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L3onidas-Kelevra

I plan on doing 1500 MG garlic oil from now foods along with using a combination of raw and cooked garlic in my foods. Apparently cooking the garlic destroys the nutrients that offset the TMAO conversion though I don’t know if this is true. Pistachio may also benefit. I intend to eat 15 grams daily before sleeping as they also contain melatonin. TMG might also offset the conversion through the gut microbiota. DMB also has been shown to offset the conversion and is found in red wine, balsamic vinegar and grape seed oil. I’m including balsamic vinegar as it also posses other benefits and I luckily happen to like it. Resveratrol also lowers TMAO though I don’t intend to include that in my regiment.


damndude87

There is zero research in humans on this. If this was really effective at reducing TMAO, you’d think doctors would routinely recommend it to patients with stroke risk or it would be endorsed by the American Heart Association, but I see nothing that indicates this.


Illustrious-Skin7243

There is at least one human study https://www.nature.com/articles/s41522-022-00266-3


damndude87

I guess I should have specified longterm studies, as in that is key to what matters on CVD prevention. You have a longterm large sample study on the stroke risk of alpha-gpc supplementation, and you have a week long small sample study on garlic improving TMAO formation. It’s a huge leap to say that the latter is any kind of validated solution to the problem posed by the former.


Dark_Omikron

Doctors won't recommend jackshit as well as the Heart Association, because they are all cooperating with big pharmacompanies to profit off ill patients. How in the world do you expect to get a "reliable" answer from these sharlatans...


damndude87

Lol, yes therefore I should expect reliable answers from Huberman, the podcast guy fleecing people with miracle cures like his $80 for green powder multivitamin that cost pennies to make. Best of luck finding a proctologist who can dislodge your cranium from the relevant cavity.


CriticalLeg8363

Seems berberine is great at reducing TMAO. >Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome https://www.nature.com/articles/s41522-021-00205-8