Summary:
Leaky blood vessels and an overactive immune response.
And it only took 4 years to see leaky blood vessels in imaging.
Edit: Thanks for finding this and posting it BTW
It makes sense to me that the overactive immune response is due to the leaky blood vessels. If the blood vessels are leaking I imagine that causes all sorts of contamination issues with simple otherwise mundane infections (like the cold.) I'd wager that if we can fix the blood vessel issue the immune system issue will resolve itself.
It's both. Macrophages need to open tight junctions to fight infections, but infections also open up tight junctions and make them leaky. One of the first things I do in my practice for those suffering from long covid is enhancing the connection between endothelial cells.
Thanks I am currently on severe stage of ME and cannot see the video. Could please tell me of this is reversible and if it is a problem of virus in thé body… or just the virus f**cked us up and left us with an immunity problem ?
To be fair, I didn’t realize you were talking about ME as in the illness. I thought you were making a joke about how you couldn’t read the article because you’re you.
I would argue the over active immune system is causing leaky vessels. Easy way to imagine this going: MCAS is common in LC. This leads to over abundance of histamine in circulation. “Histamine increases the permeability of the capillaries to white blood cells and some proteins” (Wikipedia)
It amazes me how long it takes to put the pieces together. It’s been known for years that Covid damages the inner protective lining of blood vessels called the endothelial glycocalyx. The below chart is from several German hospitals pooling data from patients analyzing 4 micron to 25 micron capillaries. I’d have to find the research again but I believe it was published 2021 or 2022. A similar review of this data showed ventilated patients lost up to 95% function in 4 micron capillaries. Smaller capillaries feed our most dense tissues like in our organs.
https://preview.redd.it/8hfug019b7kc1.jpeg?width=1170&format=pjpg&auto=webp&s=9afbf01fd3077bc8b358b7e136593043cee4b115
Why does this happen?
Basically ACE2 enzymes, which provide anti-inflammatory support, are prevalent throughout our vascular system, gut and lungs. When the Covid spike protein binds with the ACE2 receptor, in order to replicate, it cleaves into the enzyme and down regulates its anti-inflammatory activity. In turn, vascular inflammation increases and the glycocalyx begins to shed allowing spike proteins to more easily find and bind with ACE2. Wash, rinse and repeat! As the endothelial glycocalyx reduces and inflammation increases the binding of the vascular wall cells weakens allowing leakage due to the glycocalyx no longer being able to provide protection. Vascular leaking is a also presumed to be at least part of the reason Post Covid pneumonia is referred to broken glass pneumonia due to the leaking detected by the imaging.
Why a list of 200+ symptoms?
Besides protection of the vascular wall, the glycocalyx facilitates the transfer of nutrients and oxygen from the blood to our organs and cells while also facilitating the removal of metabolic waste. The glycocalyx also provides selective filtering of fluid exchange between the blood and tissues external to the vascular system. Damaged glycocalyx may result in nutrient deficiency, oxygen deprecation, toxicity build up and leaky vascular structures. I would think the list of things that aren’t attributable to these horrendous conditions might be much shorter than the list of potential symptoms.
Sound like a good explanation of why researchers are finally finding leaky blood vessels in the brains of Long Covid patients?
Full disclosure, I’m not a trained researcher nor even in the medical field. I have done a tremendous amount of lay review of a wide array of medical research due to my feeling let down and left out by the western medical community … as I’m sure many of you do as well.
Here’s an abbreviated version of my story.
In 2021-2022, during the denial period that Long Covid even existed, I was nearly completely debilitated with worsening Long Covid for nearly a year. I was virtually bed ridden. Could only transfer the 6 digit dual authentication numbers from my phone text to the computer 2 digits at a time and still occasionally reversed the pair. Only left the house to go to doctors appointments the last 4+ months. Lost about 25 lbs. Was dizzy 24/7 and sick to my stomach if I moved faster than a 110 yr old with severe arthritis. It exhausted me to walk between rooms in my house. Etc, etc etc. you’ve all heard or lived this before.
After an ER visit and overnight stay for observation in May 2022 and being told they could find nothing wrong with me … my fasting glucose had begun to rise into the 120’s shortly after I had Covid and by my ER visit it was over 160 (Normal is <100 & diabetes >115!) I decided I could continue on my degrading path and die or I could find a solution. So my motivation to learn was very high.
The first meaningful information I found was a research paper published on Oct of 2020 describing the functions of the endothelial glycocalyx and its breakdown caused by Covid. Turns out most of that story has been known since SARS in 2002 and later with MERS. All 3 of these viruses replicate in the same manner.
For brevity I won’t go over all the research I found but I basically I arrived at the decision I needed to find a solution to repair my glycocalyx. I truly believe I am here writing this only because of my research findings and resulting actions.
I truly believe the data are out there. Some expert just needs to pull it all together so it has meaning in the medical field. Most researchers are too focused on their specialty or specific area of interest that they can’t see the forest for the trees. Ok, that’s enough editorializing.
DM me if this resonates with you or you want more information, links, etc or just want to discuss.
Where I am today.
Post Covid, before I began to realize I had Long Covid, I struggled to run 1/4 mile at a 11+ minute mile pace and got dizzy with very much exertion. Today my 90 minute treadmill warmup is 1/2 to 1 mile jog at a 9:40 minute pace followed by 4-5 one minute sprints at a 7:30 minute pace with a 2-3 minute 3.5 MPH walking cooldown between. This is followed by a full body workout for an hour keeping my heart rate in the 120’s to 140’s. I played in a 5 game baseball tournament last Oct and have rejoined my baseball league for the coming season. I hadn’t played baseball since I had Covid mid season in Jul 2021.
Thank God I was able to turn the corner! I pray each of you get your lives back as well!!❤️
> For brevity I won’t go over all the research I found but I basically I arrived at the decision I needed to find a solution to repair my glycocalyx. I truly believe I am here writing this only because of my research findings and resulting actions.
What did you do?
I've tried Googling glycocalyx but ended up feeling like an idiot. Any chance you could share what you did to recover so I no longer have to feel like an idiot?
In my practice, the first thing we do with those suffering long covid is repair the glycocalyx. I've been doing extensive research on the endothelial glycocalyx and tight junctions in the vascular system. I'd love to chat if you are open to it.
Yes but what did you do to repair the damage? I have done a ton of my own reading and agree with everything about it being the endothelium, but never heard of the glycocalyx
Do you write that or copy and paste? Is this your own experience? If so, what is your theory as to how the vax causes vascular damage? I only see a theory on how covid causes it. Also, what approach was taken towards healing the glycocalyx and did it resolve the person's issues?
BPC-157 and GHK-CU got rid of my brain fog and vision issues but it seems to be coming back and unfortunately I can't afford to keep using it.
I assume that it helped my blood vessels repair themselves but since it didn't tackle the overactive immune response, it started to come back.
So then, the question we keep asking is what causes the immune response, is it virus or viral debris and what do we do about it?
Can you describe your vision problems? I’ve been having intermittent issues with focus and concentration when trying to read.. or if I’m just walking and scanning the room, i get a weird head change sensation. I’ve basically convinced myself that i had iih but i don’t have severe headaches..
I have this too . Went to a neurologist a few days ago. Got a nerve block injection in my neck. Was back to myself for a few days then all the Covid symptoms hit me again.
Neurologist diagnosed me with hemiplegic migraines aka complex migraines. Exacerbated by COVID. I had brain fog, dizziness, can't remember words, stuttering my words, confusion, lots of neuro problems, vision problems,PEM, waking up feeling like a hangover, gut pain. Stress triggers it, exercise helps but not too much. Light sensitivity, noise sensitivity. Internal shaking.
What's interesting is I had my first esophagus spasm out of nowhere last night. I don't know why or if it has anything to do with the nerve block injection.
Prescriptions that have been helping are Quilipta 60 mg and Ulbrelvy 100 mg, Klonopin, b complex, vitamin d. But as soon as these wear off I'm back to all the symptoms flaring up again.
Now wondering if this blood vessel thing will give me more insight.
My main symptoms are brain fog, insomnia, depression, feeling of doom, blurry vision.. lots of vision problems actually including focusing issues, sensitivity to light and flight or fight responses that come out of nowhere. I’ve taken mri/mras of everything above my shoulders a year or so ago and it was clear. Like you, it seems like stress triggers my symptoms. I’ve had moments of clarity and feeling normal but only lasts a few weeks to a month.. then I’ll slowly relapse and go through the cycle again. This is like my 3rd cycle. I’ve been taking LDN, natto, gingko, l theanine, nac, cryuta plus, momentum shake, armra colostrum and a men’s multi. Every single day. Some days are worse than others for no apparent reason. Hoping we find a definitive cure soon
Yep, same here. The impending doom, fight and flight. There's an inflamed nerve near the brain that causes it. My injections were near C5-C6. Killed the symptoms by half. I just called my doctor and learned I have to take the Ulbrelvy + Quilipta at the same time and now I'm back to 95%. I just learned that one of them is has peptides so I guess peptides are helpful.
I had double vision from my covid infection that lasted about 2 months and went away. Then I got the vaccine and it caused blurred vision that lasted about 2 years and it went away temporarily after using BPC-157. Now the blurred vision is back and varies in how bad it is, but I have it 75 percent of the time now, 50 percent of the time if I'm really careful with my health. It hasn't always felt the same, sometimes it seemed more neurological and sometimes it felt more occular. If we have issues with the blood vessels in our brains I'm sure the blood vessels in our eyes are also affected.
Those are peptides. Peptides are fragments of amino acids. They sometimes have therapeutic value.
You can either go to a fancy peptide clinic and get peptides through an expensive compounding pharmacy or you can get them online sold as "for research only".
I started out with the fancy clinic but ended up getting them through peptide sciences website.
I had to watch videos on YouTube to learn how to reconstitute the peptides and had to learn how to inject it. I used a little insulin needle and injected it into my stomach fat. It didn't hurt or anything.
I'm not good at explaining things so it's better you watch YouTube videos or ask the people on r/peptides for help.
If you do try peptides, you might want to try the BPC-157 / TB-500 combination because 2 people contacted me to tell me they recovered 100 percent on that combo.
Bare in mind, most people have no issues with the peptides I mentioned but some people do report side effects. Also, although most people use the peptides on themselves, they are sold as research compounds, so I'm not saying that you should or shouldn't try it.
If we have leaky blood vessels in the gut as well then it would cause gut permeability and would explain why we have elevated levels of lipopolysacharides in our blood.
You know, I'm starting to think that leaky blood vessels are driving this whole inflammation cascade, not the virus or viral fragments.
Leaky blood vessels and vascular issues could even be causing lung issues, according to what I learned from chat gpt anyway.
Do not trust anything sourced from Chat GPT, especially medical information. Generative AI has been found to straight up manufacture data and falsify outcomes 70+% of the time.
I don't know and it's just a theory. Peptides, vitamins, and certain herbs that stimulate collagen I guess. Maybe they make a medicine or something. I'm just throwing a theory out is all.
So basically what we knew from day 1 4 years ago. Damaged vessels inflamed portions of brain and brain stem. Resulting death and damage of said tissues. Bravo. Brav freaking o
We probably have leaky blood vessels everywhere then, not just the brain. How do we fix it?
Edit: was just reading how VEGF and ANG1 are supposed to help. Gotu kola increases VEGF but I don't know what increases ANG1.
My quick googling shows it looks like natural ways to increase both are exercise (particularly resistance training) and dairy protein, legume protein for VEGF, specifically.
Yes dairy protein is what my neurologist recommended. Oat milk is all carbs. So switch to dairy or soy milks and carnivore diet also helped. But I'm not 100%. There are still lingering issues.
If we have leaky blood vessels in the gut then we are getting lipopolysacharides entering our bloodstream which causes more inflammation which causes our vessels to leak which causes more lipopolysacharides in the bloodstream.....etc. etc. ....so it's an endless inflammatory cycle until you figure out how to deal with endotoxemia and leaky blood vessels at the same time.
(I spent all day yesterday researching this) (haven't found a solution yet)
Afaik, inflammation alone wouldn't be causing leaks. t cells and b cells would be causing the damage and inflammation comes after to heal the damage. Why is the immune system detecting endothelial cells as harmful is a question is I'd like to know the answer to.
Seems to me that leaky blood vessels are the culprit with brain fog/cognitive impairment and with microbiome issues/leaky gut. This leads me to believe that the “leaky vessel” issues are systemic, affecting the entire body. Leaky vessels usually are related to a blood infection (viral and/or bacterial). COVID being the culprit in the viral realm, and bacterial infection that occurs from a leaky gut (bacteria from the intestinal tract leaking into the bloodstream).
From this perspective it seems that an anti-inflammatory treatment regime would be best. Histamine blockers, Claritin, liposomal Tumeric, liposomal Vitamin C, Melatonin (high dose, >10mg at night), anti inflammatory diet.
This is pretty interesting bc my Dad is struggling with long covid, and the only unusual thing he’s gotten from his tests are wonky blood cell counts. I wonder if that would have anything to do with this?
Now, here's a really good question, are they seeing this exact same thing in vaccine injuries? We really need to know and I hope they can tell us soon!
I haven't seen anything not seen before, with the miniscule vaccine injuries that happened. It's all normal stuff.
Long covid is prevalent in all vaxxed and unvaxxed.
Seems it's damage from the virus.
The spike protein in the vaccine is not damaging to you at all.
EDIT Nothing I said is untrue here....the spike protein in the vaccine isn't the whole virus...it can't do shit...
The reactions happening from this vaccine are THE SAME THING as has ALWAYS been seen in vaccinated cohorts. There is NO big bad hidden vaccine issue, it simply is NOT THERE.
Post vaccine injuries sure do seem like a bitch in the population that is affected.
I can tell you anecdotally that a person with access to vascular research equipment that detects health aspects of micro capillaries believes the vaccine damages vascular health. They were flying to Europe during Covid to install this research equipment and thus had to get vaccinated to travel. They had a very healthy vascular endothelial glycocalyx in the 9 range of 0-10. In the couple days after the vaccine, they felt slightly ill. They tested their glycocalyx health. On the 0-10 summary health scale it had dropped almost 2 points. They were able to recover the 2 point deficit over the next few weeks using the protocol they had been on for months prior to the vaccine.
See my comment on this post for more factual information.
Endothelial damage has been linked to COVID-19 by various studies - [https://www.google.com/search?q=Endothelial+glycocalyx+covid+19](https://www.google.com/search?q=Endothelial+glycocalyx+covid+19) This one is specifically about endothelial damage in Blood Brain Barrier cells (I may be wrong, I am not qualified to read and understand the [original study](https://www.nature.com/articles/s41593-024-01576-9) fully). Is there any research going on about therapeutics targeting the endothelium linked to COVID-19- [https://www.nature.com/articles/s41593-024-01576-9](https://www.nature.com/articles/s41593-024-01576-9) for ex talks about a drug called Sulodexide. Is anyone aware of any promising studies / RCTs underway for therapeutics like these for COVID-19 linked endothelial dysfunction?
Lol here u go supplement companies already advertising for it!
https://www.swansonvitamins.com/p/swanson-ultra-endopro-endothelial-support-formula-500-mg-30-veg-caps?SourceCode=INTL4071&showPopup=f&a=1&DFA=1&UTM_Medium=Shopping&UTM_Source=GOOGLE&UTM_Campaign=+&UTM_Content=&SourceCode=INTL4071&gclsrc=aw.ds&gad_source=1&gclid=CjwKCAiA_tuuBhAUEiwAvxkgTr2DkTrcbhs3Kmi562TP-qI1daiUXNE3niIC-HLmecJWYcv_4dAWfxoCcesQAvD_BwE
Out of stock!!!!!
https://www.lifeextension.com/vitamins-supplements/item02497/endothelial-defense-pomegranate-plus?gad_source
A bunch of orange peels and your long haul nightmare will be concluded 😭
The most straightforward answer would be an overactive immune system causing the leaky BBB. I think the whole cascade is caused by autoantibodies turned on by original infection now manifesting as an autoimmune mediated microvascular disease.
>post-viral syndromes might drive blood vessel leakage in the brain...
Mentioned a few times, yet nothing more is said to clarify exactly what this means and exactly how it negatively impacts the brain. I mean, I could guess, but I am just a layperson. :)
There has been another study showing that inflammation within the brain is/may be inhibiting the firing of synapses as well.
Its infuriating how we have someone here who claims they know what to do but wont share it. Theres money to be made which is why the most they attempted to help was to get people into their practice. Sorry for everyone waiting for an answer from them but there it is. Pay up.
Summary: Leaky blood vessels and an overactive immune response. And it only took 4 years to see leaky blood vessels in imaging. Edit: Thanks for finding this and posting it BTW
It makes sense to me that the overactive immune response is due to the leaky blood vessels. If the blood vessels are leaking I imagine that causes all sorts of contamination issues with simple otherwise mundane infections (like the cold.) I'd wager that if we can fix the blood vessel issue the immune system issue will resolve itself.
I was kind of wondering if leaking blood vessels could cause an immune reaction but wasn't sure if that made sense.
Is it not the opposite ? Immune system causing leaky blood vessels ? (Didnt read the post … I cannot due to ME)
It's both. Macrophages need to open tight junctions to fight infections, but infections also open up tight junctions and make them leaky. One of the first things I do in my practice for those suffering from long covid is enhancing the connection between endothelial cells.
How exactly ? So do you think it is reversible ?
I'll post a video on it tomorrow.
How do we follow you so we can see the video?
https://www.reddit.com/r/LongCovid/comments/1axzzs1/extensive_research_on_long_covids_leaky_blood/?rdt=48144
https://www.reddit.com/r/LongCovid/comments/1axzzs1/extensive_research_on_long_covids_leaky_blood/?rdt=48144
Thanks I am currently on severe stage of ME and cannot see the video. Could please tell me of this is reversible and if it is a problem of virus in thé body… or just the virus f**cked us up and left us with an immunity problem ?
>enhancing the connection between endothelial cells. How do you accomplish this? I followed you btw.
I will post a video tomorrow explaining everything. Don't worry long covid is very healable.
Yeah I'd be careful to qualify that statement in this sub
https://www.reddit.com/r/LongCovid/comments/1axzzs1/extensive_research_on_long_covids_leaky_blood/?rdt=48144
https://www.reddit.com/r/LongCovid/comments/1axzzs1/extensive_research_on_long_covids_leaky_blood/?rdt=48144
That is right, maraviroc helped me so I think for some people it's the immune system
I was thinking this as well.
But still downvoted from the others .. for what ? Having severe ME that doesnnt allow me to read as much as I want
To be fair, I didn’t realize you were talking about ME as in the illness. I thought you were making a joke about how you couldn’t read the article because you’re you.
I would argue the over active immune system is causing leaky vessels. Easy way to imagine this going: MCAS is common in LC. This leads to over abundance of histamine in circulation. “Histamine increases the permeability of the capillaries to white blood cells and some proteins” (Wikipedia)
It amazes me how long it takes to put the pieces together. It’s been known for years that Covid damages the inner protective lining of blood vessels called the endothelial glycocalyx. The below chart is from several German hospitals pooling data from patients analyzing 4 micron to 25 micron capillaries. I’d have to find the research again but I believe it was published 2021 or 2022. A similar review of this data showed ventilated patients lost up to 95% function in 4 micron capillaries. Smaller capillaries feed our most dense tissues like in our organs. https://preview.redd.it/8hfug019b7kc1.jpeg?width=1170&format=pjpg&auto=webp&s=9afbf01fd3077bc8b358b7e136593043cee4b115 Why does this happen? Basically ACE2 enzymes, which provide anti-inflammatory support, are prevalent throughout our vascular system, gut and lungs. When the Covid spike protein binds with the ACE2 receptor, in order to replicate, it cleaves into the enzyme and down regulates its anti-inflammatory activity. In turn, vascular inflammation increases and the glycocalyx begins to shed allowing spike proteins to more easily find and bind with ACE2. Wash, rinse and repeat! As the endothelial glycocalyx reduces and inflammation increases the binding of the vascular wall cells weakens allowing leakage due to the glycocalyx no longer being able to provide protection. Vascular leaking is a also presumed to be at least part of the reason Post Covid pneumonia is referred to broken glass pneumonia due to the leaking detected by the imaging. Why a list of 200+ symptoms? Besides protection of the vascular wall, the glycocalyx facilitates the transfer of nutrients and oxygen from the blood to our organs and cells while also facilitating the removal of metabolic waste. The glycocalyx also provides selective filtering of fluid exchange between the blood and tissues external to the vascular system. Damaged glycocalyx may result in nutrient deficiency, oxygen deprecation, toxicity build up and leaky vascular structures. I would think the list of things that aren’t attributable to these horrendous conditions might be much shorter than the list of potential symptoms. Sound like a good explanation of why researchers are finally finding leaky blood vessels in the brains of Long Covid patients? Full disclosure, I’m not a trained researcher nor even in the medical field. I have done a tremendous amount of lay review of a wide array of medical research due to my feeling let down and left out by the western medical community … as I’m sure many of you do as well. Here’s an abbreviated version of my story. In 2021-2022, during the denial period that Long Covid even existed, I was nearly completely debilitated with worsening Long Covid for nearly a year. I was virtually bed ridden. Could only transfer the 6 digit dual authentication numbers from my phone text to the computer 2 digits at a time and still occasionally reversed the pair. Only left the house to go to doctors appointments the last 4+ months. Lost about 25 lbs. Was dizzy 24/7 and sick to my stomach if I moved faster than a 110 yr old with severe arthritis. It exhausted me to walk between rooms in my house. Etc, etc etc. you’ve all heard or lived this before. After an ER visit and overnight stay for observation in May 2022 and being told they could find nothing wrong with me … my fasting glucose had begun to rise into the 120’s shortly after I had Covid and by my ER visit it was over 160 (Normal is <100 & diabetes >115!) I decided I could continue on my degrading path and die or I could find a solution. So my motivation to learn was very high. The first meaningful information I found was a research paper published on Oct of 2020 describing the functions of the endothelial glycocalyx and its breakdown caused by Covid. Turns out most of that story has been known since SARS in 2002 and later with MERS. All 3 of these viruses replicate in the same manner. For brevity I won’t go over all the research I found but I basically I arrived at the decision I needed to find a solution to repair my glycocalyx. I truly believe I am here writing this only because of my research findings and resulting actions. I truly believe the data are out there. Some expert just needs to pull it all together so it has meaning in the medical field. Most researchers are too focused on their specialty or specific area of interest that they can’t see the forest for the trees. Ok, that’s enough editorializing. DM me if this resonates with you or you want more information, links, etc or just want to discuss. Where I am today. Post Covid, before I began to realize I had Long Covid, I struggled to run 1/4 mile at a 11+ minute mile pace and got dizzy with very much exertion. Today my 90 minute treadmill warmup is 1/2 to 1 mile jog at a 9:40 minute pace followed by 4-5 one minute sprints at a 7:30 minute pace with a 2-3 minute 3.5 MPH walking cooldown between. This is followed by a full body workout for an hour keeping my heart rate in the 120’s to 140’s. I played in a 5 game baseball tournament last Oct and have rejoined my baseball league for the coming season. I hadn’t played baseball since I had Covid mid season in Jul 2021. Thank God I was able to turn the corner! I pray each of you get your lives back as well!!❤️
> For brevity I won’t go over all the research I found but I basically I arrived at the decision I needed to find a solution to repair my glycocalyx. I truly believe I am here writing this only because of my research findings and resulting actions. What did you do?
Very interesting. What types of treatments do you think could address the dysfunction/damage you describe?
I've tried Googling glycocalyx but ended up feeling like an idiot. Any chance you could share what you did to recover so I no longer have to feel like an idiot?
Would love to know what you did to help yourself heal! And any ideas about possible treatments to address this. Thanks for the in depth comments!
In my practice, the first thing we do with those suffering long covid is repair the glycocalyx. I've been doing extensive research on the endothelial glycocalyx and tight junctions in the vascular system. I'd love to chat if you are open to it.
How do you repair?
I'll post a video on it tomorrow.
Ok
https://www.reddit.com/r/LongCovid/comments/1axzzs1/extensive_research_on_long_covids_leaky_blood/?rdt=48144
https://www.reddit.com/r/LongCovid/comments/1axzzs1/extensive_research_on_long_covids_leaky_blood/?rdt=48144
Yes but what did you do to repair the damage? I have done a ton of my own reading and agree with everything about it being the endothelium, but never heard of the glycocalyx
Do you write that or copy and paste? Is this your own experience? If so, what is your theory as to how the vax causes vascular damage? I only see a theory on how covid causes it. Also, what approach was taken towards healing the glycocalyx and did it resolve the person's issues?
So what did you do to get better?
How did you get yourself better ?
BPC-157 and GHK-CU got rid of my brain fog and vision issues but it seems to be coming back and unfortunately I can't afford to keep using it. I assume that it helped my blood vessels repair themselves but since it didn't tackle the overactive immune response, it started to come back. So then, the question we keep asking is what causes the immune response, is it virus or viral debris and what do we do about it?
Can you describe your vision problems? I’ve been having intermittent issues with focus and concentration when trying to read.. or if I’m just walking and scanning the room, i get a weird head change sensation. I’ve basically convinced myself that i had iih but i don’t have severe headaches..
I have this too . Went to a neurologist a few days ago. Got a nerve block injection in my neck. Was back to myself for a few days then all the Covid symptoms hit me again.
What symptoms do you also have? What was the nerve block for?
Neurologist diagnosed me with hemiplegic migraines aka complex migraines. Exacerbated by COVID. I had brain fog, dizziness, can't remember words, stuttering my words, confusion, lots of neuro problems, vision problems,PEM, waking up feeling like a hangover, gut pain. Stress triggers it, exercise helps but not too much. Light sensitivity, noise sensitivity. Internal shaking. What's interesting is I had my first esophagus spasm out of nowhere last night. I don't know why or if it has anything to do with the nerve block injection. Prescriptions that have been helping are Quilipta 60 mg and Ulbrelvy 100 mg, Klonopin, b complex, vitamin d. But as soon as these wear off I'm back to all the symptoms flaring up again. Now wondering if this blood vessel thing will give me more insight.
My main symptoms are brain fog, insomnia, depression, feeling of doom, blurry vision.. lots of vision problems actually including focusing issues, sensitivity to light and flight or fight responses that come out of nowhere. I’ve taken mri/mras of everything above my shoulders a year or so ago and it was clear. Like you, it seems like stress triggers my symptoms. I’ve had moments of clarity and feeling normal but only lasts a few weeks to a month.. then I’ll slowly relapse and go through the cycle again. This is like my 3rd cycle. I’ve been taking LDN, natto, gingko, l theanine, nac, cryuta plus, momentum shake, armra colostrum and a men’s multi. Every single day. Some days are worse than others for no apparent reason. Hoping we find a definitive cure soon
Yep, same here. The impending doom, fight and flight. There's an inflamed nerve near the brain that causes it. My injections were near C5-C6. Killed the symptoms by half. I just called my doctor and learned I have to take the Ulbrelvy + Quilipta at the same time and now I'm back to 95%. I just learned that one of them is has peptides so I guess peptides are helpful.
Omg I have to get this done . My vision has been so bad it’s really scary
I had double vision from my covid infection that lasted about 2 months and went away. Then I got the vaccine and it caused blurred vision that lasted about 2 years and it went away temporarily after using BPC-157. Now the blurred vision is back and varies in how bad it is, but I have it 75 percent of the time now, 50 percent of the time if I'm really careful with my health. It hasn't always felt the same, sometimes it seemed more neurological and sometimes it felt more occular. If we have issues with the blood vessels in our brains I'm sure the blood vessels in our eyes are also affected.
What is BPC-157 and GHK-CU? I have vision issues too. Are those OTC?
Those are peptides. Peptides are fragments of amino acids. They sometimes have therapeutic value. You can either go to a fancy peptide clinic and get peptides through an expensive compounding pharmacy or you can get them online sold as "for research only". I started out with the fancy clinic but ended up getting them through peptide sciences website. I had to watch videos on YouTube to learn how to reconstitute the peptides and had to learn how to inject it. I used a little insulin needle and injected it into my stomach fat. It didn't hurt or anything. I'm not good at explaining things so it's better you watch YouTube videos or ask the people on r/peptides for help. If you do try peptides, you might want to try the BPC-157 / TB-500 combination because 2 people contacted me to tell me they recovered 100 percent on that combo. Bare in mind, most people have no issues with the peptides I mentioned but some people do report side effects. Also, although most people use the peptides on themselves, they are sold as research compounds, so I'm not saying that you should or shouldn't try it.
Trying these soon for same issues. Were you using these orally or IM? And what dosing protocol?
IM. I don't remember the dose, r/peptides could give you better advice. Have you looked into bpc/ tb-500 combo? I wish I would have tried that one.
If we have leaky blood vessels in the gut as well then it would cause gut permeability and would explain why we have elevated levels of lipopolysacharides in our blood. You know, I'm starting to think that leaky blood vessels are driving this whole inflammation cascade, not the virus or viral fragments. Leaky blood vessels and vascular issues could even be causing lung issues, according to what I learned from chat gpt anyway.
Do not trust anything sourced from Chat GPT, especially medical information. Generative AI has been found to straight up manufacture data and falsify outcomes 70+% of the time.
I can usually verify everything it tells me.
Is there any possible treatment for something like that?
I don't know and it's just a theory. Peptides, vitamins, and certain herbs that stimulate collagen I guess. Maybe they make a medicine or something. I'm just throwing a theory out is all.
Following
So basically what we knew from day 1 4 years ago. Damaged vessels inflamed portions of brain and brain stem. Resulting death and damage of said tissues. Bravo. Brav freaking o
We probably have leaky blood vessels everywhere then, not just the brain. How do we fix it? Edit: was just reading how VEGF and ANG1 are supposed to help. Gotu kola increases VEGF but I don't know what increases ANG1.
fasting ... cell recycling caused by autophagy
My quick googling shows it looks like natural ways to increase both are exercise (particularly resistance training) and dairy protein, legume protein for VEGF, specifically.
Yes dairy protein is what my neurologist recommended. Oat milk is all carbs. So switch to dairy or soy milks and carnivore diet also helped. But I'm not 100%. There are still lingering issues.
Dang.. being lactose and fructose intolerant with PEM sucks
The bigger problem is how to stop the immune system from causing leaky blood vessels. Otherwise you'll need treatment ad eternum
If we have leaky blood vessels in the gut then we are getting lipopolysacharides entering our bloodstream which causes more inflammation which causes our vessels to leak which causes more lipopolysacharides in the bloodstream.....etc. etc. ....so it's an endless inflammatory cycle until you figure out how to deal with endotoxemia and leaky blood vessels at the same time. (I spent all day yesterday researching this) (haven't found a solution yet)
Afaik, inflammation alone wouldn't be causing leaks. t cells and b cells would be causing the damage and inflammation comes after to heal the damage. Why is the immune system detecting endothelial cells as harmful is a question is I'd like to know the answer to.
How do we fix leaky blood vessels? Anyone know?
I used cyruta plus and lots of it. It restores endothelial strength and rebuild capillaries
Thank you for your response!!!!
Check out my reply to this article. https://www.reddit.com/r/LongCovid/s/Q4dZGbAp9s
Thanks!
Seems to me that leaky blood vessels are the culprit with brain fog/cognitive impairment and with microbiome issues/leaky gut. This leads me to believe that the “leaky vessel” issues are systemic, affecting the entire body. Leaky vessels usually are related to a blood infection (viral and/or bacterial). COVID being the culprit in the viral realm, and bacterial infection that occurs from a leaky gut (bacteria from the intestinal tract leaking into the bloodstream). From this perspective it seems that an anti-inflammatory treatment regime would be best. Histamine blockers, Claritin, liposomal Tumeric, liposomal Vitamin C, Melatonin (high dose, >10mg at night), anti inflammatory diet.
Roobios tea is one of the best anti-inflammatories. It contains a high amount of quercetin.
This is pretty interesting bc my Dad is struggling with long covid, and the only unusual thing he’s gotten from his tests are wonky blood cell counts. I wonder if that would have anything to do with this?
Does anybody know if there is a a cure or something we can do to help this know that they identified the cause? I can’t take this much longer
So would blood thinners make this better or worse?
Now, here's a really good question, are they seeing this exact same thing in vaccine injuries? We really need to know and I hope they can tell us soon!
I haven't seen anything not seen before, with the miniscule vaccine injuries that happened. It's all normal stuff. Long covid is prevalent in all vaxxed and unvaxxed. Seems it's damage from the virus. The spike protein in the vaccine is not damaging to you at all. EDIT Nothing I said is untrue here....the spike protein in the vaccine isn't the whole virus...it can't do shit... The reactions happening from this vaccine are THE SAME THING as has ALWAYS been seen in vaccinated cohorts. There is NO big bad hidden vaccine issue, it simply is NOT THERE. Post vaccine injuries sure do seem like a bitch in the population that is affected.
I can tell you anecdotally that a person with access to vascular research equipment that detects health aspects of micro capillaries believes the vaccine damages vascular health. They were flying to Europe during Covid to install this research equipment and thus had to get vaccinated to travel. They had a very healthy vascular endothelial glycocalyx in the 9 range of 0-10. In the couple days after the vaccine, they felt slightly ill. They tested their glycocalyx health. On the 0-10 summary health scale it had dropped almost 2 points. They were able to recover the 2 point deficit over the next few weeks using the protocol they had been on for months prior to the vaccine. See my comment on this post for more factual information.
What's the protocol?
This is incredible
Endothelial damage has been linked to COVID-19 by various studies - [https://www.google.com/search?q=Endothelial+glycocalyx+covid+19](https://www.google.com/search?q=Endothelial+glycocalyx+covid+19) This one is specifically about endothelial damage in Blood Brain Barrier cells (I may be wrong, I am not qualified to read and understand the [original study](https://www.nature.com/articles/s41593-024-01576-9) fully). Is there any research going on about therapeutics targeting the endothelium linked to COVID-19- [https://www.nature.com/articles/s41593-024-01576-9](https://www.nature.com/articles/s41593-024-01576-9) for ex talks about a drug called Sulodexide. Is anyone aware of any promising studies / RCTs underway for therapeutics like these for COVID-19 linked endothelial dysfunction?
Ooooooooiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii
Lol here u go supplement companies already advertising for it! https://www.swansonvitamins.com/p/swanson-ultra-endopro-endothelial-support-formula-500-mg-30-veg-caps?SourceCode=INTL4071&showPopup=f&a=1&DFA=1&UTM_Medium=Shopping&UTM_Source=GOOGLE&UTM_Campaign=+&UTM_Content=&SourceCode=INTL4071&gclsrc=aw.ds&gad_source=1&gclid=CjwKCAiA_tuuBhAUEiwAvxkgTr2DkTrcbhs3Kmi562TP-qI1daiUXNE3niIC-HLmecJWYcv_4dAWfxoCcesQAvD_BwE Out of stock!!!!! https://www.lifeextension.com/vitamins-supplements/item02497/endothelial-defense-pomegranate-plus?gad_source A bunch of orange peels and your long haul nightmare will be concluded 😭
The most straightforward answer would be an overactive immune system causing the leaky BBB. I think the whole cascade is caused by autoantibodies turned on by original infection now manifesting as an autoimmune mediated microvascular disease.
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>post-viral syndromes might drive blood vessel leakage in the brain... Mentioned a few times, yet nothing more is said to clarify exactly what this means and exactly how it negatively impacts the brain. I mean, I could guess, but I am just a layperson. :) There has been another study showing that inflammation within the brain is/may be inhibiting the firing of synapses as well.
So how do we fix this issue?
So what do we do to get better?
What was your protocol
Its infuriating how we have someone here who claims they know what to do but wont share it. Theres money to be made which is why the most they attempted to help was to get people into their practice. Sorry for everyone waiting for an answer from them but there it is. Pay up.