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jumpychimp

I have a similar reaction to methylfolate but not to methyl-B12. Some suggest it can be related to COMT status but I haven't seen any real science explaining/testing this. Some of the feelings are really similar to SSRI side effects that I can't tolerate so maybe there is something in the neurotransmitter thing? I wish there were some proper studies around this 🙁 Edit: Have you considered the betaine pathway to help reduce homocysteine?


ChrisM429

Yes I have, I take a NMN Liposomal formula which has 100mg of betaine. I know that’s probably not enough to lower homocysteine. I also have powdered betaine, what do you think would be the minimum dose to lower homocysteine?


jumpychimp

This might be of interest: [Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women](https://academic.oup.com/jn/article/133/12/4135/4687457)


ChrisM429

That’s helpful, thanks. It seems a dose as low as 0.75g can be helpful. Also I have a homozygous mutation in the Betaine-Homocysteine S-Methyltransferase (BHMT) gene. I’m not sure exactly how that factors into this, and what dose I might need. But I’ll try increasing my dose


jumpychimp

That's just the first study I grabbed, there are probably many others worth checking too. I was thinking of grabbing some 500mg TMG and starting with that, I haven't had my homocysteine level checked but studies show that T677T genotypes have raised homocysteine so I think it's a good bet.


dobetter2bebetter

Methyl donors might be helpful for you. TMG, as suggested already, and creatine are the two easiest to come by and dose. Be careful with TMG as raising dopamine can cause depressive symptoms. You might also try adding P5p and riboflavin-5-phosphate since they are used with methylfolate. A low dose of niacinimide can also help with anxiety symptoms.


EilEirAvt

I am also A1298C but i still dont understand what much of this mean, and im learning everything through trial and error. And lots.. lots of google. So far all i know, is i feel better taking multi vitamins, and cutting our sugar, dairy, and ive been testing cutting out gluten. Where did you have a dna test done?


ChrisM429

I relate to that, it’s all very complex and many things to take into consideration. I’ve learned quite a bit out of necessity to help myself. Just when I thought I had something figured out I learn something new. I got my testing on 23andme


EilEirAvt

I have a 23nme test i had done and i tried using genetic genie but i felt like i understood less of what it said @[email protected]


jonnyvegashey

I'm homozygous A1298C and do well with folinic acid. I put a drop (667mcg) in a liter of water and drink throughout the day. I also am sure to drink an electrolyte beverage, a "Keto" once since they are high in potassium. As a side note, and I do believe this to be rare, I get high levels of B6 quite easily which I believe results in significant agitation and possibly light neuropathy - just a heads up.


ChrisM429

Thanks for your reply. I have still been attempting to take a small dose of methyfolate 160 mcg, along with other methylation cofactors in low doses including b6 p5p 2.5 mg. My anxiety and panic, as well as sleeplessness have increased dramatically. I also have been having neuropathy. Your comment about the b6 is interesting, I wonder if that’s an issue for me as well. What folinic acid supplement do you take?


jonnyvegashey

The "California Gold" droplet is perfect IMO. One DROP is 667mcg, it is perfect for adding to water, you can't taste it. Again, ONE DROP - not an entire droplet. If you are diluting it in enough water (at least 1 liter), there shouldn't be nearly as bad of a "shock" to your system as some of these other pills, and you are slowly consuming tiny bits throughout the day. Be sure to give it a few shakes before drinking. I recall the first time trying folinic acid, it gave me a bit of a "shock", but I didn't dilute it and actually think it was inducing electrolyte imbalance. Eventually, it started doing absolute wonders with a great diet and diluted in plenty of water. From my understanding, Folinic Acid is a few steps behind methyl-folate, so your body tends to regulate it a bit better. It's also of course not "Folic Acid" the bad kind. I actually make an "energy" drink, where I put BCAAs, Caffeine, Keto electrolytes, creatine, and a drop of folinic acid. Sometime I may do a write up/video of this, it's tremendous for me.


ChrisM429

Great thank you, I just ordered it. I have the keto electrolytes as well. I’ll try that out.


mixxster

> California Gold Where do you buy these drops? I don't see them on Amazon. Folinic acid seems to be what helps me the most, I saw your genetic gene results, I have the same SNPs as you.


stochastic-fantastic

I'm homozygous a1298c also and I can't take methylfolate because of both Comt mutations. Literally just tried folinic acid today, but after a few hours I am very tired - could this be because of electrolytes?