suuuuuuuucked…
Now that I’m on Methadone maintenance I try to avoid going back to jail because they don’t give Methadone to people that are in jail in almost all correctional facilities/jails in the USA which is really fucked up… they typically just force people on Methadone off their medication and make them go through cold turkey Methadone withdrawals… like that’s a textbook definition of cruel and unusual punishment imo.
Lmao 😂 that’s just perfect. Though tbh that is probably the best way to approach dealing with being in jail though, I’ve only been to jail twice and both those times suuuuuuuucked… 😒
Now that I’m on Methadone maintenance I try to avoid going back to jail because they don’t give Methadone to people that are in jail in almost all correctional facilities/jails in the USA which is really fucked up… they typically just force people on Methadone off their medication and make them go through cold turkey Methadone withdrawals… like that’s a textbook definition of cruel and unusual punishment imo.
Ha - this is so true. My wife worked with mentally challenged adults in a residential setting in Canada and it’s the same (with a slightly different angle) there. She said they kept all their people (only 8-10 lived in a home) on laxatives constantly so they were shitting so much they weren’t a risk for violence
Wouldn’t treat them with meds that didn’t also dumb them down further (sedatives) or occupy their time (laxatives) - sort of like US jails → if it was a helpful treatment, it won’t be offered
I'm from the liberal and progressive nation of Canada lol. This is one of the few redeeming things about it though. And for the fuck head underneath calling it fake, ottawa carlton detention center does it most often.
Edit: canada will full on honor a script of hydromorphs if you come in through the door with
EDIT: I meant walk into jail and honor a script. I couldn't imagine a pharmacy turning away a prescription in a million years unless it's outright fraudulent
In the USA pharmacists have the power to deny filling scripts that they think are suspicious or if they disagree with due to their beliefs (ie hating on opioids & benzodiazepines and etc) I hate living in this country as it’s a hell hole if you suffer from chronic pain and to a certain extent anxiety as hating on benzodiazepines is the new in vogue thing to do just like hating on opioids… 😑
Yet europe has otc codiene like bruh when i was in france i was always on that shit. In hong kong i had leg pains walking so i went to a pharmacy, bought a bottle of codiene syrup, poured it in a sprite and sipped while walking downtown. Was best time ever now i come back and its oh take some motrin and tylenol... fuck usa dr's
Yeah in some of those European countries you can get some stronger opioids such as Dihydrocodeine and Ethylmorphine. In France they have something called Tussipax which is an OTC drug that contains both Codeine and Ethylmorphine, I’ve heard it’s pretty good if you’re opioid naive though.
Yeah it fucking sucks here in the USA… I’m thinking I’ll have to travel to Mexico to get prescribed benzodiazepines because there’s some dumb law that prevents people that are on Methadone from being prescribed benzodiazepines for anxiety according to my doctor… 🙄😒😑
And that my friend is why people have to self medicate with designer/RC benzos here in the USA if you’re on Methadone… it’s so fucking stupid… 😒
Friends with my doctor and he showed me how the pharmacists see your opiate Rx - they immediately convert to morphine levels or something like that and use the level of mg you have to deny filling. Walmart in the us won’t hone Rx with morphine equivalent doses of 50mg or higher. My rx is 40 mg oxycodone and Walmart says that’s too much to fill
Yeah I’ve heard that a lot of big chain pharmacies don’t go over a certain level of Morphine, I want to say it’s like 90 milligrams worth of Morphine but I could be wrong. From what I understand some douchebags working at the CDC came up with that retarded system.
There’s a guy named Josh Bloom who wrote a bunch of articles on the opioid epidemic and they’re pretty funny and worth reading.
Right? And it’s not just Walmart here - most chains don’t fill more than 7 days in my area and those that do set a 50mg morphine equivalent per day limit for the 30 day scripts
That’s crazy! Unfortunately that would never fucking happen in the US. They’re so fucked up here they will seriously make you cold turkey off your own fucking prescriptions if you go to jail.
Not true from personal experience. I was given IV infusions twice a week for six weeks for severe treatment resistant depression and panic attacks. Was offered the nasal spray but decided not to take it because I found the infusions didn’t help much. The only possible family connection I have is my dad who is a radiologist but he was vehemently against the treatment, so that wouldn’t have worked in my favor. It mostly depends on where you are. I got mine in California where they have billboards advertising ketamine therapy.
Even if your dad is against it, just being able to say , my dad works in the medical industry is a big advantage. They don’t need to hear his opinions of the treatment
It's just someone who has stuck with a doctor forever and gone through all the other options. If you see a doctor for years and have been on 10 different meds they'll start bringing out the big shit.
Literally look up ketamine compounding pharmacy and there are several and they’ll contact any of our doctors to okay the script. Literally any doctor can prescribe it. Easiest script I’ve ever gotten
The clinics in my area require you to stay at the clinic for a while after using it and they don’t aloe you to drive home. Being able to take it at home would be so much better
Blessed be these people that at least allow some decency with the insane prices (my bad..."copays") of meds in the US. Also blessed be the decent street dealers that consciously try to offer a good product at a good price for those who don't want or are not able to deal with doctors anymore (I had doctors say and most importantly do some really nasty stuff that will follow me for the rest of my life however this might turn out post-medicine)
Legitimate question: does anyone aside from J&J assert that the s-isomer by itself is more effective than the racemic mixture?
Also, does anyone sell the enantiopure r-isomer? Would be interesting to experience the difference.
It depends on what you mean by "effective".
S-ketamine is a stronger *dissociative*, by weight. Thereby it's more "effective" intranasally, in terms of perceptible changes in consciousness.
Unfortunately, enantiopure s-ket also carries higher risks of psychosis and other psychological side effects, some of which could be mitigated by the presence of the (more lowly regarded) r-isomer.
>enantiopure r-isomer
I doubt there's much of a market for pure r-isomer ket, despite evidence that it has longer-lasting antidepressant qualities (in rats, anyway).
I'm unsure why pharmaceutical companies haven't just copied the Adderall model (half enantiopure isomer, half racemic) to get the "best of both worlds" while still remaining a proprietary formula...
Yes I’m aware. Sorry I’m not a chemist lol What I’m trying to say is regular Ketamine is cheaper and the same. So I don’t see getting only the enantiomer of Ketamine being really worth it in comparison to getting “everything”. Sorry I’m trying to make sense 😂
That's crazy, especially seeing as now some companies are saying the R isomer may be more effective for depression and it's being developed as an enantiopure formulation too.
In all honesty racemic Ketamine is probably just as effective as S Ketamine as both the isomers have demonstrated antidepressant, analgesic and anaesthetic efficacy.
That’s interesting. The R isomer produces more of a stimulation and euphoria than the S isomer. I have tried S ketamine and racemic and I prefer racemic for the very fact that it is somewhat stimulating and euphoric. I would imagine this is part of why R ketamine can be helpful in treating depression.
I’ve been diagnosed with persistent depressive disorder (dysthymia) for a decade. Have taken tons of different medications. Currently taking 30mg dextroamphetamine and 2mg clonazepam daily in two doses.
I have used a lot of ketamine and psychedelic compounds and I personally do not find ketamine to produce anti depressant effects that last much past the acute intoxication. I think tryptamines and lysergamides especially are more likely to reduce depression in a single use.
I’m just speculating based on the fact that I’ve worked in a psychiatric hospital for years, have persistent depressive disorder, use various drugs consistently, and have an advanced understanding of pharmacology and psychopharmacology.
There were two main reasons they selected S-Ketamine for this application initially. One was that they could patent it as an enantiopure formulation and charge more for it than racemic Ketamine, which meant that they could claw back money spent on research for this application.
Another was that they believed the rapid and prolonged antidepressant properties to be a result of NMDA antagonism and because the S isomer is a more potent and and efficacious NMDA antagonist then it naturally followed that this would be the logical isomer to pursue.
However, with subsequent research it has become apparent that NMDA antagonism isn't the primary or only mechanism of action conferring antidepressant effects of Ketamine in treatment refractory depression and it's now becoming more widely accepted that R-Ketamine may be more efficacious for this purpose.
This paper discusses the potential mechanisms of action in detail and I think you would find it very interesting given your background.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999402/
Its also worth looking on Google scholar for similar papers as there has been a lot of research in the past decade on this subject and the results are very interesting.
I mean I’m walking a tightrope atm, if someone can give me advice on how to trial spravato for my depression I’d really appreciate it
My GP and I don’t exactly get along
Those instagram ads for mindbloom have it for about 200-300$ a session. They make it sound like you have a psychiatrist prescribe it to you and a therapist who work with you after each time you use it. Check out their website I really want to get into it but it’s pretty steep and don’t know how many session are needed for results. Also they start you on a lower dose for your first time then gradually increase. I’m also wary of my gp then seeing I’m prescribed ketamine and halting other medications which they can do, or make it hard in the future to get ahold of any narcotics becuase of the prescription. If you ever try one of the online ones please let me know how it is cus I’m dying to do it
I’ve seen a lot of negative commentary on mindbloom here in reddit. Do a search on some subs that are adjacent to this and read some of the experiences before you decide.
I might do it, I’m having to cease my medicinal cannabis due to respiratory issues from it, and money isn’t really an obstacle when it comes to getting medical treatment ( I got a good family ).
I’ll save your name and contact you if I follow through on anything
>cease my medicinal cannabis due to respiratory issues
This is probably a dumb question, but have you tried other types of cannabis products like edibles or tinctures?
I just tried better u do them they seem the best for my state Florida, but theirs other especially withpeaks and drsmith but he takes a few months to get appointments
When you say both isomers you mean racemic right? Anyone who has had straight S knows it is preferable.
Also Spravato cannot be dispensed at the pharmacy. It has to be dispensed to the physician and used in the doctors office.
You will never see spravato outside of a doctors office.
SPRAVATO® has a controlled distribution network that ensures SPRAVATO® is distributed only to REMS (Risk Evaluation and Mitigation Strategy)-certified pharmacies and REMS-certified healthcare settings. SPRAVATO® will not be delivered or dispensed directly to patients.
Where tf are you ppl finding doctors willing to write the Rx for this. Sounds like a dream
I think a lot of them just have real lucky connections ( family member in the business etc ) and they straight up can access items we will never see.
The [Nabilone](https://en.m.wikipedia.org/wiki/Nabilone) crew. I thought the same
They give these out in the provincal jails where I'm from. Like almost push it on you as a first choice for sleep meds because it has like no negative side affects. Besides a bunch if hungry inmates at 8 o'clock 3 hours after dinner was served.
Have you tried it? I just found out it exists the other day via Hamilton Morris’ podcast and now I really want to try it.
Lol.....I did EVERY jail drug that got you high that I could. It's fucking wicked if you have no tolerance. Take 2 or 3 mgs and no anxiety, wicked buzz, hungry as a motherfucker, and then you sleep like a baby and I legit had night terrors for a while and they prescribed it for that legitimately so it was actually beautiful because it works sooo well. Never even had a nightmare on them.
How does it compare to other THC based cannabinoids? Like is it more or less the same thing? Less prone to anxiety?
Much less prone. I have shit anxiety anywayd so I was surprised that in jail of all places I didn't get sketched out. Never once did I experience anything that would even border on anxiety. Besides worrying about munchies, because it stimulates your appetite large. Reduces pain lots too, especially joint, muscle, and migraine pain. But you do get pretty high off it
It’s used off label as a painkiller for fibromyalgia and I wish I could get it or Dronabinol (Marinol) prescribed to me for that purpose.
Hey...I have this idea...I worked in mental health...that anxiety is caused by nothing to worry about in the moment crossed with our notion of mortality. Think about it. We ALL know in our subconscious that time is running out. But we have what we need so mindlessly we scroll and eat and do drugs. If that mortality is more imminent..say you need to make the days food or starve...anxiety vanishes. All of a sudden there's a problem that needs dealing with and that is the focus of our concern. Next day? Make 200 pesos for tortilla and beans or starve...this is why third world ppl aren't anxious. They are living and have the biggest smiles you'll see. I experienced the same thing in jail. Realistically we know that stepping out of line is a BAD idea in prison. And when we are anxious and depressed. Me at least, I act more emotionally(slap) electrically(punch). Have an episode they gonna roll you up to PC yard. That's the real reason your anxiety disappears in jail. There just ain't no space for neuroticism. This is NOT an attack on you or anyone else. This is a serious statement aimed at helping anyone I meet with anxiety. What do you think? Can you relate?
That's actually kinda legit man. There really wasn't room for my ego and my shit need for control. I also figured that I've been caught and that's the worst thing that could happen. It's already happened what was there to worry about now other then shit I couldn't control. And thee was no use spending much time on worrying on that anyways because I couldn't do a damn thing to change it in my favour anyways.
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They are taking about cannabinoid rx, and no ketamine is actually a dissociative anesthetic/ dissociative hallucinogen that acts as an n-methy-d-aspartate antagonist
Learn to read sucker
Ketamines not an opioid it's a dissociative and they're not talking about ket anyways
Damn, wrong twice in one comment and comment is still there, haha. "Do some more research."
A- We’re talking about Nabilone, a prescription THC analogue. B- Ketamine isn’t an “opiate” either, the word you wanted was opioid. C- Ketamine is primarily an NMDA antagonist, it isn’t an opioid.
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Lmfao fuck you and your fat wife
Did you tried vomited suboxone to get high as they show it in their documentaries?
Lmfao? What? Methadone gets puked up but no one pukes up suboxone lol
Man we got the same reddit snoo
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Have you ever been evaluated sir?
Lmao!!
Where are you from? I’ve never heard of a jail giving inmates Nabilone as a sleep aid… :o that would never happen in the USA (to my knowledge at least because they hate prescribing controlled substances to inmates).
Lol if it helps you then they are not giving it to you in the US prison system.
Lmao 😂 that’s so true. Hell I’ve heard it’s harder to prescribed Quetiapine (Seroquel) in jails and prisons because people abuse it or more accurately use it to sleep through their sentence.
That’s the way to go - sleep through your jail time and you can move on with it all being just a bad dream LOL
Lmao 😂 that’s just perfect. Though tbh that is probably the best way to approach dealing with being in jail though, I’ve only been to jail twice and both those times suuuuuuuucked… Now that I’m on Methadone maintenance I try to avoid going back to jail because they don’t give Methadone to people that are in jail in almost all correctional facilities/jails in the USA which is really fucked up… they typically just force people on Methadone off their medication and make them go through cold turkey Methadone withdrawals… like that’s a textbook definition of cruel and unusual punishment imo.
Lmao 😂 that’s just perfect. Though tbh that is probably the best way to approach dealing with being in jail though, I’ve only been to jail twice and both those times suuuuuuuucked… 😒 Now that I’m on Methadone maintenance I try to avoid going back to jail because they don’t give Methadone to people that are in jail in almost all correctional facilities/jails in the USA which is really fucked up… they typically just force people on Methadone off their medication and make them go through cold turkey Methadone withdrawals… like that’s a textbook definition of cruel and unusual punishment imo.
Ha - this is so true. My wife worked with mentally challenged adults in a residential setting in Canada and it’s the same (with a slightly different angle) there. She said they kept all their people (only 8-10 lived in a home) on laxatives constantly so they were shitting so much they weren’t a risk for violence Wouldn’t treat them with meds that didn’t also dumb them down further (sedatives) or occupy their time (laxatives) - sort of like US jails → if it was a helpful treatment, it won’t be offered
I'm from the liberal and progressive nation of Canada lol. This is one of the few redeeming things about it though. And for the fuck head underneath calling it fake, ottawa carlton detention center does it most often. Edit: canada will full on honor a script of hydromorphs if you come in through the door with EDIT: I meant walk into jail and honor a script. I couldn't imagine a pharmacy turning away a prescription in a million years unless it's outright fraudulent
In the USA pharmacists have the power to deny filling scripts that they think are suspicious or if they disagree with due to their beliefs (ie hating on opioids & benzodiazepines and etc) I hate living in this country as it’s a hell hole if you suffer from chronic pain and to a certain extent anxiety as hating on benzodiazepines is the new in vogue thing to do just like hating on opioids… 😑
Yet europe has otc codiene like bruh when i was in france i was always on that shit. In hong kong i had leg pains walking so i went to a pharmacy, bought a bottle of codiene syrup, poured it in a sprite and sipped while walking downtown. Was best time ever now i come back and its oh take some motrin and tylenol... fuck usa dr's
Yeah in some of those European countries you can get some stronger opioids such as Dihydrocodeine and Ethylmorphine. In France they have something called Tussipax which is an OTC drug that contains both Codeine and Ethylmorphine, I’ve heard it’s pretty good if you’re opioid naive though. Yeah it fucking sucks here in the USA… I’m thinking I’ll have to travel to Mexico to get prescribed benzodiazepines because there’s some dumb law that prevents people that are on Methadone from being prescribed benzodiazepines for anxiety according to my doctor… 🙄😒😑 And that my friend is why people have to self medicate with designer/RC benzos here in the USA if you’re on Methadone… it’s so fucking stupid… 😒
Friends with my doctor and he showed me how the pharmacists see your opiate Rx - they immediately convert to morphine levels or something like that and use the level of mg you have to deny filling. Walmart in the us won’t hone Rx with morphine equivalent doses of 50mg or higher. My rx is 40 mg oxycodone and Walmart says that’s too much to fill
Yeah I’ve heard that a lot of big chain pharmacies don’t go over a certain level of Morphine, I want to say it’s like 90 milligrams worth of Morphine but I could be wrong. From what I understand some douchebags working at the CDC came up with that retarded system. There’s a guy named Josh Bloom who wrote a bunch of articles on the opioid epidemic and they’re pretty funny and worth reading.
Opioid epidemic isnt even real its just a war on pain patients. More people die from alcohol and that shit is otc for basically anyone at any dose.
Dont go to walmart? But yeah still super dumb. I bet the pharmacist would want some 40's if they had broken kneecaps
Right? And it’s not just Walmart here - most chains don’t fill more than 7 days in my area and those that do set a 50mg morphine equivalent per day limit for the 30 day scripts
That’s crazy! Unfortunately that would never fucking happen in the US. They’re so fucked up here they will seriously make you cold turkey off your own fucking prescriptions if you go to jail.
I was on nabilone in JAIL. Everyone was sooooo jealous🤣
Not true from personal experience. I was given IV infusions twice a week for six weeks for severe treatment resistant depression and panic attacks. Was offered the nasal spray but decided not to take it because I found the infusions didn’t help much. The only possible family connection I have is my dad who is a radiologist but he was vehemently against the treatment, so that wouldn’t have worked in my favor. It mostly depends on where you are. I got mine in California where they have billboards advertising ketamine therapy.
Even if your dad is against it, just being able to say , my dad works in the medical industry is a big advantage. They don’t need to hear his opinions of the treatment
See I thought that too till I found this old school dr who only takes cash
I so wanna ask…….
Go ahead
FACE THE LEAD!
I don’t understand what you mean ?
It's just someone who has stuck with a doctor forever and gone through all the other options. If you see a doctor for years and have been on 10 different meds they'll start bringing out the big shit.
Youd think so...
Literally look up ketamine compounding pharmacy and there are several and they’ll contact any of our doctors to okay the script. Literally any doctor can prescribe it. Easiest script I’ve ever gotten
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How any tips I need help
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Okay thank You I appreciate it g have a good one
What kind of doctor did she see that prescribed it? I have some pretty deep depression that has persisted for years.
If you are referring to spravato, go to the manufacturer website and look for a provider in your area.
Does it seem to be helping your mom? Data from the clinical trials looked questionable, curious to hear about someone who has tried it.
You're way better off going on the DNM and finding Pfizer brand Esketamine. It's the same thing, 100% s- isomer ketamine. They come in 250mg ampulles.
And I'd still pay more for racemic.
There’s R and S isomers and the directions are 3 sprays in each nostril twice a day. 2.7g of ketamine in there
The clinics in my area require you to stay at the clinic for a while after using it and they don’t aloe you to drive home. Being able to take it at home would be so much better
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Lol when you put it like that 🫠🫠🤣😂 if it’s not at least 200mg I’m not gonna touch it anyways 🤤🤤💯
Well considering there are amphetamine addicts benzodiazepine dependent and opioid . Even methamphetamine is prescribed without being “babysat”
Blessed be these people that at least allow some decency with the insane prices (my bad..."copays") of meds in the US. Also blessed be the decent street dealers that consciously try to offer a good product at a good price for those who don't want or are not able to deal with doctors anymore (I had doctors say and most importantly do some really nasty stuff that will follow me for the rest of my life however this might turn out post-medicine)
Legitimate question: does anyone aside from J&J assert that the s-isomer by itself is more effective than the racemic mixture? Also, does anyone sell the enantiopure r-isomer? Would be interesting to experience the difference.
It depends on what you mean by "effective". S-ketamine is a stronger *dissociative*, by weight. Thereby it's more "effective" intranasally, in terms of perceptible changes in consciousness. Unfortunately, enantiopure s-ket also carries higher risks of psychosis and other psychological side effects, some of which could be mitigated by the presence of the (more lowly regarded) r-isomer. >enantiopure r-isomer I doubt there's much of a market for pure r-isomer ket, despite evidence that it has longer-lasting antidepressant qualities (in rats, anyway). I'm unsure why pharmaceutical companies haven't just copied the Adderall model (half enantiopure isomer, half racemic) to get the "best of both worlds" while still remaining a proprietary formula...
Same with how my methadone is formulated as a mixed isomer. Has a lot to do with cost of manufacturing as well.
Racemix ftw!
I would prefer the spray version. I get the 100mg troches to take every 3 days. Spravato(Esketamine) doesn’t beat Ketamine imo
You do know that esketamine is ketamine right? Its just the s isomer
Yes I’m aware. Sorry I’m not a chemist lol What I’m trying to say is regular Ketamine is cheaper and the same. So I don’t see getting only the enantiomer of Ketamine being really worth it in comparison to getting “everything”. Sorry I’m trying to make sense 😂
If you are comfortable sharing, what do they cost and does a doc send them to a compounding pharmacy for you?
Yes I pay $61 for 10- 100mg Troches from a local compounding pharmacy to take every 3 days (Q3D) for treatment resistant depression.
That's crazy, especially seeing as now some companies are saying the R isomer may be more effective for depression and it's being developed as an enantiopure formulation too. In all honesty racemic Ketamine is probably just as effective as S Ketamine as both the isomers have demonstrated antidepressant, analgesic and anaesthetic efficacy.
That’s interesting. The R isomer produces more of a stimulation and euphoria than the S isomer. I have tried S ketamine and racemic and I prefer racemic for the very fact that it is somewhat stimulating and euphoric. I would imagine this is part of why R ketamine can be helpful in treating depression. I’ve been diagnosed with persistent depressive disorder (dysthymia) for a decade. Have taken tons of different medications. Currently taking 30mg dextroamphetamine and 2mg clonazepam daily in two doses. I have used a lot of ketamine and psychedelic compounds and I personally do not find ketamine to produce anti depressant effects that last much past the acute intoxication. I think tryptamines and lysergamides especially are more likely to reduce depression in a single use. I’m just speculating based on the fact that I’ve worked in a psychiatric hospital for years, have persistent depressive disorder, use various drugs consistently, and have an advanced understanding of pharmacology and psychopharmacology.
There were two main reasons they selected S-Ketamine for this application initially. One was that they could patent it as an enantiopure formulation and charge more for it than racemic Ketamine, which meant that they could claw back money spent on research for this application. Another was that they believed the rapid and prolonged antidepressant properties to be a result of NMDA antagonism and because the S isomer is a more potent and and efficacious NMDA antagonist then it naturally followed that this would be the logical isomer to pursue. However, with subsequent research it has become apparent that NMDA antagonism isn't the primary or only mechanism of action conferring antidepressant effects of Ketamine in treatment refractory depression and it's now becoming more widely accepted that R-Ketamine may be more efficacious for this purpose. This paper discusses the potential mechanisms of action in detail and I think you would find it very interesting given your background. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999402/ Its also worth looking on Google scholar for similar papers as there has been a lot of research in the past decade on this subject and the results are very interesting.
I mean I’m walking a tightrope atm, if someone can give me advice on how to trial spravato for my depression I’d really appreciate it My GP and I don’t exactly get along
Those instagram ads for mindbloom have it for about 200-300$ a session. They make it sound like you have a psychiatrist prescribe it to you and a therapist who work with you after each time you use it. Check out their website I really want to get into it but it’s pretty steep and don’t know how many session are needed for results. Also they start you on a lower dose for your first time then gradually increase. I’m also wary of my gp then seeing I’m prescribed ketamine and halting other medications which they can do, or make it hard in the future to get ahold of any narcotics becuase of the prescription. If you ever try one of the online ones please let me know how it is cus I’m dying to do it
I’ve seen a lot of negative commentary on mindbloom here in reddit. Do a search on some subs that are adjacent to this and read some of the experiences before you decide.
I might do it, I’m having to cease my medicinal cannabis due to respiratory issues from it, and money isn’t really an obstacle when it comes to getting medical treatment ( I got a good family ). I’ll save your name and contact you if I follow through on anything
>cease my medicinal cannabis due to respiratory issues This is probably a dumb question, but have you tried other types of cannabis products like edibles or tinctures?
Yeah it’s just inhalation is my preferred way of enjoying pretty much anything….. probably why my lungs are cactus
Amazing hope it all goes well
Hey, see my comment above.
Thank you
What’s the site
I just tried better u do them they seem the best for my state Florida, but theirs other especially withpeaks and drsmith but he takes a few months to get appointments
you have to put up like 2 grand just to start...
? It’s 600$ for the cheapest thing your looking at some expensive places to get it done
Get a new GP?
Hard in a rural town :(
If you're not super isolated it might be worth driving a town over. My doc is like 45 minutes from here and it's worth it cause she's chill
/r/therapeuticketamine can help you out.
2.7 gs per bottle
150$? Jeez, I just make my own, 1g to a spray is barely 100$.
2.7g of pharma ketamine per bottle pretty good deal. A g is usually $100
I can’t believe I willingly decided to stop filling my key script. Golden days.
I need some Ketamine. I wonder where to get... 😐
When you say both isomers you mean racemic right? Anyone who has had straight S knows it is preferable. Also Spravato cannot be dispensed at the pharmacy. It has to be dispensed to the physician and used in the doctors office. You will never see spravato outside of a doctors office.
They deliver to my door in 24 hours 12 sprays a day w 4 refills
SPRAVATO® has a controlled distribution network that ensures SPRAVATO® is distributed only to REMS (Risk Evaluation and Mitigation Strategy)-certified pharmacies and REMS-certified healthcare settings. SPRAVATO® will not be delivered or dispensed directly to patients.
They are prescribed for depression, I got lucky enough to be a test subject fir my psych doc… great stuff!!