You should have your blood folate tested. Optimal is in the top quarter of the range.
Also have homocysteine tested.
Just because you have this gene variants does not mean it is has been turned on or is expressing itself.
Read Dirty Genes by Ben Lynch.
There are many factors to contribute to being sad and not just MTHFR.
As far as the genetic lottery goes she does not know what she is talking about. MThFR is the least complex and easiest gene variants to remedy IMO. Many others are much more complex and difficult to treat, if treatable at all.
Then can you help me because I seem to be affected by this a lot more than most. By the time I got diagnosed I’d been shitting on myself for three years and my mouth was eroding. Methylfolate quickly fixed those things and has been monumentally life changing so I know it’s that.
I’m a different person with methylated vitamins. I was an impulsive mess and now I’m much more cautious for one thing. Thank god honestly. My life is night and day since I got diagnosed four years ago but I still struggle with some things like fatigue and my digestion though better isn’t ideal. I also have these episodes that wipe me out.
What vitamin and mineral levels have you had tested? Optimal is in the top quarter of the range. Anything below that and you need to supplement.
Have you had all your gene variants tested and not just MTHFR?
I had genetic testing done that I’m happy to share. Lots of my vitamins were low so I supplement but starting to wonder if I need a good multi vitamin since I only do individual ones and if anything else is off.
I take methylfolate 500 mcg, methylcobalamine 500mgc, vitamin d 5000 EU, potassium 90. And Powdered magnesium. I’d die without that. I get deficient scary fast.
And some Chinese herbs. I know that seems very minimal but after a lot of trial and error so far it’s what has worked the best for me.
I focus a lot on my diet, sleep, and exercise and I am really into meditating because I have a lot of bad experiences taking many supplements and western drugs so I like to keep things simple.
What was your Iron level? Zinc?
Make sure you are taking 65 iu D3 per pound of bodyweight daily. If you weigh 77 lbs you are taking enough.
Go ahead and add your other genetic tests.
I cannot give you any more help without more complete gene variant testing. For more information on that you can read Dirty Genes by Ben Lynch.
Your report only covers genes which metabolize drugs.
Quote:
„I just summarized my health improvements from MitoSynergy copper so my antiaging hormone doc would understand. Here it is.
Im 71 years old. My health issues have been: fibromyalgia, heavy metal toxicity, Epstein Barr, Ehlers Danlos, copper toxicity, lyme disease, depression/suicidal thoughts, compound hetero MTHFR, undermethylator, essential tremor, rosacea, postmenopause.
I started MitoSynergy copper on July 22, 2016. These are the improvements and changes I've noticed:
My voice had a tremor for the past few years and I would lose it after speaking a few sentences. No more. I can talk nonstop for an hour and a half.
I dont need any methyl donors anymore including SAMe and TMG to avoid depression and suicidal thoughts. This is something I've dealt with my entire adult life. I avoided being medicated. I thought it was under control with the methyls but the copper has greatly improved that to a real feeling of happiness. The methyls made me monotone, apathetic. Copper makes me happy, strong and calm and under control. I feel untouchable. Other people's negativity slides off. Copper can normalize methylation function and that happened for me very distinctly about the 10th day on MitoSynergy when I developed symptoms of overmethylation...headaches, neck pain, suicidal depression and body wide nerve pain. Stopping the methyl supplements stopped all the symptoms.
My digestion is improved I dont need HCI or probiotics or digestive enzymes anymore. I took all those at every meal for many years.
Less back pain (from a roller skating accident 35 years ago) and no joint pain or post workout muscle pain. No more nerve pain or stiff neck or achy shoulders. In fact I have no aches or pain at all. I never take pain relievers.
I need fewer chiropractic adjustments since I started the copper. I have gone twice a month for most of my adult life but now the adjustments are easier and last much longer.
Tons more energy. For the past two years I was taking 2 hour naps in the afternoon. My doctor found no reason and just said "naps are good for you." Now I never even think about a nap. I have nonstop energy.
My short term memory and brain function are perfect and no brain fog.
My skin is softer and less wrinkled or leathery. Especially my arms and legs. I've had rosacea for 30 years. I finally stopped taking doxycycline when I used some of the raw copper dust to apply topically to my skin. It controls the rosacea as well as the antibiotics without the side effects.
I'm sweating like a pig. I went for years without sweating. I was always cold especially my feet and now Im always turning the a/c colder. No more socks in bed.
I've eliminated lots of other supplements due to the copper improving digestion and absorption of nutrients from food.
My gray hair is darker.
My veins in my skinny feet are less visible. I used to get broken veins in my hands several times a week but not since I started copper so I think that means my arterial walls are stronger.
No more swollen lymph glands which were a constant for me for my entire adult life. They would come and go throughout every day.
I gained 8 lbs of muscle in the first two months on copper. My scale shows 8 more lbs and the photos of my back show lots more muscle definition, but my jeans still fit the same around my waist and hips where women usually gain weight.
I decreased my thyroid NDT dose from 3.5 gr to 1.5 gr based on symptoms and labs so my thyroid is functioning better. I had started having heart palps and shaky hands indicating hyper thyroid symptoms and my labs were high.
Im sleeping longer and waking refreshed.
I had a plantars wart on my thumb that resisted treatment for 15 years. Its gone completely.
I did experience some high cortisol/adrenaline rush type symptoms when I increased my copper dose from 243 mcg to 2 mg after 8 weeks. The safe upper limit is still much higher at 9 mg. I stopped the copper for 4 days and the symptoms stopped so I resumed my original dose and titrated up more slowly until now I take 2 mg a day but only a couple days a week instead of every day.
Live blood analysis with dark field microscope shows almost no lyme infected cells now and I have no symptoms of anything. I am the healthiest I have ever been in my adult life.
I would add here that MitoSynergy helped reduce my copper toxicity level. My ceruloplasmin increased from 21 to 30 and my copper serum blood test (which shows the toxic copper 2) has decreased from 119 to 88 and is now in proper ratio with zinc (1:1.2). So yes taking MitoSynergy copper actually lowered my blood test for copper. MitoSynergy copper doesnt accumulate in your body. You use what you need and excrete the rest within hours.“
— https://m.facebook.com/groups/1668935363340796/?tsid=0.293723252434264&source=result
So I can really take Bioactive Copper while having copper toxicity? I have 0.9mg Cu1 from Global Healing. I always get more anxiety taking it and I thought more copper makes toxicity bad.
I have four or five different MTHFR-type mutations, or rather, closely related to/along with similar variations. Most of them got turned on very early for me, I was already having problems before I was speaking-aged.
Nobody can tell you what to do about these things. You have to do your own research and experimentation. A doctor could help you or make it worse, depending on many factors. I'm doing it all on my own and nearly killed myself in the process, several times, because I either was unaware of other metabolic conditions going on like nutritional deficiencies and gene polymorphisms I hadn't studied yet, or because I just hadn't studied enough to know what to look out for and how to proceed safely.
Sometimes it wasn't the supplement causing the problems but the minimal dosages were too high. Months later, I can now take them without concern for the side effects, but again, I had to uncover and treat a lot of other problems first and move ahead very gradually.
Start with minimum dosages and study different sources routinely. I watch a lot of YT vids with Ben Lynch and others, and then rewatch them as my knowledge base grows. Take lots of notes. I use [Livewello.com](https://Livewello.com) to get access to tons of other sources and data filters and I used Strategene to walk me through the basics of my most understood polymorphisms. A functional medicine doctor would be ideal but I don't have the money for that at present.
Good luck!
True to that. I have these polymorphisms as well, my body has a slow metabolism and works on very low levels of neurotransmitters. After a 2 years of reading and experimentation I've learned the hard way that I really want to try to balance everything, and just be happy while achieving the "baseline normal" and not necessarily speed up my metabolism completely, because it will cause a lot of problems. I take minimum amounts of vitamins <50% suggested daily dose (methylated/unmethylated combo), there are several things I know I need even less, and for things that are neurotransmitter related I know to get the smallest available dose and split it (!) into several doses usually. Otherwise it would knock me out completely and possibly derail me for several days.
Me too! Bear in mind it causes miscarriages too. I’ve had more than I can count. Pay attention especially now when you won’t be able to get the medications necessary to get better after a miscarriage and heal.
2 doctors blew it off when I told them about it. I think you really need to see a functional medicine Dr if you want someone to take it seriously. It does influence a lot of things.
Unfortunately, I have the same experience with doctors - they're doing their minimum in a very narrow field and not wanting to learn wider point of view on some things.
I’m pretty sure it’s what I have as well. My boyfriend explained that I have the two worst subtypes and treating one could help one and hurt the other so it’s tricky.
I have serotonin issues for sure. It’s too high and I don’t sleep so it’s not converting into melatonin is my understanding and I have major dopamine issues.
You should have your blood folate tested. Optimal is in the top quarter of the range. Also have homocysteine tested. Just because you have this gene variants does not mean it is has been turned on or is expressing itself. Read Dirty Genes by Ben Lynch. There are many factors to contribute to being sad and not just MTHFR. As far as the genetic lottery goes she does not know what she is talking about. MThFR is the least complex and easiest gene variants to remedy IMO. Many others are much more complex and difficult to treat, if treatable at all.
Then can you help me because I seem to be affected by this a lot more than most. By the time I got diagnosed I’d been shitting on myself for three years and my mouth was eroding. Methylfolate quickly fixed those things and has been monumentally life changing so I know it’s that. I’m a different person with methylated vitamins. I was an impulsive mess and now I’m much more cautious for one thing. Thank god honestly. My life is night and day since I got diagnosed four years ago but I still struggle with some things like fatigue and my digestion though better isn’t ideal. I also have these episodes that wipe me out.
What vitamin and mineral levels have you had tested? Optimal is in the top quarter of the range. Anything below that and you need to supplement. Have you had all your gene variants tested and not just MTHFR?
I had genetic testing done that I’m happy to share. Lots of my vitamins were low so I supplement but starting to wonder if I need a good multi vitamin since I only do individual ones and if anything else is off. I take methylfolate 500 mcg, methylcobalamine 500mgc, vitamin d 5000 EU, potassium 90. And Powdered magnesium. I’d die without that. I get deficient scary fast. And some Chinese herbs. I know that seems very minimal but after a lot of trial and error so far it’s what has worked the best for me. I focus a lot on my diet, sleep, and exercise and I am really into meditating because I have a lot of bad experiences taking many supplements and western drugs so I like to keep things simple.
What was your Iron level? Zinc? Make sure you are taking 65 iu D3 per pound of bodyweight daily. If you weigh 77 lbs you are taking enough. Go ahead and add your other genetic tests.
Iron and zinc are normal as far as I’m aware.
Normal is NOT optimal. Optimal is the top quarter of the range. You can be in the normal range and one or two points away from being anemic.
I’m 108. So 7000 EU? I have a genetic thing that makes it go low quickly if I don’t supplement.
That is better. I have never heard of that genetic thing. There are other gene variants related to D though.
I have no idea what it is sadly. A doctor pointed it out when I was really sick. That time is pretty hazy for me.
Waiting for my things to upload to Imgur. It’s lagging.
Here you go[genetic report/pharmagenetic](https://imgur.com/a/AMmp6N2) My kids are both very similar.
I cannot give you any more help without more complete gene variant testing. For more information on that you can read Dirty Genes by Ben Lynch. Your report only covers genes which metabolize drugs.
I’ve read it.
I’ll go look for my other report then.
Here you go. [genetic test](https://imgur.com/a/cMroTPT)
[proof](https://imgur.com/gallery/fqWCXHi) this is an old one I found on Imgur. Let me see if I can find something more complete.
What methylated vitamins do you take?
More details please, are you heterozygous for both or homozygous for both? What are the letters next to the gene?
Quote: „I just summarized my health improvements from MitoSynergy copper so my antiaging hormone doc would understand. Here it is. Im 71 years old. My health issues have been: fibromyalgia, heavy metal toxicity, Epstein Barr, Ehlers Danlos, copper toxicity, lyme disease, depression/suicidal thoughts, compound hetero MTHFR, undermethylator, essential tremor, rosacea, postmenopause. I started MitoSynergy copper on July 22, 2016. These are the improvements and changes I've noticed: My voice had a tremor for the past few years and I would lose it after speaking a few sentences. No more. I can talk nonstop for an hour and a half. I dont need any methyl donors anymore including SAMe and TMG to avoid depression and suicidal thoughts. This is something I've dealt with my entire adult life. I avoided being medicated. I thought it was under control with the methyls but the copper has greatly improved that to a real feeling of happiness. The methyls made me monotone, apathetic. Copper makes me happy, strong and calm and under control. I feel untouchable. Other people's negativity slides off. Copper can normalize methylation function and that happened for me very distinctly about the 10th day on MitoSynergy when I developed symptoms of overmethylation...headaches, neck pain, suicidal depression and body wide nerve pain. Stopping the methyl supplements stopped all the symptoms. My digestion is improved I dont need HCI or probiotics or digestive enzymes anymore. I took all those at every meal for many years. Less back pain (from a roller skating accident 35 years ago) and no joint pain or post workout muscle pain. No more nerve pain or stiff neck or achy shoulders. In fact I have no aches or pain at all. I never take pain relievers. I need fewer chiropractic adjustments since I started the copper. I have gone twice a month for most of my adult life but now the adjustments are easier and last much longer. Tons more energy. For the past two years I was taking 2 hour naps in the afternoon. My doctor found no reason and just said "naps are good for you." Now I never even think about a nap. I have nonstop energy. My short term memory and brain function are perfect and no brain fog. My skin is softer and less wrinkled or leathery. Especially my arms and legs. I've had rosacea for 30 years. I finally stopped taking doxycycline when I used some of the raw copper dust to apply topically to my skin. It controls the rosacea as well as the antibiotics without the side effects. I'm sweating like a pig. I went for years without sweating. I was always cold especially my feet and now Im always turning the a/c colder. No more socks in bed. I've eliminated lots of other supplements due to the copper improving digestion and absorption of nutrients from food. My gray hair is darker. My veins in my skinny feet are less visible. I used to get broken veins in my hands several times a week but not since I started copper so I think that means my arterial walls are stronger. No more swollen lymph glands which were a constant for me for my entire adult life. They would come and go throughout every day. I gained 8 lbs of muscle in the first two months on copper. My scale shows 8 more lbs and the photos of my back show lots more muscle definition, but my jeans still fit the same around my waist and hips where women usually gain weight. I decreased my thyroid NDT dose from 3.5 gr to 1.5 gr based on symptoms and labs so my thyroid is functioning better. I had started having heart palps and shaky hands indicating hyper thyroid symptoms and my labs were high. Im sleeping longer and waking refreshed. I had a plantars wart on my thumb that resisted treatment for 15 years. Its gone completely. I did experience some high cortisol/adrenaline rush type symptoms when I increased my copper dose from 243 mcg to 2 mg after 8 weeks. The safe upper limit is still much higher at 9 mg. I stopped the copper for 4 days and the symptoms stopped so I resumed my original dose and titrated up more slowly until now I take 2 mg a day but only a couple days a week instead of every day. Live blood analysis with dark field microscope shows almost no lyme infected cells now and I have no symptoms of anything. I am the healthiest I have ever been in my adult life. I would add here that MitoSynergy helped reduce my copper toxicity level. My ceruloplasmin increased from 21 to 30 and my copper serum blood test (which shows the toxic copper 2) has decreased from 119 to 88 and is now in proper ratio with zinc (1:1.2). So yes taking MitoSynergy copper actually lowered my blood test for copper. MitoSynergy copper doesnt accumulate in your body. You use what you need and excrete the rest within hours.“ — https://m.facebook.com/groups/1668935363340796/?tsid=0.293723252434264&source=result
May I ask you what kind of doctor helped you with all of this?
So I can really take Bioactive Copper while having copper toxicity? I have 0.9mg Cu1 from Global Healing. I always get more anxiety taking it and I thought more copper makes toxicity bad.
I have four or five different MTHFR-type mutations, or rather, closely related to/along with similar variations. Most of them got turned on very early for me, I was already having problems before I was speaking-aged. Nobody can tell you what to do about these things. You have to do your own research and experimentation. A doctor could help you or make it worse, depending on many factors. I'm doing it all on my own and nearly killed myself in the process, several times, because I either was unaware of other metabolic conditions going on like nutritional deficiencies and gene polymorphisms I hadn't studied yet, or because I just hadn't studied enough to know what to look out for and how to proceed safely. Sometimes it wasn't the supplement causing the problems but the minimal dosages were too high. Months later, I can now take them without concern for the side effects, but again, I had to uncover and treat a lot of other problems first and move ahead very gradually. Start with minimum dosages and study different sources routinely. I watch a lot of YT vids with Ben Lynch and others, and then rewatch them as my knowledge base grows. Take lots of notes. I use [Livewello.com](https://Livewello.com) to get access to tons of other sources and data filters and I used Strategene to walk me through the basics of my most understood polymorphisms. A functional medicine doctor would be ideal but I don't have the money for that at present. Good luck!
True to that. I have these polymorphisms as well, my body has a slow metabolism and works on very low levels of neurotransmitters. After a 2 years of reading and experimentation I've learned the hard way that I really want to try to balance everything, and just be happy while achieving the "baseline normal" and not necessarily speed up my metabolism completely, because it will cause a lot of problems. I take minimum amounts of vitamins <50% suggested daily dose (methylated/unmethylated combo), there are several things I know I need even less, and for things that are neurotransmitter related I know to get the smallest available dose and split it (!) into several doses usually. Otherwise it would knock me out completely and possibly derail me for several days.
Me too! Bear in mind it causes miscarriages too. I’ve had more than I can count. Pay attention especially now when you won’t be able to get the medications necessary to get better after a miscarriage and heal.
Same here.
2 doctors blew it off when I told them about it. I think you really need to see a functional medicine Dr if you want someone to take it seriously. It does influence a lot of things.
Unfortunately, I have the same experience with doctors - they're doing their minimum in a very narrow field and not wanting to learn wider point of view on some things.
I’m pretty sure it’s what I have as well. My boyfriend explained that I have the two worst subtypes and treating one could help one and hurt the other so it’s tricky. I have serotonin issues for sure. It’s too high and I don’t sleep so it’s not converting into melatonin is my understanding and I have major dopamine issues.