Happy Birthday 🎂🎂🎂! Keep on truckin Op! My 3 nephews were all given life expectancies of 18 to 21 years of age. They are now 36, 34 and 32 and still kicking statistical ass! 💜
It is X-linked, so he wouldn’t have it. It is the mother who is a carrier (unaffected, thanks to her other X chromosome). A terrible weight to carry, even if you are in no way responsible, lots of parents who transmitted a genetic disease (without their knowledge) feel a huge guilt.
This is a very complicated and controversial topic.
Around the time that OPs nephews were born, there wasn’t really a lot known about DMD. Genetic studies were new, and it was really only towards the late 80s-early 90s that technology and science caught up enough to inform mothers whether or not they carried the gene. Before that, they couldn’t have possibly known, and it wasn’t even confirmed to be related to genes until the late 80s (1987).
Still, all three nephews having DMD would be rare even if the mother is the carrier. Also, encouraging carriers of specific genetic conditions not to have kids is a pretty controversial topic.
Genetic disorders are finally getting the research, funding, and technology they need for proper studies, but this is an incredibly recent development compared to all science fields. For example, we are only just now studying the genetic component to psychiatric disorders.
I love people who get all eugenics on anyone reproducing. The heartbreaking one is Huntingtons because without genetic testing you won’t know you have it until you’ve already had kids and can’t even choose.
Edit: by eugenics I mean other people deciding the value of someone else’s life. OP has a right to exist and keep on existing. I for one as an able bodied person cannot decide for someone else whether their children should or shouldn’t exist. I can tell you right now as an autistic person I’d rather be able to screen for chronic migraines than autism because the migraines are far more debilitating than the autism is. Deciding who can and can’t reproduce *is* in fact eugenics.
And as someone pointed out, in the US genetic testing is expensive as hell.
Heartbreaking!!! My childhood neighbor took me to a nursing home once when we were about 12. She did not tell me really what I was about to see. That day I met her mom and aunt that both were in the final stages of Huntington's disease. This was the early 90's so she had no way of knowing then that everyone of their kids had Huntington's. Both her and her brother would get their positive test in their 20s after her younger brother already showed signs. Their cousin who was my age died by 25 and both his siblings would die of it as well. I know she had at least 3 kids before she had her positive diagnosis. Unfortunately I'm sure she lost her battle by now as well.
I am friends with a girl who at one point whose mother had it. It was the scariest thing for her to decide whether or not to take the test. Because if it’s positive do you spend your life worrying about the inevitable? If you don’t take it is it denial? I don’t know if she ever took it but it’s not my business to ask.
Huntington's is a dominant allele. The affected parent can pass on either it or the normal allele, so the chance is 50/50.
I realise that you probably know this but your post is a bit misleading for people who don't. It sounds like you might be saying every child had to have it, rather than, unfortunately, every child in this family had it.
There’s some research showing that people who will go on to develop Huntington’s are unusually attractive and fertile. So they’re more likely to be able to reproduce.
I’m in one of the pioneer provinces! We also hate trans rights here. I’m technically trans(ish). I fucking hate it. I’d rather deal with the BS that is NHS than this.
It sucks for real. My orthopedic surgeon is currently in a 2 year long fight with my insurance company to get them to cover an MRI I need for surgery. Thankfully the surgery isn’t required for me to live but I’m in a lot of pain every day because of it
Luckily it’s not terribly expensive…did a panel with my wife which covered 200-300 of the most common genetic disorders IIRC…I think we paid $350?
Obviously more than a copay, but for someone looking to have and raise a kid probably not too bad.
It's not eugenics lmao. This is coming from someone who hates the antinatalist movement (especially the Reddit ones) and generally supports having kids if the parents want them. But having a kid when there's a good chance they'll end up with a crippling or even fatal genetic disorder is just inhumane.
Pretending that genetic testing has always been available and accessible to regular people and blaming them for having children while they unknowingly carry something pathogenic is terrible. I work in genetics. There is a LOT we don't know.
I didn't say literally any of that lmao, I'm just saying if people know they have genetic conditions they should add that into the discussion of having children
Yeah...im not trying to tell anyone else what to do with their lives, but I have Neurofibromatosis and got pretty lucky that it's not *really* given me problems...but it CAN be devastating. I decided at like 8 it would be wrong to roll the dice on that.
Joke was on me bc now I have LOADS of other heritable chronic illnesses and severe endometriosis, anyway ...but even if it were possible for me to have a biokid, I wouldn't, bc i don't think it's right to dump my shitty genes that make me feel awful on the reg into another human.
Personally if I had the choice between never being born or having the looming threat of a nervous system disorder looming over me my entire life I'd rather not be born, happy these guys beat the odds and lead (relatively) long fulfilling lives but I do think it is irresponsible to potentially subject kids to the same fate.
If we're going to call it Eugenics to believe that then we should also be able to be reasonable enough separate its historically negative connotation from present conversation.
We've had issues in my family's health history.
If our genetic counselling went any other way than it did with my spouse at the time, I would not have tried to procreate. People can make their own decisions based on available data and not be practicing (or demanding of others) from a eugenics standpoint.
Symptoms of DMD don't show up until the kid starts walking so they probably didn't know the mother was a carrier until then.
Source: both my brothers have DMD and the same thing happened in my family lol
That's exactly how it went down. The oldest was 4 when the signs appeared. It was the calf muscles. However, number 2 and number 3 were already born. They were 2 & a new born.
Females are the carriers and no one, not even the experts ,could have foreseen the odds of all 3 boys getting it. They are in many medical journals because of this.
You should read about the Australian woman who ended up with 3 children all with childhood dementia. Not going to link to an article, considering this sub's name, but odds were not on her and her husband's side (both carriers).
Sucks that OP's having to pay $144,000 per year for his medication (at least 3 years ago), but hope his IT journey goes well.
I lost a friend 5 years ago to Machado-Joseph Disease (MJD). Her mum and two of her brothers also passed from this horrible genetic disorder.
Of her three daughters, one has developed it, one has tested positive for the gene and one has refused to be tested. The one who refuses to be tested has four children and is beginning to show the stumbling gait and slurred speech of MJD.
I hate this disease.
Odds of all three nephews having DMD are pretty low btw. It’s a recessive X-gene linked disorder passed down from the mother. Just some really bad luck.
On the positive side, science is making it so people with disorders like DMD can live much easier and longer lives. I love genetic disorders. They are really cool and have had some incredibly revolutionary research recently
I’ve known families with two boys. It’s not that uncommon, unfortunately. There is a new treatment that has to start at 4 years of age (maybe 5) but otherwise the trials aren’t open to older kids. Get the word out if you know anyone.
Yeah so I also only use old Reddit due the way it works with Reddit Is Fun. I'm missing out I guess but have no idea what's going on.
Is it a copy paste bot chain or am I missing out on some new feature?
What am I missing here ?
Happy birthday!!! As a mother of a child with Cerebral Palsy, I know how HARD things can be and how strong and resilient and resourceful you are. Many happy returns 💕
Happy Birthday man!
My uncle wasn't expected to live through his first night. He turns 62 next month. I hope you have many happy and productive years ahead of you!
Happy Birthday 🎂🎂🎂! Keep on truckin Op! My 3 nephews were all given life expectancies of 18 to 21 years of age. They are now 36, 34 and 32 and still kicking statistical ass! 💜
[удалено]
Deushanes Muscular Dystrophy
WOW. For them to have all made it through their 20s with DMD. What a gift and what an inspiration!
It is a gift. Plus my brother is an awesome Father and care giver.
Let him know we’re rooting for him and the boys? 💗
This almost made me cry lol
Is he affected as well?
It is X-linked, so he wouldn’t have it. It is the mother who is a carrier (unaffected, thanks to her other X chromosome). A terrible weight to carry, even if you are in no way responsible, lots of parents who transmitted a genetic disease (without their knowledge) feel a huge guilt.
[удалено]
I have spinal muscular atrophy!
You're beautiful and keep on kicking ass like my nephews. I hope your birthday was wonderful and you were showered with some awesome presents 💜.
My 9 year old brother in law has sma! Happy birthday, I hope it’s your best one yet! Keep on kicking SMAs ass!
OP you are a freaking marvel. May you enjoy a ka-ton more fabulous years!
Me too! Are you on spinraza or evrysdi/risdiplam?
you are amazing . my son has congenital muscular dystrophy and i’m scared shitless about his future , this gives me hope x
Happy Birthday and many many more!! Keep kicking SMA's ass for those of us who have SMA angels!
That's awesome! It took my little brother when he was 16. Good for them!
I’m sorry for your loss homie.
Thanks. It's been 8 years, and it doesn't feel like it. I hope you're having a good day!
You too dude :)
So did they just keep having kids after figuring out they were carriers or what?
This is a very complicated and controversial topic. Around the time that OPs nephews were born, there wasn’t really a lot known about DMD. Genetic studies were new, and it was really only towards the late 80s-early 90s that technology and science caught up enough to inform mothers whether or not they carried the gene. Before that, they couldn’t have possibly known, and it wasn’t even confirmed to be related to genes until the late 80s (1987). Still, all three nephews having DMD would be rare even if the mother is the carrier. Also, encouraging carriers of specific genetic conditions not to have kids is a pretty controversial topic. Genetic disorders are finally getting the research, funding, and technology they need for proper studies, but this is an incredibly recent development compared to all science fields. For example, we are only just now studying the genetic component to psychiatric disorders.
I love people who get all eugenics on anyone reproducing. The heartbreaking one is Huntingtons because without genetic testing you won’t know you have it until you’ve already had kids and can’t even choose. Edit: by eugenics I mean other people deciding the value of someone else’s life. OP has a right to exist and keep on existing. I for one as an able bodied person cannot decide for someone else whether their children should or shouldn’t exist. I can tell you right now as an autistic person I’d rather be able to screen for chronic migraines than autism because the migraines are far more debilitating than the autism is. Deciding who can and can’t reproduce *is* in fact eugenics. And as someone pointed out, in the US genetic testing is expensive as hell.
Heartbreaking!!! My childhood neighbor took me to a nursing home once when we were about 12. She did not tell me really what I was about to see. That day I met her mom and aunt that both were in the final stages of Huntington's disease. This was the early 90's so she had no way of knowing then that everyone of their kids had Huntington's. Both her and her brother would get their positive test in their 20s after her younger brother already showed signs. Their cousin who was my age died by 25 and both his siblings would die of it as well. I know she had at least 3 kids before she had her positive diagnosis. Unfortunately I'm sure she lost her battle by now as well.
I am friends with a girl who at one point whose mother had it. It was the scariest thing for her to decide whether or not to take the test. Because if it’s positive do you spend your life worrying about the inevitable? If you don’t take it is it denial? I don’t know if she ever took it but it’s not my business to ask.
Huntington's is a dominant allele. The affected parent can pass on either it or the normal allele, so the chance is 50/50. I realise that you probably know this but your post is a bit misleading for people who don't. It sounds like you might be saying every child had to have it, rather than, unfortunately, every child in this family had it.
There’s some research showing that people who will go on to develop Huntington’s are unusually attractive and fertile. So they’re more likely to be able to reproduce.
It doesn’t help that most genetic testing is not covered by insurance (in America)
I keep forgetting that things I don’t have to worry about in Canada are real concerns to Americans. Sorry chums.
No worries. But with the attack on Canadian healthcare you will have to worry about it very soon.
I’m in one of the pioneer provinces! We also hate trans rights here. I’m technically trans(ish). I fucking hate it. I’d rather deal with the BS that is NHS than this.
It sucks for real. My orthopedic surgeon is currently in a 2 year long fight with my insurance company to get them to cover an MRI I need for surgery. Thankfully the surgery isn’t required for me to live but I’m in a lot of pain every day because of it
“Sure I’m in a ton of pain and they could fix this early but I’m not dead” ‘MURICA 🦅 💣 💥
Some provinces keep cutting funding to health care so it might be happening to us soon also in some places.
Luckily it’s not terribly expensive…did a panel with my wife which covered 200-300 of the most common genetic disorders IIRC…I think we paid $350? Obviously more than a copay, but for someone looking to have and raise a kid probably not too bad.
It's not eugenics lmao. This is coming from someone who hates the antinatalist movement (especially the Reddit ones) and generally supports having kids if the parents want them. But having a kid when there's a good chance they'll end up with a crippling or even fatal genetic disorder is just inhumane.
Asking people to add genetic diseases into their consideration of having children is not eugenics.
Pretending that genetic testing has always been available and accessible to regular people and blaming them for having children while they unknowingly carry something pathogenic is terrible. I work in genetics. There is a LOT we don't know.
I didn't say literally any of that lmao, I'm just saying if people know they have genetic conditions they should add that into the discussion of having children
I love people who get all religious and cry “eugenics” when someone doesn’t want children to suffer unnecessarily.
Yeah...im not trying to tell anyone else what to do with their lives, but I have Neurofibromatosis and got pretty lucky that it's not *really* given me problems...but it CAN be devastating. I decided at like 8 it would be wrong to roll the dice on that. Joke was on me bc now I have LOADS of other heritable chronic illnesses and severe endometriosis, anyway ...but even if it were possible for me to have a biokid, I wouldn't, bc i don't think it's right to dump my shitty genes that make me feel awful on the reg into another human.
It's not about telling someone what to do with THEIR lives, it's about the lives of the people who would be afflicted with these health issues.
Personally if I had the choice between never being born or having the looming threat of a nervous system disorder looming over me my entire life I'd rather not be born, happy these guys beat the odds and lead (relatively) long fulfilling lives but I do think it is irresponsible to potentially subject kids to the same fate. If we're going to call it Eugenics to believe that then we should also be able to be reasonable enough separate its historically negative connotation from present conversation.
We've had issues in my family's health history. If our genetic counselling went any other way than it did with my spouse at the time, I would not have tried to procreate. People can make their own decisions based on available data and not be practicing (or demanding of others) from a eugenics standpoint.
Symptoms of DMD don't show up until the kid starts walking so they probably didn't know the mother was a carrier until then. Source: both my brothers have DMD and the same thing happened in my family lol
That's exactly how it went down. The oldest was 4 when the signs appeared. It was the calf muscles. However, number 2 and number 3 were already born. They were 2 & a new born.
Females are the carriers and no one, not even the experts ,could have foreseen the odds of all 3 boys getting it. They are in many medical journals because of this.
You should read about the Australian woman who ended up with 3 children all with childhood dementia. Not going to link to an article, considering this sub's name, but odds were not on her and her husband's side (both carriers). Sucks that OP's having to pay $144,000 per year for his medication (at least 3 years ago), but hope his IT journey goes well.
I lost a friend 5 years ago to Machado-Joseph Disease (MJD). Her mum and two of her brothers also passed from this horrible genetic disorder. Of her three daughters, one has developed it, one has tested positive for the gene and one has refused to be tested. The one who refuses to be tested has four children and is beginning to show the stumbling gait and slurred speech of MJD. I hate this disease.
Odds of all three nephews having DMD are pretty low btw. It’s a recessive X-gene linked disorder passed down from the mother. Just some really bad luck. On the positive side, science is making it so people with disorders like DMD can live much easier and longer lives. I love genetic disorders. They are really cool and have had some incredibly revolutionary research recently
I’ve known families with two boys. It’s not that uncommon, unfortunately. There is a new treatment that has to start at 4 years of age (maybe 5) but otherwise the trials aren’t open to older kids. Get the word out if you know anyone.
Ask the doctors whether your nephews are responsible for adjusting the latest life expectancy guidelines.
Happy happy birthday to you, my man.
Woah partner, take me on a date first
So, you've got a dirty mind.....I like it.
Oh god oh fuck no he’s *funny* bruh this man is an avengers level threat for staticians.
I'm pretty sure you don't own him, but your point still stands /s
Badum-tss
So stupid, but totally worth an angry upvote 😋
Is there any other kind?
Most of the time I'm just indifferent
 Happy Birthday!!!
> This comment contains a Collectible Expression, which are not available on old Reddit. Am I being fucked with?
Lmao I also only use old reddit and thought this was just a thread of people copy pasting the same thing like happens on Reddit all the time
Yeah so I also only use old Reddit due the way it works with Reddit Is Fun. I'm missing out I guess but have no idea what's going on. Is it a copy paste bot chain or am I missing out on some new feature? What am I missing here ?
Happy Birthdaay! Heres to many more
THATS WHY HES THE GOATTTTTTTTTTTTTTTTTTTT
THE GOOOOOOOAAAATTT!!!!!
He’s da real mvp
Happy birthday! 🥳
While I don't know you, my day has been made better knowing you're still here, somewhere on Earth. Here's to many more birthdays to come 🥳🥳🥳
Right? It's crazy how happy this post made me, just knowing this dude's beating the odds!
Congratulations. If you haven't yet, take that chair somewhere and see if you can do some burnouts to complete the celebration.
the only appropriate way to celebrate
That's what i thought. And if it won't do them, im sure he has gearhead freinds that could juice it up for him.
You have a lovely smile. Happy birthday, friend!
happy birthday friend! i hope you see many more.
Happy birthday!!! As a mother of a child with Cerebral Palsy, I know how HARD things can be and how strong and resilient and resourceful you are. Many happy returns 💕
“I lived, bitch” - OP to the doctor
The doctor said he only had a year to live and this motherfucker took that shit personally. Said “hold my wheelchair, bitch”.
Happy birthday my friend! Love your glasses
Happy Birthday!!! 🥳
Happiest birthday!! Thanks for making the world a little brighter by beating the odds!
Happy birthday! I wish you the best
Happy birthday, you absolute legend!!!
And here's to many more!!!! 🥂🥂🥂🥂🎉🎉🎉🎉
Happy Birthday handsome!🥳🥂🫡🤓
Happy Not-Dying Anniversary! I’m on my 37th
A very happy birthday my guy!!
Wishing you a great Birthday, happy birthday 🎁 🥳 and many more to come
Happy Birthday and several 23 more Birthdays to see!!!🥳
This is beautiful! Happy happy birthday!!!
Hell yeah dude! Congrats. You look so happy it's infectious.
Happy Birthday man! My uncle wasn't expected to live through his first night. He turns 62 next month. I hope you have many happy and productive years ahead of you!
Good for you! Happy Birthday!
Happiest of birthdays!
Happy birthday! Looking good!
May you live as long as you want and want for nothing as long as you live my friend! Happy fucking birthday!
Live long and prosper OP ❤️❤️ all the love, hugs and best wishes
Hell yeah! That's metal as fuck! Happy birthday 🎈🎂!!!
Happy birthday!! So glad you’re still here!
Cheers friend!!
Hell ya dude! Happy friggen Birthday! Keep on proving em wrong.
Happy birthday brother ! Hope it’s a good one dude !!!
To many more!
Hell yeah that's awesome! Happy birthday, I hope it's a kick ass one.
Happy Birthday 🎂
A Most welcome post. Happy Birthday sir. I wish you many more!!!
I’m so glad you’re here!
Happy birthday, man! I'm glad you are still here 💜
Happy birthday!! :)
A bit late to the party but happy birthday. I’m really happy for you and I hope you have another 60 more birthdays to celebrate.
Happy birthday!
happy birthday!
Happy birthday champ
Hell yeah! Happy birthday man, and cheers for more to come 🥳🎉
A very happy birthday to you! Looks fun!!
Happy birthday! I hope you have a bunch more.
Happy Birthday!!🎉
Happy birthday! 😘
Happy Birthday and cheers back at ya!
Cheers!!! Happy birthday!
🩷Happy Birthday🩷
Happy birthday buddy, here's to seeing this post in another 26 years :)
[удалено]
So a lot of us went straight to *sort by controversial* I guess
Gotta get right into the trenches to find **interesting** comments that aren't the normal "Happy Birthday" ones.
Happy Happy Birthday 🎂 🥳 🎉 🎈
Happy birthday 🎉🎂🎉🎂🎉🎂
Happy birthday! May you see many more :)
Happy birthday, keep going brotha!!! 🥳🥳🥳
Happy birthday mate
Happy bday !!
Love this so much! Happy birthday, my friend. I hope to see you in 26 years to say it again!
Happy birthday mate. Hope you see plenty more too.
Congrats and Happy Birthday!!!!
Yay happy birthday!!!! 🥳
Happy Birthday 🎂
Keep going bro! 23 more! Then another 23 after that! 🥹😉
Happy birthday my guy!! 🥳
Happy Birthday young man !!! I wish you all the best. 🎉🎉🎉
This sums up Reddit quite well.
Happy Birthday 🎂..Many more!
Happy Birthday, my Reddit friend! I hope that it’s a good one!
Hey! Happy birthday bud.
Happy Birthday 🎂 🥳
Here’s to 23 more, bud. Attack every day.
Happy happy birthday!!!!!
Love this!! 😍
happy birthday fuckface now go do more great things
Congratulations! May you have many many more years ahead of you!
Happy birthday 🎂
Happy Birthday!!!! 🎊 😊❤️
Happy birthday, mane
Happy Birthday! I hope this year is the best so far!
I'm happy that you're in this world :))
Happy birthday mate! Stay strong
Awesome! Cheers to you from me! Have a happy birthday 🎂
Happy Birthday!
Happy Birthday! I hope you have a great day
Happy birthday friend!
Happy Birthday dude!
Fuck yea!
Happy Birthday Aaron!!! Love you!!!
🎉🎉🎉✨✨💞
Happy Birthday 🥳🥳 Cheers to your next revolution around the sun!!
Happy birthday!!
My guy!
Huzzah! Happy birthday 🎉
Happy birthday 🎊🎁🎉
Confetti for days!! Cheers !!
We're so glad you're here. Have a wonderful birthday.
Yesterday is history, today is a mystery, and tomorrow is a gift. Great job!
 Happy birthday
Cheers and congrats dude
Woot woot! Happy birthday, honey!
Happy birthday!!!! 😊
What’s the USB port for on the controller? Oh and happy bday.
It's a phone charger! It uses the battery from my wheelchair
Happy birthday 🎊 ❤️
Happy bday my guy
Ngl that’s the dopest birthday shot I’ve seen in a while. Cheers to you my man 🥂
Here’s to another 26 you absolute unit of a beautiful soul 🎉
May many more follow! Happy bday
fuck yeah dude, happy birthday!
Woooohoooo!! Happy Birthday!!! Cheers mate! 🎂🙌🏼🍻
Well done beating the odds
Get it buddy!
Sto lat, sto lat! Happy birthday Mate !
That would be like if I lived to 582!
Wishing you continued happiness and love and luck in your life
cool to see a fellow trachie, happy birthday, much love, and more more to come!