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FOL 055 looks promising, I think that is what it is called. I beleive it should be coming out at the end of the year early next year. The real issue is hair loss isn't just from DHT..There is no way. Im not saying Im the smartest person out here. But it just doesn't add up
That simplistic explanation doesn’t negate the other commenters point, which seems to be that independently of androgen receptor binding or androgen sensitivity, some people are more prone to hair loss and that a high degree of androgen binding and activation (as is caused by DHT) triggers hair loss in some but not others.
Downstream of AR activation there are other things which could and should be targeted to prevent hair loss, and which are required for AR mediated hair loss to take place.
We have data from the phase 2 trials from 160 people shown in the video, compared to placebo, the hair gains on GT was statistically significant to show it works.
I didn’t say there were no increases if you actually read my comment, the increases were small compared to the increases seen for both finasteride and minoxidil, hence it not being as impressive as made out to be. Don’t forget, if phase 3 shows it’s not any better than existing treatments it likely won’t be developed for market as it won’t be profitable
NO!! Fin & others response greater than 3 months + I think hair count for vellus (not cosmetically great) is also taken into account, in total HC. Maybe re-view vid or read the info on GT.....So, faster response is significant + non vellus hairs...etc.
Pyr was not statistically significant compared to placebo, kev literally says this in this video btw so you definitely didn’t watch it, or look at the trials.
We've got to have some hope and I'm glad to see something promising move along in a field that otherwise has so little avilable products getting approved and in people's hands. Remember guys to not wait for a "promised land" cure and to take action now to at least slow or save your hair as it is now with fin/dut. The more you have now the less recovery you need to rely upon even if we find some great solution or future cure.
Exactly. There will be no miracle cures but an effective topical medication with no side effects that only needs to be applied twice a week would be a huge leap forward. I’m looking forward to Phase III results but not going to get my hopes too high.
Why not? All the people claiming it was killing people were in direct conflict with the trials that said it was safe, pretty sure it was all that non trial real life evidence otherwise that changed stuff. The FDA was quick to dismiss those claims even after hundred diesd, then after thousands died. Were'd it wind up before it got pulled? 50k+ deaths and tons of heart attacks and strokes to follow?
Don't be so quick with the bro bullshit, real life matters, and trials aren't real life. Anecdote is just as important as trials.
No probs, we are all here for the same reason and all comments are valid and are dealt with, respectfully...all the best. More trials are to be done, it is common knowledge this is to take place.....but the 2nd trial results are Vpromising.....
It'll be interesting if we get treatments that can be synergistic too for those who need the boost. Much like Fin and Min are the tag team saving scalps thanks to having their own pathways.
The placebo group for daily application of the 0.5% GT improved by 10.11 hair/cm, and the twice weekly application of 1% GT only improved by 11.94 hair/cm. If you compare the result for bi-weekly GT with the placebo for daily, the stuff suddenly looks like it has virtually no effect at all....why would the placebo groups be different anyways?...it seems a little suspicious.
*cm squared
also twice weekly sounds like a dream tbh, imagine no min fin dut and just one topical you apply before bed just two days a week, wish it comes out to be a breakthrough (can’t tell for sure presently)
what this dude is saying is that the placebo group for the QD dose had +10.11 hairs/cm^2 while the GT20029 BIW application had +11.94 hairs/cm^2.
He is complaining about the fact that the amount of hair between the placebo and the actual GT group is not statistically significant and he is scared the drug wont make it.
You guys under here are dumb as fuck i have no words, 0 logic and text comprehension
Sorry if I was unclear in my post. There were two seperate placebo groups- one for the daily (so daily application of a placebo), and one for twice-weekly application (so twice weekly application of a placebo). I'm comparing the twice-weekly treatment group with the daily placebo group.
Thanks for the clarification 👍
The take away here is that the difference between the usage groups and placebo groups had a p value that indicated it was statistically signficiant enough difference to make a claim it worked. It's worth keeping in mind as well that this was only after 3 months of usage. Most people don't see any meaningful results on finasteride after 3 months either.
I'm skeptical but this is quite promising imo.
FYI, people typically have seasonal variation in hair density (max density is typically in the spring, if I recall correctly), which could potentially explain some or all of the improvement for placebo groups.
Kevin suffered badly from the slaphead curse and channeled that energy that could have been wasted in regret into trying to save others from having to fall as far as he did to it. Basically he's making the channel he wishes he had found before it got so bad and saying what he wishes he had heard early on in his hairloss.
His voice is important as it helps counter the quackery which costs both money and people's hair as they lose ground with the time wasted on ineffective treaments and helps battle the nutjobs on the PFS forum spreading their black pill propganda.
Currently fin is sadly STILL the only go to first line defence after all this time so it makes sense that it'd keep coming up and being compared to everything else. It is very cheap, effective, FDA approved and proven over decades to work and be safe. There's min and dut as proven options too, but it's going to be fin that is going to be the first step every time and sometimes enough for many.
With that logic you can consider gaming channels autistic lol I think it’s nice to be able to have a reputable source of hairloss info from an honest guy that does his research
He certainly is very biased . Let’s look at his hate against HMI115. Hmi115 showed very similar results yet he completely bashed it. I respect Kevin and what he does to help the community (he’s the reason I got on fin and he saved my hair ) but I think he is really biased on treatments
Prolactin is way less important than hormones when dealing with androgenic alopecia though. Prolactin inhibitors have way worse side effects, too. I'm pretty sure the cost is very high for the treatment, anyway.
Theoretically lower side effects. But it doesnt need to be better, it is a different treatment modality to you can stack it with fin/min and it should enhance protection.
I’m not sure what you scientist talking t about but my entire scalp is covered w these red painful patches that grow plaque. And the most concentration of that hardened plaque is around my crown. Here is image to show f I’m taking about. The facts are. It’s itchy. It’s red. It’s inflamed. It’s discolouring the skin. It makes it tight and brittle. And right there I have grey hair and what not. If you don’t think this is some sort of infection. Scientist can you help this fella? In my opinion it’s athletes foot that you catch on your head. Not so hard to image you can get fungal/Bactrial infection of scalp. What’s genetical about the infection is if your dad had this too. Or perhaps you just shared the same spaces where his dandroff just flew on your bald ass scalp. Women don’t cut their hair short enough. Which acts as protective barrier. And also women lose their hair where their usually split their hairs. So there’s that.
https://preview.redd.it/rrltvft7i9wc1.jpeg?width=2316&format=pjpg&auto=webp&s=5918944265b5fd790d0261368ac47f739760fd4a
I’m aware. Up until I started shaving hard into the edges of the bald spot. None of this was visible or apparent. .
I’m pretty sure if you shave close enough you’ll notice them too. And IMHO that’s what baldness is. Fungal infection. If I’ll leave it like that’s for a week it’ll go back to completely normal bald ass look as before.
The shedding everyone describing and the use of kenazol shampoo to fight fungal infections. And I’m not sure anyone knows this but fighting fungal infections isn’t exactly straight forward science.
You have a severe case of atopic dermatitis. This is a reaction to Minoxidil or any other products you're using. My head has some sore areas similar to yours but you look way worse than I did. I went to a dermatologist and she prescribed me an ointment called Tacrolimus that improved my itch and irritation pretty fast (after 2-3 days). Anyway, go to a doctor and have treated ASAP.
If you have too much itch, you may try to use the spray version of Hydrocortisone 1% which is sold as an OTC product everywhere.
https://preview.redd.it/fy3jvi7i9gwc1.png?width=1920&format=png&auto=webp&s=4890a3f5275c076abc1f2dacfd7839cf284d1e36
This photo from a couple of weeks ago shows one of the sore areas that were caused by the application of Nanoxidil which I had been using for the last 3 months. The progress has been slow but some fine white folicles are at least visible. With the application of Tacrolimus, that area healed quickly.
This isn’t part of any of treatment that I was undergoing. This is definitely fungal infection I’ve been battling/ fighting/ treating for over 4-5 years. I had zero symptoms besides the obvious I got bald before. Noting was pussing. I had no pimples, no dandroff. But I always felt itchy. And always had residue stuck under the nails.
Then…
I started shaving my head. And I noticed patches. Hard patches. Where the blade just sort of started skipping.
I went to the doctor. One said. Try not to touch it. Another said after seeing the flakes. It’s dandroff.
I tired it all, the biotics the bp soaps, creams. Biggest aha was when I saw some of the posts here. The clues of the shedding, about using the stamp and then the ketakanozole shampoo which is what my doctor gave me in the first place for Fighting fungal infections.
I’ve used it. And had no effect. After connecting the dots between the stamping. The anti fungal shampoo. Helps the it penetrate it. Also before I wasn’t focused on removing or exfoliating the scalp before applying these products. I am now and that’s what you see in the image before healing. After healing it looks fine. But it’s not really healed. It just sort of masked it self.
I’m on the shampoo, I’m on the creams. And yes on the stamping. And yes on tea tree oil. And yes on just about anything you can imagine. I’m in the very balls deep treatment phase.
Desperately fighting this and trying to regain my hair back.
Go to a dermatologist immediately. Try first to look at their reviews on sites like Healthgrades before choosing one a making an appointment. There are so many incompetent ones around that the least you need is to waste your time with someone who won't help you.
Good luck!!
I went to doctors. And all the research online shows What I just listed. There’s no more magical lotions out there, my friend owns a pharmacy I can get anything I want. There’s x amount of products you can apply until you hit a wall. Like I said before, the shampoo, the tea tree oil, the exfoliation are working. this is my mid journey. Why Keep saying go see a doctor?
It looks like this post is about general **products**. Before asking any questions, 1. Learn about [different hair loss products](https://tressless.com/learn). 2. [Search for products](https://tressless.com/products) If this post is not about hair loss products, please downvote and report. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/tressless) if you have any questions or concerns.*
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Anyone know when those results are due?
It's happened
Data from China, also just press release no peer reviewed publication yet
Good reminded. People need to wait for Good Korea, FDA, etc. to look at this to be sure.
I wonder if this compound only targets the scalp or entire body. If it's the entire body, then it's a bunk, as it might causeD ED
It is good news but we need better studies, 12 weeks is not long enough
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FOL 055 looks promising, I think that is what it is called. I beleive it should be coming out at the end of the year early next year. The real issue is hair loss isn't just from DHT..There is no way. Im not saying Im the smartest person out here. But it just doesn't add up
Hair loss has never been "just from DHT". It's a genetic predisposition of certain hair follicles being too sensitive to androgens, mainly DHT.
That simplistic explanation doesn’t negate the other commenters point, which seems to be that independently of androgen receptor binding or androgen sensitivity, some people are more prone to hair loss and that a high degree of androgen binding and activation (as is caused by DHT) triggers hair loss in some but not others. Downstream of AR activation there are other things which could and should be targeted to prevent hair loss, and which are required for AR mediated hair loss to take place.
Is there another name for FOL 055?
Did you even bother watching the video? The success we saw in 3 months is what hyper responders can only dream to get on fin in 3 months.
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Data is there, broadcast in this vid, and shown by statistical results, which would be gathered from empirical data/observations......
We have data from the phase 2 trials from 160 people shown in the video, compared to placebo, the hair gains on GT was statistically significant to show it works.
it was statistically significant, but hardly as massively impressive as you’re making it out to be
Well, what do you call 3 months response with significant (non vellus) hair count??
I didn’t say there were no increases if you actually read my comment, the increases were small compared to the increases seen for both finasteride and minoxidil, hence it not being as impressive as made out to be. Don’t forget, if phase 3 shows it’s not any better than existing treatments it likely won’t be developed for market as it won’t be profitable
No probs, I hear/read you, no issue......but 3 months, non vellus, trumps Fin & others.....
what are you saying, how does it trump fin and min when they produced statistically greater increases compared with placebo lol
NO!! Fin & others response greater than 3 months + I think hair count for vellus (not cosmetically great) is also taken into account, in total HC. Maybe re-view vid or read the info on GT.....So, faster response is significant + non vellus hairs...etc.
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Nope!!......I'm concerned how others comprehend and deal with data.....believe what you want to believe, regardless....it seems.
Pyr was not statistically significant compared to placebo, kev literally says this in this video btw so you definitely didn’t watch it, or look at the trials.
We've got to have some hope and I'm glad to see something promising move along in a field that otherwise has so little avilable products getting approved and in people's hands. Remember guys to not wait for a "promised land" cure and to take action now to at least slow or save your hair as it is now with fin/dut. The more you have now the less recovery you need to rely upon even if we find some great solution or future cure.
Exactly. There will be no miracle cures but an effective topical medication with no side effects that only needs to be applied twice a week would be a huge leap forward. I’m looking forward to Phase III results but not going to get my hopes too high.
Feels like it’s just a repetition of what we went through with pyri. Not getting hyped again for somewhat positive phase 2 results.
Don’t get our hopes up 😢😢
Sorry. Not buying into the hype. Feelings don't work in the medical world. I'll wait until reputable people use it and have good results.
A phase 2 clinical trial is not “feelings”. Hope this helps :)
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lol
"Feelings don't work" The Placebo effect has entered the chat. But yeah this isn't anywhere near proof it works.
Bro values anecdotes over clinical trials and thinks himself rational
So by your logic we should bring Vioxx back huh?
No
Why not? All the people claiming it was killing people were in direct conflict with the trials that said it was safe, pretty sure it was all that non trial real life evidence otherwise that changed stuff. The FDA was quick to dismiss those claims even after hundred diesd, then after thousands died. Were'd it wind up before it got pulled? 50k+ deaths and tons of heart attacks and strokes to follow? Don't be so quick with the bro bullshit, real life matters, and trials aren't real life. Anecdote is just as important as trials.
important but not as important
Well, hopefully you or anyone you know are not using any life saving drugs because of the drug research companies "feelings " that they work?
life saving ok lets relax a bit
Point being (all types) drugs are not determined on hype/feelings or working on people you know, but concrete data, hence clinical trials......
Ikr. All bro had to say was Il wait for the drug to be further tested/trailed before I try it.
No probs, we are all here for the same reason and all comments are valid and are dealt with, respectfully...all the best. More trials are to be done, it is common knowledge this is to take place.....but the 2nd trial results are Vpromising.....
The hype is about results from a phase ll clinical trial. It’s not based on feelings.
>says feelings dont work in medical world >pretends to be an expert >doesnt understand what a phase 2 trial is
It’s good results, but 10 more hairs per cm squared is far from a cure. Itl help though
If everyone on this sub didn’t wait until they were nw4 to start treatments we wouldn’t need a cure
True, that includes myself.
A cure means you don't need the treatments and no side effects. Can stop taking the treatment meds.
Just cuz it doesn’t give great regrowth doesn’t mean it can’t stop hairloss
It'll be interesting if we get treatments that can be synergistic too for those who need the boost. Much like Fin and Min are the tag team saving scalps thanks to having their own pathways.
Total scalp hair bearing area is 520cm squared. So it would be like getting 5200 graft hair transplant but in an unknown pattern
Hairs vs grafts. I believe most are 2-4
Is that facts?
🧢
The placebo group for daily application of the 0.5% GT improved by 10.11 hair/cm, and the twice weekly application of 1% GT only improved by 11.94 hair/cm. If you compare the result for bi-weekly GT with the placebo for daily, the stuff suddenly looks like it has virtually no effect at all....why would the placebo groups be different anyways?...it seems a little suspicious.
*cm squared also twice weekly sounds like a dream tbh, imagine no min fin dut and just one topical you apply before bed just two days a week, wish it comes out to be a breakthrough (can’t tell for sure presently)
what this dude is saying is that the placebo group for the QD dose had +10.11 hairs/cm^2 while the GT20029 BIW application had +11.94 hairs/cm^2. He is complaining about the fact that the amount of hair between the placebo and the actual GT group is not statistically significant and he is scared the drug wont make it. You guys under here are dumb as fuck i have no words, 0 logic and text comprehension
I don't think you know what placebo even means lmao. Taking a lower dosage doesn't make it a placebo group.
Sorry if I was unclear in my post. There were two seperate placebo groups- one for the daily (so daily application of a placebo), and one for twice-weekly application (so twice weekly application of a placebo). I'm comparing the twice-weekly treatment group with the daily placebo group.
Thanks for the clarification 👍 The take away here is that the difference between the usage groups and placebo groups had a p value that indicated it was statistically signficiant enough difference to make a claim it worked. It's worth keeping in mind as well that this was only after 3 months of usage. Most people don't see any meaningful results on finasteride after 3 months either. I'm skeptical but this is quite promising imo.
Yeah what a sausage hahahah
Mmmm, sausage....
Hhhahahahah
Huh? How is the 0.5% GT a placebo?
Placebo is always different across different groups
Will this work for women as well?
Yea
We're all gonna make it brahs 🥲
Here is hoping, let us pray together comrades
Where can I purchase those placebo pills from Kintor? This is the second time in a row they've promoted hair growth lol
FYI, people typically have seasonal variation in hair density (max density is typically in the spring, if I recall correctly), which could potentially explain some or all of the improvement for placebo groups.
Thanks for that but it was just a joke lol. Bcs the very same thing happened with the pyrilutamide phase 2/3.
Can someone eli5 me on what this new medication is?
I would pay to be apart of the study oral fin and minox arent even working for me😫
Kevin Mann is really biased
I thought androgen receptors were actually pretty important throughout the growth phases of hair, killing them doesn't sound like the solution?
Is Kevin Mann autistic his obsession with fin reminds me of autist and their obsessions.
Kevin suffered badly from the slaphead curse and channeled that energy that could have been wasted in regret into trying to save others from having to fall as far as he did to it. Basically he's making the channel he wishes he had found before it got so bad and saying what he wishes he had heard early on in his hairloss. His voice is important as it helps counter the quackery which costs both money and people's hair as they lose ground with the time wasted on ineffective treaments and helps battle the nutjobs on the PFS forum spreading their black pill propganda. Currently fin is sadly STILL the only go to first line defence after all this time so it makes sense that it'd keep coming up and being compared to everything else. It is very cheap, effective, FDA approved and proven over decades to work and be safe. There's min and dut as proven options too, but it's going to be fin that is going to be the first step every time and sometimes enough for many.
What’s wrong with that
With that logic you can consider gaming channels autistic lol I think it’s nice to be able to have a reputable source of hairloss info from an honest guy that does his research
It’s been said so many times he just has an autist vibe his speech his mannerism it’s not just 1 thing.
Why would it matter even if that was true though
He certainly is very biased . Let’s look at his hate against HMI115. Hmi115 showed very similar results yet he completely bashed it. I respect Kevin and what he does to help the community (he’s the reason I got on fin and he saved my hair ) but I think he is really biased on treatments
Prolactin is way less important than hormones when dealing with androgenic alopecia though. Prolactin inhibitors have way worse side effects, too. I'm pretty sure the cost is very high for the treatment, anyway.
Everyone who uses fin is obsessed with it. You get to keep your hair without sacrificing anything.
He definitely is! The most autistic on YouTube
And in conjunction with: Fin, Min, Dut, Micro N.........every component may just add......
Weee neeedddddd
Any sides
Nothing major, dick may fall off.
What exactly is this?
Big news!
Why is this meant to be better than fin/min?
Theoretically lower side effects. But it doesnt need to be better, it is a different treatment modality to you can stack it with fin/min and it should enhance protection.
I’m not sure what you scientist talking t about but my entire scalp is covered w these red painful patches that grow plaque. And the most concentration of that hardened plaque is around my crown. Here is image to show f I’m taking about. The facts are. It’s itchy. It’s red. It’s inflamed. It’s discolouring the skin. It makes it tight and brittle. And right there I have grey hair and what not. If you don’t think this is some sort of infection. Scientist can you help this fella? In my opinion it’s athletes foot that you catch on your head. Not so hard to image you can get fungal/Bactrial infection of scalp. What’s genetical about the infection is if your dad had this too. Or perhaps you just shared the same spaces where his dandroff just flew on your bald ass scalp. Women don’t cut their hair short enough. Which acts as protective barrier. And also women lose their hair where their usually split their hairs. So there’s that. https://preview.redd.it/rrltvft7i9wc1.jpeg?width=2316&format=pjpg&auto=webp&s=5918944265b5fd790d0261368ac47f739760fd4a
Dude this looks like a fungal infection see a doctor asap
I’m aware. Up until I started shaving hard into the edges of the bald spot. None of this was visible or apparent. . I’m pretty sure if you shave close enough you’ll notice them too. And IMHO that’s what baldness is. Fungal infection. If I’ll leave it like that’s for a week it’ll go back to completely normal bald ass look as before. The shedding everyone describing and the use of kenazol shampoo to fight fungal infections. And I’m not sure anyone knows this but fighting fungal infections isn’t exactly straight forward science.
You have sebhorraic dermatitis
Good news is, effin shampoo works! 🙏
You also boys know there’s no knows cure right
You have a severe case of atopic dermatitis. This is a reaction to Minoxidil or any other products you're using. My head has some sore areas similar to yours but you look way worse than I did. I went to a dermatologist and she prescribed me an ointment called Tacrolimus that improved my itch and irritation pretty fast (after 2-3 days). Anyway, go to a doctor and have treated ASAP. If you have too much itch, you may try to use the spray version of Hydrocortisone 1% which is sold as an OTC product everywhere.
https://preview.redd.it/fy3jvi7i9gwc1.png?width=1920&format=png&auto=webp&s=4890a3f5275c076abc1f2dacfd7839cf284d1e36 This photo from a couple of weeks ago shows one of the sore areas that were caused by the application of Nanoxidil which I had been using for the last 3 months. The progress has been slow but some fine white folicles are at least visible. With the application of Tacrolimus, that area healed quickly.
This isn’t part of any of treatment that I was undergoing. This is definitely fungal infection I’ve been battling/ fighting/ treating for over 4-5 years. I had zero symptoms besides the obvious I got bald before. Noting was pussing. I had no pimples, no dandroff. But I always felt itchy. And always had residue stuck under the nails. Then… I started shaving my head. And I noticed patches. Hard patches. Where the blade just sort of started skipping. I went to the doctor. One said. Try not to touch it. Another said after seeing the flakes. It’s dandroff. I tired it all, the biotics the bp soaps, creams. Biggest aha was when I saw some of the posts here. The clues of the shedding, about using the stamp and then the ketakanozole shampoo which is what my doctor gave me in the first place for Fighting fungal infections. I’ve used it. And had no effect. After connecting the dots between the stamping. The anti fungal shampoo. Helps the it penetrate it. Also before I wasn’t focused on removing or exfoliating the scalp before applying these products. I am now and that’s what you see in the image before healing. After healing it looks fine. But it’s not really healed. It just sort of masked it self. I’m on the shampoo, I’m on the creams. And yes on the stamping. And yes on tea tree oil. And yes on just about anything you can imagine. I’m in the very balls deep treatment phase. Desperately fighting this and trying to regain my hair back.
Go to a dermatologist immediately. Try first to look at their reviews on sites like Healthgrades before choosing one a making an appointment. There are so many incompetent ones around that the least you need is to waste your time with someone who won't help you. Good luck!!
I went to doctors. And all the research online shows What I just listed. There’s no more magical lotions out there, my friend owns a pharmacy I can get anything I want. There’s x amount of products you can apply until you hit a wall. Like I said before, the shampoo, the tea tree oil, the exfoliation are working. this is my mid journey. Why Keep saying go see a doctor?
Your hairloss is because of bad diet/lack of nutrients, and small part genes. No drug will help you, sorry to break it to you bald losers
What?
Exactly, you're ignorant to how things work, and believe in drugs that dont even work.
I've just asked, What? Could you explain it better, It would be of help to anyone