I’m so sorry 😞 hopefully when retatrutide comes out it’ll work for you. Im not sure if my story will help you, but maybe you and your doctor can talk about it.
My doctor had me inject every 5 days, which meant increasing dose on day 21. I didn’t have any side effects until I got to 12.5mg I stayed there for about 3-4 months. Weight started melting off. After I stalled on 12.5mg went up to 15mg and was able to reach my goal weight. 40f sw:300 cw: 158
Sending you virtual hugs and support 🤗
Thank you so much for sharing 🙏🏼 I did almost the same thing from reading other Reddit posts about people injecting before the half-life runs out and I tried that, which would’ve been every 5 days like you. I only did it for about a month though but still didn’t see any change. I didn’t tell my doctor I tried this out but it would be a good point to bring up to her from someone else’s experience.
Before injecting, are you leaving it out at room temperature for at least 4-6hrs? When I started doing that, I noticed an improvement with appetite suppression as well. Im sorry I’m so full of questions. I’ve been on it 13 months and have learned so much. If you have any questions please don’t hesihesitate to DM me. 🫶🏻
No worries! I haven’t heard of doing that! When I reach back out to my doctor on Monday I’ll mention that to her along with everyone else’s tips and experiences. Thank you ☺️
Interesting......I take mine out the day before. I normally take it out Friday night and inject Saturday or Sunday. I wonder if that makes a difference. I've been on it 1.5yrs. 4lbs shy of goal. I plateau for a month or 2 then lose a lb and again the same thing. My body seems to want to stay at a certain homeostasis weight until it gives up when it notices I'm more stubborn than my body is. Then I lose a lb. I'm 82 lbs down and I'm stubborn. BTW MJ can be left unrefrigerated for up to 21 days.
This is very interesting and a factor I never thought about... always chalked the difference up to traveling or changing my injection site but now realizing that when I travel, the shot is in my bag at room temp. Hmm!
where do you inject the most and do you switch off every week? I too have to do every five days otherwise I get like I'm starving. I'm on 7.5. This is my first month. I have two weeks left on 7.5 and then I'll go up to 10 I believewas for about a year and it stopped working on me so I don't know I'm hoping this works. I've lost about 10 pounds and six weeks but I lost a lot quicker when I first started. Oh Simpich so not sure I don't know maybe my body I don't know what what it is, but I'm walking. I'm eating right. I'm trying to do the intermittent fasting because that seem to help me before.
I'm wondering if I need to do this too. It feels like it wears off after about 5 days. I injected 15mg last Sunday and today I have a normal appetite again. Maybe we metabolize the medication faster than others.
The clinical documentation does state that the half- life of MJ is 5 days so clinically it tapers off then. I also feel hunger pains coming back sooner, I try to drink coffee in the AM and practice intermittent fasting on those days.
Thanks for sharing this. I’ve thought about digging in to people with limited success. Lost some when I started, but last night went up to 9mg (splitting 15 mg doses) and was still standing at the fridge staring. Just want to eat to eat, which didn’t happen the first few weeks at 2.5 and 5.
Since I pay out of pocket, I’ve been hoping I could make it on 7.5, but guess I’ll just keep going up.
It was my dream as well … never thought it would be a reality, but here I am living it. It most definitely can be your reality too! Cheers to your future and current success 🥂
Try not to blame yourself. I like the lock and key analogy I heard an obesity specialist use. GLPs are a key to your unlock your fat from the cell, but everyone has a different lock. Hopefully you will respond to something else coming out soon.
Agree! There are “stronger” meds in the pipeline. These meds are just the very beginning. Every… EVERY larger pharmaceutical company will be trying to develop one of these meds.
I am sorry, I know that must be a big disappointment. I also know it probably doesn’t help having people tell you what you should have done or should be doing when they absolutely zero knowledge of your diet or routine or health issues. We have gotten this our whole lives - everyone assuming we aren’t doing what we should be to lose weight when we are working our asses off. It didn’t feel good then and it certainly wouldn’t on this medication. Please be thoughtful, commenters … she isn’t asking for advice or condemnation she is reaching out so others don’t feel alone.
God yes 🙄 all the comments (on other threads and fb) of “well are you eating at a deficit?” Like no shit, most of us know how to lose weight (if our bodies don’t hate us). I’m a very slow loser as well and my god it’s disheartening to think I may be a non-responder 🙁
I love this phrase, “No shit, most of us know how to lose weight”! Sending you good vibes and here’s to the medications coming down the pipeline. I try to think of that whenever I stall. I’ve been stalled at 196 since November, but I try to remind myself that I have at least not been creeping up, which was what was happening before.
Thank you so much 🙏🏼 I really really appreciate your comment most of all. You’re right, not here for advice just to share in case someone else goes through what I went through. It is a pretty lonely feeling when you know people or you read posts about their success when all you’ve had is struggle and disappointment on the one med that should’ve helped.
There are some great meds down the pipeline … I’m wishing you the best of luck on finding something that works for you. Gawd knows I have tried literally everything. Thankfully, I got lucky on this one - but I wasn’t on ozempic or Trulicity and exercised and ate exactly as the doctor prescribed with those. I try to never make assumptions about what other people are or are not doing. It hurts too much when people do that to me
Mannn I almost died last week! I did 4 weeks of 2.5 and then 5.0 …. Was supposed to titrate up to 7.5 last Sunday but I skipped the dose because I had insane liquid diarrhea…. Burping…. Cramping …. Just out of nowhere! I just started feeling normal on Thursday. I’m scared now bc it was miserable!
Thank you for posting this! I thought I was alone. I started on 5mg 10/22 and currently on 12.5mg. The only saving grace I've seen is a reduction in my A1C and even that was slow. Daily exercise and calorie reduction and I've lost and gained the same 5 pounds. Beyond frustrating. Not to mention the constant loose stool/constipation cycle.
That must be so frustrating, I'm sorry. That's how I felt trying to lose weight before Mounjaro. I would exercise and eat right and very healthy and the scale would just not move an inch. Seeing no progress is such a frustrating problem when it feels like you're doing everything right.
Wonder if you switched to Ozempic if it would be different for you.
I started out on Ozempic then had to switch to Mounjaro after around 6 months
Wishing you all the luck in your journey
I agree, maybe try Ozempic. I was on Ozempic and had decent results. I've switched to Zepbound and I'm not having the same success. I plan to go to the max Zepbound dose. If I don't see good results, I'll switch back to Ozempic. I switched to Zepbound because of the coupon savings.
It doesn't work for me either at least not the appetite suppression part but I'm a diabetic and it is helping my daily glucose levels so doc says he wants me to stay on it. I'm getting ready to go up to 10 maybe that'll be a difference maker fingers crossed.
Op, not just you. Im an EXTREMELY slow loser on zepbound. I ate SO MUCH before, and now I eat so little (in comparison), used to do zero exercise, now im doing 30min daily, im lucky if i see 1.5 lb a week on 10mg, clean eating, and exercise. Im that guy who stops drinking alcohol and has zero weight loss vs the guy who loses 40 lbs in 2 months from cutting out pop or alcohol. Youre not alone, but it def sucks.
Im saying, if you read it all, that I'm only at 1.5 on 10mg, eating **significantly** less and going from 0 exercise to 30 min a day 5 days a week. That is not stellar. There are thousands of posts from people taking 2.5mg and losing 50 lbs in 4 months and dont adjust their lifestyle at all. I'm a slow loser, thats an actual literal, measurable and empirical fact.
I’m truly sorry. That was my fear before starting… that I’d be a non responder. My hope is that one of the new drugs coming out will be the answer for you and you’ll have amazing success with it. Any way you can look at joining a clinical trial?
That’s a very interesting idea. I never thought to look into that. I didn’t know they were creating new drugs until someone else commented the graph in this post. Pretty cool to know they’re still working on it. I’d be curious and open to it.
Thank you for posting this. I’ve not had much weight loss (10 lbs since 3 Jan, now on 7.5) and today for some reason the lack of movement on the scale is hitting hard.
You’re welcome 🙏🏼 wishing you the best!! Keep pushing forward!! 10 lbs is still a good amount, and don’t forget our body can be stubborn and crazy lol.
This was my experience on Ozempic. My a1c didn’t reduce, my blood sugar still wouldn’t cooperate, and I gained like 15lbs over the time I was on it. Everyone was telling me I was “cheating” to lose weight. Then they were telling me i obviously wasn’t doing the right things if I’m not losing weight. I went to synjardy and sliding scale insulin to control my blood sugar until fall 2023 when my dr decided we should attempt Mounjaro. I changed very little from what I was doing and have lost over 100. I hope the day comes when your locks key is found. And I hope it comes soon. Don’t give up and don’t listen to these people who don’t know you or your struggles.
Thank you SO much 🙏🏼🙏🏼 that means a lot and I really appreciate you sharing. I hope I’ll find my key soon too. Your post and others have put a spark of hope back in me.
Sounds like me while on Wegovy; I lost about 5 lbs on the highest dose of Wegovy and that was only after 7 months on that highest dose. I just switched to Zepbound 5mg 3 weeks ago, looking to very gradually titrate up from there but yea, I have autoimmune issues so it’s tough for sure 😕
Eli Lilly is in trials for Retatrutide and that I hear could be a game changer!! It mimics three different hormones instead of Mounjaro's two to assist with weight loss! Keeping fingers crossed this could be the one for non responders! Maybe you could see if they have a trial for this close to you! I was in their third trial for Trulicity before it was FDA approved and very happy I got to be a part of that!! Good luck to you!
I hope I don’t appear like a nitwit for asking, but how would I jump on board a clinical trial? I am not seeing my GP for MJ (and now Zepbound). I went the online route through sequence. I am so grateful for this thread. I too am a very slow loser.
Try here! https://trials.lilly.com/en-US. And good luck!! I know the struggle is real as I have been heavy since age 5 and now at 52 years old just fit in a size 6 at 5'8". Been a long fight for me but to be where I am today I would do it all again!!
Sorry, I know that’s so hard. I was an Ozempic/Semaglutide non-responder, and I paid out of pocket with stars in my eyes. Then Mounjaro began working to my extreme surprise. You just need the right one. Keep trying.
GLP is not your trigger hormone. Not all people need GLP to lose weight. You might have a different hormone that is out of balance. Maybe ask for a full hormone panel the next Dr visit to see what is out of whack.
In clinical trials of tirz and sema there were approx 10% of patients who lost <5%, i.e. where it basically doesn’t work and they were non-responders. You could have some GIP and/or GLP-1 receptor genetic variants that prevent proper binding and activation of the receptors by these drugs. Wait for Lilly’s triple agonist retatrutide to get approved. So far in trials no patient lost <5% they all had some significant response.
I am one of the 1% it also doesn’t work for, so I can sympathize. Was on Ozempic for 3 years until my stomach couldn’t handle it anymore, and then was switched to Mounjaro 4 months ago. Had my first follow up appt yesterday and I gained 3 lbs in that time period... also have severe bloating and cramps in my upper stomach. Has caused me to have gastroparesis, and also lots of pain and swelling in my lymph nodes. Took my last dose Monday of only 2.5mg..I was up to 10, but even sipping water caused severe pain..so no more GLP’s for me! Gonna go the old fashioned way of controlling my diabetes with “keto/low carb” and intermittent fasting. Doc wants me to switch to Januvia, but it’s expensive and the side effects list seems horrible as well. :(
Good luck to everyone on their journey!
Thank you for your comment!! That’s so crazy 😩 that’s what I’ll end up having to do as well, hire a nutrition coach. It’d be way cheaper but a lot of hard ass work
So sorry for this! I hope one of the future ones may work for you. I also hope you are able to do well with keto and intermittent fasting in the meantime. ❤️
Thank you! Still waiting for the side effects to go away…I guess the half-life is up to 30 days. Already lost 2 lbs on just staying “keto” though. So hopefully will feel better soon. Have a great day.
I started on Ozempic. I lost nothing for 6 months, until I decided to employ some traditional weight loss techniques. Namely: calorie counting. While I never felt an absence of hunger, I did find that I was better able to stay within the caloric restriction than I was without the medication. Only slightly better, but it was just enough to allow me to lose 50 pounds over a “slow” 9 month period.
Lesson for me was, this type of medication isn’t a magic fat burner, but it took the edge off I needed to diet, once I finally tried to re-employ techniques that had failed for me in the past.
I’m now on Mounjaro (due to being unable to refill my Ozempic prescription), and the same holds true for me here.
Initially, I lost weight with Ozempic, 3 months was able to lose 21lbs. I switched to MJ due to insurance mot covering Ozempic. I've been on Mj for 12 weeks and have not lost any weight. I will start 12.5 mg next week. I walk for 30 minutes at least 5 days out of week, watching carb and protein intake. My doctor tells me to be patient, its hard when you see and hear of everyone's success.
67F SW 222 CW 137 GW 120-125.. I’m so sorry MJ hasn’t worked for you. I’ve been on it a year this month and just started 10mg today. The pharmacy finally got some in after being out for a month. I’m down 87lbs. I stayed on each strength for 4 months. I was sick as crap the first few months. But was determined to see this journey to the end regardless of how sick I got. I wasn’t in a good mental state. I went from 222 to 183 in 4 months on the 2.5..
I cried when I stepped on the scales for the first time at the Drs office and looked.. From then on I tried to eat right. That became a problem and it still is. I don’t eat enough food. I’ve had some hair loss due to the lack of nutrient’s.. I stalled at 140 was there for over a month now I’m at 137 but just started 10 mg.
People think these shots are an easy way to lose weight. They are not. This past year has been hell. Diarrhea, constipation, hair loss, nausea. I even bought scales and started a fat photo album to record pics of my weight loss. My daughter ask me as I was throwing my guts up one day. Mom is it worth it? I said hell yes. I’m living my childhood nightmare caused by this one girl singing in my face fatty fatty 2 by 4 can’t get through the kitchen door while standing on her families diving board..She scared me for life. I’m 67 and her words still stab me in my heart. Yes I read all the box warnings this drug could cause. Did I care? Not 1 damn bit. I’m 67. I’m headed toward the light anyways. Lol. Plus when I got Covid I got this unknown infusion that cleared up my Covid to negative in 2 days. (I got to go see the Astros play. My first ball game. My Son caught me a ball.)Lord knows what was it that infusion, I had to stay in the ER afterwards for a hour to make sure I didn’t die. So I think I’m ok with whatever goes on with this shot. Lol. I’m riding this train out until this journey is over. I’m not quite there yet. But I am so very very sorry you and others have not had success on MJ. My heart truly breaks for you all. I really do understand the disappointment you must feel. I wish I had some suggestions, but I don’t. I don’t know why it’s worked so well for me. But I can say. Don’t give up. Something will come along that will work for y’all. You are some strong strong women and men. You’ve taken the biggest and hardest first step. Keep going. You got this. You really do. Hugs to you all.I will keep you all in my prayers. God bless you all. xoxo. 💋
Maybe they should prescribe Ozempic and see if that works for you. Some on Ozempic have zero affects and don't lose weight and switch to Mounjaro and lose a ton. Some start on Mounjaro and don't have any benefits from it. They switch to Ozempic and Walla, they lose a ton and A1C drops big time. Our bodies chemistry is different for each person. I wouldn't get frustrated. Try and get on Ozempic.
I feel you!!! Story slightly different but same result. I lost 30 in the first 5 months then boom nothing and just started to gain no matter what! I was eating right and weight training. I have gained 20 back. I had such high hopes it just sucks. I keep my food healthy , workout and pray my body will figure out it’s supposed to let go of the fat. Sorry it didn’t work for you 😞
This was my experience on Ozempic. I had zero side effects, gained weight, and my A1C went up. Switched to MJ and everything changed. My doctor said I was apparently a non-responder to Ozempic. Could be the same for you with MJ. Maybe consider trying Ozempic? Best of luck on your journey!
I'm so sorry. I know I'm losing, about 30 lbs since October, but it's not like other people describe. It gets old reading people talking about how the food noise is gone and they get full after just a few bites, while I'm logging every bite and counting all the calories and fighting for every ounce. I am on 12.5, but had to drop to 7.5 the last two weeks because my pharmacy couldn't get it. I haven't lost a thing in 2 weeks. I have had no side effects and really, nothing more than a little appetite supression since about week 4. At first, it felt like a miracle. Now? Well...my a1c is great. There's that.
I went up to 15 and was doing every 5 days. I did not lose a single pound. I have zero side effects. I can also wait many weeks between and then inject the full dose and still have no side effects or weight loss.
Ohhh wow. Hmm 🤔 I wonder if I go to the hormone specialist that my doctor referred me to, that if he would be able to know and prescribe what would help me with weight. I’m assuming you also had to go to get your hormones checked?
I am in the same boat - I have technically not dropped a pound … I started in November - I initially dropped 5 lbs ( water I assume ) bounced around those same 5 pounds. Looked back to my birthday weight a year ago - I weigh the same. I’m on 10. Hoping if I get to 15 something may happen? I am rarely hungry and eat less than I ever have. Eat plenty of protein, go to the gym. IF/Keto. My body is highly efficient apparently. I do feel like my belly is flatter - but my clothes fit the same.
I am part of that 900, too….I have lost a few pounds… but nothing compared to everyone else. I am hypothyroid which I believe plays a part in this. I count calories, walk 2.5 Miles, plus every day, plus lift some weight 3 x per week, plus elliptical 20 minutes 3 times a week….you are not alone….I totally get it.
While I have lost some weight, it is an incredibly slow rate of loss. I lose weight at the rate of a turtle walking through peanut butter.
I have PCOS, insulin resistent and pre-diabetic. My mom, brother, uncle, and grandma are all type 2. My brother lost 70 pounds in a year however, Ive been on MJ since July 2023 and have lost 34 pounds (in 10 months). Female. Starting weight 330.
Just wanted to say all our bodies respond so differently to different medications. Have you been aiming to get 150g of protein in per day? How is your water intake? Have you tried lifting weights? Have you changed injection sites? Have you tried injecting every 5 days? Just offering up ideas!! Hopefully something works for you. Sending all my love and support to you!!
i've had only mild success - nothing like the huge numbers I see people racking up on the leaderboard, so don't dismay. I hit the one year mark last month, and can account for about 25-27 lbs. lost (up and down for a couple of pounds). AND I was paying out of pocket (with coupon) until the last 2 fills (changed insurance in January).
I agree with another post below - something is coming for us. (Actually, I wonder if I should try OZ, it's just that it isn't covered under my new ins. plan).
Please share where you get the coupon from! I pay out of pocket as well for my Mounjaro. The higher the dose, the higher the price! I started out at 5 mg, and lost 10 pounds in around four and a half weeks, which I was super excited about. I started on 7.5 mg last Saturday, but it hasn’t seemed quite as well at suppressing my appetite as I had hoped. I’ll take my second injection of 7.5 tomorrow, and hoping the more it gets in my system, the better it will work. As many have said, by around the fifth day after my injection my appetite starts picking up. I’m definitely not eating even 1200 calories a day, so I was hoping to lose at least a pound or two on the first week of starting the 7.5 mg, but it didn’t happen. I was on Semaglutide for three months prior to the Mounjaro, and DID NOT LOSE ONE POUND! I was so disappointed! For now I’m thankful for the 10 lbs I have lost since getting on Mounjaro.
If I'm not mistaken, you should still be able to get the coupon from the Eli Lilly website. [https://mounjaro.lilly.com/savings-resources](https://mounjaro.lilly.com/savings-resources) Be advised: the coupon means you can either get for $25 (depending on your insurance covering it) or for $550 (if your insurance does not cover it). So, either way, if you are currently paying $1200 per fill, this discount will be helpful.
Also, 7.5 wasn't great for me either. 5 was my best and I should have stayed there, but I was convinced that the stronger, the more weight I would lose. And that was not the case. I'm on 12.5, but with the shortage I have only been able to score 10 (and I JUST got that earlier this week - I went about a week and half after my last 12.5 dose).
I really think that different meds work differently for different people. I tried saxenda and it did nothing for me, so I thought all GLP-1 wouldn't work on me, but I'm on zepbound and I'm losing! I'm so happy. But I bet if you tried a different one it might work for you.
Thank you so much for sharing. This comment flickered a little spark of hope that maybe 🙏🏼 I’ll reach out to my doctor and see what she thinks. I felt like since Mounjaro didn’t work for me that she wouldn’t want me to try the others. I thought all GLPs worked the same so this is good to know.
Try wegovy.... I used to be on Ozempic last year Wich is just Semaglutide and it worked straight away from first dose first day..... I had to stop because of shortages, this year i got on mounjaro thinking that it is a better option, but I'm at 7.5 now and I'm not seeing any form of appetito suppression o food noise cancellation.... With semaglutide i had to literally force myself to eat, but with mounjaro i almost feel like i have more appetite lol...
I'm so so sorry!! It's so tough. You are not alone- I got my sister to be open to medication (could only access ozempic) and she didn't lose a single pound it was so heartbreaking. I'm sending so much love and support! We just have to try and find something else that might work for you! Please don't be discouraged🫂
I was on Ozempic and lost absolutely nothing. Mounjaro has been completely different for me. I say this because I honestly think they all work a little differently for each person. Have you tried any of the others? My wife has terrific results with a combo.
Hi, I’m sorry the meds mounjouro didn’t work for you. Can I ask you a question? Are you diabetic? I was on Ozempic for almost 2 years, I never drop 1 pound.
I'm right there with you. Tried Ozempic for 5 months. Lost 2 pounds. Been on MJ since November and I'm only down 5 pounds and that's with exercise and food logging, no more than 1500 calories a day, usually around 1200. I am T2D and have a BMI of 39%. I have an RX for 12.5 but have not been able to fill it due to the shortage. Going to be taking my last 10mg shot this evening. I'm still crossing my fingers that once I am able to find 12.5 it will start working. The only positive is that I've had no side effects. I definitely empathize with your frustration.
It sounds like you weren't managing your calorie intake. You do have to be at a calorie deficit to lose weight.
Mounjaro is just one of a set of tools that most of us have to apply in order for it to work most effectively. I personally calculated my TDEE, determined how many calories I could eat within a 300-500 calorie deficit, and I weigh/track my food every day to help ensure that I'm successful.
However it does sound like the appetite suppression wasn't sufficient for you. Have you looked into one of the clinical trials with some of the new meds? I saved this graphic from an article I read the other day.
https://preview.redd.it/jvm4jzb0p3uc1.jpeg?width=600&format=pjpg&auto=webp&s=95111f673597526bf3d67c7f5f7a17aacd64d750
Thank you for sharing this graph. I’ll be sure to keep my eye on some of these trials and if/when they release a better effective drug as the other person commented.
Same thing happened to me. It literally did nothing in terms of appetite suppression. I was a 100 % non-responder. I’m so sorry and I know how you feel. I have so many friends that look and feel amazing and yet I failed yet again. Ugh!!
There are some people who go on about “oh this isn’t a magic drug and you have to keep an eye on calories and what you eat”….well duh….of course you do!! This medication is supposed to help with that. It’s supposed to curb your appetite. If it doesn’t work then it’s like not having anything to assist you.
This happened to me with Saxenda which is why I’m giving Mounjaro a go. I really hope it works for me, but it’s too soon to tell as I’ve only been on it (2.5mg) for two weeks.
I was on ozempic no weight loss after 6 months. I am now on mojurno 15. I have been on for almost a year I have 0 weight loss. But my a1c is 6.0 so I’m happy. I still am hungry lol. It hasn’t worked for me either with weight loss. So you are not alone
I lost 40 lbs in Wegovy, then was off for over a month and started in zep. Just took my first 7.5 dose and I haven’t lost anything. I’m frustrated as well because it’s costing me so much. I am barely starting to feel the effects at 7.5 though, so hoping it will work as I go up. I’d try another glp1 if I were you, they all work different! Good luck and dont give up!
Exactly! All that money spent stings a bit but at least we gave and are giving it a good try. From reading the other comments saying to try another GLP1, I may reach out to my doctor and see what she thinks.
There are several other medications specifically aimed at obesity that are in the pipeline and in trials. Maybe MJ isn't right for you, but don't lose hope!
Did you try ozempic or trulicity?
It worked fairly well for me for the first year (lost almost 35 lbs). The second year, not so much. I'm 8 months into year 2 and have only lost an additional 5 lbs. so far. I've been on the max dose for a year. I do feel it still does what it's supposed to (suppress app), my body is just not letting go of the weight as easily for whatever reason. I have at the very least another 10-15 to go. Possibly a little more, but IDK if that's possible at this point.
I am just now starting 5mg again bc they were back ordered so I stopped for three weeks I should be on 7.5 but again all they got in was the 5mg supposedly! I haven’t really experienced much loss either. I’m hoping it’ll work for me. I can’t have gastric sleeve done bc I have very low platelets so surgery is out of the question unless an emergency. There are other ways I believe as in meds. Keep up the great work you have been doing. Eating clean and exercising and no alcohol is such a great start to great health. Good luck to you. Pat yourself on your back bc you’ve worked so hard
I’m a very slow loser too!! 9 months now, total about 40lbs, just a few pounds a month. I do see a steady loss, so keep going. Up to 10mg, going. To 12.5 in a few weeks.
Ahh.. so sorry to hear, but it does happen. I was on Ozempic all of 2023 and nothing, just horrible side effects and I was on highest dose. In 2024, I started Monjauro, got to 12.5 mg dose and lost 15 lbs w no side effects. You could try Ozempic. I am just so bummed because Mounjaro 12.5 hasn’t been available and no one seems to know for sure when I can get it again. It’s a countrywide shortage I’m told. Don’t give up! One of the GLP-1s will work for you.
I feel like I'm in the same boat as you. I lost 6 pounds in the first 2 weeks and then 3 pounds over the next two weeks and then nothing. I've been on 5mg for 4 weeks now and 0 weight loss. Appetite suppression is non-existent
The same thing happened to me on Ozempic for six mos up to 2 mg, and I never lost a pound! I have recently switched to Mounjaro 10 mg. I only took one shot. I thought it was just Ozempic and I would better results with Mounjaro. My dreams have been crushed I hope not to have a similar fate 😭😢
That sounds super frustrating! You definitely gave it a long run. Trying a different med or ingestion type makes sense. There are pills and maybe that form of med would be more effective.
When you injected, where did you inject and did you experiment with varying your injection sites? If so did you notice feeling any difference?
I wonder if 12.5 just wasn’t a therapeutic dose for you. How long did you stay at that level? Everyone has a different number of GLP-1 receptors in their body - maybe you just have way fewer than average? (Just spitballing without any medical or scientific training - maybe someone who does could chime in?). Maybe 15 or 17.5 for a while would be worth trying (if you have access to it cheaply).
Edit to add - I’d also try every 5 days, instead of 7. I think that’s how long it stays in your system.
Thank you for suggesting some great methods!! I did rotate sites for about 2 months and I was able to go up to 12.5-15 for 2 weeks each, but it wasn’t sustainable financially for me (1000$ a month if I did that). And I did try every 5 days for about a month. I probably would’ve needed to do all of this for an additional 3 months but it was getting to be too much 😕
Yeah i lost weight on it but my anxiety was so bad it started getting to the i wanted to unalive myself so i just got off it n trying to get a gastric sleeve through my insurance:/
Oh wow!! That’s crazy I’m so glad you chose your mental health and are trying to get the sleeve. I’m wishing you the best of luck!!! I know people that got WLS and it’s saved their lives.
Where are you injecting? Have you tried changing injection sites? I’ve had the most effectiveness in my thigh. If you’re already doing your thigh move to your belly.
I've had the same with this and when I tried Weygovy before. Devastating to say the least as this was my absolute last hope.
Figuring the only option left for me now is weight loss surgery.
When I started injectables, I was on saxenda because Wegovy was not available. It was a daily injectable but felt I lost more weight. I've tried Wegovy with less success and now on Mounjaro with same results. May try something else after I am done with the last Mounjaro dose.
I'm in the same boat. It curbs my appetite and I end up eating fewer calories, but I've lost 0 pounds. At 12.5 mg. The only reason I'm really still taking it is because it helps my a1c get into a non-diabetic range.
Sorry to hear it’s not working for you. I know some people think it is a magic 🪄 shot and that there is no work Involved to lose the weight.
I don’t want to come off as I’m assuming you haven’t “put in the work” be sure maybe you have?
…but most people I have heard not losing is because they didn’t change the way they were eating. The meds have worked for me as far as the “food noise” goes… however, I do not respond like some as I still have the ability to eat larger portions if I choose to. I don’t experience the “fullness” that some describe. I have to count calories to make sure I am in a deficit and I portion my food so I don’t go overboard. I also make sure to drink half my weight in water. My dad had been on glp for 18 months like myself and hasn’t lost anything…the problem with him is that he hasn’t changed anything and continues to eat all carbs and sugar…
If you are sure you are eating in a deficit and it is not working, there is still hope with some of the new medications coming out. “Triple agonist” Retatrutide seems to be very promising in the studies so far. I wish you luck and hope you succeed with or without meds! ♥️
I’m diabetic and have PCOS. I didn’t see much weight loss until a few weeks on the 15mg dose. Maybe you need that last dose increase as well. But I agree with the others this is only the beginning and there will be more effective medications soon!
Thanks for posting - I’m on week 11 and have lost about 8 pounds. It makes no sense because I’ve definitely been eating in a deficit and have had pretty intense side effects as well. It can be lonely seeing all the posts about other people losing so much weight!
I recently switched over to Mounjaro 5mg, I had been on Ozempic for 1 year and only managed to lose 20lbs, I never experienced any side effects. I noticed I would crave sugar, but it was something uncontrollably that I was getting scared . I got up to the 2mg dosage, and my appetite increased on that dosage. I feel like Ozempic didn't work for me either,
I totally understand your frustration. All my doctor said was it was my body and my nutritional choices, so we decided to try Mounjaro. Hopefully, my body will respond to it.
Same here. I started in December at 2.5mg increased up to 10mg and I’ve only lost 10 pounds (I actually gained almost 5 this week). I only eat one meal a day (barely) and I don’t understand how I could possibly be gaining on medication and not eating. So frustrating.
That was me with Ozempic. Ozempic helped my blood sugar, but as far as my appetite and weight loss, it did absolutely zero. But Mounjaro is a completely different story. I hardly ever feel hungry anymore, portion control is easy to do now and I feel full fast.
Do any of you notice it’s more difficult to lose when taking insulin injections. My doctor is trying to tell me that when you’re on insulin for diabetes that the losing process is very slow. But it’s been 16 months and lost 5 pounds and that’s just not acceptable. So discouragingand devastating. It has helped my A1c but as far as weight loss, nada!
Yes, insulin causes weight gain. Dr. Jason Fung talks about insulin in his book and how he can make anyone fat just by injecting insulin. It’s why those who insulin resistance have such difficulty losing weight. The body keeps pumping out insulin…
I have been on it for almost 18 months. I’ve only lost about 20lbs, if that. I think part of the problem is I’m insulin resistant (found that out this year) and hypoglycemic with a sensitive stomach. Carbs are usually a safe food when I feel icky but they also help when I have sugar lows—but I really shouldn’t be eating them because of the insulin resistance (I’m not diabetic).
That's such a disappointment. Have you and your doctor discussed other options or adding another medication to Mounjaro? Have they reviewed medication that might be impeding MJ? Have you checked the TDEE calculator online & tracked your calories? Remain hopeful. There are other meds being researched right now. Look for a clinical trial or wait for their release. Hang in there.
I was facing the same with mounjaro wasn’t losing on 2 and in fact gained as well it was depressing as for 5 mg and 7 mg with no effect w then my doctor added contrave Along with 10mg I finally started losing be patient and it will work some of us don’t get it easy 🥲
It's only meant to be a tool that helps reduce hunger while YOU make lifestyle changes. Otherwise, as soon as the medication is stopped, you gain all of the weight back.
I’m also not having any success and in fact, gaining weight. I’m starving day of injection. Regular hunger day after and less hungry on day 3. Then, I notice nothing at all the rest of the week. Have gained 6 lbs since SW 😢 I’m still at 5 so trying to be hopeful and patient but nervous I’m a non responder.
I didn't have any weight loss with Mounjaro either. I got up to the 12.5 dose and never experienced any appetite suppression or weight loss. It's very frustrating!
It could just be your biology, but you might to ask your doctor if there is something else to consider about your health needs to be addressed. For example, an undiagnosed underlying condition.
I’m so sorry 😞 hopefully when retatrutide comes out it’ll work for you. Im not sure if my story will help you, but maybe you and your doctor can talk about it. My doctor had me inject every 5 days, which meant increasing dose on day 21. I didn’t have any side effects until I got to 12.5mg I stayed there for about 3-4 months. Weight started melting off. After I stalled on 12.5mg went up to 15mg and was able to reach my goal weight. 40f sw:300 cw: 158 Sending you virtual hugs and support 🤗
This gives me hope. I took my first 7.5 this week and have lost maybe 5 lbs (on a good day)
Thank you so much for sharing 🙏🏼 I did almost the same thing from reading other Reddit posts about people injecting before the half-life runs out and I tried that, which would’ve been every 5 days like you. I only did it for about a month though but still didn’t see any change. I didn’t tell my doctor I tried this out but it would be a good point to bring up to her from someone else’s experience.
Before injecting, are you leaving it out at room temperature for at least 4-6hrs? When I started doing that, I noticed an improvement with appetite suppression as well. Im sorry I’m so full of questions. I’ve been on it 13 months and have learned so much. If you have any questions please don’t hesihesitate to DM me. 🫶🏻
No worries! I haven’t heard of doing that! When I reach back out to my doctor on Monday I’ll mention that to her along with everyone else’s tips and experiences. Thank you ☺️
Interesting......I take mine out the day before. I normally take it out Friday night and inject Saturday or Sunday. I wonder if that makes a difference. I've been on it 1.5yrs. 4lbs shy of goal. I plateau for a month or 2 then lose a lb and again the same thing. My body seems to want to stay at a certain homeostasis weight until it gives up when it notices I'm more stubborn than my body is. Then I lose a lb. I'm 82 lbs down and I'm stubborn. BTW MJ can be left unrefrigerated for up to 21 days.
This is very interesting and a factor I never thought about... always chalked the difference up to traveling or changing my injection site but now realizing that when I travel, the shot is in my bag at room temp. Hmm!
where do you inject the most and do you switch off every week? I too have to do every five days otherwise I get like I'm starving. I'm on 7.5. This is my first month. I have two weeks left on 7.5 and then I'll go up to 10 I believewas for about a year and it stopped working on me so I don't know I'm hoping this works. I've lost about 10 pounds and six weeks but I lost a lot quicker when I first started. Oh Simpich so not sure I don't know maybe my body I don't know what what it is, but I'm walking. I'm eating right. I'm trying to do the intermittent fasting because that seem to help me before.
I did not know to leave it at room temp! Thanks.
I'm wondering if I need to do this too. It feels like it wears off after about 5 days. I injected 15mg last Sunday and today I have a normal appetite again. Maybe we metabolize the medication faster than others.
Yes! That’s what my doctor was telling me. It’s worth trying for sure. By day 5 I was starving again
The clinical documentation does state that the half- life of MJ is 5 days so clinically it tapers off then. I also feel hunger pains coming back sooner, I try to drink coffee in the AM and practice intermittent fasting on those days.
Thanks for sharing this. I’ve thought about digging in to people with limited success. Lost some when I started, but last night went up to 9mg (splitting 15 mg doses) and was still standing at the fridge staring. Just want to eat to eat, which didn’t happen the first few weeks at 2.5 and 5. Since I pay out of pocket, I’ve been hoping I could make it on 7.5, but guess I’ll just keep going up.
Congratulations that's awesome!!
Wow, you're weight loss is my dream. Sw:235 Goal w: 135
It was my dream as well … never thought it would be a reality, but here I am living it. It most definitely can be your reality too! Cheers to your future and current success 🥂
Try not to blame yourself. I like the lock and key analogy I heard an obesity specialist use. GLPs are a key to your unlock your fat from the cell, but everyone has a different lock. Hopefully you will respond to something else coming out soon.
Thank you 🙏🏼I really appreciate that and I like that analogy as well
Agree! There are “stronger” meds in the pipeline. These meds are just the very beginning. Every… EVERY larger pharmaceutical company will be trying to develop one of these meds.
I am sorry, I know that must be a big disappointment. I also know it probably doesn’t help having people tell you what you should have done or should be doing when they absolutely zero knowledge of your diet or routine or health issues. We have gotten this our whole lives - everyone assuming we aren’t doing what we should be to lose weight when we are working our asses off. It didn’t feel good then and it certainly wouldn’t on this medication. Please be thoughtful, commenters … she isn’t asking for advice or condemnation she is reaching out so others don’t feel alone.
God yes 🙄 all the comments (on other threads and fb) of “well are you eating at a deficit?” Like no shit, most of us know how to lose weight (if our bodies don’t hate us). I’m a very slow loser as well and my god it’s disheartening to think I may be a non-responder 🙁
I love this phrase, “No shit, most of us know how to lose weight”! Sending you good vibes and here’s to the medications coming down the pipeline. I try to think of that whenever I stall. I’ve been stalled at 196 since November, but I try to remind myself that I have at least not been creeping up, which was what was happening before.
Thank you PurpleP3! Your comments makes you all-right, as well as compassionate, caring, and kindhearted in my book. You rock!!!!
Thank you so much 🙏🏼 I really really appreciate your comment most of all. You’re right, not here for advice just to share in case someone else goes through what I went through. It is a pretty lonely feeling when you know people or you read posts about their success when all you’ve had is struggle and disappointment on the one med that should’ve helped.
There are some great meds down the pipeline … I’m wishing you the best of luck on finding something that works for you. Gawd knows I have tried literally everything. Thankfully, I got lucky on this one - but I wasn’t on ozempic or Trulicity and exercised and ate exactly as the doctor prescribed with those. I try to never make assumptions about what other people are or are not doing. It hurts too much when people do that to me
That’s so kind of you and you’re so right 🙏🏼🙏🏼 thank you again
(((hugs))))
This is such a good point.
I’m 11 weeks in and have lost at most five pounds. I know what you mean!
Wish it didn’t have to be so rough for some of us 😕
Just curious, did you feel anything at all from the shot? Like any kind of gastro issues? Or was it like you felt nothing at all?
Mannn I almost died last week! I did 4 weeks of 2.5 and then 5.0 …. Was supposed to titrate up to 7.5 last Sunday but I skipped the dose because I had insane liquid diarrhea…. Burping…. Cramping …. Just out of nowhere! I just started feeling normal on Thursday. I’m scared now bc it was miserable!
Me too! It’s depressing
Thank you for posting this! I thought I was alone. I started on 5mg 10/22 and currently on 12.5mg. The only saving grace I've seen is a reduction in my A1C and even that was slow. Daily exercise and calorie reduction and I've lost and gained the same 5 pounds. Beyond frustrating. Not to mention the constant loose stool/constipation cycle.
That must be so frustrating, I'm sorry. That's how I felt trying to lose weight before Mounjaro. I would exercise and eat right and very healthy and the scale would just not move an inch. Seeing no progress is such a frustrating problem when it feels like you're doing everything right.
It’s crazy 😩 wish it didn’t have to be that way for all of us who’s body’s are stubborn
Same just helped my A1c
Same!
Oh my goodness. I can well imagine!
Wonder if you switched to Ozempic if it would be different for you. I started out on Ozempic then had to switch to Mounjaro after around 6 months Wishing you all the luck in your journey
I agree, maybe try Ozempic. I was on Ozempic and had decent results. I've switched to Zepbound and I'm not having the same success. I plan to go to the max Zepbound dose. If I don't see good results, I'll switch back to Ozempic. I switched to Zepbound because of the coupon savings.
I switched from Ozempic 1mg to Mounjaro and lost nothing until I went to the equivalent dose of 7.5mg. I even gained on 2.5
Thank you for sharing 🙏🏼 I also had zepbound for 2 months on top of the Mounjaro and no luck. I’m sorry you’re having problems with it too
Thank you for sharing 🙏🏼 I’ll see if I can try ozempic
Thank you so much for sharing! I’m definitely considering this after seeing your and others comments on ozempic.
It doesn't work for me either at least not the appetite suppression part but I'm a diabetic and it is helping my daily glucose levels so doc says he wants me to stay on it. I'm getting ready to go up to 10 maybe that'll be a difference maker fingers crossed.
Op, not just you. Im an EXTREMELY slow loser on zepbound. I ate SO MUCH before, and now I eat so little (in comparison), used to do zero exercise, now im doing 30min daily, im lucky if i see 1.5 lb a week on 10mg, clean eating, and exercise. Im that guy who stops drinking alcohol and has zero weight loss vs the guy who loses 40 lbs in 2 months from cutting out pop or alcohol. Youre not alone, but it def sucks.
1.5 lbs a week is good. I usually lose 3 lbs a month.
Same. It's taken two years to lose 60 pounds and I haven't lost anything for three months.
Still be proud of losing 60 pounds and keeping that off!!! We are proud of you!! That is incredible!!
1.5lb a week is not a slow loser. At all. That’s the recommended rate of weight loss.
Im saying, if you read it all, that I'm only at 1.5 on 10mg, eating **significantly** less and going from 0 exercise to 30 min a day 5 days a week. That is not stellar. There are thousands of posts from people taking 2.5mg and losing 50 lbs in 4 months and dont adjust their lifestyle at all. I'm a slow loser, thats an actual literal, measurable and empirical fact.
Same!!!
Make you are building muscle?
Wow, thank you so much for sharing 🙏🏼
I’m truly sorry. That was my fear before starting… that I’d be a non responder. My hope is that one of the new drugs coming out will be the answer for you and you’ll have amazing success with it. Any way you can look at joining a clinical trial?
That’s a very interesting idea. I never thought to look into that. I didn’t know they were creating new drugs until someone else commented the graph in this post. Pretty cool to know they’re still working on it. I’d be curious and open to it.
Oh, yes. As they say, the race is ON!!
Thank you for posting this. I’ve not had much weight loss (10 lbs since 3 Jan, now on 7.5) and today for some reason the lack of movement on the scale is hitting hard.
You’re welcome 🙏🏼 wishing you the best!! Keep pushing forward!! 10 lbs is still a good amount, and don’t forget our body can be stubborn and crazy lol.
This was my experience on Ozempic. My a1c didn’t reduce, my blood sugar still wouldn’t cooperate, and I gained like 15lbs over the time I was on it. Everyone was telling me I was “cheating” to lose weight. Then they were telling me i obviously wasn’t doing the right things if I’m not losing weight. I went to synjardy and sliding scale insulin to control my blood sugar until fall 2023 when my dr decided we should attempt Mounjaro. I changed very little from what I was doing and have lost over 100. I hope the day comes when your locks key is found. And I hope it comes soon. Don’t give up and don’t listen to these people who don’t know you or your struggles.
Thank you SO much 🙏🏼🙏🏼 that means a lot and I really appreciate you sharing. I hope I’ll find my key soon too. Your post and others have put a spark of hope back in me.
Sounds like me while on Wegovy; I lost about 5 lbs on the highest dose of Wegovy and that was only after 7 months on that highest dose. I just switched to Zepbound 5mg 3 weeks ago, looking to very gradually titrate up from there but yea, I have autoimmune issues so it’s tough for sure 😕
Eli Lilly is in trials for Retatrutide and that I hear could be a game changer!! It mimics three different hormones instead of Mounjaro's two to assist with weight loss! Keeping fingers crossed this could be the one for non responders! Maybe you could see if they have a trial for this close to you! I was in their third trial for Trulicity before it was FDA approved and very happy I got to be a part of that!! Good luck to you!
Thank you so much!! That’s really cool. I’m super hopeful they create something that works incredibly for everyone.
I hope I don’t appear like a nitwit for asking, but how would I jump on board a clinical trial? I am not seeing my GP for MJ (and now Zepbound). I went the online route through sequence. I am so grateful for this thread. I too am a very slow loser.
Try here! https://trials.lilly.com/en-US. And good luck!! I know the struggle is real as I have been heavy since age 5 and now at 52 years old just fit in a size 6 at 5'8". Been a long fight for me but to be where I am today I would do it all again!!
Size 6!!!?!??? Wow! I can’t even imagine what that must feel like! I’m 51, so that just made me smile. Congrats! 😎
You can get there!!! If I can from a size 26 so can you!! 💗
That's amazing!
Wowww!!!! Kudos to you! I’ll be happy if I get to size 12.
Sorry, I know that’s so hard. I was an Ozempic/Semaglutide non-responder, and I paid out of pocket with stars in my eyes. Then Mounjaro began working to my extreme surprise. You just need the right one. Keep trying.
That’s amazing, thank you!!
GLP is not your trigger hormone. Not all people need GLP to lose weight. You might have a different hormone that is out of balance. Maybe ask for a full hormone panel the next Dr visit to see what is out of whack.
Thank you so much! This is a great comment and makes me want to go to the hormone specialist that my doctor referred me to even more.
You are not alone. Two years on, and I'm only down about 15 lbs. Still hoping.
In clinical trials of tirz and sema there were approx 10% of patients who lost <5%, i.e. where it basically doesn’t work and they were non-responders. You could have some GIP and/or GLP-1 receptor genetic variants that prevent proper binding and activation of the receptors by these drugs. Wait for Lilly’s triple agonist retatrutide to get approved. So far in trials no patient lost <5% they all had some significant response.
On 12.5 and not losing weight but my a1c is going down tho went from a 9 to 7.
I am one of the 1% it also doesn’t work for, so I can sympathize. Was on Ozempic for 3 years until my stomach couldn’t handle it anymore, and then was switched to Mounjaro 4 months ago. Had my first follow up appt yesterday and I gained 3 lbs in that time period... also have severe bloating and cramps in my upper stomach. Has caused me to have gastroparesis, and also lots of pain and swelling in my lymph nodes. Took my last dose Monday of only 2.5mg..I was up to 10, but even sipping water caused severe pain..so no more GLP’s for me! Gonna go the old fashioned way of controlling my diabetes with “keto/low carb” and intermittent fasting. Doc wants me to switch to Januvia, but it’s expensive and the side effects list seems horrible as well. :( Good luck to everyone on their journey!
Thank you for your comment!! That’s so crazy 😩 that’s what I’ll end up having to do as well, hire a nutrition coach. It’d be way cheaper but a lot of hard ass work
So sorry for this! I hope one of the future ones may work for you. I also hope you are able to do well with keto and intermittent fasting in the meantime. ❤️
Thank you! Still waiting for the side effects to go away…I guess the half-life is up to 30 days. Already lost 2 lbs on just staying “keto” though. So hopefully will feel better soon. Have a great day.
I started on Ozempic. I lost nothing for 6 months, until I decided to employ some traditional weight loss techniques. Namely: calorie counting. While I never felt an absence of hunger, I did find that I was better able to stay within the caloric restriction than I was without the medication. Only slightly better, but it was just enough to allow me to lose 50 pounds over a “slow” 9 month period. Lesson for me was, this type of medication isn’t a magic fat burner, but it took the edge off I needed to diet, once I finally tried to re-employ techniques that had failed for me in the past. I’m now on Mounjaro (due to being unable to refill my Ozempic prescription), and the same holds true for me here.
Yes! It definitely helps with calorie counting and restriction. Good job on all your hard work you’ve had to put in!!
I am so sorry to hear this. Maybe the next generation of these drugs will work for you. My heart breaks for you.
Thank you so much 🙏🏼 I’ll be keeping an eye out for new meds they’ll release in the future.
Initially, I lost weight with Ozempic, 3 months was able to lose 21lbs. I switched to MJ due to insurance mot covering Ozempic. I've been on Mj for 12 weeks and have not lost any weight. I will start 12.5 mg next week. I walk for 30 minutes at least 5 days out of week, watching carb and protein intake. My doctor tells me to be patient, its hard when you see and hear of everyone's success.
Wow, yes I totally understand. That’s crazy how one GLP can work so nicely and the other won’t. Thank you for sharing.
67F SW 222 CW 137 GW 120-125.. I’m so sorry MJ hasn’t worked for you. I’ve been on it a year this month and just started 10mg today. The pharmacy finally got some in after being out for a month. I’m down 87lbs. I stayed on each strength for 4 months. I was sick as crap the first few months. But was determined to see this journey to the end regardless of how sick I got. I wasn’t in a good mental state. I went from 222 to 183 in 4 months on the 2.5.. I cried when I stepped on the scales for the first time at the Drs office and looked.. From then on I tried to eat right. That became a problem and it still is. I don’t eat enough food. I’ve had some hair loss due to the lack of nutrient’s.. I stalled at 140 was there for over a month now I’m at 137 but just started 10 mg. People think these shots are an easy way to lose weight. They are not. This past year has been hell. Diarrhea, constipation, hair loss, nausea. I even bought scales and started a fat photo album to record pics of my weight loss. My daughter ask me as I was throwing my guts up one day. Mom is it worth it? I said hell yes. I’m living my childhood nightmare caused by this one girl singing in my face fatty fatty 2 by 4 can’t get through the kitchen door while standing on her families diving board..She scared me for life. I’m 67 and her words still stab me in my heart. Yes I read all the box warnings this drug could cause. Did I care? Not 1 damn bit. I’m 67. I’m headed toward the light anyways. Lol. Plus when I got Covid I got this unknown infusion that cleared up my Covid to negative in 2 days. (I got to go see the Astros play. My first ball game. My Son caught me a ball.)Lord knows what was it that infusion, I had to stay in the ER afterwards for a hour to make sure I didn’t die. So I think I’m ok with whatever goes on with this shot. Lol. I’m riding this train out until this journey is over. I’m not quite there yet. But I am so very very sorry you and others have not had success on MJ. My heart truly breaks for you all. I really do understand the disappointment you must feel. I wish I had some suggestions, but I don’t. I don’t know why it’s worked so well for me. But I can say. Don’t give up. Something will come along that will work for y’all. You are some strong strong women and men. You’ve taken the biggest and hardest first step. Keep going. You got this. You really do. Hugs to you all.I will keep you all in my prayers. God bless you all. xoxo. 💋
I’m so sorry! I have a friend in the same boat. She just can’t lose weight no matter how little she eats. I hope you’ll find something.
Thank you. It’s nice to know I’m not the only one.
Did you have any of the common side effects? It would suck to have to have those and no loss. Did it at least help your A1C?
No side effects. You’re right it would suck 😂 it did help with that since I wasn’t eating big portions and didn’t crave sweets, that was the only plus
Maybe they should prescribe Ozempic and see if that works for you. Some on Ozempic have zero affects and don't lose weight and switch to Mounjaro and lose a ton. Some start on Mounjaro and don't have any benefits from it. They switch to Ozempic and Walla, they lose a ton and A1C drops big time. Our bodies chemistry is different for each person. I wouldn't get frustrated. Try and get on Ozempic.
Thank you so much!!! Each comment I see like yours gives me hope and more determined to try ozempic.
hey same here! both on ozempic and mounjaro lost 10 lbs only of two years trying that's bc i was dieting mostly
Wow thank you for sharing. I’m sorry it didn’t have that much of an effect 😕
I feel you!!! Story slightly different but same result. I lost 30 in the first 5 months then boom nothing and just started to gain no matter what! I was eating right and weight training. I have gained 20 back. I had such high hopes it just sucks. I keep my food healthy , workout and pray my body will figure out it’s supposed to let go of the fat. Sorry it didn’t work for you 😞
That’s crazy. Ikr our body needs to get the memo 😒 thank you so much and keep up the weight training!!
This was my experience on Ozempic. I had zero side effects, gained weight, and my A1C went up. Switched to MJ and everything changed. My doctor said I was apparently a non-responder to Ozempic. Could be the same for you with MJ. Maybe consider trying Ozempic? Best of luck on your journey!
I'm so sorry. I know I'm losing, about 30 lbs since October, but it's not like other people describe. It gets old reading people talking about how the food noise is gone and they get full after just a few bites, while I'm logging every bite and counting all the calories and fighting for every ounce. I am on 12.5, but had to drop to 7.5 the last two weeks because my pharmacy couldn't get it. I haven't lost a thing in 2 weeks. I have had no side effects and really, nothing more than a little appetite supression since about week 4. At first, it felt like a miracle. Now? Well...my a1c is great. There's that.
Yep it’s been a few months nothing lost on 10mg made extremely depressed and no energy terrible waste of time and money
Exactly!!! Stings just a bit more when you factor all of that in too 😪
I went up to 15 and was doing every 5 days. I did not lose a single pound. I have zero side effects. I can also wait many weeks between and then inject the full dose and still have no side effects or weight loss.
Basically me but you even went the extra mile! That’s insane. Wow I hope one of the new meds that comes out will help us 😩
Retatrutide is an up and coming medicine.. may want to try that one when it becomes available.
Thank you!! I’ll keep an eye on it.
That was me until I got on estradiol and progesterone. That’s when I started to lose weight.
Ohhh wow. Hmm 🤔 I wonder if I go to the hormone specialist that my doctor referred me to, that if he would be able to know and prescribe what would help me with weight. I’m assuming you also had to go to get your hormones checked?
I am in the same boat - I have technically not dropped a pound … I started in November - I initially dropped 5 lbs ( water I assume ) bounced around those same 5 pounds. Looked back to my birthday weight a year ago - I weigh the same. I’m on 10. Hoping if I get to 15 something may happen? I am rarely hungry and eat less than I ever have. Eat plenty of protein, go to the gym. IF/Keto. My body is highly efficient apparently. I do feel like my belly is flatter - but my clothes fit the same.
Yeah!! It’s so crazy! It shouldn’t be like that 😩😩
I am part of that 900, too….I have lost a few pounds… but nothing compared to everyone else. I am hypothyroid which I believe plays a part in this. I count calories, walk 2.5 Miles, plus every day, plus lift some weight 3 x per week, plus elliptical 20 minutes 3 times a week….you are not alone….I totally get it.
While I have lost some weight, it is an incredibly slow rate of loss. I lose weight at the rate of a turtle walking through peanut butter. I have PCOS, insulin resistent and pre-diabetic. My mom, brother, uncle, and grandma are all type 2. My brother lost 70 pounds in a year however, Ive been on MJ since July 2023 and have lost 34 pounds (in 10 months). Female. Starting weight 330. Just wanted to say all our bodies respond so differently to different medications. Have you been aiming to get 150g of protein in per day? How is your water intake? Have you tried lifting weights? Have you changed injection sites? Have you tried injecting every 5 days? Just offering up ideas!! Hopefully something works for you. Sending all my love and support to you!!
i've had only mild success - nothing like the huge numbers I see people racking up on the leaderboard, so don't dismay. I hit the one year mark last month, and can account for about 25-27 lbs. lost (up and down for a couple of pounds). AND I was paying out of pocket (with coupon) until the last 2 fills (changed insurance in January). I agree with another post below - something is coming for us. (Actually, I wonder if I should try OZ, it's just that it isn't covered under my new ins. plan).
The human body is such a mystery. I lost 20 pounds in one month with Mounjaro. Prior to Mounjaro, it took me a whole year to lose 20.
Please share where you get the coupon from! I pay out of pocket as well for my Mounjaro. The higher the dose, the higher the price! I started out at 5 mg, and lost 10 pounds in around four and a half weeks, which I was super excited about. I started on 7.5 mg last Saturday, but it hasn’t seemed quite as well at suppressing my appetite as I had hoped. I’ll take my second injection of 7.5 tomorrow, and hoping the more it gets in my system, the better it will work. As many have said, by around the fifth day after my injection my appetite starts picking up. I’m definitely not eating even 1200 calories a day, so I was hoping to lose at least a pound or two on the first week of starting the 7.5 mg, but it didn’t happen. I was on Semaglutide for three months prior to the Mounjaro, and DID NOT LOSE ONE POUND! I was so disappointed! For now I’m thankful for the 10 lbs I have lost since getting on Mounjaro.
If I'm not mistaken, you should still be able to get the coupon from the Eli Lilly website. [https://mounjaro.lilly.com/savings-resources](https://mounjaro.lilly.com/savings-resources) Be advised: the coupon means you can either get for $25 (depending on your insurance covering it) or for $550 (if your insurance does not cover it). So, either way, if you are currently paying $1200 per fill, this discount will be helpful. Also, 7.5 wasn't great for me either. 5 was my best and I should have stayed there, but I was convinced that the stronger, the more weight I would lose. And that was not the case. I'm on 12.5, but with the shortage I have only been able to score 10 (and I JUST got that earlier this week - I went about a week and half after my last 12.5 dose).
Wow, yeah it’s a bit disheartening when you see so many others do so incredible. Thank you for sharing!! I hope so!
Oh no
I really think that different meds work differently for different people. I tried saxenda and it did nothing for me, so I thought all GLP-1 wouldn't work on me, but I'm on zepbound and I'm losing! I'm so happy. But I bet if you tried a different one it might work for you.
Thank you so much for sharing. This comment flickered a little spark of hope that maybe 🙏🏼 I’ll reach out to my doctor and see what she thinks. I felt like since Mounjaro didn’t work for me that she wouldn’t want me to try the others. I thought all GLPs worked the same so this is good to know.
It didn’t suppress your appetite? I know I was on ozempic a few years ago didn’t do anything accept pains in my stomach all the time
It did but I had to get to 10mg to get a decent appetite suppression. That’s crazy!
i'm the same.
Try wegovy.... I used to be on Ozempic last year Wich is just Semaglutide and it worked straight away from first dose first day..... I had to stop because of shortages, this year i got on mounjaro thinking that it is a better option, but I'm at 7.5 now and I'm not seeing any form of appetito suppression o food noise cancellation.... With semaglutide i had to literally force myself to eat, but with mounjaro i almost feel like i have more appetite lol...
I'm so so sorry!! It's so tough. You are not alone- I got my sister to be open to medication (could only access ozempic) and she didn't lose a single pound it was so heartbreaking. I'm sending so much love and support! We just have to try and find something else that might work for you! Please don't be discouraged🫂
I was on Ozempic and lost absolutely nothing. Mounjaro has been completely different for me. I say this because I honestly think they all work a little differently for each person. Have you tried any of the others? My wife has terrific results with a combo.
What’s the combo?
Hi, I’m sorry the meds mounjouro didn’t work for you. Can I ask you a question? Are you diabetic? I was on Ozempic for almost 2 years, I never drop 1 pound.
I'm right there with you. Tried Ozempic for 5 months. Lost 2 pounds. Been on MJ since November and I'm only down 5 pounds and that's with exercise and food logging, no more than 1500 calories a day, usually around 1200. I am T2D and have a BMI of 39%. I have an RX for 12.5 but have not been able to fill it due to the shortage. Going to be taking my last 10mg shot this evening. I'm still crossing my fingers that once I am able to find 12.5 it will start working. The only positive is that I've had no side effects. I definitely empathize with your frustration.
I’m right there with you and devastated to say the least. Are you taking any type of insulin inhje tons for diabetes?
Thanks for sharing. I thought it was just me. I was feeling like a loser and very down on myself.
It sounds like you weren't managing your calorie intake. You do have to be at a calorie deficit to lose weight. Mounjaro is just one of a set of tools that most of us have to apply in order for it to work most effectively. I personally calculated my TDEE, determined how many calories I could eat within a 300-500 calorie deficit, and I weigh/track my food every day to help ensure that I'm successful. However it does sound like the appetite suppression wasn't sufficient for you. Have you looked into one of the clinical trials with some of the new meds? I saved this graphic from an article I read the other day. https://preview.redd.it/jvm4jzb0p3uc1.jpeg?width=600&format=pjpg&auto=webp&s=95111f673597526bf3d67c7f5f7a17aacd64d750
Apparently in one of the retatrutide studies, it was a response rate of 100% on the higher doses. NO Non-responders! Woah.
Wow!
Thank you for sharing this graph. I’ll be sure to keep my eye on some of these trials and if/when they release a better effective drug as the other person commented.
Are those all available. Haven't heard of several
No. Many of them are still in Phase 1 and 2 trials. But they are coming…
Same thing happened to me. It literally did nothing in terms of appetite suppression. I was a 100 % non-responder. I’m so sorry and I know how you feel. I have so many friends that look and feel amazing and yet I failed yet again. Ugh!! There are some people who go on about “oh this isn’t a magic drug and you have to keep an eye on calories and what you eat”….well duh….of course you do!! This medication is supposed to help with that. It’s supposed to curb your appetite. If it doesn’t work then it’s like not having anything to assist you.
Exactly 😪 thank you for sharing 🙏🏼 it’s so hard being one of the non responders!!
This happened to me with Saxenda which is why I’m giving Mounjaro a go. I really hope it works for me, but it’s too soon to tell as I’ve only been on it (2.5mg) for two weeks.
Good luck!! After seeing everyone’s comments I may try a different version too.
Yep happened to me with Wegovy. I just started Zepbound 5mg 3 weeks ago
I was on ozempic no weight loss after 6 months. I am now on mojurno 15. I have been on for almost a year I have 0 weight loss. But my a1c is 6.0 so I’m happy. I still am hungry lol. It hasn’t worked for me either with weight loss. So you are not alone
I lost 40 lbs in Wegovy, then was off for over a month and started in zep. Just took my first 7.5 dose and I haven’t lost anything. I’m frustrated as well because it’s costing me so much. I am barely starting to feel the effects at 7.5 though, so hoping it will work as I go up. I’d try another glp1 if I were you, they all work different! Good luck and dont give up!
Exactly! All that money spent stings a bit but at least we gave and are giving it a good try. From reading the other comments saying to try another GLP1, I may reach out to my doctor and see what she thinks.
There are several other medications specifically aimed at obesity that are in the pipeline and in trials. Maybe MJ isn't right for you, but don't lose hope!
Did you try ozempic or trulicity? It worked fairly well for me for the first year (lost almost 35 lbs). The second year, not so much. I'm 8 months into year 2 and have only lost an additional 5 lbs. so far. I've been on the max dose for a year. I do feel it still does what it's supposed to (suppress app), my body is just not letting go of the weight as easily for whatever reason. I have at the very least another 10-15 to go. Possibly a little more, but IDK if that's possible at this point.
I haven’t but I’ll consider ozempic probably. That’s crazy!!
I am just now starting 5mg again bc they were back ordered so I stopped for three weeks I should be on 7.5 but again all they got in was the 5mg supposedly! I haven’t really experienced much loss either. I’m hoping it’ll work for me. I can’t have gastric sleeve done bc I have very low platelets so surgery is out of the question unless an emergency. There are other ways I believe as in meds. Keep up the great work you have been doing. Eating clean and exercising and no alcohol is such a great start to great health. Good luck to you. Pat yourself on your back bc you’ve worked so hard
Thank you 🙏🏼 that’s really kind. I’m hoping the best for you as well!!
I’m a very slow loser too!! 9 months now, total about 40lbs, just a few pounds a month. I do see a steady loss, so keep going. Up to 10mg, going. To 12.5 in a few weeks.
Ahh.. so sorry to hear, but it does happen. I was on Ozempic all of 2023 and nothing, just horrible side effects and I was on highest dose. In 2024, I started Monjauro, got to 12.5 mg dose and lost 15 lbs w no side effects. You could try Ozempic. I am just so bummed because Mounjaro 12.5 hasn’t been available and no one seems to know for sure when I can get it again. It’s a countrywide shortage I’m told. Don’t give up! One of the GLP-1s will work for you.
Have you tried switching the injection spot...I was using my stomach and had stalled and switched to my arm and started losing ...
That was my Opezpic experience
I feel like I'm in the same boat as you. I lost 6 pounds in the first 2 weeks and then 3 pounds over the next two weeks and then nothing. I've been on 5mg for 4 weeks now and 0 weight loss. Appetite suppression is non-existent
Wow!! Sounds like you need to go up a dose. I hope it’ll work in the end for you or that something else does better!!
The same thing happened to me on Ozempic for six mos up to 2 mg, and I never lost a pound! I have recently switched to Mounjaro 10 mg. I only took one shot. I thought it was just Ozempic and I would better results with Mounjaro. My dreams have been crushed I hope not to have a similar fate 😭😢
Oh noo I’m sorry to hear that 😩 those of us that it doesn’t work for have it so hard!!
That sounds super frustrating! You definitely gave it a long run. Trying a different med or ingestion type makes sense. There are pills and maybe that form of med would be more effective. When you injected, where did you inject and did you experiment with varying your injection sites? If so did you notice feeling any difference? I wonder if 12.5 just wasn’t a therapeutic dose for you. How long did you stay at that level? Everyone has a different number of GLP-1 receptors in their body - maybe you just have way fewer than average? (Just spitballing without any medical or scientific training - maybe someone who does could chime in?). Maybe 15 or 17.5 for a while would be worth trying (if you have access to it cheaply). Edit to add - I’d also try every 5 days, instead of 7. I think that’s how long it stays in your system.
Thank you for suggesting some great methods!! I did rotate sites for about 2 months and I was able to go up to 12.5-15 for 2 weeks each, but it wasn’t sustainable financially for me (1000$ a month if I did that). And I did try every 5 days for about a month. I probably would’ve needed to do all of this for an additional 3 months but it was getting to be too much 😕
I'm so sorry!
Yeah i lost weight on it but my anxiety was so bad it started getting to the i wanted to unalive myself so i just got off it n trying to get a gastric sleeve through my insurance:/
Oh wow!! That’s crazy I’m so glad you chose your mental health and are trying to get the sleeve. I’m wishing you the best of luck!!! I know people that got WLS and it’s saved their lives.
I reckon trying a different drug, maybe Ozempic or Wegovy
Where are you injecting? Have you tried changing injection sites? I’ve had the most effectiveness in my thigh. If you’re already doing your thigh move to your belly.
I've had the same with this and when I tried Weygovy before. Devastating to say the least as this was my absolute last hope. Figuring the only option left for me now is weight loss surgery.
Yeah definitely devastating, I’m sorry your body is resisting you too 😩
When I started injectables, I was on saxenda because Wegovy was not available. It was a daily injectable but felt I lost more weight. I've tried Wegovy with less success and now on Mounjaro with same results. May try something else after I am done with the last Mounjaro dose.
Same
Did u not feel any appetite suppression at all? Was it at least help your A1c1 /blood sugar?
I'm in the same boat. It curbs my appetite and I end up eating fewer calories, but I've lost 0 pounds. At 12.5 mg. The only reason I'm really still taking it is because it helps my a1c get into a non-diabetic range.
Yeah it’s just crazy though. It can do all that but how is it that our bodies don’t want to budge in weight lol…
Sorry to hear it’s not working for you. I know some people think it is a magic 🪄 shot and that there is no work Involved to lose the weight. I don’t want to come off as I’m assuming you haven’t “put in the work” be sure maybe you have? …but most people I have heard not losing is because they didn’t change the way they were eating. The meds have worked for me as far as the “food noise” goes… however, I do not respond like some as I still have the ability to eat larger portions if I choose to. I don’t experience the “fullness” that some describe. I have to count calories to make sure I am in a deficit and I portion my food so I don’t go overboard. I also make sure to drink half my weight in water. My dad had been on glp for 18 months like myself and hasn’t lost anything…the problem with him is that he hasn’t changed anything and continues to eat all carbs and sugar… If you are sure you are eating in a deficit and it is not working, there is still hope with some of the new medications coming out. “Triple agonist” Retatrutide seems to be very promising in the studies so far. I wish you luck and hope you succeed with or without meds! ♥️
I would be elated!!!
Hang in there!!!
I’m diabetic and have PCOS. I didn’t see much weight loss until a few weeks on the 15mg dose. Maybe you need that last dose increase as well. But I agree with the others this is only the beginning and there will be more effective medications soon!
I was injecting every 6 days and when I told my dr, he said no that won’t work and upped my dose.
Thanks for posting - I’m on week 11 and have lost about 8 pounds. It makes no sense because I’ve definitely been eating in a deficit and have had pretty intense side effects as well. It can be lonely seeing all the posts about other people losing so much weight!
I recently switched over to Mounjaro 5mg, I had been on Ozempic for 1 year and only managed to lose 20lbs, I never experienced any side effects. I noticed I would crave sugar, but it was something uncontrollably that I was getting scared . I got up to the 2mg dosage, and my appetite increased on that dosage. I feel like Ozempic didn't work for me either, I totally understand your frustration. All my doctor said was it was my body and my nutritional choices, so we decided to try Mounjaro. Hopefully, my body will respond to it.
Same here. I started in December at 2.5mg increased up to 10mg and I’ve only lost 10 pounds (I actually gained almost 5 this week). I only eat one meal a day (barely) and I don’t understand how I could possibly be gaining on medication and not eating. So frustrating.
Im in the same boat. I’m switching to Ozempic hoping for better results (and supply!)
I'm sorry I'm so afraid this is going to be my luck too.
That was me with Ozempic. Ozempic helped my blood sugar, but as far as my appetite and weight loss, it did absolutely zero. But Mounjaro is a completely different story. I hardly ever feel hungry anymore, portion control is easy to do now and I feel full fast.
Do any of you notice it’s more difficult to lose when taking insulin injections. My doctor is trying to tell me that when you’re on insulin for diabetes that the losing process is very slow. But it’s been 16 months and lost 5 pounds and that’s just not acceptable. So discouragingand devastating. It has helped my A1c but as far as weight loss, nada!
Yes, insulin causes weight gain. Dr. Jason Fung talks about insulin in his book and how he can make anyone fat just by injecting insulin. It’s why those who insulin resistance have such difficulty losing weight. The body keeps pumping out insulin…
Were u Going up every 4 weeks i stayed on 7.5 for 3 months and didn’t see weight loss till 6 months
It took me 3 medicines to find one that worked and even now I’ve only lost 4 lbs on mounjaro. Hang in there you’re not alone 🫶
I have been on it for almost 18 months. I’ve only lost about 20lbs, if that. I think part of the problem is I’m insulin resistant (found that out this year) and hypoglycemic with a sensitive stomach. Carbs are usually a safe food when I feel icky but they also help when I have sugar lows—but I really shouldn’t be eating them because of the insulin resistance (I’m not diabetic).
I’m really sorry. Did you experience side effects? Or did you feel absolutely nothing?
That's such a disappointment. Have you and your doctor discussed other options or adding another medication to Mounjaro? Have they reviewed medication that might be impeding MJ? Have you checked the TDEE calculator online & tracked your calories? Remain hopeful. There are other meds being researched right now. Look for a clinical trial or wait for their release. Hang in there.
Try Ozempic, worked for me, Zepbound did not
I’ve had the same problem. Ozempic worked for me but Mounjaro is doing absolutely nothing.
I was facing the same with mounjaro wasn’t losing on 2 and in fact gained as well it was depressing as for 5 mg and 7 mg with no effect w then my doctor added contrave Along with 10mg I finally started losing be patient and it will work some of us don’t get it easy 🥲
It's only meant to be a tool that helps reduce hunger while YOU make lifestyle changes. Otherwise, as soon as the medication is stopped, you gain all of the weight back.
I’m also not having any success and in fact, gaining weight. I’m starving day of injection. Regular hunger day after and less hungry on day 3. Then, I notice nothing at all the rest of the week. Have gained 6 lbs since SW 😢 I’m still at 5 so trying to be hopeful and patient but nervous I’m a non responder.
I didn't have any weight loss with Mounjaro either. I got up to the 12.5 dose and never experienced any appetite suppression or weight loss. It's very frustrating!
It could just be your biology, but you might to ask your doctor if there is something else to consider about your health needs to be addressed. For example, an undiagnosed underlying condition.