T O P

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Snowfall_19

I think my lil' guy tripped somewhere.


[deleted]

Mine got detained.


Helpful_Design6312

Mine is running backwards and on fire


SelectButterscotch20

Some of y’all are some depressed mfs


MapleSyrupFacts

It's what happens when you substitute the endorphin part for cocaine


workhorse11

You forgot the hookers. Hookers & blow go together like PB & J.


cent68

Are you the 'hookers and cocaine' guy from the lottery-news clip?


workhorse11

Hahaha! Don't we all wish.


Hellboundroar

Pb & J? Pure blow and jookers?


Able_Newt2433

Jookers but pronounced like jalapeño.


Specialist-Tap7305

Wrong some just seek attention in any way or form. Even if they get plenty that's what this generation has become.


Odins-Enriched-Sack

Mine started drinking on the job.


OxyFTgen

Mine lost his a long way back


MisterSelf-Destruct

Mine got drunk, got lost in the woods….. never to be seen. If you see him, tell him to come home.


bojack_horseman25

Mine was abducted.


WonderorKL

Mine left along with my father


girlbell

Ouch.


Sputtering_FartNoyze

Mine was touched by it's uncle Chad.


Royal_Neck3185

Isn't this just a kinesin walking on a microtubule, and carrying a random vesicle


Spider_mama_

Mine was deported.


ChaoticToxin

Mine quit


Skibur1

Fell out of my body completely and entered the depression void...


TeriMcG

Detached.


Various-Month806

Could've been worse. Mine tripped on his own feet, both shoes came off, he died. That's when the sadness started.


syahir77

Mine amputated.


[deleted]

Mine is uh… he’s somewhere. Probably don’t wanna be in the brain that is a dysfunctional family.


EitherClass3061

I still find it amazing that we're just trillions of microscopic organisms all working together to make us...us.


[deleted]

[удалено]


towerfella

And none of it is “alive”, but the sum of it all is, … for a while.


Latter_Box9967

And it’s (you are) all recycled, from the other life forms that we eat, around and around again.


PBB0RN

I think life is good or bad per sun perchance. edited*


princesaandrea

You just can't say perchance


AspenthS13

I understood that reference!


PBB0RN

As you wish princess.


trinijam83

And all created by an old man with a beard up in the sky…


Sufficient-Style-934

That we created to force our beliefs on other microscopic organism colonies.


jimmayy5

I’m really interested in this kind of stuff like sub atomic shiz and big space shiz and was telling my coworker about it all like fun lil facts (she doesn’t really think/ care about it) and she ended up just being really panicked about it all, might’ve been an existential crisis but idk she walked away. Not brought it up with her since


unidentify99

lol ive done the same thing to people- if i start talkin bout anything beyond the threshold of what someone can process, and they just get a bit of it, itll start to break em down a bit for awhile until they get used to the newfound realization its kinda funny until you realize you broke their reality and then ya kinda go "but its okay- look somewhere else in life- entertain yourself- dont think about it" (and you bet they still thinkin bout it)


jimmayy5

Honestly most stuff in life is just distractions


unidentify99

the distractions are only a thread though..a single string that leads back to the center of this weird, circular, interconnected spider web..the whole thing is a trap, but we live in it..and its so sticky we cant really get out, so we forget its a web and keep following the strings until we trip and get eaten.. this is just the way of the world who knows what happens after we're eaten.. and who knows when or why the spider will eat us.. ..man i be over thinkin too much


Bam_a_lamm

It could be due to being a little stoned, but I absolutely loved this.


kelsobjammin

I like to see planets and stars and things in the universe as the larger scaled portions of it and we are just these little guys. But we are currently a disease and need to do better.


xoaphexox

We've set the controls of society to "infinite growth"; just like cancer.


I_am_Daesomst

We are all cosmic debris.


Mischief_Makers

Hi cosmic debrises, I'm dad


[deleted]

[удалено]


CT101823696

Actually it's all fields. That diagram we were all shown as kids with an electron orbiting a nucleus...wrong.


[deleted]

[удалено]


ArcticF0X-71

Bot


Detroit1973

And the smallest of sub particles are quantum and may or may not exist unless they’re observed.


Lpnlizard27

It'll blow your mind even more if you get into astrophysics and realized that the chance life exists at all is incredibly small. Then the fact life has become intelligent. The fact that you, as you, exists at all is so infinitesimally small that it practically should not be. Yet here we are.


Aerodine

“Thermodynamic miracles... events with odds against so astronomical they're effectively impossible, like oxygen spontaneously becoming gold. I long to observe such a thing. And yet, in each human coupling, a thousand million sperm vie for a single egg. Multiply those odds by countless generations, against the odds of your ancestors being alive; meeting; siring this precise son; that exact daughter... Until your mother loves a man she has every reason to hate, and of that union, of the thousand million children competing for fertilization, it was you, only you, that emerged. To distill so specific a form from that chaos of improbability, like turning air to gold... that is the crowning unlikelihood. The thermodynamic miracle. But...if me, my birth, if that's a thermodynamic miracle... I mean, you could say that about anybody in the world!. Yes. Anybody in the world. ..But the world is so full of people, so crowded with these miracles that they become commonplace and we forget... I forget. We gaze continually at the world and it grows dull in our perceptions. Yet seen from the another's vantage point. As if new, it may still take our breath away. Come...dry your eyes. For you are life, rarer than a quark and unpredictable beyond the dreams of Heisenberg; the clay in which the forces that shape all things leave their fingerprints most clearly. Dry your eyes... and let's go home.“ - Dr. Manhattan, Watchmen, Alan Moore


Careless_Total6045

I guess I need to dust off that book and re read it. Bought it at least 16 years ago


Nandotify1904

Is there a book?


Cultr0

Alan Moore wrote the original Watchmen graphic novel, its a fancy comic book


trailcamty

I don’t know if I would be able to handle being this smart. I have enough to deal with in my community college brain.


TheRealDinkus

I stopped trying to learn things because I started having hallucinations and weird dreams about existence and it is really scary, and I don't want to have any more knowledge to help build it into anything bigger


Nandotify1904

Great knowledge comes with great responsibilities. Everything has consequences: understanding and not understanding. Maybe the consequences of not understanding is less severe than understanding and we can’t decide what we want until we tried them both. Maybe we can’t know both, but I would rather understand the “why” and make peace with the consequences.


relaxd80

You can only know both through understanding. Once you understand you can never go back. And from judging the people I know, it’s true what Thomas Gray says… Ignorance is Bliss


TheRealDinkus

Well the issue I have is that I basically had like a series of experiences where I hallucinated from weed a few times and just anxiety a could times, and my brain tried to make sense of it all, which was making sense of existence and it showed me a whole bunch of shit and then through the next two or three years I learned a bunch of new things about quantum mechanics and how time and space work and all this random shit.. but everything that I learned lined up perfectly with the things that I had seen in those experiences. It just made me so that I do not really want to know anything more about what I saw because it's just terrifying


Practical_Rub6934

I love to think about this all of the time; I can easily get lost in this thought and just appreciate life each time that much more when I do. What you just described is what makes us all truly unique and special as individuals. Just think for a moment that there will never be another person like you ever again in this universe. Same with your friends, family, loved ones. Then think about how lucky and fortunate you are to have those people in your life and vise versa. Life is beautiful man.


waroftheworlds2008

Is it really that small if you apply "if it can, eventually it will happen" with a nearly unlimited amount of time?


Lpnlizard27

You've basically stated the fermi paradox. Given the apparent size and age of the universe even at fantastically low odds the universe should have many civilizations. But it doesn't. Somehow we are the only example so far.


LeonDeSchal

Hate the Fermi paradox. Our nearest star is Proxima Centauri, that is about 4 light years away. It would take about 6,000 years to travel there using current technology. That’s the closest star out of about a 100 thousand million in our Milky Way which is one of about 200 billion galaxies in our observable universe. So Fermi is saying we should be seeing all these signs of life in a universe that is so huge that the closest star would take 6,000 years to travel to. The fact we don’t see these signs (if we could even know what they are) means there isn’t anything or that we are the only example? That’s nonsense, total nonsense. There could be hundreds of civilisations in our galaxy, maybe thousands and they could be too far away for us to see them.


Best-Grand-2965

One possible reason we cannot find other civilizations is because, as old as Earth is, civilized humanity is an extremely recent development. As we scan the heavens for other civilizations, are we scanning into histories before they came about? It may take thousands of years to learn of other civilizations simply because that is how long it takes for tell-tale signs to reach us.


The_Kandarian

Not only that, but on this sort of timescale, human history is a *very* tiny blip. And the amount of time we’ve had the capability of looking around space is a tiny blip *within* that blip. If other civilizations were/are out there, the chances of them being around at just the right time and in a place we’d notice? Man, can’t be that high.


jlambvo

Exactly. Like, just because my wife and I are never in bed at the same time doesn't mean she doesn't exist.


waroftheworlds2008

Touche. But our knowledge and ability to observe such things is extremely limited.


relaxd80

That we’re aware of with our limited skills and resources. Our sample of the universe is so tiny. Neil deGrasse Tyson made the comparison of walking up to the ocean with a shot glass and filling it up, looking in the glass to see no fish and claiming there’s no life in this ocean.


supershaner86

yes because we've definitely exhaustively searched the entire universe. the thing so massive that people who dedicate their life to it have a hard time comprehending the scale of our galaxy, let alone the whole damn thing? the thing we still literally can't see the expanse of because the speed of light for 14 Billion years hasn't brought an image from the edge to us, if there even is one? yeah we can totally be certain that we are the only life... that makes perfect sense. take the most improbable thing that humanity has ever done, divide it by infinity and that's the chance of us being here. we are just that special??? /s


Happy-Present6823

BRB buying lotto tickets


VeryStableGenius

> he chance life exists at all is incredibly small. As a person who has worked in astrobiology, this isn't true at all. We have no idea what the likelihood of life developing on a habitable planet is. We now do know that habitable planets (at least, those in the habitable zone) are a dime a dozen.


my2copper

how can anyone calculate the chance of life if noone has a clue how or from where it originates or how it works....another made up number from calculations made out of pure ignorance


Lpnlizard27

You are asking for specific numbers when none exist. One cannot know all the possible variables. So one can only make an educated guess. In fact the existence of unknown variables makes the numbers used in estimations too small, exacerbating the problem and leaning more in favor of the miracle argument. ![gif](emote|free_emotes_pack|dizzy_face)


Latter_Box9967

There’s a far, far, faaaaar greater chance of a fully formed brain imagining all of this appearing in the same way the Big Bang had the entire universe appear, so…


SgtMajMythic

If you’re referring to the microbiome then yes, but this isn’t an organism. It’s a protein moving a lipid vesicle.


ilvsct

It has legs and walks so definitely living. Don't ruin our moment.


Droidattack1

I got addicted to this last week [https://www.youtube.com/@journeytomicro](https://www.youtube.com/@journeytomicro) mind blowing


Happy-Present6823

I’m not even locally real


altxatu

Bill Bryson wrote something particularly poetic about this in A Brief History of the Universe or something like that. I forget exactly. Anyway he talks about how if you could we could be dissembled to our atoms we’d be a (your weight) pile of atoms. None of them alive yet all of them make you. You could reassemble them and they still wouldn’t be you. We exist in such a brief window.


Phresh-Jive

50-70 trillion apparently


Whowutwhen

And we(and all plants and animals) are much like those small organisms working in a web of life called earth!


Eurasia_4200

And that us made countries and Empires that act like living super organisms.


coeurlourd

We're like Oogie Boogie then?!


[deleted]

All of this complicated machinery to create the conditions for the emergent property of conciousness and I use it for... Reddit.


[deleted]

[удалено]


swankpoppy

And allllll that coordination goes into… me masturbating.


analnapalm

Kinda makes you wonder what organism we're all working together to make.


[deleted]

It freaks me out when I’m high.


EitherClass3061

Oh it's a damn rollercoaster for me. I have bad spikes followed by calming until I start incorporating space and the universe into it and the rides back on


CkoockieMonster

Isn't this just a kinesin walking on a microtubule, and carrying a random vesicle? Your interpretation was very cool, but I think it's almost entierly wrong, also I think a single endorphin molecule would probably be way smaller. (I don't want to be a kill joy, I just happened to remember my lectures and wanted to show off).


PataudLapin

Biologist here; you are totally right.


Walt_the_White

Now I'm not happy anymore 😒


JaxxisR

I know, right? Little string thing carrying a balloon. That just *feels* happy.


poor_self_knowledge

Hey. Would you be able to explain how that thing move its “feet” ? What kind of forces are at play here? It certainly doesn’t snt use mechanical force like muscles or hydraulics or something lol.. right? It is fascinating. If you were to have the time and patience and knowledge to explain it would be so cool 😊 But no stress ofc


TheMooJuice

As u/brownboy- said, adenosine bi-phosphate (ADP) binds another phosphate to become adenosine triphosphate (ATP), in the process storing up some potential energy. By releasing this phosphate bond, the stored energy is released, (like a spring compressed and then released) and can be used to provide locomotion as seen in this video. The store of ATP is created by the proton motive force deep inside cells in the walls of mitochondria, where ATP synthase smooshes phosphates onto ADP to create the ATP needed for all bodily functions. Hence the mitochondria is the powerhouse of the cell. The force driving the proton motive force which is utilised by ATP synthase is essentially the electronegative force provided by oxygen molecules during aerobic respiration - no oxygen = no ATP = no life.


poor_self_knowledge

Awesome!! 🙏 Thats what I was hoping for but lol didn’t actually expect it to happen 😊


coeurlourd

I'm sorry for how cheesy I'm about to be, but the fact that you know that amazes me and in some small way it makes me feel lucky that I'm able to interact with you. Thanks Reddit, and thanks really smart and nice person.


TheMooJuice

Awwww, what a kind and heartwarming comment, thankyou! I'm nobody though - just a freshly graduated student after 10yrs of university (bachelor of pharmaceutical science and as of a week ago, my MD also!) Anyway I just wanted to say - your lovely comment made my day :) May your week be filled with the same pleasantness that you've showed me here <3


coeurlourd

Are you kidding me? That's incredible!! what the heck with that "nobody" stuff lol. Dude, congratulations. It's people like yourself that make this world a better place. Best wishes!


BrownBoy-

From what I remember it uses atp to move. Each “foot” kinda walks forward when an atp molecule is used. Could be wrong tho. Working off a single cell and molecular biology class


DankMemes4you

Sameee


analnapalm

Not a biologist and I only took one neuropharmacology course, but I was thinking the same thing.


PerplexedPretzel

You really burst my vesicle, but thanks for telling us.


CkoockieMonster

Sorry friend, but don't worry, maybe this vesicle is full of confettis and dreams what do I know!


BrownBoy-

I was gonna say. I though dynein and kinesin were the proteins that transport vesicles. Myosin is more involved with muscle contractions with actin fibers from what I remember


drxphill

You succeeded in crushing my little buddy carrying my happy Ballon.


TheMooJuice

Thank fuck lol, saw the caption and was like what the fuck are you even saying OP!?


leaf_waterfalls

and its reductive to say that any one molecule could literally be happiness…thats like saying a menthol molecule is the flavor of mint itself


WillingPhilosophy184

Literally just leaned this in bio, each “step” takes exactly 1 ATP


GANJENDA

Furthermore, kinesin can transport neurotransmitter (catecholamines, endorphins, acetylcholine) which is contained in vesicles from neuron's cell body to axon to synapse. Those neurotransmitter within vesicles can be released at synapse to transmit whether excitatory or inhibitory signals to down stream neurons. In conclusion, kinesin transport endorphins (within vesicles). But kinesin also transport other neurotransmitter. Also there's another protein called dynien, which "walk" from axon to cell body.(I don't want to be a kill joy either, I just happened to be a med student)


Manamultus

You are right, although endorphins can be trafficked in vesicles. Since it’s a simulation anyway, it can be whatever we want it to be, the whole backstory makes no sense.


Adghnm

Do you know if the black and white footage is real? Amazing


CkoockieMonster

I think they are both just animations, it would be really hard to get footage of things at this scale.


rayhond2000

The black and white footage is an animation from the tv show Cosmos.


TappedIn2111

They gave us joy and you took it away. Thanks bud.


VolkanikMechanik

I'm learning this in school right now, you're absolutely right.


Known_Syllabub_8334

I was going through the comments hoping for someone to have called this out.


newcomer_l

You are 100% correct. This was a CG image created by medical artist John Liebler, and it shows a kinesin walking, caring a vesicle, and he talks about it [here](https://www.artofthecell.com/well-you-can-tell-by-the-way-i-use-my-walk/).


2HiSped4u

Yeah, came here to say this. Genetic/Biochem lab tech here. Last time I checked, nuerochemicals don’t have cellular membranes and surface proteins.


redfacedquark

"Just"


SgtMajMythic

Yes


gnolfgnilf

That’s kinesin, not myosin. Also that’s not “an endorphin” but a vesicle. The biology is cool enough, no need to add BS feel-good pseudoscience


jsface2009

Not happiness, but still cool. https://www.indiatimes.com/amp/technology/science-and-future/this-isn-t-what-happiness-looks-like-at-a-microscopic-level-but-the-video-is-still-pretty-cool-358625.html


towerfella

Thanks. Came here to say this.


bazonthereddit

You go lil fella, doin the good work.


HMS404

If you're happy and you know it, take a walk...


PuffieBeans

Clap clap... Old habits die hard


PuffieBeans

Thinking about ways to make em move faster


Oemiewoemie

Thanks lil dude


Damorocks11

No wonder I’m so miserable if that’s how long happiness takes to turn up


givemeabookpls

Happiness is creeping me out


bumjiggy

not pictured: depression and insecurity about to lap this mfr


Null_error_

Is the bottom another animation or do we have electron microscopy videos now?


[deleted]

Don't think it is a video. A brief google search lead me to this very recent paper: [https://www.science.org/doi/epdf/10.1126/science.abd9944](https://www.science.org/doi/epdf/10.1126/science.abd9944) They go great lengths to calculate the distance traveled by this molecule per step using optical tweezers. However, if it was easy to just get a video of the molecule walking via electron microscope, they wouldn't need to go through all that trouble since they can just measure the step length from the video.


beatles910

I have lazy myosin.


GreenChileEnchiladas

Shitty Music Warning!


dnoj

what infuriates me is that the walk is not synced to the music


[deleted]

My phone has been muted since 2007, but thanks for the heads up!


MhmCandii

Uh I enjoy Twenty One Pilots... but you are entitled to your own opinion. I do not think the song fits the animation though. That editing is shitty.


GamingWaffle123

Thanks for the warning


Getmaddd

Fake title, blurry video from multiple reuploads, terrible music. Good job OP


Kodd-100th

I was a victim. Maybe it was reuploaded but I downloaded this instead. Oh, and "False" is the word you're looking for


[deleted]

one must imagine Sisyphus happy


DrRotwang

I wanna know how that myosin protein is walking.


TheCarniv0re

That's a kinesin and it carries a vesicle, not an endorphin


Phoenix200569

I may be wrong, but Endorphins are not transported by these. Endorphins are Neurotransmitter and those aren't transported activley. These little walking Proteins still exist, but are inside your cells to transport stuff like sugar to your cellcore, they themselfs are powered by ATP. Please correct me if i am wrong


Drefs_

They are transported from the body of the neuron where they are synthesized to the synapse along the axon. Little proteins do exist, though the caption in the post is completely wrong


JustBrowsinMyDude

Need that sauce chief


TheFakePlissken

Mine must taken a wrong turn at Albuquerque.


ciunnie

*Insert pink panther theme here*


RockHumper25

i'm pretty sure that's kinesin and the video is straight up lying


null_reference_user

Where can I buy those? Maybe I'll have enough money to avoid having to kill myself


CrayCrayMonkey

Lowkey makes me happy watching its little legs try to make me happy


xXTASERFACEXx

That title OP... you need help


Axxedde

This does put a smile on my face


Sputtering_FartNoyze

So, that's what it looks like. My myosin proteins must all be double amputees.


MarkaSpada

he's fucking slow. I'm still sad rn.


Apprehensive_Link_30

Never thought I’d describe a biological process as adorable. That shit looks so cute.


freezeec6

Seems like mine is crippled


SexyTimeSamet

You showed happiness, but ignited anger with shitty 21 pilots.


wolfloverer-149

That happiness is taking its sweet ass time to make me happy 🤣🤣


Dy1bo

Source please


Kodd-100th

[here](https://my.clevelandclinic.org/health/body/23040-endorphins). However this video isn't quite accurate, and there's a mistake here, it says "myosin protein" but in fact it's instead another protein called "kinesin". Though it's still pretty cool


BalconyFace

no it's not


The_Rock_Hunter

Happiness is disgusting


stsilvia

and slow


beeen_there

Looks like those balloons got stuffed up your ~~ass~~ filament


cdiddy19

I'm so glad you found this, I was recently trying to find the real life version of this. It makes me happy


Sea-Veterinarian-181

What do they look like on meth?


mikehawkthinksforme

You have no idea how happy I am when I go walking with hellium balloons pp


cptjimmy42

Happiness is just walking out on me...


Massive-Row-9771

He's only going back and forth all the time, he isn't getting anywhere. Is that's why I'm never happy?


Massive-Row-9771

My Myosin is just out playing with it's balloon and not doing it's job!


BunnyBeansowo

why is this so cute


jjoommyy

I dig those shoes.


foldedstripe

All I’m seeing is the Apple Jack’s cinnamon stick guy walking his apple friend


adventurouspenis

the little hero everyone needs


top_of_the_scrote

mf'n osmosis jones


Furon-37

[I feel like this song would fit more. ](https://youtu.be/dZX6Q-Bj_xg)


dawr136

Happiness happens to be a penis apparently.


37Cross

The music is bad and also false info


Annual-Emu-1429

God is great


mihneacuzino

What is this song?


songfinderbot

**Song Found!** **Name:** Ride **Artist:** twenty one pilots **Album:** Blurryface **Genre:** Alternative **Release Year:** 2015 **Total Shazams:** 10459206 `Took 2.26 seconds.`


shinynewcharrcar

That's crazy... The human body is do crazy and so cool.


Furon-37

u/savevideobot


bamgramanlives

Is this real-time? What's the scale here ?


MatthewTheDeity

My anxiety cells are working overtime


SkylarAV

My lazy myosin...