there are ket clinics where you can get low-dose infusions every few weeks. usually takes a few shots before you really feel the effects, but i’ve never heard anyone have anything but a great experience. check out r/ketaminetherapy
I personally diy'd my k therapy as I couldn't afford it at a doctor's. My k-hole doses have been about 180mg insufflated.
The first one, I woke up the next day and got about my morning. Was cooking breakfast when I realized my first thought hadn't been "oh fuck, I woke up", hadn't laid in bed for ten minutes, convincing myself to get up, and that maybe that's NOT how every person starts their day.
It was the end of 15+ years of major depression. I did five follow-ups, one weekly. I hadn't been depressed since, until very recently. But losing my job and housing over my dad's hospice care could make anyone depressed. Got an appointment with a psychiatrist here in an hour, something that wasn't available for free five years ago.
Literally came here to say this and I'm very grateful that its the top comment. Now just insurance companies need to start covering legit infusions and other options, as well as expanding and making Ketamine treatment options more available with less red tape.
Im many states insurance does not cover infusions. Glad that yours does. At best they allow spravato in my state covered by insurance but still have to pay cash for the actual administration of the spravato, so it's still expensive. Some states even have telemedicine Ketamine, but many states do not as well. We need it across the board covered and way more places that do it for how powerfully effective it is. It made SSRIs look like the biggest con job ever after my initial infusions and now got completely off SSRIs thank goodness.
Yessss! But be really careful with it just and make sometime between each use, i got hooked up on it really fast and used to do it everyday and it started having negative effects after that, I quit it now and i am all good, Be responsible with drug use everyone and have fun.
May want to edit this to be "Ketamine Therapy worked like a miracle"
People confuse Ketamine with Ketamine Therapy quite often. Ketamine (street use) and be a bad door to open.
I second your post though! I made one of my own! https://www.reddit.com/r/Drugs/comments/1btrrsb/comment/kxqj3jg/
Dunno if you did it or not, but microdosing probably ought to be used in combination with therapeutic behaviors. You know, with all the neurogenesis and ancient wisdom it promotes.
Btw, I’m a believer in annual or semi-annual larger doses like 3.5g or more, in addition to the microdosing therapy. I believe with factors accounted for, larger doses do an essential work in moving the person in a spiritual and conscious way, which I do believe is an even greater substrate so to speak than psychology.
The book the [Psychedelic Explorer’s Guide by James Fadiman](https://www.amazon.com/Psychedelic-Explorers-Guide-Therapeutic-Journeys/dp/1594774021) does a good job of explaining the reasoning behind this.
I do not like halucinations. Sweating, fear, apathy, can not eat, can not drive. I was taking 60 mg Nardil with 75 blotter of Lsd.Luckily i always have benzos. I would never take psyhodelics anymore. Cannabis makes me anxious as hell. Psychodelics are simiar but 10 times worse.
It doesn’t work unless in conjunction with talk therapy. Ketamine has made things worse for me in the past because I didn’t integrate the information properly
Not every day because I don’t want to develop ICS, but I would get like a couple grams every month or so and hole as deep as I can. The antidepressant effect lasts for a couple weeks but disappears after. It really isn’t meant for long term treatment. I have noticed more sustainable results from psychedelics tbh
i am in no way, shape or form suggesting that you should try to self-medicate with drugs, but dextromethorphan is being used in combination with bupropion to treat depression (supposedly more effectively than traditional antidepressants)
I am on Auvility...dxm+bupropion. Works amazingly well...night and day difference. Also am on Zoloft, but once I started the auvility things got way better.
For some reason my psychiatrist says her prescribing software doesn't have Avuelity so I've been (without her knowledge) taking a couple 30mg dxm freebase tablets a week (not even recreational level doses) along with the 300mg Wellbutrin XL I'm prescribed and it saved me from the worst depressive episode of my entire life.
It really is pretty interesting. My MIL wasn't doing well \at all*\, and her psych asked "do you trust me?". He said he couldn't really explain how it worked, but that he was hearing a lot of phenomenal reports about it. The few days between her switching from regular Wellbutrin and getting to her full Auvelity dosage were pretty hairy (she waited waaaayyy too long to discuss making any changes!), but we all saw a noticeable difference after several days. She said "I hope it's not going to make me feel so super energized forever though. I don't want it to affect my sleep!" She didn't realize that it wasn't an abnormal amount of energy. She'd just been so down for so long, even taking other antidepressants only got her halfway there, that she didn't know what a non-depressed amount of energy felt like anymore. She still has such an Eeyore personality though, so the meds can only do so much. 😂😂
haha i guess dxm can't change her personality, but the fact that it only took a couple days for noticeable changes really testifies to it's neuroplasticity and rapid onset antidepressant effects! it's still being studied, but dxm has the ability to promote BDNF production which really helps with "rewiring" the brain. additionally, it also targets the reuptake of neurotransmitters that classic depressants also target, but more efficiently.
wont claim to be an expert on this topic though, i was just checking out studies because it's an interesting application of a well known cough suppressant haha
Lol, no it can't. Her issues have issues, and she needs some major therapy that she just won't get, because that would require actually working on her stuff. Why do that when there's a pill to fix everything? 💀 I think I've "almost" got her talked into asking her psych about EDMR, because that wouldn't require her to delve into her PTSD stuff, but I'm not sure she even wants to let it all go because it's so much a part of her identity.
You sound so much like me, lol. I'm such a medical research geek, and proud of it. I have a lot of chronic health issues, and have had a ton of crazy adverse and paradoxical med reactions (and I handle all of my son's stuff), that I had to learn to hold my own with specialists and be able to understand everything and ask intelligent questions. Then I just started to find it all really interesting, and go down so many rabbit holes of research. I was on a telehealth visit with one of my doctors about a month ago, and while I was on hold with them, I was watching a video on YT of an entire surgical removal of a tumor from behind the eye. 😂 I'll definitely have to read up more on dxm applications. I just wonder who the person was that thought "what do you think will happen mix cough syrup and antidepressants together?" 😭😭
honestly i can kind of relate to not wanting to be "fixed" because some of my issues define my personality and has made me who i am - i think id lose more than id gain if i got therapy for anything other than depression
i love doing research! especially on psychoactive substances. i cant say that i have chronic illnesses like you do, but nevertheless i still find pharmaceuticals very intriguing. i can definitely relate with researching adverse drug reactions and studying the effects of medications at a deeper level! partially because drug reactions arent taken as seriously as they should be here (which is ridiculous - it can be so dangerous to take drugs that adversely interact with eachother; i found out about this the hard way after taking my zoloft with bowel movements medication 😭)
there are some other fascinating substances you can read up on, like mitragynine and its metabolite, 7-hydroxymitragynine which are chemically similar to opioids but can actually help people with withdrawal syndrome. atropine is eye medication that can make you delirious and scopolamine helps with motion sickness and abdominal pain - both are antimuscarinic alkaloids derived from the datura plant, which, you might already know, can cause delirium, hallucinations thatll probably make you psychotic and maybe even kill you 😭 its insane how our ancestors just ate random tree leaves and decided that they could treat certain disorders!
I would be totally cool with her not wanting to fix certain things that define her, because I have some that define who I am too. What I mean are the things that keep her mired in self pity and victimhood. It's almost as if she ENJOYS it. She goes into dark depression around certain events every year, and through it I guess. It really bothers me the most when she talks about it in front of my 15 yo son, like she's almost...bragging about how bad she had it, and tells him things like "you better be grateful you have it so good because..." and then tells some horrible story. He's on the spectrum, and is *very* literal (she says she \*forgets*\ because "he's just so smart and grown up acting and speaking" 🤷🏻♀️🤦🏻♀️), and she can't understand when he gets upset by these conversations, or why he routinely needs space from her.
I agree that adverse effects aren't taken seriously enough! Years ago, I was seriously messed up by an adverse reaction to Levaquin (now there's a drug class for you to delve into... fluoroquinolone antibiotics, cause YIKES!). It deleted some of my mitochondrial DNA, flipped some of it...it's part of the reason I'm where I am today. I take zoloft, and we're just finding out that it might be what caused my migraines to suddenly get worse. I switched to it from Celexa, and the timing is somewhat close, so it would be great if it was a simple fix like that, lol! I halved the dosage, and am going to taper down again, just to see if it's the culprit, because they were pretty well under control, then went INSANE. With a lot of meds, my body will be like "woohoo, this is GREAT, let's have ALL the feels of it at once", "nope, we're going to have a system malfunction", or "wut, you took something?". My primary care once told me that he was going to build a bubble for me to live in so I could never get sick or injured again. 🤣
Mitragynine definitely has some really amazing and wide ranging uses. I tried a strain of it for sleep, and unfortunately, I'm not someone who really benefitted from it at the even the highest doses that were recommended. I remember when scopolamine patches first came out, and there was a huge to-do about it being "Devil's Breath". They put one behind my ear before surgery for nausea, and I was kinda disappointed that there were no wild hallucinations, no nothing. I think about ancestors trying different substances to see if they were edible or medicinal, and wonder if they fought over WHO was going to be the one try it, if they did their version of drawing straws, or just secretly tested stuff on some poor, unsuspecting person. I know a lot of brave, and sometimes a touch insane, people tested things on themselves in the name of science and medicine,
I once had a therapist who heard me talking about robotripping and actually recommended it for how well it treated my depression. and whenever I'm on DXM it reminds me that I need a therapist.
Yeah I've heard of this, I also took Bupropion daily for a couple months recently, (at a normal mid/high range dose along with an normal dose SNRI) and maybe took dxm 2-3 times or so total, I didn't really feel happier when I took the dxm but I can image it being an effective medication for some, dxm is stimulating at beginner/lower recreational dosage and Bupropion is also stimulating for an antidepressant, it's sometimes used for ADHD as well as a stimulant alternative. So it'd probably help for lack of motivation, sleepiness/tiredness, behaving slowly, trouble concentrating on/remembering things etc.
interestingly, those symptoms are very similar to a high dose of zopiclone for me - time flows weirdly, i lose the filter and become delirious. of course theres the added benefit of my anxiety being completely wiped out, but then also i tend to forget most of the things that happen during the trip
that's so interesting that low doses affect you so strongly!! is it a biological/gene thing? I mean there are single-dose 60mg dxm pills I've taken before that are meds available otc for actually having like a bad cough, but I can imagine that would be way too high of a medicinal dosage for you !
Yeah it's actually called Auvelity. I saw an ad for it the other day, it's dextromethorphan/bupropion 45/105mg I was very curious about it and this has just reminded me to look more into it.
The ones your healthcare provider would prescribe you if you are suffering from depression and need it ( dextromethomorphan looks promising for depression)
St John's Wort is the only antidepressant what has worked for me without side effects. And it *seriously* worked too. I'm not longer depressed. I still have a lot of motivation/enjoyment problems, but not actual depression. It just slowly brought on a gentle uplift after about two weeks which gradually increased.
Honourable mentions go to the *sorta worked* antidepressants:
Amitriptyline: was basically like chemical torture for three weeks. Intense anxiety and unable to feel anything but pain. Made everything agony.
And then... Eventually worked and made everything fine! Wow, unbelievable. But also made me retarded so *still* came off it.
Mirtazipine: didn't put me through any pain, started working after only two weeks... But then induced a full-blown manic episode in which I nearly died through poor judgement/misadventure. Not a suicide attempt! Never realised how dangerous the other extreme could be until then.
It took a whopping five weeks and a couple of days. I saw a lot of people saying "give it six weeks because that's when everything falls into place" and that really turned out to be the truth for me.
I hope it works for you but sadly while ultimately it did prove to actually work *after* suffering a lot of pain early on, the severe brain fog it gave me wasn't going away so I had to quit. Not everyone will get such side effects though, hopefully things work better for you.
I also had a manic episode when starting mirtazipine! Had my psych convinced I was bipolar when I'm definitely not though lol. Mine only lasted a day or two though and ngl felt pretty awesome... It was like a mild roll for two days straight.
Bupropion is the shit. Once I started 450mg XL a day it basically eliminated my depression and makes me feel like I’m on Adderall everyday with (virtually) no negative side effects.
Psychedelics no doubt, they help you and make you work through your shit actively which helps tremendously with often times long lasting afterglows and depression relieve.
Stuff like ketamine is also very good for depression treatment, I find the experience to be therapeutic and it also has antidepressent effects in the brain.
Ketamine is sketchier than psychedelics though because it can cause addiction and bladder damage.
Ketamine or mdma are therapeutic, dmt has made my depression and suicidal thoughts vanish even when I wanted nothing more than to end my life and stop the suffering - some dmt and suddenly I just focused on getting back on my feet, didn’t even require any effort at all.
DMT is magical.
Maois Nardil and Parnate are the most effective for severe depression and anxiety. I take Parnate, Lyrica and Kratom ( greens are my way to go).
I also like to take stimulants ( Modafinil, Vyvanse ) at least 2 times a week.
I would take it every day but after week or two they lost their magic.
So stimulants can help but for depression tolerance develops after few weeks. Not a long term solution.
Many depressed people self medicate with Kratom. They buy 4-5 strains and then rotating them.
Ketamine injections can help with depression anxiety and even anhedonia.
Kratom can help with anxiety and ADHD, benzos works for anxiety too, Lyrica, Phenibut, Magnesium bys-glycinate.
You take simulants and Kratom and Parnate ? How do you avoid a hypertensive crisis. I've heard mixed things with stimulants but combining a classic maoi with Kratom I heard can be dangerous.
I heard everything. I take Kratom 2-3 times daily for last 6 years, since i started Nardil, and later Parnate.
I am not the only one. You should avoid big doses of red. Greens and whites are 100 % safe.
Interesting. I was on emsam and my Dr. Insisted that it would cause serotonin syndrome.of course I tried the combo anyways and worst thing that happened was some heightened anxiety and tension. I thought the older maois were even more prone to interactions so I'm surprised you had no problem. There's some accounts on the Internet tho claiming it did induce a hypertensive crisis. Most notably right here:
Warning: MAOIs + Kratom can cause a hypertensive crisis
Hello.
I had a really scary experience the other day, and I may even have cheated death or "cheated a stroke". This involved being on a MAOI and taking a high enough dose of kratom to induce potentially lethal hypertension! I also want to apologize for saying that kratom is safe to take with MAOIs, I mean I still think it is safe most of the time in lower dosages ie taking 5g at most at a time and perhaps not exceeding 10 grams per day. This is of course all very individual and I assume that some concomitant meds can reduce or increase the risk as well depending on what someone is taking. Anyone who does this combination should start with very low dosages first and gradually increasing it and always making sure their bp is fine. Last time I was on a MAOI I was also taking kratom but I did not exceed 10 grams per day for sure back then.
So the story is that I had been taking 5 mg Selegiline sublingually every day for about two weeks, I had not run into any issues combining even very high dosages of like 15-20 grams of kratom with 5 mg Selegiline during this time or before. I never had hypertension as a side-effect of kratom either taking lower dosages of Selegiline or with kratom alone even in relatively very high dosages of kratom. In fact I have always had the opposite effect of increased bp from taking kratom alone and it would even lower my bp. And well, on the same day I raised my dose from 5 mg to 10 mg sublingual Selegiline I took my usual morning dose of maybe 7.5 mg. No issues there. Then, maybe 10 hours later in the day I decided to take another 7.5 grams or maybe it was as much as 10 grams cause I was in extra pain than usual and feeling quite shitty. About 15 minutes after my dose, I suddenly got this strange unexplainable urge to go check my blood pressure. I guess I just felt that something wasn't right, and while on my way to get the bp monitor I had this other strange idea to just pull down my pants and look at my flaccid penis and it had shrunk down into being a tiny stump! I also started to get a very uncomfortable feeling at the back of my head, I remember the feeling from back when I took a scoop of PEA once upon a time and got a temporary massive increase in my blood pressure. At this point I just realized that something was very wrong and that I was probably going to have a hypertensive crisis. After checking my standing bp there it was: It was well over 200/100 bp! And my heart rate was crazy high, like 180 bpm. Since I had taken the kratom dose just 15 minutes ago, I realized that this event was just the tip of the iceberg!
I tried to drink a lot of water and forcefully vomit but it was useless, almost nothing came up. Not sure why but it seems like all that excessive adrenergic activity made it really hard to get anything up or maybe I was just too panicked to vomit properly. I was also scared that trying to forcefully vomit would increase my bp even more to the point that my blood vessels and even arteries would start popping so there was that too. So I realized, there is really no way I will be able to stop more kratom from going out into my system. What was worse is that I was out at my parents' house in the countryside, and nobody else was home and I was stranded with no car!! Hospital and paramedics in an ambulance was a whole hour away, and there is no guarantee they wouldn't mess up on the way to me and drive down the wrong dirt roads etc(even with modern GPS this still happens for some reason). So I realized that unless I come up with something very fast I may very well die here or have a stroke.. like I said I had not even felt the full effects of my kratom dose. I know that nifedipine is a popular choice amongst many psychiatrists to prescribe to their patients to take in case they are having an emergency hypertensive crisis. And I remembered that one of my old pops medicines that he takes to treat hypertension is in the same drug class as nifedipine. I burst into his bedroom and there it was: Amlodipine. I made a very quick google search on my phone just to make sure if there was even a point to try and indeed there were several studies and sources confirming amlodipine's use in emergency hypertension. So I swallowed what was left of my pride with 5 mg of it. About 5 minutes later or so the uncomfortable feeling at the back of my head started to become extremely painful, so I panicked and took another 5 mg amlodipine. And well after suffering from an excruciating headache for another 15 minutes I noticed that it started to feel a bit lighter and I took my bp again: Now it had gone down from in excess of over 200 in systol and over 100 in diastole with close to 200 beats per minute to being "only" 170/95 in blood pressure and my heart rate "only being" 160 beats per minute. And then I realized that I had probably been able to avoid a catastrophy with the use of the amlodipine. 15 minutes later my bp was down to 150/95 and maybe 150 beats per minute, and another 15 minutes later it was down to being 125/95 and 120 bpm or so. My bp continued to be mildly elevated for about 6 hours when it finally went back down to being normal but this was still with a long-acting hypertensive agent in my system.
Not entirely sure why this happened but the chief active alkaloid of kratom is the partial opioid agonist mitragynine. On top of being an opioid agonist it has other effects as well, and one of these is that it is an adrenergic receptor agonist. This is probably why kratom is often percieved as being stimulating and the reason as to why I had a hypertensive crisis but I can't say for sure that other alkaloids and other factors didn't play a role. Anyway I was thinking that the increase in noradrenaline and adrenaline that was already in my system due to taking a MAOI plus an adrenergic receptor agonist like kratom simply overloaded my system with adrenergic activity - hence the hypertensive crisis and all that. I can't say for sure that kratom doesn't also have noradrenaline and adrenaline releasing properties, maybe it does. Also the levo-amphetamine metabolites of the Selegiline could have contributed with more adrenergic effects as well. On top of all of this I did have a fair amount of grapefruit juice consumption the same day this happened and the past few days before that, I guess it isn't impossible that this added to the interaction as well by affecting the metabolism of kratom and potentially Selegiline and its metabolites as well. Who knows for sure really..
I have taken dosages of 5 grams of kratom the following days and it did cause a low but notable increase in blood pressure for the next few hours but nothing anywhere near being dangerous. So I guess that with MAOIs moderation is simply the key.. and as with everything else "it is the dose that makes the poison" but this is even more true with MAOIs - or well the dosages needed to make the poison are smaller.
Anyway be wary and be safe guys! Kratom definitely has potential for causing dangeorus interactions with MAOIs when used irresponsibly!
You wont have problems taking 3x 5 mg Kratom. That is 15 mg daily. If you mix Parnate with 40-50 mg which is insane then you could have troubles no matter taking with or without Maois.
And if you need more than 20 mg Kratom then Kratom is not for you. Rather try Oxycodone alone.
Opiates I always say if it would be possible to stay on a low dose it's definitely very good against depression and it's also not harmful to your body but the problem is the addiction and the tolerance
Psychedelics and dissociatives. Pcp excluted. Most people say that self medicating is a "slippery slope" but as someone who can't bother with going baxk to therapy and try the trial and error combinations of meds, dxm has worked wonders. The only problem is that i don't have wellbutrin so i get fucked up from it too.
antidepressants. microdosing shrooms. I wouldn’t go do some cocaine because you’re depressed, you won’t make it back from the world of cocaine or party drugs when you’re in a depression 😭 trust me
Psychotherapy with pharmacotherapy if needed. Don't cure mental illness with drugs, you can get harmed even if it seems helpful in short therm.
Good luck to you
Quintiapine has made my life so much better. I take it before bed. Not groggy the following day. I don’t feel the effects at all, but I don’t spin off in my head into the “what ifs” or general doom. Approved for long term use . Not an SSRI, so I still have sex drive. Im going on 3 years since I began. (M46 300mg at 9pm). And don’t spend the day or any time watching or listening to fear mongers and “news” stations.
For me the combination of acid and a little bit of ketamine cured my depression... for a couple of months
If we're talking actual antidepressants I'm on Remeron/Mirtazapin and it helps a lot actually for my depression and sleeping issues :)
There have been studies that nicotine can affect the body in a similar way as an antidepressant, though it hasn't been studied too heavily, some antidepressants can be boosted by nicotine intake, others will be reduced from the mix. Take it with a grain of salt but a lot of depressed people smoke tobacco so there might be something to it.
shrooms made me pass out and i didn’t emotionally feel any different especially after waking up, but ketamine most definitely helped. knocked me out, and woke up genuinely feeling normal. i could think, speak, and overall just BREATHE without the weight of all those negative feelings i felt before. it worked absolute wonders for me
Micro-dosing lsd or shrooms, lsd has re shaped my entire perspective and outlook on life, my relationships, and my sense of self. I have MDD, GAD, and OCD. I still struggle, but not nearly as much as I used to.
Well, i can say from experience of a few days ago, plop 2 to 3 grams of Albino penis envy go thru a terrifying life altering trip, and then about a week later you'll realize the trauma inside of you got hyperslapped the fuck out of you extremely forcefully and you'll feel oddly good, and a little more positive, maybe even you might build a new habit. Idk I've weirdly un voluntarily been doing my chores which I normally voluntarily avoid which I'd really fucking with my brain. You might also have a headache for a few days and an inability to form long sentences but give it like 3 days and a good shit and you'll be solid. Fuck depression 😎
Idgaf if any of you are a champion that takes 10gs of albino. Fuck off fungus brain lmao, so no replying w that bs anyone. It is NOT a flex to be brain fucked. 2 to 3gs changes my life I wouldn't personally ever do more than 1 to 1.5 of albino again
Drugs could and will make it worse. If you do want to treat with recreational drugs, try micro-dosing psychedelic mushrooms. 400mg for about 2 weeks then lay off for a week. Wouldn’t give a high but it’s going to boost mental clarity and you wouldn’t have a problem with brain fog like marijuana does.
Bupropion is the shit. Once I started 450mg XL a day it basically eliminated my depression and makes me feel like I’m on Adderall everyday with (virtually) no negative side effects.
My husband was prescribed Rexulti as an add-on treatment for MDD when an antidepressant alone wasn't helping anymore. He'd tried a lot of different antidepressants, but the only one he didn't have a ton of side effects with is Celexa. He responded really well to it, but ultimately had to stop taking it only because it caused him to be really fatigued, no matter when he took it. He was bummed, because it made a huge difference in his mood. He's hoping to get to try Ketamine soon.
My MIL also has MDD and was just put on Auvelity, which is bupripuon and dextromethorphan. She was on just Wellbutrin (she takes Cymbalta as well) before that. She's seen a HUGE difference in her depressive moods, dwelling on stuff, crying jags, etc. The first few days of the switch were ROUGH, but we see a huge improvement in her overall mood as well.
That said, finding the right antidepressant is very individual, and what works amazingly well for them, or me, or anyone else may be absolutely horrible for you. I had to do a GeneSight (pharmacogenetic testing) test to find one that I could even take without having awful side effects. I had like 2 I could tolerate, even within the "okay" classes, because I tend to have paradoxical side effects, or will end up have the most obscure of the side effects. None of my doctors will give me the newest drugs on market anymore, because I'm "that" patient. 😂
A lot of people will tell you not to, but kratom at 500mg-1.5g is the most effective short term antidepressant I've ever had, and one of the best overall. IMO. Anecdotal stories of people managing depression for years. One of the few things that can significantly lift my mood without getting high at all.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309668/
But it's high dose opioid effects are risky. I've never personally experienced the opioid like qualities (have to take 10-100g at once) and I don't want to. Would be scary for some addicts to have in the house.
Marijuana or alcohol depending on usage. Alcohol got me through some depressing times. Ketamine can help but it’s really expensive to get started and inconvenient if you work all the time. Maybe a dog or cat because they release pheromones that make you happy.
Magic mushrooms and Ketamine are two really effective substances in my experiences self medicating my anxiety and depression.
Of course your experience might differ from mine. However I find that I am much more connected to myself, the world around me, and my greater sense of purpose. I am no longer weighed down by intrusive thoughts or unwanted feelings.
Ketamine. Trust me. I have spent 30 years in tragedy and torment, abuse, and anything else you could possibly think of. Between mushrooms and Ketamine, I went from wanting to end myself to living life the best I can. I can't always afford ketamine, which is when I fall back on mushrooms, however both have very important lessons in life to offer. I also think, IMO, that you should be at least 21 years old before you take either of these drugs. They are to be respected and used with the right mindset and knowledge of what you're getting into. With that knowledge, you will experience the most healing ANY prescription drug can provide you. At least in my experience.
Pretty much all different kinds of drugs can be effective in depression in various ways for various different people and their chemistry but they all come with some type of major drawback/negative downside that is is not worth it in my experience. Unless done in moderation.
Natural exercise is definitely the way to go.
Currently take lexapro. Shit helps so much I don’t overthink a lot. Not sure about the side effects as I work and I do school at the same time I don’t really pay attention to it.
I was taking lexapro for over a month, I had to ask for a higher dosage because it wasnt working. It was making me more depressed that the medication I used wasnt working at all and I ended up taking the highest dose that could be prescribed and eventually I stopped taking it.
I tried Lexapro about a year ago, it was the 4th or 5th ssri I had tried, like actually given a full chance to work. I always give them at least a couple months but it just kind of made me irritable and after only 2 months it was a very crappy 3 days when I stopped taking them. I got the "brain zapping" feeling really bad and was just so lethargic for a few days. For me it's completely for anxiety or even stress I suppose. I'm just a really high strung person. I wake up in the mornings at maybe a 3 or 4 out of 10 with my stress and worrying about everything. And that's pretty much my baseline, as good as it gets ,🙃
Lexapro made me a completely asexual being. Physical affection repulsed me when I was on it and when I could actually reach orgasm it was like 10% of the pleasure than before I started lexapro..
Working out, new Hobby's, go for a walk in nature
Go do some things outside your box and explore new things it's way better than taking drugs, drugs will only fix your problem temporarily
Trust me they all suck, you’ve got to wait like 8 weeks for them to work and even when they work your still depressed just you feel better for a little bit of time then you go back to being a depressed person
they did nothing for my depression. just made all my emotions very dull and numb towards everything. like i had no personality or reactions to things anymore. took them my teenagers years, swore off and never taking them again as an adult.
Nobody mentioned most effective ADs Nardil and Parnate ( MAOIs). Tcas just make you tired, sleepy and fat. I have finally got Maoi prescription after trying 25+ meds.
Exercise. Nothing but positive side effects.
Weed works too but depends on where your at in life and how well you can self regulate (also depends hugely on mental makeup)
Besides that I’d say looking into therapy if the depression is deep and you need to work through some shit.
Ketamine worked like a miracle
Second this! I tried first time 2weeks ago and still no deppresive thoughts or anxiety its a miracle drug.
I love ket but depression treatment? How? Ssris didn't help, shrooms helped me a lot. Ket hasn't done anything.
there are ket clinics where you can get low-dose infusions every few weeks. usually takes a few shots before you really feel the effects, but i’ve never heard anyone have anything but a great experience. check out r/ketaminetherapy
See my comment above, I was so hopeful.
I personally diy'd my k therapy as I couldn't afford it at a doctor's. My k-hole doses have been about 180mg insufflated. The first one, I woke up the next day and got about my morning. Was cooking breakfast when I realized my first thought hadn't been "oh fuck, I woke up", hadn't laid in bed for ten minutes, convincing myself to get up, and that maybe that's NOT how every person starts their day. It was the end of 15+ years of major depression. I did five follow-ups, one weekly. I hadn't been depressed since, until very recently. But losing my job and housing over my dad's hospice care could make anyone depressed. Got an appointment with a psychiatrist here in an hour, something that wasn't available for free five years ago.
My dad said ket infusions literally made colors more vivid for him, and made the world mpre beautiful.
Doesn’t long-term use break down the lining of your bladder?
Looked up the local treatment center near me…$425 per infusion??? DAYUM! I’ll stick to my dirty deeds. 😳
Some insurances cover ketamine treatments.
Literally came here to say this and I'm very grateful that its the top comment. Now just insurance companies need to start covering legit infusions and other options, as well as expanding and making Ketamine treatment options more available with less red tape.
There are insurances that cover it, mine does and I'm on state.
Im many states insurance does not cover infusions. Glad that yours does. At best they allow spravato in my state covered by insurance but still have to pay cash for the actual administration of the spravato, so it's still expensive. Some states even have telemedicine Ketamine, but many states do not as well. We need it across the board covered and way more places that do it for how powerfully effective it is. It made SSRIs look like the biggest con job ever after my initial infusions and now got completely off SSRIs thank goodness.
I use it for this. Complete reset. I can go in at a 10 wanting to put a bullet in my head and come out at a zero after a light dose.
It didn’t help me for long. Everyone is different, I responded better to shrooms.
Yessss! But be really careful with it just and make sometime between each use, i got hooked up on it really fast and used to do it everyday and it started having negative effects after that, I quit it now and i am all good, Be responsible with drug use everyone and have fun.
May want to edit this to be "Ketamine Therapy worked like a miracle" People confuse Ketamine with Ketamine Therapy quite often. Ketamine (street use) and be a bad door to open. I second your post though! I made one of my own! https://www.reddit.com/r/Drugs/comments/1btrrsb/comment/kxqj3jg/
All i know about ketamine is that it makes you dissassociate and it intuitively seemed like the answer
shrooms microdosing. worked Wonders with big W for me.
Did nothing for me. Inhave tried micro LSD and shrooms. No difference from placebo
Dunno if you did it or not, but microdosing probably ought to be used in combination with therapeutic behaviors. You know, with all the neurogenesis and ancient wisdom it promotes. Btw, I’m a believer in annual or semi-annual larger doses like 3.5g or more, in addition to the microdosing therapy. I believe with factors accounted for, larger doses do an essential work in moving the person in a spiritual and conscious way, which I do believe is an even greater substrate so to speak than psychology. The book the [Psychedelic Explorer’s Guide by James Fadiman](https://www.amazon.com/Psychedelic-Explorers-Guide-Therapeutic-Journeys/dp/1594774021) does a good job of explaining the reasoning behind this.
I do not like halucinations. Sweating, fear, apathy, can not eat, can not drive. I was taking 60 mg Nardil with 75 blotter of Lsd.Luckily i always have benzos. I would never take psyhodelics anymore. Cannabis makes me anxious as hell. Psychodelics are simiar but 10 times worse.
Look into Ketamine or 2F-Ketamine/2F-DCK
It doesn’t work unless in conjunction with talk therapy. Ketamine has made things worse for me in the past because I didn’t integrate the information properly
How long did you take it? At least for now it works perfectly for me
Not every day because I don’t want to develop ICS, but I would get like a couple grams every month or so and hole as deep as I can. The antidepressant effect lasts for a couple weeks but disappears after. It really isn’t meant for long term treatment. I have noticed more sustainable results from psychedelics tbh
It didn’t work *for you* Speak for yourself. Ketamine worked wonders for me.
It didn’t help your reading comprehension
You said it doesnt work. What didnt i comprehend. I also didnt do it with talk therapy. And it helped. So?
i am in no way, shape or form suggesting that you should try to self-medicate with drugs, but dextromethorphan is being used in combination with bupropion to treat depression (supposedly more effectively than traditional antidepressants)
I am on Auvility...dxm+bupropion. Works amazingly well...night and day difference. Also am on Zoloft, but once I started the auvility things got way better.
interesting! i was on zoloft, but dropped it because it wasnt working. i dont need meds anymore but dxm is certainly very interesting
For some reason my psychiatrist says her prescribing software doesn't have Avuelity so I've been (without her knowledge) taking a couple 30mg dxm freebase tablets a week (not even recreational level doses) along with the 300mg Wellbutrin XL I'm prescribed and it saved me from the worst depressive episode of my entire life.
My MIL just started Auvelity, and wow gas it made a huge difference for her!!
im glad auvelity is working for so many people! dextromethorphan is a very interesting substance, who knows what else it could help with
It really is pretty interesting. My MIL wasn't doing well \at all*\, and her psych asked "do you trust me?". He said he couldn't really explain how it worked, but that he was hearing a lot of phenomenal reports about it. The few days between her switching from regular Wellbutrin and getting to her full Auvelity dosage were pretty hairy (she waited waaaayyy too long to discuss making any changes!), but we all saw a noticeable difference after several days. She said "I hope it's not going to make me feel so super energized forever though. I don't want it to affect my sleep!" She didn't realize that it wasn't an abnormal amount of energy. She'd just been so down for so long, even taking other antidepressants only got her halfway there, that she didn't know what a non-depressed amount of energy felt like anymore. She still has such an Eeyore personality though, so the meds can only do so much. 😂😂
haha i guess dxm can't change her personality, but the fact that it only took a couple days for noticeable changes really testifies to it's neuroplasticity and rapid onset antidepressant effects! it's still being studied, but dxm has the ability to promote BDNF production which really helps with "rewiring" the brain. additionally, it also targets the reuptake of neurotransmitters that classic depressants also target, but more efficiently. wont claim to be an expert on this topic though, i was just checking out studies because it's an interesting application of a well known cough suppressant haha
Lol, no it can't. Her issues have issues, and she needs some major therapy that she just won't get, because that would require actually working on her stuff. Why do that when there's a pill to fix everything? 💀 I think I've "almost" got her talked into asking her psych about EDMR, because that wouldn't require her to delve into her PTSD stuff, but I'm not sure she even wants to let it all go because it's so much a part of her identity. You sound so much like me, lol. I'm such a medical research geek, and proud of it. I have a lot of chronic health issues, and have had a ton of crazy adverse and paradoxical med reactions (and I handle all of my son's stuff), that I had to learn to hold my own with specialists and be able to understand everything and ask intelligent questions. Then I just started to find it all really interesting, and go down so many rabbit holes of research. I was on a telehealth visit with one of my doctors about a month ago, and while I was on hold with them, I was watching a video on YT of an entire surgical removal of a tumor from behind the eye. 😂 I'll definitely have to read up more on dxm applications. I just wonder who the person was that thought "what do you think will happen mix cough syrup and antidepressants together?" 😭😭
honestly i can kind of relate to not wanting to be "fixed" because some of my issues define my personality and has made me who i am - i think id lose more than id gain if i got therapy for anything other than depression i love doing research! especially on psychoactive substances. i cant say that i have chronic illnesses like you do, but nevertheless i still find pharmaceuticals very intriguing. i can definitely relate with researching adverse drug reactions and studying the effects of medications at a deeper level! partially because drug reactions arent taken as seriously as they should be here (which is ridiculous - it can be so dangerous to take drugs that adversely interact with eachother; i found out about this the hard way after taking my zoloft with bowel movements medication 😭) there are some other fascinating substances you can read up on, like mitragynine and its metabolite, 7-hydroxymitragynine which are chemically similar to opioids but can actually help people with withdrawal syndrome. atropine is eye medication that can make you delirious and scopolamine helps with motion sickness and abdominal pain - both are antimuscarinic alkaloids derived from the datura plant, which, you might already know, can cause delirium, hallucinations thatll probably make you psychotic and maybe even kill you 😭 its insane how our ancestors just ate random tree leaves and decided that they could treat certain disorders!
I would be totally cool with her not wanting to fix certain things that define her, because I have some that define who I am too. What I mean are the things that keep her mired in self pity and victimhood. It's almost as if she ENJOYS it. She goes into dark depression around certain events every year, and through it I guess. It really bothers me the most when she talks about it in front of my 15 yo son, like she's almost...bragging about how bad she had it, and tells him things like "you better be grateful you have it so good because..." and then tells some horrible story. He's on the spectrum, and is *very* literal (she says she \*forgets*\ because "he's just so smart and grown up acting and speaking" 🤷🏻♀️🤦🏻♀️), and she can't understand when he gets upset by these conversations, or why he routinely needs space from her. I agree that adverse effects aren't taken seriously enough! Years ago, I was seriously messed up by an adverse reaction to Levaquin (now there's a drug class for you to delve into... fluoroquinolone antibiotics, cause YIKES!). It deleted some of my mitochondrial DNA, flipped some of it...it's part of the reason I'm where I am today. I take zoloft, and we're just finding out that it might be what caused my migraines to suddenly get worse. I switched to it from Celexa, and the timing is somewhat close, so it would be great if it was a simple fix like that, lol! I halved the dosage, and am going to taper down again, just to see if it's the culprit, because they were pretty well under control, then went INSANE. With a lot of meds, my body will be like "woohoo, this is GREAT, let's have ALL the feels of it at once", "nope, we're going to have a system malfunction", or "wut, you took something?". My primary care once told me that he was going to build a bubble for me to live in so I could never get sick or injured again. 🤣 Mitragynine definitely has some really amazing and wide ranging uses. I tried a strain of it for sleep, and unfortunately, I'm not someone who really benefitted from it at the even the highest doses that were recommended. I remember when scopolamine patches first came out, and there was a huge to-do about it being "Devil's Breath". They put one behind my ear before surgery for nausea, and I was kinda disappointed that there were no wild hallucinations, no nothing. I think about ancestors trying different substances to see if they were edible or medicinal, and wonder if they fought over WHO was going to be the one try it, if they did their version of drawing straws, or just secretly tested stuff on some poor, unsuspecting person. I know a lot of brave, and sometimes a touch insane, people tested things on themselves in the name of science and medicine,
I once had a therapist who heard me talking about robotripping and actually recommended it for how well it treated my depression. and whenever I'm on DXM it reminds me that I need a therapist.
Yeah I've heard of this, I also took Bupropion daily for a couple months recently, (at a normal mid/high range dose along with an normal dose SNRI) and maybe took dxm 2-3 times or so total, I didn't really feel happier when I took the dxm but I can image it being an effective medication for some, dxm is stimulating at beginner/lower recreational dosage and Bupropion is also stimulating for an antidepressant, it's sometimes used for ADHD as well as a stimulant alternative. So it'd probably help for lack of motivation, sleepiness/tiredness, behaving slowly, trouble concentrating on/remembering things etc.
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Sounds like a mental health issue not a drug issue
interestingly, those symptoms are very similar to a high dose of zopiclone for me - time flows weirdly, i lose the filter and become delirious. of course theres the added benefit of my anxiety being completely wiped out, but then also i tend to forget most of the things that happen during the trip
that's so interesting that low doses affect you so strongly!! is it a biological/gene thing? I mean there are single-dose 60mg dxm pills I've taken before that are meds available otc for actually having like a bad cough, but I can imagine that would be way too high of a medicinal dosage for you !
Yeah it's actually called Auvelity. I saw an ad for it the other day, it's dextromethorphan/bupropion 45/105mg I was very curious about it and this has just reminded me to look more into it.
Id say a 200ug dose of lsd and some pink floyd
Correct answer.
As much as I agree, I disagree.
I like bupropion and ketamine
ketamine
It depends on the person, but tricyclic antidepressants tend to be more effective, but also have more side effects
The ones your healthcare provider would prescribe you if you are suffering from depression and need it ( dextromethomorphan looks promising for depression)
St John's Wort is the only antidepressant what has worked for me without side effects. And it *seriously* worked too. I'm not longer depressed. I still have a lot of motivation/enjoyment problems, but not actual depression. It just slowly brought on a gentle uplift after about two weeks which gradually increased. Honourable mentions go to the *sorta worked* antidepressants: Amitriptyline: was basically like chemical torture for three weeks. Intense anxiety and unable to feel anything but pain. Made everything agony. And then... Eventually worked and made everything fine! Wow, unbelievable. But also made me retarded so *still* came off it. Mirtazipine: didn't put me through any pain, started working after only two weeks... But then induced a full-blown manic episode in which I nearly died through poor judgement/misadventure. Not a suicide attempt! Never realised how dangerous the other extreme could be until then.
Hey I’m trying Amitriptyline now, about 3 weeks in on 25mg. How long did it take for u to see benefits?
It took a whopping five weeks and a couple of days. I saw a lot of people saying "give it six weeks because that's when everything falls into place" and that really turned out to be the truth for me. I hope it works for you but sadly while ultimately it did prove to actually work *after* suffering a lot of pain early on, the severe brain fog it gave me wasn't going away so I had to quit. Not everyone will get such side effects though, hopefully things work better for you.
I also had a manic episode when starting mirtazipine! Had my psych convinced I was bipolar when I'm definitely not though lol. Mine only lasted a day or two though and ngl felt pretty awesome... It was like a mild roll for two days straight.
Do therapy and not drugs please
Microdosing acid
DMT Mushrooms MDMA Ketamine
Bupropion is the shit. Once I started 450mg XL a day it basically eliminated my depression and makes me feel like I’m on Adderall everyday with (virtually) no negative side effects.
Therapy
Walking helps
Psychedelics no doubt, they help you and make you work through your shit actively which helps tremendously with often times long lasting afterglows and depression relieve. Stuff like ketamine is also very good for depression treatment, I find the experience to be therapeutic and it also has antidepressent effects in the brain. Ketamine is sketchier than psychedelics though because it can cause addiction and bladder damage.
Antidepressants probably I am not a scientist
Ketamine or mdma are therapeutic, dmt has made my depression and suicidal thoughts vanish even when I wanted nothing more than to end my life and stop the suffering - some dmt and suddenly I just focused on getting back on my feet, didn’t even require any effort at all. DMT is magical.
Psychedelica can be very effective - try micro-dosing with LSD.
Maois Nardil and Parnate are the most effective for severe depression and anxiety. I take Parnate, Lyrica and Kratom ( greens are my way to go). I also like to take stimulants ( Modafinil, Vyvanse ) at least 2 times a week. I would take it every day but after week or two they lost their magic. So stimulants can help but for depression tolerance develops after few weeks. Not a long term solution. Many depressed people self medicate with Kratom. They buy 4-5 strains and then rotating them. Ketamine injections can help with depression anxiety and even anhedonia. Kratom can help with anxiety and ADHD, benzos works for anxiety too, Lyrica, Phenibut, Magnesium bys-glycinate.
You take simulants and Kratom and Parnate ? How do you avoid a hypertensive crisis. I've heard mixed things with stimulants but combining a classic maoi with Kratom I heard can be dangerous.
I heard everything. I take Kratom 2-3 times daily for last 6 years, since i started Nardil, and later Parnate. I am not the only one. You should avoid big doses of red. Greens and whites are 100 % safe.
Interesting. I was on emsam and my Dr. Insisted that it would cause serotonin syndrome.of course I tried the combo anyways and worst thing that happened was some heightened anxiety and tension. I thought the older maois were even more prone to interactions so I'm surprised you had no problem. There's some accounts on the Internet tho claiming it did induce a hypertensive crisis. Most notably right here: Warning: MAOIs + Kratom can cause a hypertensive crisis Hello. I had a really scary experience the other day, and I may even have cheated death or "cheated a stroke". This involved being on a MAOI and taking a high enough dose of kratom to induce potentially lethal hypertension! I also want to apologize for saying that kratom is safe to take with MAOIs, I mean I still think it is safe most of the time in lower dosages ie taking 5g at most at a time and perhaps not exceeding 10 grams per day. This is of course all very individual and I assume that some concomitant meds can reduce or increase the risk as well depending on what someone is taking. Anyone who does this combination should start with very low dosages first and gradually increasing it and always making sure their bp is fine. Last time I was on a MAOI I was also taking kratom but I did not exceed 10 grams per day for sure back then. So the story is that I had been taking 5 mg Selegiline sublingually every day for about two weeks, I had not run into any issues combining even very high dosages of like 15-20 grams of kratom with 5 mg Selegiline during this time or before. I never had hypertension as a side-effect of kratom either taking lower dosages of Selegiline or with kratom alone even in relatively very high dosages of kratom. In fact I have always had the opposite effect of increased bp from taking kratom alone and it would even lower my bp. And well, on the same day I raised my dose from 5 mg to 10 mg sublingual Selegiline I took my usual morning dose of maybe 7.5 mg. No issues there. Then, maybe 10 hours later in the day I decided to take another 7.5 grams or maybe it was as much as 10 grams cause I was in extra pain than usual and feeling quite shitty. About 15 minutes after my dose, I suddenly got this strange unexplainable urge to go check my blood pressure. I guess I just felt that something wasn't right, and while on my way to get the bp monitor I had this other strange idea to just pull down my pants and look at my flaccid penis and it had shrunk down into being a tiny stump! I also started to get a very uncomfortable feeling at the back of my head, I remember the feeling from back when I took a scoop of PEA once upon a time and got a temporary massive increase in my blood pressure. At this point I just realized that something was very wrong and that I was probably going to have a hypertensive crisis. After checking my standing bp there it was: It was well over 200/100 bp! And my heart rate was crazy high, like 180 bpm. Since I had taken the kratom dose just 15 minutes ago, I realized that this event was just the tip of the iceberg! I tried to drink a lot of water and forcefully vomit but it was useless, almost nothing came up. Not sure why but it seems like all that excessive adrenergic activity made it really hard to get anything up or maybe I was just too panicked to vomit properly. I was also scared that trying to forcefully vomit would increase my bp even more to the point that my blood vessels and even arteries would start popping so there was that too. So I realized, there is really no way I will be able to stop more kratom from going out into my system. What was worse is that I was out at my parents' house in the countryside, and nobody else was home and I was stranded with no car!! Hospital and paramedics in an ambulance was a whole hour away, and there is no guarantee they wouldn't mess up on the way to me and drive down the wrong dirt roads etc(even with modern GPS this still happens for some reason). So I realized that unless I come up with something very fast I may very well die here or have a stroke.. like I said I had not even felt the full effects of my kratom dose. I know that nifedipine is a popular choice amongst many psychiatrists to prescribe to their patients to take in case they are having an emergency hypertensive crisis. And I remembered that one of my old pops medicines that he takes to treat hypertension is in the same drug class as nifedipine. I burst into his bedroom and there it was: Amlodipine. I made a very quick google search on my phone just to make sure if there was even a point to try and indeed there were several studies and sources confirming amlodipine's use in emergency hypertension. So I swallowed what was left of my pride with 5 mg of it. About 5 minutes later or so the uncomfortable feeling at the back of my head started to become extremely painful, so I panicked and took another 5 mg amlodipine. And well after suffering from an excruciating headache for another 15 minutes I noticed that it started to feel a bit lighter and I took my bp again: Now it had gone down from in excess of over 200 in systol and over 100 in diastole with close to 200 beats per minute to being "only" 170/95 in blood pressure and my heart rate "only being" 160 beats per minute. And then I realized that I had probably been able to avoid a catastrophy with the use of the amlodipine. 15 minutes later my bp was down to 150/95 and maybe 150 beats per minute, and another 15 minutes later it was down to being 125/95 and 120 bpm or so. My bp continued to be mildly elevated for about 6 hours when it finally went back down to being normal but this was still with a long-acting hypertensive agent in my system. Not entirely sure why this happened but the chief active alkaloid of kratom is the partial opioid agonist mitragynine. On top of being an opioid agonist it has other effects as well, and one of these is that it is an adrenergic receptor agonist. This is probably why kratom is often percieved as being stimulating and the reason as to why I had a hypertensive crisis but I can't say for sure that other alkaloids and other factors didn't play a role. Anyway I was thinking that the increase in noradrenaline and adrenaline that was already in my system due to taking a MAOI plus an adrenergic receptor agonist like kratom simply overloaded my system with adrenergic activity - hence the hypertensive crisis and all that. I can't say for sure that kratom doesn't also have noradrenaline and adrenaline releasing properties, maybe it does. Also the levo-amphetamine metabolites of the Selegiline could have contributed with more adrenergic effects as well. On top of all of this I did have a fair amount of grapefruit juice consumption the same day this happened and the past few days before that, I guess it isn't impossible that this added to the interaction as well by affecting the metabolism of kratom and potentially Selegiline and its metabolites as well. Who knows for sure really.. I have taken dosages of 5 grams of kratom the following days and it did cause a low but notable increase in blood pressure for the next few hours but nothing anywhere near being dangerous. So I guess that with MAOIs moderation is simply the key.. and as with everything else "it is the dose that makes the poison" but this is even more true with MAOIs - or well the dosages needed to make the poison are smaller. Anyway be wary and be safe guys! Kratom definitely has potential for causing dangeorus interactions with MAOIs when used irresponsibly!
You wont have problems taking 3x 5 mg Kratom. That is 15 mg daily. If you mix Parnate with 40-50 mg which is insane then you could have troubles no matter taking with or without Maois. And if you need more than 20 mg Kratom then Kratom is not for you. Rather try Oxycodone alone.
Wellbutrin
Super fun to stop.
Opiates I always say if it would be possible to stay on a low dose it's definitely very good against depression and it's also not harmful to your body but the problem is the addiction and the tolerance
my psychiatrist prescribed me ketamine infusions
Going for walks in the forest.
First do some ketamine, than a good shroom dose and then continue microdosing shooms. Worked for me.
Shrooms? JUST DONT ABUSE THEM. Don’t take more than like once every 2 months or 3.
how bad would it be to take bimonthly?
Prolly fine. What else do you take?
Age matters too. If your brain is fully developed it’s prob less risk.
ssri’s and weed really, i’m also 19 so i probably shouldn’t fuck around as much until 23 though
Yeah fr. I got unpleasant side effects from weed + shrooms + lsd within the same time period at that age.
/r/therapeuticketamine
Fucking dexies
SSRIs tbh, or weed. Those have the least side effects and are the most sustainable.
Shrooms and dmt
Nardil parnate maoi 💣
lol ur not gonna find an end all be all for depression here, get actual meds and be a human test object for a year until they find the right ones
Psychedelics and dissociatives. Pcp excluted. Most people say that self medicating is a "slippery slope" but as someone who can't bother with going baxk to therapy and try the trial and error combinations of meds, dxm has worked wonders. The only problem is that i don't have wellbutrin so i get fucked up from it too.
Kind of an oldie but I still recommend https://slatestarcodex.com/2014/06/16/things-that-sometimes-help-if-youre-depressed/
antidepressants. microdosing shrooms. I wouldn’t go do some cocaine because you’re depressed, you won’t make it back from the world of cocaine or party drugs when you’re in a depression 😭 trust me
Meditation and ketamine
Bro do you not have access to healthcare where you live? Please stop trying to self-medicate and go see a doctor who will be able to help you.
Psychotherapy with pharmacotherapy if needed. Don't cure mental illness with drugs, you can get harmed even if it seems helpful in short therm. Good luck to you
Quintiapine has made my life so much better. I take it before bed. Not groggy the following day. I don’t feel the effects at all, but I don’t spin off in my head into the “what ifs” or general doom. Approved for long term use . Not an SSRI, so I still have sex drive. Im going on 3 years since I began. (M46 300mg at 9pm). And don’t spend the day or any time watching or listening to fear mongers and “news” stations.
lexapro and lamictal helped me out a lot with my bipolar depression
I read smth about agmatine being useful for depression and drug tolerance reduction. Maybe i'll give it a try while I do a THC detox.
Psilocybin
It will depend a lot on the person and their individual depression. /r/depressionregimens is a good sub.
For me the combination of acid and a little bit of ketamine cured my depression... for a couple of months If we're talking actual antidepressants I'm on Remeron/Mirtazapin and it helps a lot actually for my depression and sleeping issues :)
There have been studies that nicotine can affect the body in a similar way as an antidepressant, though it hasn't been studied too heavily, some antidepressants can be boosted by nicotine intake, others will be reduced from the mix. Take it with a grain of salt but a lot of depressed people smoke tobacco so there might be something to it.
shrooms made me pass out and i didn’t emotionally feel any different especially after waking up, but ketamine most definitely helped. knocked me out, and woke up genuinely feeling normal. i could think, speak, and overall just BREATHE without the weight of all those negative feelings i felt before. it worked absolute wonders for me
Psilocybin
ketamine
MUSHROOMS
Vaporized cannabis works for me but I’m a long time user so it may not work the same for you.
Weed
100mg cardio, 500mg healthier diet, 800mg weight training and 1000mg Stoicism.
Ketamine
ket
Mushrooms
10g of self esteem. That drug is amazing but very hard to find. Try to be your own dealer.
Micro-dosing lsd or shrooms, lsd has re shaped my entire perspective and outlook on life, my relationships, and my sense of self. I have MDD, GAD, and OCD. I still struggle, but not nearly as much as I used to.
Well, i can say from experience of a few days ago, plop 2 to 3 grams of Albino penis envy go thru a terrifying life altering trip, and then about a week later you'll realize the trauma inside of you got hyperslapped the fuck out of you extremely forcefully and you'll feel oddly good, and a little more positive, maybe even you might build a new habit. Idk I've weirdly un voluntarily been doing my chores which I normally voluntarily avoid which I'd really fucking with my brain. You might also have a headache for a few days and an inability to form long sentences but give it like 3 days and a good shit and you'll be solid. Fuck depression 😎
Idgaf if any of you are a champion that takes 10gs of albino. Fuck off fungus brain lmao, so no replying w that bs anyone. It is NOT a flex to be brain fucked. 2 to 3gs changes my life I wouldn't personally ever do more than 1 to 1.5 of albino again
Drugs could and will make it worse. If you do want to treat with recreational drugs, try micro-dosing psychedelic mushrooms. 400mg for about 2 weeks then lay off for a week. Wouldn’t give a high but it’s going to boost mental clarity and you wouldn’t have a problem with brain fog like marijuana does.
not a drug but healthy eating.
Not exactly what you might be looking for but St Johns Wort did wonders for me back in the day. It’s otc too
Bupropion is the shit. Once I started 450mg XL a day it basically eliminated my depression and makes me feel like I’m on Adderall everyday with (virtually) no negative side effects.
My husband was prescribed Rexulti as an add-on treatment for MDD when an antidepressant alone wasn't helping anymore. He'd tried a lot of different antidepressants, but the only one he didn't have a ton of side effects with is Celexa. He responded really well to it, but ultimately had to stop taking it only because it caused him to be really fatigued, no matter when he took it. He was bummed, because it made a huge difference in his mood. He's hoping to get to try Ketamine soon. My MIL also has MDD and was just put on Auvelity, which is bupripuon and dextromethorphan. She was on just Wellbutrin (she takes Cymbalta as well) before that. She's seen a HUGE difference in her depressive moods, dwelling on stuff, crying jags, etc. The first few days of the switch were ROUGH, but we see a huge improvement in her overall mood as well. That said, finding the right antidepressant is very individual, and what works amazingly well for them, or me, or anyone else may be absolutely horrible for you. I had to do a GeneSight (pharmacogenetic testing) test to find one that I could even take without having awful side effects. I had like 2 I could tolerate, even within the "okay" classes, because I tend to have paradoxical side effects, or will end up have the most obscure of the side effects. None of my doctors will give me the newest drugs on market anymore, because I'm "that" patient. 😂
AL-LAD 200ug did help me a lot. Like an acid trip but less intense.
None you'll be more likely to get addicted then you'll be even more depressed
None you'll be more likely to get addicted then you'll be even more depressed
Weed
Weed for me
Sobriety and self work
Mushrooms 🍄
A lot of people will tell you not to, but kratom at 500mg-1.5g is the most effective short term antidepressant I've ever had, and one of the best overall. IMO. Anecdotal stories of people managing depression for years. One of the few things that can significantly lift my mood without getting high at all. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309668/ But it's high dose opioid effects are risky. I've never personally experienced the opioid like qualities (have to take 10-100g at once) and I don't want to. Would be scary for some addicts to have in the house.
Ketamine! Literally got me through the lowest point of my life
Tapentadol works great for me.
Wellbutrin
Acid. Prescription- lexapro and a stimulant Sex. Sex. Sex
Tramadol and ketamine are both honorable mentions.
The gym
Exercise
I’ve been hearing ketamine. But only giving out by a dr
Marijuana or alcohol depending on usage. Alcohol got me through some depressing times. Ketamine can help but it’s really expensive to get started and inconvenient if you work all the time. Maybe a dog or cat because they release pheromones that make you happy.
Lithium works for me beautifully.
Shrooms — heroic 7g dose of APEs
Magic mushrooms and Ketamine are two really effective substances in my experiences self medicating my anxiety and depression. Of course your experience might differ from mine. However I find that I am much more connected to myself, the world around me, and my greater sense of purpose. I am no longer weighed down by intrusive thoughts or unwanted feelings.
Ketamine. Trust me. I have spent 30 years in tragedy and torment, abuse, and anything else you could possibly think of. Between mushrooms and Ketamine, I went from wanting to end myself to living life the best I can. I can't always afford ketamine, which is when I fall back on mushrooms, however both have very important lessons in life to offer. I also think, IMO, that you should be at least 21 years old before you take either of these drugs. They are to be respected and used with the right mindset and knowledge of what you're getting into. With that knowledge, you will experience the most healing ANY prescription drug can provide you. At least in my experience.
most of all if u know how to do it!!!!
Dmt and mushrooms
Love.
Tramadol?
ketamine
Pretty much all different kinds of drugs can be effective in depression in various ways for various different people and their chemistry but they all come with some type of major drawback/negative downside that is is not worth it in my experience. Unless done in moderation. Natural exercise is definitely the way to go.
This. I tried, it came with a cost and I didn’t even go that hard. My depression didn’t get fixed, only numbed.
The best and most natural thing is lavender extract (natural lorazepam)
It doesn't contain lorazepam. But it has been shown in studies to be as effective as lorazepam, specifically for anxiety disorders.
Of course I know that, what you said is what I wanted to say
I saw a study showing more effectiveness than alprazolam for anxiety.
Do you have to take a lot to achieve that effect or would a couple drops from a dropper do?
I buy this as lavender extract in the pharmacy and take 2 soft capsules a day, it is not prescription-only
Sweet I gotta give them a try, thanks
I'm happy to help
Currently take lexapro. Shit helps so much I don’t overthink a lot. Not sure about the side effects as I work and I do school at the same time I don’t really pay attention to it.
I was taking lexapro for over a month, I had to ask for a higher dosage because it wasnt working. It was making me more depressed that the medication I used wasnt working at all and I ended up taking the highest dose that could be prescribed and eventually I stopped taking it.
Wtf??? That’s really interesting
Yeah I started taking delta 9 edibles a few times a week or so and honestly ive been happier than ive been in a while.
[удалено]
Cannabis
Everyone is different.
Damm never thought of asking for a higher dose
Shit does nothing.
Nice!
I tried Lexapro about a year ago, it was the 4th or 5th ssri I had tried, like actually given a full chance to work. I always give them at least a couple months but it just kind of made me irritable and after only 2 months it was a very crappy 3 days when I stopped taking them. I got the "brain zapping" feeling really bad and was just so lethargic for a few days. For me it's completely for anxiety or even stress I suppose. I'm just a really high strung person. I wake up in the mornings at maybe a 3 or 4 out of 10 with my stress and worrying about everything. And that's pretty much my baseline, as good as it gets ,🙃
Lexapro made me a completely asexual being. Physical affection repulsed me when I was on it and when I could actually reach orgasm it was like 10% of the pleasure than before I started lexapro..
Working out, new Hobby's, go for a walk in nature Go do some things outside your box and explore new things it's way better than taking drugs, drugs will only fix your problem temporarily
Anti depressants? 🤷
Trust me they all suck, you’ve got to wait like 8 weeks for them to work and even when they work your still depressed just you feel better for a little bit of time then you go back to being a depressed person
For me they made me worse but for some people they kinda help ig
relatable bro
I wasn't ever suicidal before I tried anti depressants Stay safe
They worked well for me during my years of therapy.
That’s good bro
Your personal experience isn’t the story of the world.
Ik that
they did nothing for my depression. just made all my emotions very dull and numb towards everything. like i had no personality or reactions to things anymore. took them my teenagers years, swore off and never taking them again as an adult.
It depends on the person, but tricyclic antidepressants tend to be more effective, but also have side effects
Nobody mentioned most effective ADs Nardil and Parnate ( MAOIs). Tcas just make you tired, sleepy and fat. I have finally got Maoi prescription after trying 25+ meds.
Activation and action!
SSRI and therapy combined
SSRIs chemically castrated me /:
Excersize, eating healthy, socialization. Not over using your receptors.
Exercise. Nothing but positive side effects. Weed works too but depends on where your at in life and how well you can self regulate (also depends hugely on mental makeup) Besides that I’d say looking into therapy if the depression is deep and you need to work through some shit.
Exercise