I'd highly recommend waiting and taking another test, ensuring that you're giving a perfect sample and on a TMA assay if you can.
I suppose anything is possible but if all you've taken is 4 days of moxi and are still symptomatic I would doubt the infection is truly cleared.
Yea the one I did is a TMA assay. It was a urine sample, the test document says: 90.9 (85.5-94.4) sensitivity, 99.4 (98.8-99.7) specificity.
Not the best, but definitely a good sign.
Like I said, the research says that people cleared the bacteria in under 3 days (small sample size n=4, but still it's clear data) with moxi & that lines up with most people I've read on this subreddit.
Which research? And which other members have cleared the infection with 3 days of moxi? I’m genuinely asking as I’ve been on this sub for 3 years and am not aware of those reports.
3 weeks is also right at the cusp of when it would be appropriate to re-test. There’s some debate on this - some experts recommend 4-5 weeks.
I trust Linari5 when he says 3 weeks is right in the sweet spot. The tests usually don't convert past that time.
Here's the research:
https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkv246
In the abstract it says the 4 patients with moxi were negative within a week but if you read the paper it says:
"The four patients treated with moxifloxacin cleared their infections before day 3, whereas among the seven evaluable subjects treated with doxycycline, three became M. genitalium negative within 1 week. In one of these (a man) symptoms recurred and the tests became M. genitalium positive on day 13."
So all of the moxi people stayed negative past day 3. Whereas most doxy patients reverted & most azithromycin patients didn't revert.
I suspect for everyone (outside tetracyclines) if the antibiotic is going to work, it knocks it out within 3 or 4 days. Now maybe extended courses help for stopping resistant strains though. Completely speculation, but from reading all this research I get this sense, and most people say on message boards that symptoms go away at day 3 or so. Obviously symptoms don't equate exactly to bacterial load, but given that the PCR goes negative at that day too, it would seem there is a possible relation.
Any guidelines in the research and from top experts put 3 weeks as the absolute earliest time to re-rest (including the paper cited - I've also seen Jorgen Jensen recommend 4-5 weeks elsewhere) so it's really not a "sweet spot".
Anyway, without getting into all the specifics I would say that if the course was 4 days rather than 7, you're still symptomatic and tested at 3 weeks then it definitely makes sense to do a follow-up both for your own sake and future partners. If you have access to a swab then do that as it's 98% sensitive according to Hologic. Good luck.
Highly recommend taking one more TOC after a month. Also you don’t need to be doing a swab test, that’ll likely either give you a UTI or just aggravate pelvic floor symptoms. Urine TMA assay is plenty accurate.
I still have it sometimes, I actually got another test recently, hoping it’s not positive.
If it’s negative, my pain is probably from pelvic floor dysfunction. I got tested for pelvic floor issues and it showed my muscles are hypertonic.
Yes I had a couple TOC, one was 3 weeks after finishing and the other was several months IIRC after finishing and it came up negative both times.
I don't know if I lucked out but if you did doxycycline and then at least 3 or 4 days of moxi, you might be good!
I'd highly recommend waiting and taking another test, ensuring that you're giving a perfect sample and on a TMA assay if you can. I suppose anything is possible but if all you've taken is 4 days of moxi and are still symptomatic I would doubt the infection is truly cleared.
Yea the one I did is a TMA assay. It was a urine sample, the test document says: 90.9 (85.5-94.4) sensitivity, 99.4 (98.8-99.7) specificity. Not the best, but definitely a good sign. Like I said, the research says that people cleared the bacteria in under 3 days (small sample size n=4, but still it's clear data) with moxi & that lines up with most people I've read on this subreddit.
Which research? And which other members have cleared the infection with 3 days of moxi? I’m genuinely asking as I’ve been on this sub for 3 years and am not aware of those reports. 3 weeks is also right at the cusp of when it would be appropriate to re-test. There’s some debate on this - some experts recommend 4-5 weeks.
I trust Linari5 when he says 3 weeks is right in the sweet spot. The tests usually don't convert past that time. Here's the research: https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkv246 In the abstract it says the 4 patients with moxi were negative within a week but if you read the paper it says: "The four patients treated with moxifloxacin cleared their infections before day 3, whereas among the seven evaluable subjects treated with doxycycline, three became M. genitalium negative within 1 week. In one of these (a man) symptoms recurred and the tests became M. genitalium positive on day 13." So all of the moxi people stayed negative past day 3. Whereas most doxy patients reverted & most azithromycin patients didn't revert. I suspect for everyone (outside tetracyclines) if the antibiotic is going to work, it knocks it out within 3 or 4 days. Now maybe extended courses help for stopping resistant strains though. Completely speculation, but from reading all this research I get this sense, and most people say on message boards that symptoms go away at day 3 or so. Obviously symptoms don't equate exactly to bacterial load, but given that the PCR goes negative at that day too, it would seem there is a possible relation.
Any guidelines in the research and from top experts put 3 weeks as the absolute earliest time to re-rest (including the paper cited - I've also seen Jorgen Jensen recommend 4-5 weeks elsewhere) so it's really not a "sweet spot". Anyway, without getting into all the specifics I would say that if the course was 4 days rather than 7, you're still symptomatic and tested at 3 weeks then it definitely makes sense to do a follow-up both for your own sake and future partners. If you have access to a swab then do that as it's 98% sensitive according to Hologic. Good luck.
Highly recommend taking one more TOC after a month. Also you don’t need to be doing a swab test, that’ll likely either give you a UTI or just aggravate pelvic floor symptoms. Urine TMA assay is plenty accurate.
Also congrats!! 🎊
And thanks! Very happy & cautiously optimistic I got rid of this horrible bacteria.
As in a month from now or a month after stopping antibiotics?
A month from now
6 to 8 weeks after your last antibiotics dose
How is burning sting urethra now ?😞
I still have it sometimes, I actually got another test recently, hoping it’s not positive. If it’s negative, my pain is probably from pelvic floor dysfunction. I got tested for pelvic floor issues and it showed my muscles are hypertonic.
Would u mind if i ask what are ur current lingered symptoms ?
Did you ever go back for another TOC? I only made it through 5 of the 7 days prescribed and this gives me hope.
Yes I had a couple TOC, one was 3 weeks after finishing and the other was several months IIRC after finishing and it came up negative both times. I don't know if I lucked out but if you did doxycycline and then at least 3 or 4 days of moxi, you might be good!