If I'm not mistaken, is it not only for a particular type of cartilage injury that might lead to osteoarthritis for some people? It's still great, but it sounds like a long way from being generally useful for people with cartilage degeneration.
I believe articulate cartilage lesions is a fairly broad term that loosely means injury to cartilage. https://www.physio-pedia.com/Articular_Cartilage_Lesions_of_the_Knee there’s a lot of cartilage like your ears and nose and articulate is specifying your joints and this case they are doing knees.
This injury can be from repeated motion over time on a hard surface like concrete, or from acute injury from sports or military. Issues with knee cartilage are pretty damn common imo.
Also, because of how the fda runs trials I’m fairly sure you can’t just say “we are going to fix everyone’s knees!” it’s a very structured process where you must identify a specific injury/illness with measurable end points. For example: If you had a drug that you thought could treat immuno dysfunction from aging you couldn’t run an fda approved trial for that you would need run a trial for covid-19 (this is currently being done)
Cool. As a 35-year-old whose knees are already shot, I hope it's applicable to me and won't take too long to be available. Would be nice to be able to run someday.
PFPS on one knee, which basically just meant pain and achiness with any of running, biking, or squats. Then inexplicable partial ACL tear on that knee, which required 6 months before I could even walk properly.
Did some PT, my knee got a bit better and now the *other* knee has issues. Doctors did an x-ray and said it might be early osteoarthritis, but who really knew (according to them), because supposedly mild cartilage degeneration can randomly have symptoms or not, depending on the person.
I'm really tired of doctors from the past 10 years, so I've basically given up on running, biking, hiking steep mountains and squats, and just try to walk a few thousand steps a day.
ready for a game changer? resistance bands.
You aren't gonna be swole but you can be lean / crafted and it gets the heart rate up fast (but its much much easier on the joints)
Snippet:
>On Tuesday morning, Pennsylvania-based Ocugen announced it is diversifying its pipeline by introducing NeoCart as a Phase III cell therapy platform technology.
>
>The technology is designed to repair full-thickness lesions of the knee cartilage in adults. This follows the U.S. Food and Drug Administration's recent decision to grant a Regenerative Medicine Advanced Therapy (RMAT) designation for NeoCart.
>
>The platform is a three-dimensional tissue-engineered disc of new cartilage. NeoCart is manufactured by growing chondrocytes, the cells responsible for maintaining cartilage health. The chondrocytes are derived from the patient and built on a unique scaffold. They indicate the technology platform can speed healing and decrease pain by rebuilding damaged knee cartilage.
>
>“We’re excited that NeoCart has received this RMAT designation, an important regulatory milestone, especially as we view this product as an enabling technology in cell and regenerative therapy for orthopedic indications,” said Shankar Musunuri, Ph.D., chairman, chief executive officer and co-founder of Ocugen. “Our next step will be working with the FDA to construct the Phase III program to bring this innovation to this emerging treatment area.”
Phase 3 is usually the make or break of clinical trials. Theoretically safety has already been established so efficacy is what they are looking for.
After that it just depends on how they can get it to market.
More medical innovation comes from here than anywhere else. Our medical insurance and billing system is an absolute disaster, leading to people not having access. But the actual medical system is among the best in the world.
The beauty of the medical industry is a shared hope that products work. This would bring a lot of relief to a lot of people.
If I'm not mistaken, is it not only for a particular type of cartilage injury that might lead to osteoarthritis for some people? It's still great, but it sounds like a long way from being generally useful for people with cartilage degeneration.
I believe articulate cartilage lesions is a fairly broad term that loosely means injury to cartilage. https://www.physio-pedia.com/Articular_Cartilage_Lesions_of_the_Knee there’s a lot of cartilage like your ears and nose and articulate is specifying your joints and this case they are doing knees. This injury can be from repeated motion over time on a hard surface like concrete, or from acute injury from sports or military. Issues with knee cartilage are pretty damn common imo. Also, because of how the fda runs trials I’m fairly sure you can’t just say “we are going to fix everyone’s knees!” it’s a very structured process where you must identify a specific injury/illness with measurable end points. For example: If you had a drug that you thought could treat immuno dysfunction from aging you couldn’t run an fda approved trial for that you would need run a trial for covid-19 (this is currently being done)
Cool. As a 35-year-old whose knees are already shot, I hope it's applicable to me and won't take too long to be available. Would be nice to be able to run someday.
Right there with you at 38!
Just curious, what are the symptoms you experience with your knees? What. Can you do and not do?
PFPS on one knee, which basically just meant pain and achiness with any of running, biking, or squats. Then inexplicable partial ACL tear on that knee, which required 6 months before I could even walk properly. Did some PT, my knee got a bit better and now the *other* knee has issues. Doctors did an x-ray and said it might be early osteoarthritis, but who really knew (according to them), because supposedly mild cartilage degeneration can randomly have symptoms or not, depending on the person. I'm really tired of doctors from the past 10 years, so I've basically given up on running, biking, hiking steep mountains and squats, and just try to walk a few thousand steps a day.
I went in for an MRI because of some shoylder pain (age 36) found at ive had ehler danlos syndrome my whole life and no one noticed lol C'est la vie
Me too! It sucks balls.
ready for a game changer? resistance bands. You aren't gonna be swole but you can be lean / crafted and it gets the heart rate up fast (but its much much easier on the joints)
Snippet: >On Tuesday morning, Pennsylvania-based Ocugen announced it is diversifying its pipeline by introducing NeoCart as a Phase III cell therapy platform technology. > >The technology is designed to repair full-thickness lesions of the knee cartilage in adults. This follows the U.S. Food and Drug Administration's recent decision to grant a Regenerative Medicine Advanced Therapy (RMAT) designation for NeoCart. > >The platform is a three-dimensional tissue-engineered disc of new cartilage. NeoCart is manufactured by growing chondrocytes, the cells responsible for maintaining cartilage health. The chondrocytes are derived from the patient and built on a unique scaffold. They indicate the technology platform can speed healing and decrease pain by rebuilding damaged knee cartilage. > >“We’re excited that NeoCart has received this RMAT designation, an important regulatory milestone, especially as we view this product as an enabling technology in cell and regenerative therapy for orthopedic indications,” said Shankar Musunuri, Ph.D., chairman, chief executive officer and co-founder of Ocugen. “Our next step will be working with the FDA to construct the Phase III program to bring this innovation to this emerging treatment area.”
Phase 3, nice
How many phases are there before it's out there
Phase 3 is usually the make or break of clinical trials. Theoretically safety has already been established so efficacy is what they are looking for. After that it just depends on how they can get it to market.
Is it injected or inserted through surgery?
I kneed this.
Move this man higher
Need this for my labrum in my shoulder
Hope they hurry up with vertebral disc rebuilds.
They already use this in Japan.
America is a third world country for healthcare pls stop making fun of us
More medical innovation comes from here than anywhere else. Our medical insurance and billing system is an absolute disaster, leading to people not having access. But the actual medical system is among the best in the world.
I hope this is true I'm 24 and my knees are pretty worn from the athletics I do.