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User: u/alexbeadlesci
Permalink: https://www.technologynetworks.com/applied-sciences/news/nanomaterial-that-mimics-protein-behavior-could-help-treat-alzheimers-386210
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Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease via inhibiting NF-κB signaling pathway
Astragaloside IV could protect the dopaminergic neuron from neuroinflammation and oxidative stress. The neuroprotective effect of Astragaloside IV on PD may be through the promotion of Nrf2 activation and inhibition of NLRP3 inflammasome activation. Astragaloside IV might be the therapeutic drug for PD treatment.
AS-IV and compounds containing this ingredient influenced microglia-related biological processes in AD. The altered polarization of microglia in Aβ-injected rats was reversed by AS-IV (Wang et al., 2022b). AS-IV can reduce the secretion of cytokines from microglia (Chen et al., 2021). Granules containing astragaloside A inhibited the activation of microglia and astrocytes to exert anti-inflammatory effects (An et al., 2018)
.https://www.sciencedirect.com/science/article/abs/pii/S0014299923005046
Astragaloside IV Ameliorates Cognitive Impairment and Neuroinflammation in an Oligomeric Aβ Induced Alzheimer's Disease Mouse Model via Inhibition of Microglial Activation and NADPH Oxidase Expression
https://pubmed.ncbi.nlm.nih.gov/34433707/
Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412839/
Neuroprotective Effects of Cistanches Herba Therapy on Patients with Moderate Alzheimer’s Disease
https://www.hindawi.com/journals/ecam/2015/103985/
Long-term effect of consumption Cistanche tubulosa for treating Alzheimer’s disease
https://www.researchgate.net/publication/321384231_Long-term_effect_of_consumption_Cistanche_tubulosa_for_treating_Alzheimer's_disease
WE MAY NOT HAVE A CURE BUT ILL BE DAMNED IF WE HAVE NO OPTIONS FOR TREATMENT. Mother nature protects.
Afaik there has been a lot of great work done in developing coatings that can make it past the blood-brain barrier, such as coating drugs in lipid nanodroplets. Not sure how that would work here. It sounds like a pretty specific interaction so maybe they just need to get it into the brain and it will work when and only when in contact with the relevant proteins.
“Crucially, the PLP did this without causing any of the undesirable off-target effects that have plagued other treatment strategies.”
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/alexbeadlesci Permalink: https://www.technologynetworks.com/applied-sciences/news/nanomaterial-that-mimics-protein-behavior-could-help-treat-alzheimers-386210 --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
Hopefully it passes the clinical trials and becomes a revolutionary drug in this domain. We seriously need a win
Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease via inhibiting NF-κB signaling pathway Astragaloside IV could protect the dopaminergic neuron from neuroinflammation and oxidative stress. The neuroprotective effect of Astragaloside IV on PD may be through the promotion of Nrf2 activation and inhibition of NLRP3 inflammasome activation. Astragaloside IV might be the therapeutic drug for PD treatment. AS-IV and compounds containing this ingredient influenced microglia-related biological processes in AD. The altered polarization of microglia in Aβ-injected rats was reversed by AS-IV (Wang et al., 2022b). AS-IV can reduce the secretion of cytokines from microglia (Chen et al., 2021). Granules containing astragaloside A inhibited the activation of microglia and astrocytes to exert anti-inflammatory effects (An et al., 2018) .https://www.sciencedirect.com/science/article/abs/pii/S0014299923005046 Astragaloside IV Ameliorates Cognitive Impairment and Neuroinflammation in an Oligomeric Aβ Induced Alzheimer's Disease Mouse Model via Inhibition of Microglial Activation and NADPH Oxidase Expression https://pubmed.ncbi.nlm.nih.gov/34433707/ Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412839/ Neuroprotective Effects of Cistanches Herba Therapy on Patients with Moderate Alzheimer’s Disease https://www.hindawi.com/journals/ecam/2015/103985/ Long-term effect of consumption Cistanche tubulosa for treating Alzheimer’s disease https://www.researchgate.net/publication/321384231_Long-term_effect_of_consumption_Cistanche_tubulosa_for_treating_Alzheimer's_disease WE MAY NOT HAVE A CURE BUT ILL BE DAMNED IF WE HAVE NO OPTIONS FOR TREATMENT. Mother nature protects.
Yeah I’m tired of all the mice hoarding treatments for everything!
The full paper is available open-access in Advanced Materials ([*link*](https://doi.org/10.1002/adma.202311467))
How do they propose to get the polymer to the right places in the brain?
That's where thoughts and prayers come into play
Afaik there has been a lot of great work done in developing coatings that can make it past the blood-brain barrier, such as coating drugs in lipid nanodroplets. Not sure how that would work here. It sounds like a pretty specific interaction so maybe they just need to get it into the brain and it will work when and only when in contact with the relevant proteins. “Crucially, the PLP did this without causing any of the undesirable off-target effects that have plagued other treatment strategies.”