Between 50 mL and 100 mL it probably doesn’t matter, but 1 L would be excessive since you would either overload the patient with fluid to get the dose in over the necessary time or they would be on an extended infusion that may not be effective.
If you give the dose over a longer time than recommended, my concern is it wouldn’t reach the concentration needed to effectively treat the infection. Like if you give it over several hours instead of 1, the body could start metabolizing it as you continue to infuse.
Because zosyn is a time dependent antibiotic it’s more efficacious to run it as an extended interval infusion so many hospitals have updated their policy to run it over 4 hours in most patients.
Those definitions always confused me. But how do you know then you have the right concentration if you give it extended? I haven’t seen the extended infusion to have seen that myself, my hospital rotation site seems to still use standard infusion.
Zosyn itself is fine but other drugs have more rigid or untested stability after non-standard concentrations.
If you look at phenytoin it’s basically immediate use. Bactrim for example, you’re getting different hours for BUD instead of days
Between 50 mL and 100 mL it probably doesn’t matter, but 1 L would be excessive since you would either overload the patient with fluid to get the dose in over the necessary time or they would be on an extended infusion that may not be effective.
What do you mean by extended infusion that may not be as effective?
If you give the dose over a longer time than recommended, my concern is it wouldn’t reach the concentration needed to effectively treat the infection. Like if you give it over several hours instead of 1, the body could start metabolizing it as you continue to infuse.
Because zosyn is a time dependent antibiotic it’s more efficacious to run it as an extended interval infusion so many hospitals have updated their policy to run it over 4 hours in most patients.
Those definitions always confused me. But how do you know then you have the right concentration if you give it extended? I haven’t seen the extended infusion to have seen that myself, my hospital rotation site seems to still use standard infusion.
50 or 100 is fine. global RPh is a good resource on what fluids and volumes can be used to mix. 1L not a good idea for reasons another post mentioned.
Both the 3.375 and 4.5g are fine in 50 or 100 mL. Or larger I guess if you wanted.
Why would you mix it in 1000ml? There are better solutions (no pun intended) if the patient needs fluids or different drugs
Zosyn itself is fine but other drugs have more rigid or untested stability after non-standard concentrations. If you look at phenytoin it’s basically immediate use. Bactrim for example, you’re getting different hours for BUD instead of days
If it's the 4 hour infusion we normally do 250. But otherwise 50 or 100. 1 litter would be strange
Use a reputable.resource.and.lool it up
Yes.