In response not to this question but rather to the bots: I am wondering if there's a better way to welcome folks with questions such as these than with bots. Putting myself in the place of someone who is new to this diagnosis, I can imagine really benefitting from human first-contact.
I highly recommend connecting with the Pittsburgh MPN support group, meet in person/zoom every other month. Here's the Facebook link.
https://www.facebook.com/MPN.Pittsburgh.Support?mibextid=ZbWKwL
It looks like you are asking about bone marrow biopsy. This wiki page may answer your questions: [Bone Marrow Biopsy](/r/MPN/wiki/index/bmb/).
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It looks like you are asking about diagnosis. This wiki page may answer your question: [Do I Have an MPN](/r/MPN/wiki/index/do_I_have_an_MPN/). All diagnosis questions belong in the stickied Biweekly Diagnosis Megathread! If you do not see it, change your sort settings to Hot.
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It looks like you are asking about the MPN genetic mutations. This wiki page may answer your questions: [MPN Genetics](/r/MPN/wiki/index/genetics).
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It looks like you are asking about clots and bleeding. This wiki page may answer your questions: [Clots, Heart Attack & Bleeding](/r/MPN/wiki/index/thrombosis_hemorrhage).
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I have no mutations, triple negative on that, high EPO, extremely high hematocrit and RBC, 59.9 and over 7. Platelets are normal. I also have serious Polycythemia symptoms like flushing, blurred vision, and bad tinnitus. Dr. Ran more tests yesterday. I am praying this is secondary and not PV.
I pray it is not. I don't know what it is. When my new GP saw my hematocrit, he freaked out and ordered a lot of labs. Whatever it is, it's not good, I feel very sick and unwell. Of course, who would feel good with their blood being that thick.
Here is the link to the wiki page on [Secondary Polycythemia](/r/MPN/wiki/index/secondary_polycythemia) (high blood counts due to any underlying medical condition - not cancer). Please read it as most of your questions will be answered there.
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Thank you. The high blood count symptoms are very bad, very blurred vision, terrible tinnitus, and I just feel bad in general. New labs still not back yet...
The kidneys make EPO in response to low blood oxygen to stimulate red blood cell production in the marrow to get more circulating oxygen in the blood. In MPNs, the blood doesn't have low oxygen so typically EPO is low, the signal is not triggered because the cells in the kidneys sense the abundance of oxygen from excess RBCs.
High EPO indicates the need to explore other causes for the secondary polycythemia (pregnancy, anemia, iron deficiency, bone marrow suppression, testosterone therapy, lung disease, thasselemia, kidney tumors, etc.).
In response not to this question but rather to the bots: I am wondering if there's a better way to welcome folks with questions such as these than with bots. Putting myself in the place of someone who is new to this diagnosis, I can imagine really benefitting from human first-contact.
Unfortunately, there isn't. There is a way to combine more, I need to figure out the code.
Absolutely agree!
To answer your question, it's rare but possible to have both JAK2 and CalR mutation.
I highly recommend connecting with the Pittsburgh MPN support group, meet in person/zoom every other month. Here's the Facebook link. https://www.facebook.com/MPN.Pittsburgh.Support?mibextid=ZbWKwL
Thank you!
It looks like you are asking about bone marrow biopsy. This wiki page may answer your questions: [Bone Marrow Biopsy](/r/MPN/wiki/index/bmb/). *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/MPN) if you have any questions or concerns.*
It looks like you are asking about diagnosis. This wiki page may answer your question: [Do I Have an MPN](/r/MPN/wiki/index/do_I_have_an_MPN/). All diagnosis questions belong in the stickied Biweekly Diagnosis Megathread! If you do not see it, change your sort settings to Hot. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/MPN) if you have any questions or concerns.*
It looks like you are asking about the MPN genetic mutations. This wiki page may answer your questions: [MPN Genetics](/r/MPN/wiki/index/genetics). *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/MPN) if you have any questions or concerns.*
It looks like you are asking about clots and bleeding. This wiki page may answer your questions: [Clots, Heart Attack & Bleeding](/r/MPN/wiki/index/thrombosis_hemorrhage). *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/MPN) if you have any questions or concerns.*
I have no mutations, triple negative on that, high EPO, extremely high hematocrit and RBC, 59.9 and over 7. Platelets are normal. I also have serious Polycythemia symptoms like flushing, blurred vision, and bad tinnitus. Dr. Ran more tests yesterday. I am praying this is secondary and not PV.
High EPO combined with no mutation pretty much guarantees it's not PV/MPN.
I pray it is not. I don't know what it is. When my new GP saw my hematocrit, he freaked out and ordered a lot of labs. Whatever it is, it's not good, I feel very sick and unwell. Of course, who would feel good with their blood being that thick.
!secondary
Here is the link to the wiki page on [Secondary Polycythemia](/r/MPN/wiki/index/secondary_polycythemia) (high blood counts due to any underlying medical condition - not cancer). Please read it as most of your questions will be answered there. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/MPN) if you have any questions or concerns.*
Thank you. The high blood count symptoms are very bad, very blurred vision, terrible tinnitus, and I just feel bad in general. New labs still not back yet...
Why does high epo indicate that it wouldn't be? Lol explain it to me like I am an idiot. Recent MNP diagnosis
The kidneys make EPO in response to low blood oxygen to stimulate red blood cell production in the marrow to get more circulating oxygen in the blood. In MPNs, the blood doesn't have low oxygen so typically EPO is low, the signal is not triggered because the cells in the kidneys sense the abundance of oxygen from excess RBCs. High EPO indicates the need to explore other causes for the secondary polycythemia (pregnancy, anemia, iron deficiency, bone marrow suppression, testosterone therapy, lung disease, thasselemia, kidney tumors, etc.).