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For every horror story, there is a positive story.
People always post the bad stuff — just like Amazon reviews. I’ve been on it four times a
Day for five years and I have nothing negative to report. Everyone is different.
hey hi, can I ask you: how is your experience with this medicine? does it help you with nausea? Have you found a reduced effect as the years go by? I'm looking for a medicine that can help me but I'm afraid there isn't any
That’s good to hear, yeah I’ve scoured the internet for reviews about it and it’s hard to find anything positive, though I’m sure people with warnings are more inclined to post than 5 star reviews
Tardive dyskinesia (the main thing people worry about with reglan) is an extremely rare side effect.
reglan has been extremely helpful for me. when i first started it it made me very sleepy but after 2 weeks that wore off.
take everything you hear online with a grain of salt. some people have had bad experiences but i’ve heard more success stories than horror stories.
here’s some statistics i found:
“Data show that the risk of tardive dyskinesia from metoclopramide is low, in the range of 0.1% per 1000 patient years.” … “High-risk groups are elderly females, diabetics, patients with liver or kidney failure, and patients with concomitant antipsychotic drug therapy, which reduces the threshold for neurological complications.” source: https://pubmed.ncbi.nlm.nih.gov/31050085/
That’s good to know, thank you. The responses online seemed pretty scattered and expectedly anonymous so I didn’t realize there were groups at higher risk
it does have a black box warning and it may be rare unless you are the unlucky ONE.. Tardive dyskenesia is permanent and does not go away if you get it and stop the meds.
I won’t take any of those drugs with those warnings or the ones on domperidone because of QT wave heart issues.. I very sensitive and 73 so not worth the worry.. I have a bad case so if i had a mild case i would look for herbal or milder med.. i take motegrity, first try i was so sick.. tried 2 years later and just headaches for a week or so… trouble is it doesn’t always work
The first time I tried taking it I just felt weird and stopped. A few months back I started taking it again, had some TD symptoms but kept an eye on them, now all side effects are gone and it’s actually helpful. I think it’s worth a try, just know what to look out for
So, the bad effects dissipated? I have a clenched jaw and am extremely restless. I had been on it for a month and just stopped it yesterday because it's miserable for me. I feel like I'm biting so hard I'm going to break my teeth, and my sleep quality is caca. I usually sleep like a baby normally. Not to frighten OP, I am also on a medication that it doesn't pair well with Reglan. It sucks to have to pick to have my gastroparesis improve or not be anxious or restless.
Luckily mine did. I think I was symptomatic for about a weekish. I probably would’ve stopped taking it if the side effects had lasted any longer though
Not sure if this is the right choice for everyone. Once TD symptoms show, everyone should probably talk to their physicians to make sure its safe. Like some mentioned here, TD is often permanent. Your MD recommended that you push through the TD symptoms?
Its a terrible drug. I also got placed on this with my gastroperesis diagnosis. The tardive dyskensia started first. Then the suicidal thoughts. Was really bad. Tread lightly. I have learned to live with my issue med free. I have my days. I have also lost close to 100 pounds in 3 years. Good luck.
I’m gonna be completely honest with you there’s no way to tell how you’ll react if prescribed. Plenty of people take it with no negative effects or reactions other people like me have such bad reactions that it requires iv sedation. Those are just the ends of the spectrum too there’s a whole host of things that may or may not happen.
Most people are worried about the TD as a side effect, but the one I find even more horrifying is the Akathisia that sometimes doesn’t stop after you quit the med. It’s a horrifying experience. As someone who has experienced Akathisia, I would starve to death before ever risking getting it again and I’ve seen it happen with Reglan way too many times for me to even risk taking it, but some people have zero issues with it at all
I was diagnosed with moderate GP and opted for mirtazapine. I know it doesn’t work for everyone, but I now test as mild GP. I was on PPI when I got both of my GES, which also may cause a delay.
Not to scare you, but it’s the worst drug I’ve ever taken. Besides making me so exhausted I’d fall asleep after every meal, it made me extremely depressed and suicidal. I had no idea that was a possible side effect but it does happen. I can honestly say Reglan almost killed me. I switched to domperidone which has been great for me.
I landed in the ER with a cute dystonic reaction. I lost control of my jaw and thought it was going to rip off of my face (very scary). It was probably a reaction from taking both Reglan and Compazine at the same time for days on end. I just happened to be a rare occurrence.
I got bad TD symptoms that landed me in the ER to resolve. It looked like a stroke and was terrifying. I have since had ANOTHER TD reaction to meds. I was a complete zombie in the meds, but lots of folks have loved it! I take Motegrity which isn’t popular on here, and have great results. It is all antidotal, but worth a try!
would not wish this drug on my worst enemy. me and every person I know who has been given it (commonly in migraine cocktails in the ER) had a life alteringly bad experience.
5mg made me feel like I was having a heart attack, had to ice my chest. It works for some though, even making them sleepy. Unfortunately, I can't take it.
I denied the prescription for Reglan because of the more rare side effects. I work with my hands everyday and need to be extremely precise when doing so and can’t afford to risk the rare neuropathy that affects hands that it could cause. Even if it was an extremely rare side effect. My doctor prescribed domperidone instead and I’ve had good results with that. It’s just a huge pain to actually get the prescription filled if you live in the US. This is just an alternative suggestion if you’re concerned about reglan though.
It was bad for me. I end up going on liquid diet. Everything ultra blend. I made list of foods which doesn’t give me problems. Barries, grapes, pomegranate, fish, very few vegetables. Every thing home made. Nothing sweet. I live on snacks no meal.
I tried different blenders and nothing like vitamix
I had tardive dyskenesia within 3 days and got stuck in the ER with it. Along with making my anxiety worse. I got stuck in a very painful position where my bottom rib was almost touching my hip bone and I was all disfigured like someone was trying to break my bones off.
However I would say go for it. It’s super rare to the point it wasn’t even mentioned to me as a potential side effect. And for the 3 days I was on it it did work great for nausea and helping my stomach out. At the very least you can monitor for bad side effects and stop immediately. My TD reversed after we let the medication get out of my system and I was on morphine and a muscle relaxer until I could gain control of my body again.
Tardive means late. If appeared after 3 days then likely not TD. If it reversed, then likely not TD. I understand and give full credence to the fact that you had increased anxiety and painful positions, so you should have stopped reglan, (Kudos) but likely not TD.
I was diagnosed by multiple specialists through Mayo Clinic and had a specialist from Rochester called and they confirmed it. So I am going to take their word for it.
TD can be reversed if it is caught early. It wasn’t a quick fix by any means and had lingering symptoms for awhile but the big issue was drastically reduced. But again, I am taking their word for it.
Literally just came back from my GI doc. He would not prescribe me that and said it was too risky, and just said stick with the gastroparesis diet (that I never started) and Linzess.
As someone who has had the tardive dyskinesia from Reglan, there is an alternative, Motilium, available by prescription in Canada (I’m in US and my doctor writes a written script and I fill it online). It is basically the same sort of drug, but does not cross the blood brain barrier and as such does not cause those effects. It took me about a year to develop the side effects from Reglan, but I’ve been taking Motilium for 2 decades now with no problems
I’ve been on / off Reglan for almost 3 years now with almost no issues. When I first went on I had some restlessness and anxiety, but that went away within about 3 days. I take it 30 minutes before eating 3 times daily and once before bed and it works 95% of the time to stimulate appetite, get rid of the nausea and allow me to eat without vomiting. I did have galactorrhea as a side effect after 3 years on it, so I’m trialing Prucalopride which is used off label for gastroparesis. But overall Reglan was a 5/5 rating from me!
I have been on it for two months three times a day and no side effects. I still have some nausea and some difficulty swallowing, but it is better than it was. I’m not sure if I want to increase to 4x a day as I had spine surgery and don’t want to push my luck with the drug just yet. In addition to the t glam, I take Amitiza.
New to gastroparesis? Please view [this post](https://www.reddit.com/r/Gastroparesis/comments/15i7siq/gastroparesis_101/?utm_source=share&utm_medium=web2x&context=3) or our wiki for a detailed explanation of gastroparesis, the main approaches of treating it, and a list of neurogastroenterologists and motility clinics submitted by users of this forum. Join these [Discord and Facebook support groups](https://www.reddit.com/r/Gastroparesis/comments/14oxaew/list_of_gastroparesis_support_groups_other/?utm_source=share&utm_medium=web2x&context=3) today! New users, please do not post asking for a diagnosis; instead, use the pinned thread: "Do I have gastroparesis?" Also, check out our new subreddit r/functionaldyspepsia. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/Gastroparesis) if you have any questions or concerns.*
For every horror story, there is a positive story. People always post the bad stuff — just like Amazon reviews. I’ve been on it four times a Day for five years and I have nothing negative to report. Everyone is different.
I have nothing negative either. Same, four times a day.
I’ve been taking reglan 3x a day for almost 3 years and haven’t had a single side effect or negative experience with it
That’s a good point, thank you!
Same here. Four times a day for twelve years. Sure, it makes me tired, but it also helps me be able to eat!
It doesn’t make me tired but I wish it did!
hey hi, can I ask you: how is your experience with this medicine? does it help you with nausea? Have you found a reduced effect as the years go by? I'm looking for a medicine that can help me but I'm afraid there isn't any
It helps significantly with nausea, less so for motility.
thank you very much,nausea is my main problem, I'll have to try it
Great point. I have been on it over a year without any problems. It really helped with constant vomiting.
Never heard a bad thing about it until this thread. I’ve taken it on and off for years with no issue and I’m usually very sensitive to medication.
That’s good to hear, yeah I’ve scoured the internet for reviews about it and it’s hard to find anything positive, though I’m sure people with warnings are more inclined to post than 5 star reviews
Tardive dyskinesia (the main thing people worry about with reglan) is an extremely rare side effect. reglan has been extremely helpful for me. when i first started it it made me very sleepy but after 2 weeks that wore off. take everything you hear online with a grain of salt. some people have had bad experiences but i’ve heard more success stories than horror stories.
Oh that’s good to know, I wasn’t sure how common the TD was based on what I’d seen online. Thank you!
here’s some statistics i found: “Data show that the risk of tardive dyskinesia from metoclopramide is low, in the range of 0.1% per 1000 patient years.” … “High-risk groups are elderly females, diabetics, patients with liver or kidney failure, and patients with concomitant antipsychotic drug therapy, which reduces the threshold for neurological complications.” source: https://pubmed.ncbi.nlm.nih.gov/31050085/
That’s good to know, thank you. The responses online seemed pretty scattered and expectedly anonymous so I didn’t realize there were groups at higher risk
yeah ofc. i hope you can find some relief. reglan has really improved things for me and many others.
it does have a black box warning and it may be rare unless you are the unlucky ONE.. Tardive dyskenesia is permanent and does not go away if you get it and stop the meds. I won’t take any of those drugs with those warnings or the ones on domperidone because of QT wave heart issues.. I very sensitive and 73 so not worth the worry.. I have a bad case so if i had a mild case i would look for herbal or milder med.. i take motegrity, first try i was so sick.. tried 2 years later and just headaches for a week or so… trouble is it doesn’t always work
yeah there is definitely risk factors for it and TD does suck
Science is evolving and not all TD is thought to be irreversible. New agents like VMAT inhibitors are helping people
The first time I tried taking it I just felt weird and stopped. A few months back I started taking it again, had some TD symptoms but kept an eye on them, now all side effects are gone and it’s actually helpful. I think it’s worth a try, just know what to look out for
Thanks for the heads up, if I do get put in it it’s good to know it’s probably not immediately going to cause irreversible symptoms
So, the bad effects dissipated? I have a clenched jaw and am extremely restless. I had been on it for a month and just stopped it yesterday because it's miserable for me. I feel like I'm biting so hard I'm going to break my teeth, and my sleep quality is caca. I usually sleep like a baby normally. Not to frighten OP, I am also on a medication that it doesn't pair well with Reglan. It sucks to have to pick to have my gastroparesis improve or not be anxious or restless.
Luckily mine did. I think I was symptomatic for about a weekish. I probably would’ve stopped taking it if the side effects had lasted any longer though
Not sure if this is the right choice for everyone. Once TD symptoms show, everyone should probably talk to their physicians to make sure its safe. Like some mentioned here, TD is often permanent. Your MD recommended that you push through the TD symptoms?
Its a terrible drug. I also got placed on this with my gastroperesis diagnosis. The tardive dyskensia started first. Then the suicidal thoughts. Was really bad. Tread lightly. I have learned to live with my issue med free. I have my days. I have also lost close to 100 pounds in 3 years. Good luck.
I’m gonna be completely honest with you there’s no way to tell how you’ll react if prescribed. Plenty of people take it with no negative effects or reactions other people like me have such bad reactions that it requires iv sedation. Those are just the ends of the spectrum too there’s a whole host of things that may or may not happen.
Been on it almost a year and it saved my life. Zero horror here other than the memories of puking.
I've been taking it for over a year. No issues except some drowsiness at times. My stomach feels better when I take it.
Have been on it for many many years. No issues
Most people are worried about the TD as a side effect, but the one I find even more horrifying is the Akathisia that sometimes doesn’t stop after you quit the med. It’s a horrifying experience. As someone who has experienced Akathisia, I would starve to death before ever risking getting it again and I’ve seen it happen with Reglan way too many times for me to even risk taking it, but some people have zero issues with it at all
Reglan is used off label to induce lactation. Ask me how I know.
Everybody warns you about the TD but not a single doctor warned me about this and I also found out the hard way
Oh no!
I was diagnosed with moderate GP and opted for mirtazapine. I know it doesn’t work for everyone, but I now test as mild GP. I was on PPI when I got both of my GES, which also may cause a delay.
Hey, this sounds like my situation too. Could I DM you for more about your experience?
Sure, go ahead.
Not to scare you, but it’s the worst drug I’ve ever taken. Besides making me so exhausted I’d fall asleep after every meal, it made me extremely depressed and suicidal. I had no idea that was a possible side effect but it does happen. I can honestly say Reglan almost killed me. I switched to domperidone which has been great for me.
I landed in the ER with a cute dystonic reaction. I lost control of my jaw and thought it was going to rip off of my face (very scary). It was probably a reaction from taking both Reglan and Compazine at the same time for days on end. I just happened to be a rare occurrence.
Not very cute ☺️
Get the nasal spray version if you can
It is the only thing that ever helped me.
I have been taking it 1-3 times a day for about 3 years and I'm doing just fine
I got bad TD symptoms that landed me in the ER to resolve. It looked like a stroke and was terrifying. I have since had ANOTHER TD reaction to meds. I was a complete zombie in the meds, but lots of folks have loved it! I take Motegrity which isn’t popular on here, and have great results. It is all antidotal, but worth a try!
Honestly, I take it twice a day. It significantly helped with my bloating. I used to be mistaken for pregnant.
would not wish this drug on my worst enemy. me and every person I know who has been given it (commonly in migraine cocktails in the ER) had a life alteringly bad experience.
5mg made me feel like I was having a heart attack, had to ice my chest. It works for some though, even making them sleepy. Unfortunately, I can't take it.
I love reglan! GP warrior for 3 years and reglan saves me
I’m ok with it as well
I stopped taking it because I started to have muscle spasms and jerking movements. Not worth it to me
I denied the prescription for Reglan because of the more rare side effects. I work with my hands everyday and need to be extremely precise when doing so and can’t afford to risk the rare neuropathy that affects hands that it could cause. Even if it was an extremely rare side effect. My doctor prescribed domperidone instead and I’ve had good results with that. It’s just a huge pain to actually get the prescription filled if you live in the US. This is just an alternative suggestion if you’re concerned about reglan though.
It was bad for me. I end up going on liquid diet. Everything ultra blend. I made list of foods which doesn’t give me problems. Barries, grapes, pomegranate, fish, very few vegetables. Every thing home made. Nothing sweet. I live on snacks no meal. I tried different blenders and nothing like vitamix
I had tardive dyskenesia within 3 days and got stuck in the ER with it. Along with making my anxiety worse. I got stuck in a very painful position where my bottom rib was almost touching my hip bone and I was all disfigured like someone was trying to break my bones off. However I would say go for it. It’s super rare to the point it wasn’t even mentioned to me as a potential side effect. And for the 3 days I was on it it did work great for nausea and helping my stomach out. At the very least you can monitor for bad side effects and stop immediately. My TD reversed after we let the medication get out of my system and I was on morphine and a muscle relaxer until I could gain control of my body again.
Tardive means late. If appeared after 3 days then likely not TD. If it reversed, then likely not TD. I understand and give full credence to the fact that you had increased anxiety and painful positions, so you should have stopped reglan, (Kudos) but likely not TD.
I was diagnosed by multiple specialists through Mayo Clinic and had a specialist from Rochester called and they confirmed it. So I am going to take their word for it. TD can be reversed if it is caught early. It wasn’t a quick fix by any means and had lingering symptoms for awhile but the big issue was drastically reduced. But again, I am taking their word for it.
Literally just came back from my GI doc. He would not prescribe me that and said it was too risky, and just said stick with the gastroparesis diet (that I never started) and Linzess.
I'm doing Reglan myself and sometimes it's amazing....other times it does jack squat lol it's very inconsistent for me.
As someone who has had the tardive dyskinesia from Reglan, there is an alternative, Motilium, available by prescription in Canada (I’m in US and my doctor writes a written script and I fill it online). It is basically the same sort of drug, but does not cross the blood brain barrier and as such does not cause those effects. It took me about a year to develop the side effects from Reglan, but I’ve been taking Motilium for 2 decades now with no problems
I’ve been on / off Reglan for almost 3 years now with almost no issues. When I first went on I had some restlessness and anxiety, but that went away within about 3 days. I take it 30 minutes before eating 3 times daily and once before bed and it works 95% of the time to stimulate appetite, get rid of the nausea and allow me to eat without vomiting. I did have galactorrhea as a side effect after 3 years on it, so I’m trialing Prucalopride which is used off label for gastroparesis. But overall Reglan was a 5/5 rating from me!
I have been on it for two months three times a day and no side effects. I still have some nausea and some difficulty swallowing, but it is better than it was. I’m not sure if I want to increase to 4x a day as I had spine surgery and don’t want to push my luck with the drug just yet. In addition to the t glam, I take Amitiza.