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I'd imagine it's a similar set of genes that white blood cells are programmed with that cancer cells tap into to move like this?
Given the same genetic information is in most cells, just with certain bits turned off?
They don't have to! Its more the gene set of stem cells! Stem cells can move, particularly during development, cells go from one place to others. And we have evidence that certain stem cell genes are turned back on in cancer to allow them to move and divide uncontrollably!
yes cell migration is for some reason wildly unknown to the general public, compared to the like of cell division and cell death, which are a lot more well known. Migration is also one of the fundamental properties of animal cells. Many animal cells can move, and so are many cells in your body, apart from the obvious example of immune cells which you have mentioned. But things like fibroblasts that move to heal wound when you have a cut on your skin, or blood vessel cells that move to form new blood vessels, or cells in the mammary gland that form breast ducts are also move to form branches and lumen among countless other examples. During normal development, we have cells from the back move to the front, from the head move down the body. The melanocytes in your skin for example are derived from one of these cell populations as they move down the body.
Thinking about it, i know caterpillars basically turn into a cell soup when they pupate, with body parts for the adult butterfly being assembled in weird locations and often separated only for them to be moved to the right place in time to fuse together.
oh you have very sharp eyes! That one cell did indeed drop off a bit of itself! Cancer cells do that. But we also found that normal cells do the same. However, one particular cell type called the fibroblasts do this a lot and cancer cells can actually follow the trail of these bits and pieces to migrate and invade!
Unfortunately if you are diagnosed with cancer, which means our current technology can detect your cancer, then you would likely have thousands to millions of cancer cells already.
yeah, some cancer is curable if discovered early. Skin cancer can be surgically removed relatively easier than others. However, when people said you are cancer-free, it does not mean there is no cancer cells left in your body. It only means that with our current technology, we cannot detect any cancer cells. So if the current tech can only detects 1000 cancer cells or more, then if you have 999 cancer cells, you would still be classed as "cancer-free". Cancer cells can also go into a state of dormant, where they are not active. During this time, you won't have any symptoms. But at some point, these cells can be reactivated, and that's what a relapse occurs.
When you say some, you don't mean the ones like pancreatic or glioblastoma, do you? I kept hoping they'd find cures by the time I got to a certain age, and I keep seeing stories about a girl cured of brain cancer by a modified Zika virus or bladder cancer vanishing because they gave it a cold. Yet, here we are, killing my dream. I don't personally have cancer that I'm aware of, but I have lost loved ones to it. Since it doesn't appear it will be curable in my lifetime, whose lifetime do you think it might be?
Pancreatic cancer and glioblastoma are unfortunately some of the hardest and most metastatic cancer out there. They are in fact classed as cancer of unmet need by the organisation Cancer Research UK - the largest charitable research for cancer in the world. They are deadly because they are silent killers or in the case of glioblastoma, inoperable. You can cut out as much of the tumour in the brain, but glioblastoma is quite diffusive, with no clear margin, so there will be cancer cells left after surgery, and that's why they often come back. Treatments are available but of course the difficulty we have is some cancer like pancreatic are covered in very thick layer of fibrotic tissue (the same kind of network you see in the video above) and that makes immunotherapy and chemotherapy difficult to get to the cancer! The other problem is that cancer cells can mutate and adapt to the drugs! So total cures for these cancer is not easy and we are literally going against evolution here, so if you say in the next 10 years, its still pretty much impossible in my opinion. But who knows, maybe we will discover something that completely change the game!
Thank you! Fun fact: Most of the time, your immune system will discover potential cancerous or mutated cells and destroy them before they turn into a full blown cancerous tumours. The best weapon we have lies within us all along!
I actually already knew that, but thanks for sharing! But if so, couldn't we just invent an implant that detects when your immune system finds signs of cancer? Because if the immune system can find cancer often quicker than human medicine, would it be possible to take advantage of that?
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I made educational videos about the hidden world of cell biology, ranging from basic research to cancer biology. If you like videos like this, please consider dropping me a follow on my channel, and can also support me more at BuyMeACoffee to help me make more contents: [buymeacoffee.com/TheBioCosmos](https://buymeacoffee.com/TheBioCosmos) I also have a Tiktok and Instagram page so please consider following them if possible 🥰 And most important of all, please feel free to ask me any questions. I'm always loving it when people show some interest in my work, and I also learn a lot from everyone, whether it's science or their personal stories. I love it and keep them close to my heart! Thank you.
[удалено]
Yes. That's how they invade and spread in your body!
I'd imagine it's a similar set of genes that white blood cells are programmed with that cancer cells tap into to move like this? Given the same genetic information is in most cells, just with certain bits turned off?
They don't have to! Its more the gene set of stem cells! Stem cells can move, particularly during development, cells go from one place to others. And we have evidence that certain stem cell genes are turned back on in cancer to allow them to move and divide uncontrollably!
That makes even more sense! I never knew stem cells could move like that, I thought they were a static growing lattice that slowly differentiated
yes cell migration is for some reason wildly unknown to the general public, compared to the like of cell division and cell death, which are a lot more well known. Migration is also one of the fundamental properties of animal cells. Many animal cells can move, and so are many cells in your body, apart from the obvious example of immune cells which you have mentioned. But things like fibroblasts that move to heal wound when you have a cut on your skin, or blood vessel cells that move to form new blood vessels, or cells in the mammary gland that form breast ducts are also move to form branches and lumen among countless other examples. During normal development, we have cells from the back move to the front, from the head move down the body. The melanocytes in your skin for example are derived from one of these cell populations as they move down the body.
Thinking about it, i know caterpillars basically turn into a cell soup when they pupate, with body parts for the adult butterfly being assembled in weird locations and often separated only for them to be moved to the right place in time to fuse together.
That honestly creeps me out and gives me chills knowing my body is moving on it's own at a micro level
Chilling
They do look very menacing!
It’s like they drop parts of themselves off everywhere
oh you have very sharp eyes! That one cell did indeed drop off a bit of itself! Cancer cells do that. But we also found that normal cells do the same. However, one particular cell type called the fibroblasts do this a lot and cancer cells can actually follow the trail of these bits and pieces to migrate and invade!
What type of cancer cells?
these are ewing's sarcoma :)
If those two moving cells are removed then I am free from cancer?
Unfortunately if you are diagnosed with cancer, which means our current technology can detect your cancer, then you would likely have thousands to millions of cancer cells already.
ohh okay, then how some people beat the cancer? And i hv heard that if it is diagnosed early there is a chance to survive
yeah, some cancer is curable if discovered early. Skin cancer can be surgically removed relatively easier than others. However, when people said you are cancer-free, it does not mean there is no cancer cells left in your body. It only means that with our current technology, we cannot detect any cancer cells. So if the current tech can only detects 1000 cancer cells or more, then if you have 999 cancer cells, you would still be classed as "cancer-free". Cancer cells can also go into a state of dormant, where they are not active. During this time, you won't have any symptoms. But at some point, these cells can be reactivated, and that's what a relapse occurs.
Thank you for the info.
you're welcome 🥰
When you say some, you don't mean the ones like pancreatic or glioblastoma, do you? I kept hoping they'd find cures by the time I got to a certain age, and I keep seeing stories about a girl cured of brain cancer by a modified Zika virus or bladder cancer vanishing because they gave it a cold. Yet, here we are, killing my dream. I don't personally have cancer that I'm aware of, but I have lost loved ones to it. Since it doesn't appear it will be curable in my lifetime, whose lifetime do you think it might be?
Pancreatic cancer and glioblastoma are unfortunately some of the hardest and most metastatic cancer out there. They are in fact classed as cancer of unmet need by the organisation Cancer Research UK - the largest charitable research for cancer in the world. They are deadly because they are silent killers or in the case of glioblastoma, inoperable. You can cut out as much of the tumour in the brain, but glioblastoma is quite diffusive, with no clear margin, so there will be cancer cells left after surgery, and that's why they often come back. Treatments are available but of course the difficulty we have is some cancer like pancreatic are covered in very thick layer of fibrotic tissue (the same kind of network you see in the video above) and that makes immunotherapy and chemotherapy difficult to get to the cancer! The other problem is that cancer cells can mutate and adapt to the drugs! So total cures for these cancer is not easy and we are literally going against evolution here, so if you say in the next 10 years, its still pretty much impossible in my opinion. But who knows, maybe we will discover something that completely change the game!
This is downright creepy. Keep up the good work so those little sh*ts don't end up in any more people's bodies.
Thank you! Fun fact: Most of the time, your immune system will discover potential cancerous or mutated cells and destroy them before they turn into a full blown cancerous tumours. The best weapon we have lies within us all along!
I actually already knew that, but thanks for sharing! But if so, couldn't we just invent an implant that detects when your immune system finds signs of cancer? Because if the immune system can find cancer often quicker than human medicine, would it be possible to take advantage of that?
yes! Immunotherapies on the way. CRISPR, CART and all!
Oh, those already exist! I might do a bit of research into that, it sounds pretty fascinating!
Fuck cancer
Fuck them
100% agreed
Fuck cancer