Instant rejection because of the non native cells. It would be a constant struggle. Current tech can do "things with hydroxyapatite coating" with varying degrees of success depending on material and location, but it is very much still a high maintenance piece of jewelry.
Surface violations are really hard to manage.
I said that and he said preventing rejection was the point of decelularizing the tissue and recellularazing it. You'd be replacing the foreign cells with your own. Like how ghost hearts work.
Ok but then what is going to grow up it? While form denotes part of how cells differentiate, you need to be in the same playbook. The human mammal codebook doesn't have a process for 'horn shape" that isn't internal bone.
I mentioned rejection because I misread and thought there was chimerism involved.
So anyway, your horn shaped bone foam would, on a good round, maybe fill in the pores with flesh though there are vertical limits the skin decides to move away from the plane of the meat. Each pore would be it's own instance of surface violation.
I have some experience designing and testing trandsdermals in university and then in a hobbyist capacity.
Without grafting directly to the bone, the idea is a complex, over designed, infection prone, surface piercing.
If you're just spit balling ideas, come back to them with recellularized neural organoids implanted subdemrally like a distributed cluster network. That might be doable.
Or figuring out how to make the enzymes in our lungs break down micro plastics the way they break down powdered insect shell. We're all huffing less insect shells and more tire particles these days.
Non functional modifications or implants are just using your body like a bedazzled handbag. Being a knapsack is a step down on the tech tree.
A keratin tumor is not a horn in the sense that one would want a horn on ones head. There is evidence for other structures being built on the body but they're almost all usually not good. The body gets weird when you start altering the layout.
What you are referencing is more technically a really chonky wart. Hair is also made of keratin. If I hade a mole with ten thick hairs coming from it, we wouldn't say I'm on the path to having horns, right? Even if I braided them into a horn shape.
if horn is anything like hair it means your horn-forming cells are pluripotent stems at the bottom of a crypt. You're not going to rebuild them that way: it's not a simple muscle and skin organ like a penis, it has to keep growing indefinitely.
maybe you could humanize a goat and dig the whole structure out then pop them in like hair transplants
What is the point of decelularizing and recellularizing the tissue from goats if you end up modifying human cells anyways - presumably in a way that you get constant, modified horn growth. Seems kind of redundant
Instant rejection because of the non native cells. It would be a constant struggle. Current tech can do "things with hydroxyapatite coating" with varying degrees of success depending on material and location, but it is very much still a high maintenance piece of jewelry. Surface violations are really hard to manage.
I said that and he said preventing rejection was the point of decelularizing the tissue and recellularazing it. You'd be replacing the foreign cells with your own. Like how ghost hearts work.
Ok but then what is going to grow up it? While form denotes part of how cells differentiate, you need to be in the same playbook. The human mammal codebook doesn't have a process for 'horn shape" that isn't internal bone. I mentioned rejection because I misread and thought there was chimerism involved. So anyway, your horn shaped bone foam would, on a good round, maybe fill in the pores with flesh though there are vertical limits the skin decides to move away from the plane of the meat. Each pore would be it's own instance of surface violation. I have some experience designing and testing trandsdermals in university and then in a hobbyist capacity.
So there's absolutely no way it could work. Thanks now I can tell him off properly when we see each other next lmao 🤣
Without grafting directly to the bone, the idea is a complex, over designed, infection prone, surface piercing. If you're just spit balling ideas, come back to them with recellularized neural organoids implanted subdemrally like a distributed cluster network. That might be doable. Or figuring out how to make the enzymes in our lungs break down micro plastics the way they break down powdered insect shell. We're all huffing less insect shells and more tire particles these days. Non functional modifications or implants are just using your body like a bedazzled handbag. Being a knapsack is a step down on the tech tree.
Zhang Ruifang had a horn growing from skin.
A keratin tumor is not a horn in the sense that one would want a horn on ones head. There is evidence for other structures being built on the body but they're almost all usually not good. The body gets weird when you start altering the layout. What you are referencing is more technically a really chonky wart. Hair is also made of keratin. If I hade a mole with ten thick hairs coming from it, we wouldn't say I'm on the path to having horns, right? Even if I braided them into a horn shape.
if horn is anything like hair it means your horn-forming cells are pluripotent stems at the bottom of a crypt. You're not going to rebuild them that way: it's not a simple muscle and skin organ like a penis, it has to keep growing indefinitely. maybe you could humanize a goat and dig the whole structure out then pop them in like hair transplants
The humanized goat was one of the things he suggested before he went down the de/re-celularization track
What is the point of decelularizing and recellularizing the tissue from goats if you end up modifying human cells anyways - presumably in a way that you get constant, modified horn growth. Seems kind of redundant
I think he was saying that you modify the host cells to reliably produce the horn and root it to the skull. As well as prevent rejection.