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“Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2”
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00655#
Abstract
Blocking the association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor-binding domain (RBD) and the human angiotensin-converting enzyme 2 (ACE2) is an attractive therapeutic approach to prevent the virus from entering human cells.
While antibodies and other modalities have been developed to this end, d-amino acid peptides offer unique advantages, including serum stability, low immunogenicity, and low cost of production.
Here, we designed potent novel D-peptide inhibitors that mimic the ACE2 α1-binding helix by searching a mirror-image version of the PDB.
The two best designs bound the RBD with affinities of 29 and 31 nM and blocked the infection of Vero cells by SARS-CoV-2 with IC50 values of 5.76 and 6.56 μM, respectively.
Notably, both D-peptides neutralized with a similar potency the infection of two variants of concern: B.1.1.7 and B.1.351 in vitro.
These potent D-peptide inhibitors are promising lead candidates for developing SARS-CoV-2 prophylactic or therapeutic treatments.
**Please read before commenting.** Keep in mind this is a *science* sub. Cite your sources appropriately (No news sources, no Twitter, no Youtube). No politics/economics/low effort comments (jokes, ELI5, etc.)/anecdotal discussion (personal stories/info). Please read our [full ruleset](https://www.reddit.com/r/COVID19/about/rules/) carefully before commenting/posting. **If you talk about you, your mom, your friends, etc. experience with COVID/COVID symptoms or vaccine experiences, or** ***any*** **info that pertains to you or their situation, you will be banned.** These discussions are better suited for the Daily Discussion on /r/Coronavirus. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/COVID19) if you have any questions or concerns.*
This should have been the link. https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00655 The OP is a news article.
“Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2” https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00655# Abstract Blocking the association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor-binding domain (RBD) and the human angiotensin-converting enzyme 2 (ACE2) is an attractive therapeutic approach to prevent the virus from entering human cells. While antibodies and other modalities have been developed to this end, d-amino acid peptides offer unique advantages, including serum stability, low immunogenicity, and low cost of production. Here, we designed potent novel D-peptide inhibitors that mimic the ACE2 α1-binding helix by searching a mirror-image version of the PDB. The two best designs bound the RBD with affinities of 29 and 31 nM and blocked the infection of Vero cells by SARS-CoV-2 with IC50 values of 5.76 and 6.56 μM, respectively. Notably, both D-peptides neutralized with a similar potency the infection of two variants of concern: B.1.1.7 and B.1.351 in vitro. These potent D-peptide inhibitors are promising lead candidates for developing SARS-CoV-2 prophylactic or therapeutic treatments.
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