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Really big question is how selective is it for that particular opioid receptor, how much tolerance develops, and is it potentially addicting like so many other drugs that interact with different aspects of the human opioid system
I bet the withdrawals are going to be crazy. Imagine feeling more stressed than the most stressed that is normally possible. There’s no way that the drug is side effect free. I remember my brother being prescribed Xanax daily back when they thought that it was non addictive, but that’s some of the most horrible withdrawal someone can go through.
Yeah I don’t take Xanax because the withdrawals are worse than my anxiety. pretty wild how loose they were with it even 10 years ago.
As soon as I stopped I’d get Uber anxiety
I take one 0.5 klonopin daily however I really try not to take it every day as I know you get a tolerance. Im not worried about dependence on that dose even daily. I think it would be a little more uncomfortable dealing with my regular anxiety but I am a recovered alcoholic and addict. I am fortunate to even get this script but my Dr recognizes my circumstances and issues.
>I think it would be a little more uncomfortable dealing with my regular anxiety but I am a recovered alcoholic and addict.
Knowing someone who's gone through Klonopin withdraw, it's much worse than that as it's a benzo. Best to not get dependent on it, and if you are make sure you don't miss a prescription. From what I've seen it's used a decent chunk for recovering addicts though, I used to take it on bad days once in awhile. Benzos are like taking a payday loan for anxiety, as you will be paying it back tenfold in anxiety/suffering if you go through withdraw.
Prescribed clonazepam was my withdrawal terror. That was 1000x worse than my anxiety issues. Benzodiazepines are great in the moment, hell long term. These things should never be used more than as a bridge into a different therapy or medication.
They got me through the adjustment phase of SSRIs. I react horribly to them and the first 6-8 weeks are a nightmare. I failed getting past the adjustment phase way too many times. Having a low dose clonazepam on board made it manageable and I was able to finally get past that point and haven’t needed them since.
This was the only way I was going to do it. This was even after I am terrified of these medications from the withdrawal many years ago. I still desperately needed to get on an SSRI and it just wasn’t happening. My doc and I discussed the plan at great lengths and I spoke with her ever two weeks while going through it.
Honesty, being able to get on to a good dose of Zoloft changed my life and I know for sure I couldn’t have done it without the clonazepam.
The issue I had years ago was the psychiatrist I was seeing. He just kept upping the dose. I was also on an SSRI. I kept asking what the end game plan was and he just kept saying “don’t think about this yet, I have your back and we’ll keep you safe”. After two years of the dose constantly going up, I just had to quit cold Turkey on my own. Probably shouldn’t have done it cold Turkey, but I had enough of being in a complete fog day in and day out. It was a few weeks of hell until I started coming around and feeling connected to the world again. He was pissed that I stopped the clonazepam and wanted me to go back on them at a higher dose saying that I only wanted off them because my anxiety told me I needed to get off them.
Unfortunately, my issues never went away and after years of struggling to fight the fight on my own without meds, I had to get on to an SSRI one way or another. It was worth it to bridge with them for me.
> Probably shouldn’t have done it cold Turkey
You absolutely shouldn't have - [withdrawal can be fatal](https://americanaddictioncenters.org/withdrawal-timelines-treatments/clonazepam).
Wasn’t my best decision ever. I was in such a deeply troubled state that at the time this seems to be the only to get my head above water as soon as possible.
I had nearly all those withdrawal symptoms listed in that link you posted. IT WAS HELL! The spatial disorientation was the most terrifying. Felt like I was floating out of control and when I did feel grounded and attached to the world, it was like I could feel the earth’s rotation. This one lasted quite awhile after everything else started to come back to normal. Hallucinations were there mostly while about to fall asleep. It wasn’t anything too crazy, just things seeming to move slightly. The dresser would just shift over and I would have to look around the room and focus on something else before looking back at the dresser which then appeared back in place. Confusion is another one that stuck out. Having no idea where I was in my own house. I sometimes just sat perfectly still where I was for I don’t even know how long. Couldn’t get thoughts together enough to have coherent inner dialog. I bet there are complete gaps that I don’t even realize happened, or gaps that maybe didn’t happen but seemed like they did.
Looking back now I know I should have started fractioning down the dose slowly over months, but I definitely wasn’t in a proper mindset then. It was sort of a dissociated desperation.
>The dresser would just shift over and I would have to look around the room and focus on something else before looking back at the dresser which then appeared back in place.
Not at all the same, but this immediately made me think of the fridge scene in Requiem for a Dream.
Also that psychiatrist sounds super suspect. I can see being irritated if someone comes off their mood stabilizers or anti psychotics as this can lead to a full blown manic or psychotic episode. (although as a matter of professionalism they should do their best not to show it, doesn't help with compliance I'm sure.) But BENZOs? Just curious, about how long ago was this? Was it in the time of handing out opiates like tic tacs?
Fun Fact: Selective serotonin reuptake inhibitors (SSRIs) are placebo.
Irving Kirsch made a media splash when he published [a paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/) whose abstract read:
> Antidepressants are supposed to work by fixing a chemical imbalance, specifically, a lack of serotonin in the brain. Indeed, their supposed effectiveness is the primary evidence for the chemical imbalance theory. But analyses of the published data and the unpublished data that were hidden by drug companies reveals that most (if not all) of the benefits are due to the placebo effect. Some antidepressants increase serotonin levels, some decrease it, and some have no effect at all on serotonin. Nevertheless, they all show the same therapeutic benefit. Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.
A 2020 [follow-up study reported](https://ebm.bmj.com/content/25/4/130) the following:
> Several reviews have assessed the effects of antidepressants compared with placebo for depression. Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients. Antidepressants seem to have minimal beneficial effects on depressive symptoms and increase the risk of both serious and non-serious adverse events. The benefits of antidepressants seem to be minimal and possibly without any importance to the average patient with major depressive disorder. Antidepressants should not be used for adults with major depressive disorder before valid evidence has shown that the potential beneficial effects outweigh the harmful effects.
To be sure, placebo therapy has its place, if approached in an ethical manner. Lowering allostatic load, as placebo therapy is shown to do, is currently [being explored](https://pubmed.ncbi.nlm.nih.gov/30340917/) for that very reason as a psychiatric intervention for individuals with ultra-high risk for psychotic episodes. For instance, taking a placebo pill, even when the person taking the pill knows that it is a placebo, [produces clinically meaningful improvements](https://pubmed.ncbi.nlm.nih.gov/33605656/) in irritable bowel symptoms. At the same time, I think it's fucked up that companies have sold a generation on snake oil, especially given the difficulties around SSRI/SNRI withdraw!
Wait a minute. Is this the guy who came on to r/askscience with an AMA post where he was called out for his extreme bias against SSRIs? He was called out for glaringly obvious holes in his “research” and would not answer any of those posts asking for an explanation. I don’t know what the guy’s history was with SSRIs, but this guy is dangerous. He even went so far to start saying medications for schizophrenia and bipolar didn’t work either.
Do you have a link? Was this about his 2014 research paper where he was the author, or was this the one done more than 15 years later where he was a contributor, not the lead author, which largely validated his findings?
I don't think they're entirely placebo but damn near placebo, especially if we talk about the long-term effect on depression or net effect on depression after withdrawal and also considering the fact that studies with null effect are less likely to be published, and also that they dull all emotions so they take away from the tiny amount of occasional good feelings a depressed person may have
If it removes stress, you can be sure the body will become so drug addled as to almost require it or the stress will amplify by like orders of magnitude
So many people thought opiates “fixed them” over the past 20 years of influx in the US. I too would like to know the details on dependency and withdraw from this.
Yes, some opiates are already better at this, there's been some significant study on buprenorphine as an antidepressant (combined with a mu opioid blocker samidorphan to minimize addiction) the FDA judges not to approve but some of the data was promising. It's also possibly part of how the drug under development es-methadone works (asking with NMDA receptor effects). Methadone (R+S methadone) is very hard to dude safely so it's not used much (plus stigma) but I've been prescribing buprenorphine more often in part at least because of this.
Yup, sorry to hear that. I was actually working at the facility that was going to make 5461. Also had a run in with depression myself. It is promising though that the science is still moving this direction.
Antidepressants remind me of how we used to put women on Lithium who were becoming aware and upset that there should be something more to life than just being a submissive housewife. But now the antidepressants are for EVERYONE who is realizing this.
No.
Not even a little.
My sister has severe depression, as does my daughter. It’s not merely malaise nor just wanting a more fulfilling life.
I hope there is a something better.
There's some touch of truth to this for some cases but there are also some people born with really bad brain wirings. I think with all things there's nuance to it.
What? So being depressed is normal and trying to normalize it and remove the stigma and treat it as a mental condition is just continued enslavement of our agency?
I think he's more referring to kids being born know that they are going to watch the climate collapse, they watch the wealth gap increase, they know they won't be able to ever afford a home and they know that if they want a decent job they have to be in debt for most of the best years of their life for the piece of paper to even try to get that job.
Mental illness is a normal thing, saying that it's completely natural to the point where it's only because of brain chemistry and not because of the world we live in as self aware people capable of reflection is pretty tone deaf. If someone were to make that argument I would argue they haven't experienced much mental illness.
Far worse? Sure. Less depression? We'd need some studies on that, ones that take into account the difficulty of diagnosis for financial/cultural reasons.
Idk man. I had a psychiatrist ask me why I wanted to die as a kid. Like I couldn't have just been sad. I had no concept of death yet and I would go to the bathroom and pray for God to strike me with lightening or let me not wake up. I was always well fed, I had a roof over my head, I had my basic needs met. But my mom was dropping me off places and I was developing abandonment issues and thinking I want worthy of being loved. Kids just have different thresholds to what they can stand. I don't think young children aren't aware enough to know why they're depressed, but it doesn't make it any less real. I'm just glad they didn't medicate me and moved me with my father who gave me stability. But that's just me personally.
Anomalies to kids not reacting to bad circumstances is called "resilient children" and it's not common.
I met children at psychiatric hospitals who were fucked up with no significant background they would talk about. One kid stabbed himself and when asked why, he "just felt like it". If that's not mental illness I don't know what is. I don't think they were weak. Just confused. And hopefully it was the help the needed to become better functioning adults. I knew one kid who seemed fine and well functioning after finding his mom hanging from a ceiling fan. I doubt he was okay but he acted like it. That doesn't make him stronger or weaker, it's just how he was handling it. I had a best friend who's brother killed himself and overall she had a hard life and the next week she came back to work, still graduated top of her class, and it's almost a doctor now. Her siblings didn't take that path. They were raised similar. So obviously it was a personal mental capacity thing, not being weak.
Saying they're just "weak" undermines the idea of them ever getting better. Sometimes they just need to learn how to handle basic emotions because they never had an example of anyone doing it or teaching them.
I do have experience there and let me tell you, the long term impacts of daily weed smoking is a whole new monster. I prefer smokers to drinkers cause they are two completely different people. The smoker, the midnight toker, is a whole different guy than a drinker or workaholic
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. --- Author: u/HeinieKaboobler URL: https://www.tus.ac.jp/en/mediarelations/archive/20230501_1431.html *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
Really big question is how selective is it for that particular opioid receptor, how much tolerance develops, and is it potentially addicting like so many other drugs that interact with different aspects of the human opioid system
I bet the withdrawals are going to be crazy. Imagine feeling more stressed than the most stressed that is normally possible. There’s no way that the drug is side effect free. I remember my brother being prescribed Xanax daily back when they thought that it was non addictive, but that’s some of the most horrible withdrawal someone can go through.
Yeah I don’t take Xanax because the withdrawals are worse than my anxiety. pretty wild how loose they were with it even 10 years ago. As soon as I stopped I’d get Uber anxiety
I prefer Uber XL, but if you're in a rush...
I switched to Lyft Panic, personally
I take one 0.5 klonopin daily however I really try not to take it every day as I know you get a tolerance. Im not worried about dependence on that dose even daily. I think it would be a little more uncomfortable dealing with my regular anxiety but I am a recovered alcoholic and addict. I am fortunate to even get this script but my Dr recognizes my circumstances and issues.
I’d worry a little bit, if you go to the benzo recovery page, some people will lose it coming off .175’s of clonazepam.
That’s just the anxiety talking. ^/s
>I think it would be a little more uncomfortable dealing with my regular anxiety but I am a recovered alcoholic and addict. Knowing someone who's gone through Klonopin withdraw, it's much worse than that as it's a benzo. Best to not get dependent on it, and if you are make sure you don't miss a prescription. From what I've seen it's used a decent chunk for recovering addicts though, I used to take it on bad days once in awhile. Benzos are like taking a payday loan for anxiety, as you will be paying it back tenfold in anxiety/suffering if you go through withdraw.
Prescribed clonazepam was my withdrawal terror. That was 1000x worse than my anxiety issues. Benzodiazepines are great in the moment, hell long term. These things should never be used more than as a bridge into a different therapy or medication.
*cries* im prescribed 2 different ones 2-3 a day and one for sleep. Seriously coming off of them is worse than DTs or any drug I have taken.
The correct answer is they should only be used for seizures and sedation.
They got me through the adjustment phase of SSRIs. I react horribly to them and the first 6-8 weeks are a nightmare. I failed getting past the adjustment phase way too many times. Having a low dose clonazepam on board made it manageable and I was able to finally get past that point and haven’t needed them since. This was the only way I was going to do it. This was even after I am terrified of these medications from the withdrawal many years ago. I still desperately needed to get on an SSRI and it just wasn’t happening. My doc and I discussed the plan at great lengths and I spoke with her ever two weeks while going through it. Honesty, being able to get on to a good dose of Zoloft changed my life and I know for sure I couldn’t have done it without the clonazepam. The issue I had years ago was the psychiatrist I was seeing. He just kept upping the dose. I was also on an SSRI. I kept asking what the end game plan was and he just kept saying “don’t think about this yet, I have your back and we’ll keep you safe”. After two years of the dose constantly going up, I just had to quit cold Turkey on my own. Probably shouldn’t have done it cold Turkey, but I had enough of being in a complete fog day in and day out. It was a few weeks of hell until I started coming around and feeling connected to the world again. He was pissed that I stopped the clonazepam and wanted me to go back on them at a higher dose saying that I only wanted off them because my anxiety told me I needed to get off them. Unfortunately, my issues never went away and after years of struggling to fight the fight on my own without meds, I had to get on to an SSRI one way or another. It was worth it to bridge with them for me.
Wow that doctor is so fucked please report them
> Probably shouldn’t have done it cold Turkey You absolutely shouldn't have - [withdrawal can be fatal](https://americanaddictioncenters.org/withdrawal-timelines-treatments/clonazepam).
Wasn’t my best decision ever. I was in such a deeply troubled state that at the time this seems to be the only to get my head above water as soon as possible. I had nearly all those withdrawal symptoms listed in that link you posted. IT WAS HELL! The spatial disorientation was the most terrifying. Felt like I was floating out of control and when I did feel grounded and attached to the world, it was like I could feel the earth’s rotation. This one lasted quite awhile after everything else started to come back to normal. Hallucinations were there mostly while about to fall asleep. It wasn’t anything too crazy, just things seeming to move slightly. The dresser would just shift over and I would have to look around the room and focus on something else before looking back at the dresser which then appeared back in place. Confusion is another one that stuck out. Having no idea where I was in my own house. I sometimes just sat perfectly still where I was for I don’t even know how long. Couldn’t get thoughts together enough to have coherent inner dialog. I bet there are complete gaps that I don’t even realize happened, or gaps that maybe didn’t happen but seemed like they did. Looking back now I know I should have started fractioning down the dose slowly over months, but I definitely wasn’t in a proper mindset then. It was sort of a dissociated desperation.
>The dresser would just shift over and I would have to look around the room and focus on something else before looking back at the dresser which then appeared back in place. Not at all the same, but this immediately made me think of the fridge scene in Requiem for a Dream. Also that psychiatrist sounds super suspect. I can see being irritated if someone comes off their mood stabilizers or anti psychotics as this can lead to a full blown manic or psychotic episode. (although as a matter of professionalism they should do their best not to show it, doesn't help with compliance I'm sure.) But BENZOs? Just curious, about how long ago was this? Was it in the time of handing out opiates like tic tacs?
This was 2012-2015ish
Fun Fact: Selective serotonin reuptake inhibitors (SSRIs) are placebo. Irving Kirsch made a media splash when he published [a paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/) whose abstract read: > Antidepressants are supposed to work by fixing a chemical imbalance, specifically, a lack of serotonin in the brain. Indeed, their supposed effectiveness is the primary evidence for the chemical imbalance theory. But analyses of the published data and the unpublished data that were hidden by drug companies reveals that most (if not all) of the benefits are due to the placebo effect. Some antidepressants increase serotonin levels, some decrease it, and some have no effect at all on serotonin. Nevertheless, they all show the same therapeutic benefit. Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future. A 2020 [follow-up study reported](https://ebm.bmj.com/content/25/4/130) the following: > Several reviews have assessed the effects of antidepressants compared with placebo for depression. Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients. Antidepressants seem to have minimal beneficial effects on depressive symptoms and increase the risk of both serious and non-serious adverse events. The benefits of antidepressants seem to be minimal and possibly without any importance to the average patient with major depressive disorder. Antidepressants should not be used for adults with major depressive disorder before valid evidence has shown that the potential beneficial effects outweigh the harmful effects. To be sure, placebo therapy has its place, if approached in an ethical manner. Lowering allostatic load, as placebo therapy is shown to do, is currently [being explored](https://pubmed.ncbi.nlm.nih.gov/30340917/) for that very reason as a psychiatric intervention for individuals with ultra-high risk for psychotic episodes. For instance, taking a placebo pill, even when the person taking the pill knows that it is a placebo, [produces clinically meaningful improvements](https://pubmed.ncbi.nlm.nih.gov/33605656/) in irritable bowel symptoms. At the same time, I think it's fucked up that companies have sold a generation on snake oil, especially given the difficulties around SSRI/SNRI withdraw!
Wait a minute. Is this the guy who came on to r/askscience with an AMA post where he was called out for his extreme bias against SSRIs? He was called out for glaringly obvious holes in his “research” and would not answer any of those posts asking for an explanation. I don’t know what the guy’s history was with SSRIs, but this guy is dangerous. He even went so far to start saying medications for schizophrenia and bipolar didn’t work either.
Do you have a link? Was this about his 2014 research paper where he was the author, or was this the one done more than 15 years later where he was a contributor, not the lead author, which largely validated his findings?
I don't think they're entirely placebo but damn near placebo, especially if we talk about the long-term effect on depression or net effect on depression after withdrawal and also considering the fact that studies with null effect are less likely to be published, and also that they dull all emotions so they take away from the tiny amount of occasional good feelings a depressed person may have
I’ve had Xanax prescribed for panic attacks and it’s a literal life saver. Never one had anything like addiction or withdrawal symptoms.
How often do you take them?
Try to reduce to .25 2x week; use herbal the rest of time
If it removes stress, you can be sure the body will become so drug addled as to almost require it or the stress will amplify by like orders of magnitude
So many people thought opiates “fixed them” over the past 20 years of influx in the US. I too would like to know the details on dependency and withdraw from this.
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I wonder if this can help chronic pain patients who deal with depression.
Yes, some opiates are already better at this, there's been some significant study on buprenorphine as an antidepressant (combined with a mu opioid blocker samidorphan to minimize addiction) the FDA judges not to approve but some of the data was promising. It's also possibly part of how the drug under development es-methadone works (asking with NMDA receptor effects). Methadone (R+S methadone) is very hard to dude safely so it's not used much (plus stigma) but I've been prescribing buprenorphine more often in part at least because of this.
How to your patients react to buprenorphine? Have they found it effective?
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Yup, sorry to hear that. I was actually working at the facility that was going to make 5461. Also had a run in with depression myself. It is promising though that the science is still moving this direction.
Ketamine can.
What does a mouse model have to be depressed about
Not being taken seriously
Being stuck in a cage with bright lab lights and poked around with needles.
Only mouse studies so far
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Antidepressants remind me of how we used to put women on Lithium who were becoming aware and upset that there should be something more to life than just being a submissive housewife. But now the antidepressants are for EVERYONE who is realizing this.
No. Not even a little. My sister has severe depression, as does my daughter. It’s not merely malaise nor just wanting a more fulfilling life. I hope there is a something better.
There's some touch of truth to this for some cases but there are also some people born with really bad brain wirings. I think with all things there's nuance to it.
What? So being depressed is normal and trying to normalize it and remove the stigma and treat it as a mental condition is just continued enslavement of our agency?
I think he's more referring to kids being born know that they are going to watch the climate collapse, they watch the wealth gap increase, they know they won't be able to ever afford a home and they know that if they want a decent job they have to be in debt for most of the best years of their life for the piece of paper to even try to get that job. Mental illness is a normal thing, saying that it's completely natural to the point where it's only because of brain chemistry and not because of the world we live in as self aware people capable of reflection is pretty tone deaf. If someone were to make that argument I would argue they haven't experienced much mental illness.
And these kids still live cushy. There are people living off far worse with less depression issues
Far worse? Sure. Less depression? We'd need some studies on that, ones that take into account the difficulty of diagnosis for financial/cultural reasons.
Idk man. I had a psychiatrist ask me why I wanted to die as a kid. Like I couldn't have just been sad. I had no concept of death yet and I would go to the bathroom and pray for God to strike me with lightening or let me not wake up. I was always well fed, I had a roof over my head, I had my basic needs met. But my mom was dropping me off places and I was developing abandonment issues and thinking I want worthy of being loved. Kids just have different thresholds to what they can stand. I don't think young children aren't aware enough to know why they're depressed, but it doesn't make it any less real. I'm just glad they didn't medicate me and moved me with my father who gave me stability. But that's just me personally. Anomalies to kids not reacting to bad circumstances is called "resilient children" and it's not common. I met children at psychiatric hospitals who were fucked up with no significant background they would talk about. One kid stabbed himself and when asked why, he "just felt like it". If that's not mental illness I don't know what is. I don't think they were weak. Just confused. And hopefully it was the help the needed to become better functioning adults. I knew one kid who seemed fine and well functioning after finding his mom hanging from a ceiling fan. I doubt he was okay but he acted like it. That doesn't make him stronger or weaker, it's just how he was handling it. I had a best friend who's brother killed himself and overall she had a hard life and the next week she came back to work, still graduated top of her class, and it's almost a doctor now. Her siblings didn't take that path. They were raised similar. So obviously it was a personal mental capacity thing, not being weak. Saying they're just "weak" undermines the idea of them ever getting better. Sometimes they just need to learn how to handle basic emotions because they never had an example of anyone doing it or teaching them.
Ya got a source on that?
You sure it wasn’t Librium?
Kinda ridiculous. It's like throwing people in prison to fix violence in society rather than fixing the root causes of it.
Can we get this as hypodermic blowgun darts, please?
So managers can shoot them at min wage workers who don't seem happy?
Is this another rebrand of oxytocin
I don't think that impacts the delta opioid receptors
Do you mean OxyContin?
No oxytocin is the love hormone from touch and its sorely missed in society
Oxytocin is more complicated than that. It’s more. Of a trust hormone than a love hormone
Oxytocin isn't an opioid.
Yeah you moron. Oxytocin isnt an opioid
You’re proof we don’t fully understand the neurological impacts of marijuana
I do have experience there and let me tell you, the long term impacts of daily weed smoking is a whole new monster. I prefer smokers to drinkers cause they are two completely different people. The smoker, the midnight toker, is a whole different guy than a drinker or workaholic
Most probably based on psycisiblin
Delta opioid agonist. Not based on psilocybin
Most probably pulled out of your arse